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1. 发明申请

US20180229231A1 CARTRIDGES, KITS, AND METHODS FOR AMPLIFICATION AND DETECTION OF ANALYTES 审中-公开
公开(公告)号：US20180229231A1
公开(公告)日：2018-08-16
申请号：US15945646
申请日：2018-04-04
申请人： CUE INC.
发明人： Ayub KHATTAK , Clinton SEVER , Paul NELSON , Ryan COOPER , Thomas CONGDON , Justin DEMARTINO , Raphael SHAPIRO , Mark DUNCAN
IPC分类号： B01L3/00 , F16K99/00 , G01N27/327 , G01N33/543 , G01N27/28 , B01L7/00 , G01N35/00 , C12Q1/6825 , B05D3/00 , G01N33/58 , H04M1/725 , G01N35/10 , G01N1/02 , G01N21/78
CPC分类号： B01L3/508 , B01F11/0266 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L3/5029 , B01L7/52 , B01L2200/025 , B01L2200/026 , B01L2200/027 , B01L2200/028 , B01L2200/0668 , B01L2200/0684 , B01L2200/0689 , B01L2200/087 , B01L2200/10 , B01L2200/16 , B01L2300/023 , B01L2300/025 , B01L2300/04 , B01L2300/044 , B01L2300/06 , B01L2300/0627 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/12 , B01L2300/161 , B01L2300/1827 , B01L2400/0406 , B01L2400/0439 , B01L2400/0487 , B01L2400/0677 , B01L2400/0683 , B05D3/002 , B05D2518/00 , C12Q1/6825 , F16K99/0032 , F16K99/0036 , F16K2099/0084 , G01N1/02 , G01N21/78 , G01N27/28 , G01N27/3271 , G01N27/3272 , G01N27/3273 , G01N33/54306 , G01N33/54326 , G01N33/54333 , G01N33/54366 , G01N33/54373 , G01N33/581 , G01N35/00029 , G01N35/0098 , G01N35/1095 , G01N2001/027 , G01N2001/028 , G01N2035/00277 , G01N2035/00554 , G01N2458/30 , H04M1/72527 , Y10T137/1797
摘要： Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

2. 发明授权

US09977059B2 Electrochemical analysis apparatus and electrochemical system 有权
公开(公告)号：US09977059B2
公开(公告)日：2018-05-22
申请号：US14758052
申请日：2013-12-26
申请人： WASEDA UNIVERSITY
发明人： Tetsuya Osaka , Toshiyuki Momma , Tokihiko Yokoshima , Daikichi Mukoyama , Hiroki Nara
IPC分类号： G01N27/416 , G01R23/16 , G01R31/36 , G01N27/28 , H01M10/48
CPC分类号： G01R23/16 , G01N27/28 , G01N27/4161 , G01R31/3662 , H01M10/48
摘要： An electrochemical analysis apparatus 1 includes a power controller 20 that generates a rectangular wave signal having a first frequency (f1) and applies the rectangular wave signal to an electrochemical cell 10 including a plurality of electrodes 11 to 13 and an electrolyte 14, a Fourier transform section 30 that Fourier-transforms a response signal of the electrochemical cell 10 to the rectangular wave signal and calculates frequency characteristics including a component of a second frequency f2 of an integer multiple of the first frequency f1, and a calculating section 40 that calculates an impedance characteristic of the electrochemical cell 10 based on the frequency characteristics calculated by the Fourier transform section 30.

3. 发明授权

US09880122B2 Method for enhancing current throughput in an electrochemical system 有权
公开(公告)号：US09880122B2
公开(公告)日：2018-01-30
申请号：US14267336
申请日：2014-05-01
申请人： Massachusetts Institute of Technology
发明人： Sung Hee Ko , Sung Jae Kim , Jongyoon Han , HiongYap Gan
IPC分类号： G01N27/28 , B01L3/00 , H01M8/1097 , H01M8/026
CPC分类号： G01N27/28 , B01L3/502746 , B01L2300/0816 , B01L2400/086 , H01M8/026 , H01M8/1097 , H01M2250/00 , Y10T29/49108
摘要： An electrochemical system with reduced limiting-current behavior is disclosed. The electrochemical system is useful for fuel cells and bio-sensors. In part, the invention relates a method of reducing or eliminating limiting-current behavior in the operation electrochemical systems, in particular those with ion-selective membrane or electrochemical electrodes, by spatially reducing the convection near the membrane or the electrode. The invention further relates to electrochemical systems in which micropores, microarrays or pillar arrays are used to reduce convection in comparison to conventional systems without microarrays, micropores or pillar arrays.

4. 发明授权

US09857327B2 Electrochemical sensor 有权
公开(公告)号：US09857327B2
公开(公告)日：2018-01-02
申请号：US14709537
申请日：2015-05-12
申请人： Mettler-Toledo AG
发明人： Ingo Schneider , Fritz Baltensperger , Corrado Barcella , Dario Meier
IPC分类号： G01N27/414 , G01N27/28
CPC分类号： G01N27/414 , G01N27/28
摘要： An electrochemical sensor, used with a measuring medium, has a sensor head (1), a sensor chip (6, 606) with a sensitive region (632), a sensor body (2) with an end piece (3, 503), a sealing means (10, 510, 610) and a pressing element (18, 618). The sensor body is connected to the sensor head. The end piece is hollow with a closed end region and a measuring opening (4, 504) that allows the measuring medium to contact the sensitive region, which is inside the end piece during operation. The sealing means surrounds the measuring opening, other than the sensitive region, and seals the inside of the end piece from the measuring medium during operation. The pressing element biases the sensor chip against the sealing means and the edge of the measuring opening. The end piece has an integral, gap-free design in the region that contacts the measuring medium during operation.

5. 发明授权

US09823210B2 Method of manufacturing a biosensor 有权
公开(公告)号：US09823210B2
公开(公告)日：2017-11-21
申请号：US14951094
申请日：2015-11-24
申请人： STMicroelectronics S.R.L.
发明人： Andrea Di Matteo , Vincenza Di Palma , Maria Fortuna Bevilacqua , Angela Cimmino
IPC分类号： G01N33/543 , G01N27/28 , C12Q1/00 , G01N27/327 , G01N27/403 , G03F7/00 , G03F7/16 , G03F7/20 , G03F7/26
CPC分类号： G01N27/28 , C12Q1/001 , G01N27/327 , G01N27/403 , G01N33/54386 , G03F7/0035 , G03F7/16 , G03F7/20 , G03F7/26
摘要： A method for manufacturing a biosensor includes forming an electrode layer on a flexible foil. An adhesive layer is positioned on the foil layer, and a first photo-definable hydrogel membrane is positioned over the electrode layer and the adