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1. 发明授权

US06874354B2 Sample injection valve for high-performance liquid chromatography (HPLC) devices 失效
标题翻译：用于高效液相色谱（HPLC）装置的样品注射阀
公开(公告)号：US06874354B2
公开(公告)日：2005-04-05
申请号：US10415872
申请日：2001-11-12
申请人： Hansjörg Cueni , Heinrich Scherrer
发明人： Hansjörg Cueni , Heinrich Scherrer
IPC分类号： G01N35/10 , G01N30/20 , G01N30/24 , G01N31/08
CPC分类号： G01N30/20 , G01N30/24 , G01N2030/201 , G01N2030/202 , Y10T137/86743 , G01N2030/402
摘要： The sample injection valve for high-performance liquid chromatography (HPLC) devices comprises a stator with inlets for the sample and the mobile phase, outlets leading to the chromatography column and to a waste collector, as well as connections for both ends of a sample loop. Its rotor has the customary connection channels. An additional washing liquid inlet (7) opens into the connecting channel (9) that, in one valve position, connects the sample inlet (1) to the outlet (2) leading to the waste collector. This enables the sample inlet and the pipette or syringe located therein to be rinsed.
摘要翻译：用于高效液相色谱（HPLC）装置的样品注射阀包括具有用于样品和流动相的入口的定子，通向色谱柱和废物收集器的出口，以及样品环两端的连接。其转子具有常规的连接通道。另外的洗涤液入口（7）通向连接通道（9），在一个阀位置，将样品入口（1）连接到通向废物收集器的出口（2）。这使得样品入口和位于其中的移液管或注射器能够被冲洗。

2. 发明授权

US5753795A Demountable vacuum-sealing plate assembly 失效
标题翻译：可拆卸的真空密封板组件
公开(公告)号：US5753795A
公开(公告)日：1998-05-19
申请号：US644387
申请日：1996-05-10
申请人： Ned R. Kuypers
发明人： Ned R. Kuypers
IPC分类号： B01J3/00 , B01J3/03 , F16K51/02 , H01J49/04 , G01N31/08 , G01N3/08
CPC分类号： F16K51/02 , B01J3/006 , B01J3/03 , H01J49/00
摘要： A detachable, vacuum-sealing plate assembly is provided for vacuum chamber access. The assembly has a demountable hinge, thereby permitting the plate to be swung open or closed, or completely removed from the chamber. The swung-closed plate is automatically pressure-sealed to the chamber during vacuum pump-down by the pressure differential between the interior of the chamber and the outside atmosphere. The plate is released upon vacuum venting, thereby providing swing-open access to the chamber. Functional components may be mounted to the plate. The plate may also have associated high-vacuum electrical fluid flowpath transfer or physical component feed-throughs.
摘要翻译：提供可拆卸的真空密封板组件用于真空室进入。组件具有可拆卸铰链，从而允许板被打开或关闭，或者完全从腔室移除。通过室内和室外气氛之间的压力差，在真空泵送期间，摆动封闭的板被自动压力密封到室。在真空排气时释放板，从而提供对室的摆动开放通路。功能部件可以安装在板上。该板还可以具有相关联的高真空电流体流路传输或物理部件馈通。

3. 发明授权

US5369977A Gaseous detection system 失效
标题翻译：气体检测系统
公开(公告)号：US5369977A
公开(公告)日：1994-12-06
申请号：US187779
申请日：1994-01-24
申请人： Kevin Rhodes , Ernie Vandenwijngaert
发明人： Kevin Rhodes , Ernie Vandenwijngaert
IPC分类号： G01N33/00 , G01N33/497 , G01N31/08
CPC分类号： G01N33/4972 , G01N33/0006
摘要： A gaseous detection system for detecting the existence of a certain gas and further detecting a certain level or percentage of that certain gas within a prescribed environment. An example is the use of the gas detection system in a motor vehicle or elsewhere to determine when the driver of the motor vehicle may be driving under the influence of alcohol, and alternatively, for providing signals that may be used for evidentiary purposes of the alcohol content in the breath of the driver. The system includes a sensor unit for sensing ethanol in the atmospheric contents of the test person's breath and utilizing fresh air and a reference gas to determine the amount, if any, of blood-alcohol content of a person for evidentiary or other purposes.
摘要翻译：一种气体检测系统，用于检测特定气体的存在，并进一步检测在规定环境内某一气体的一定水平或百分数。一个例子是在机动车辆或其他地方使用气体检测系统来确定机动车辆的驾驶员何时可能在酒精的影响下驾驶，或者提供可用于酒精证据目的的信号内容在司机的呼吸中。该系统包括一个传感器单元，用于感测测试人员呼吸的大气内容物中的乙醇，并利用新鲜空气和参考气体来确定用于证据或其他目的的人的血液 - 酒精含量的量（如果有的话）。

4. 发明授权

US4696187A Chromatography method 失效
标题翻译：色谱法
公开(公告)号：US4696187A
公开(公告)日：1987-09-29
申请号：US696399
申请日：1985-01-30
申请人： Reiner H. Kopp , Allen I. Panetz
发明人： Reiner H. Kopp , Allen I. Panetz
IPC分类号： G01N30/60 , G01N30/91 , G01N31/08
CPC分类号： G01N30/91 , G01N30/6065
摘要： A method for rapidly transferring chromatography or adsorption column eluates in a continuous flow directly to the chromatography plate for continuous evaporation of the solvents at a rate compatible with the flow.
摘要翻译：将连续流动的色谱或吸附柱洗脱液快速转移到色谱板上的方法，用于以与流体相容的速率连续蒸发溶剂。

5. 发明授权

US4540548A Method of detecting fluorescent materials and apparatus for their detection 失效
标题翻译：检测荧光材料的方法及其检测装置
公开(公告)号：US4540548A
公开(公告)日：1985-09-10
申请号：US499417
申请日：1983-06-02
申请人： Kazuhiro Imai , Tamura Zenzo , Kobayashi Shin-Ichiro
发明人： Kazuhiro Imai , Tamura Zenzo , Kobayashi Shin-Ichiro
IPC分类号： G01N21/76 , G01N30/74 , G01N31/08
CPC分类号： G01N30/74 , G01N21/76
摘要： A method for detecting fluorescent materials in liquid chromatography. Fluorescent materials are excited by chemical reaction with chemical reagents to yield light (chemiluminescence) and detected at high sensitivity. The detection apparatus is composed of a mixer for mixing a solution containing separated fluorescent materials and solutions of chemical reagents to afford chemiluminescence, a flow cell and a light receptive detection means for detecting the light thus produced.
摘要翻译：一种用于检测液相色谱中荧光材料的方法。荧光材料通过与化学试剂的化学反应而激发，产生光（化学发光）并以高灵敏度检测。检测装置由用于混合含有分离的荧光材料的溶液和化学试剂溶液以提供化学发光的混合器，流动池和用于检测由此产生的光的光接收检测装置组成。

6. 发明授权

US4534941A Analytical instrument thermoelectric temperature regulator 失效
标题翻译：分析仪器热电温度调节器
公开(公告)号：US4534941A
公开(公告)日：1985-08-13
申请号：US327372
申请日：1981-12-04
申请人： Donald E. Stephens , Robert J. Ehret
发明人： Donald E. Stephens , Robert J. Ehret
IPC分类号： G01N30/30 , G05D23/19 , G05D23/24 , G01N31/08
CPC分类号： G01N30/30 , G05D23/1919 , G05D23/24 , G01N2030/3007 , G01N2030/303 , G01N2030/8818
摘要： A temperature control system used to precisely and accurately control the temperature of a fluid stream in an analytical system designed for investigation of the chemical constituents of the fluid stream. One example of use is in chromatography such as for the chromatographic column in an amino acid analyzer system. The temperature control system utilizes a set of thermoelectric modules to transfer heat between a thermoconductive block which holds the chromatographic column and an air exchange heat sink which obtains heat from or disposes heat into ambient air as required. The control system regulates the temperature at a very rapid rate in order to minimize the recycle time of the instrument.
摘要翻译：温度控制系统用于精确和精确地控制设计用于研究流体流化学成分的分析系统中的流体流的温度。使用的一个实例是色谱法，例如氨基酸分析仪系统中的色谱柱。温度控制系统利用一组热电模块在保持色谱柱的导热块和根据需要从其获得热量或将热量置于环境空气中的空气交换散热器之间传递热量。控制系统以非常快的速率调节温度，以便最小化仪器的循环时间。

7. 发明授权

US4517824A Solvent dumping apparatus 失效
标题翻译：溶剂倾倒装置
公开(公告)号：US4517824A
公开(公告)日：1985-05-21
申请号：US510127
申请日：1983-07-01
申请人： Bruce D. Quimby
发明人： Bruce D. Quimby
IPC分类号： G01N30/62 , G01N30/84 , G01N31/08
CPC分类号： G01N30/84 , G01N30/62 , Y10T137/4252
摘要： A solvent dumping apparatus is described having an inlet enclosure coupled to the inlet of a detector and an outlet enclosure coupled to the outlet of a detector. Venting means are provided for both enclosures, one of which is controllable; means are provided for introducing sample gas into the inlet enclosure; and means are provided for introducing gas into the outlet enclosure. During a detection mode, at least one of the venting means is so adjusted as to cause sample gas to flow through the detector and out the venting means for the outlet enclosure, and during a diversionary mode, at least one of the venting means is so adjusted as to cause the gas introduced into the outlet enclosure to pass back through the detector and carry any sample gas out through the venting means for the inlet enclosure. In preferred forms of the invention, one of the venting means is a back pressure regulator.
摘要翻译：描述了具有耦合到检测器的入口的入口外壳和耦合到检测器的出口的出口外壳的溶剂倾倒装置。为两个外壳提供通风装置，其中一个可控制; 提供用于将样品气体引入入口外壳的装置; 并且提供用于将气体引入出口外壳中的装置。在检测模式期间，排气装置中的至少一个被调节成使得样品气体流过检测器并排出出口外壳的通风装置，并且在分流模式期间，至少一个排气装置是如此调整为使引入出口外壳的气体通过检测器返回，并将任何样品气体通过用于入口外壳的排气装置输出。在本发明的优选形式中，排气装置之一是背压调节器。

8. 发明授权

US4512181A Pressure compensation for a chromatograph 失效
标题翻译：色谱仪的压力补偿
公开(公告)号：US4512181A
公开(公告)日：1985-04-23
申请号：US467547
申请日：1983-02-17
申请人： Buell O. Ayers , Edwin K. Clardy
发明人： Buell O. Ayers , Edwin K. Clardy
IPC分类号： G01N30/32 , G01N30/62 , G01N31/08
CPC分类号： G01N30/32 , G01N2030/626
摘要： In a chromatographic analysis, errors in the chromatographic analysis caused by barometric pressure variations are corrected by dividing the actual measured analysis (C.sub.m) by a correction factor which is calculated based on the actual atmospheric pressure at the time the measurement is made (P.sub.a), the atmospheric pressure at which the chromatographic analyzer system was calibrated, and the slope of a plot of C.sub.m /C.sub.a as a function of P.sub.a /P.sub.c where C.sub.a is the magnitude that C.sub.m would have if errors were not introduced by changes in barometric pressure.
摘要翻译：在色谱分析中，通过将实际测量分析（Cm）除以基于测量时的实际大气压（Pa）计算的校正因子来校正由气压变化引起的色谱分析中的误差，校准色谱分析仪系统的大气压，以及Ca / Ca作为Pa / Pc函数的曲线的斜率，其中Ca是如果误差不是由大气压变化引起的，Cm将具有的幅度。

9. 发明授权

US4508833A Separation of interleukin-2 from phytohemagglutinin by dye matrix chromatography 失效
标题翻译：通过染料基质色谱分离白细胞介素-2与植物血凝素
公开(公告)号：US4508833A
公开(公告)日：1985-04-02
申请号：US449708
申请日：1982-12-14
申请人： Hans H. Sonneborn , Udo Schwulera , Hans Schleussner
发明人： Hans H. Sonneborn , Udo Schwulera , Hans Schleussner
IPC分类号： A61K38/00 , C07K14/55 , G01N33/68 , G01N31/08 , A61K37/02 , B01D15/08
CPC分类号： G01N33/6869 , C07K14/55 , A61K38/00 , Y10S436/807
摘要： Crude interleukin-2 extract is subjected to group-selective dye-ligand absorption chromatography in one or more stages of purification with a matrix-gel medium consisting of a Blue A ligand or variant thereof or of a Green A ligand in a concentration of approximately 1.5 to 3.0 mg/ml of expanded matrix at a pH of approximately 6.8 to 8.5, a temperature of approximately 4.degree. to 40.degree. C., and a flowthrough rate of approximately 10 to 100 ml/h, employing an eluent. Either PHA-free or extremely pure interleukin-2 is obtained, depending on the overall number of purification stages.
摘要翻译：使用由蓝A配体或其变体或浓度为约1.5的Green A配体组成的基质 - 凝胶介质在一个或多个纯化阶段对粗白细胞介素-2提取物进行组选择性染料 - 配体吸收色谱法使用洗脱液，pH为约6.8〜8.5，温度为约4〜40℃，流通速度为约10〜100ml /小时，为3.0mg / ml的发泡基质。取决于纯化阶段的总数，获得无PHA或极纯白细胞介素-2。

10. 发明授权

US4496454A Self cleaning electrochemical detector and cell for flowing stream analysis 失效
标题翻译：自清洁电化学检测器和电池流动分析
公开(公告)号：US4496454A
公开(公告)日：1985-01-29
申请号：US543663
申请日：1983-10-19
申请人： Terry A. Berger
发明人： Terry A. Berger
IPC分类号： G01N27/27 , G01N27/28 , G01N27/30 , G01N27/38 , G01N27/416 , G01N27/48 , G01N30/64 , G01N31/08
CPC分类号： G01N30/64 , G01N27/28 , G01N27/38
摘要： An improved electrochemical cell and detector which is especially suited for analysis of rapidly changing flowing streams such as found in high performance liquid chromatography is disclosed. A uniquely designed jet made of microbore drawn capillary tubing permits the construction of a cell for very low flow rates that still retains true wall-jet hydrodynamics. The invention prevents changes in cell response in time by periodically cleaning a working electrode in a novel way. Cleaning and detection are both accomplished on a time scale much shorter than the fastest liquid chromatograph peaks by means of a unique three electrode cell design utilizing a small diameter, low capacitance, metal working electrode situated close to a reference electrode. Cleaning is accomplished by means of a non-square wave periodic waveform which is effective in cleaning a wide variety of contaminants through the oxidation and reduction of the working electrode and/or solvent prior to application of one or more working potentials while providing a stable, reproducible detector. The detector thus provides improvements in both sensitivity and bandwidth over the prior art.
摘要翻译：公开了一种改进的电化学电池和检测器，其特别适用于快速变化的流动流的分析，例如在高效液相色谱中发现的。由微孔拉伸毛细管制成的独特设计的喷射器允许构造一个仍然保持真正的壁喷流体动力学的非常低流速的电池。本发明通过以新颖的方式周期性地清洁工作电极来防止时间上的细胞反应变化。清洁和检测都是通过利用位于靠近参考电极的小直径，低电容的金属工作电极的独特的三电极电池设计，在比最快的液相色谱峰更短的时间段上完成的。清洁是通过非方波周期波形完成的，其在施加一个或多个工作电位之前通过氧化和还原工作电极和/或溶剂来清洁各种各样的污染物，同时提供稳定的，可重复检测器。因此，检测器在现有技术中提供了灵敏度和带宽方面的改进。

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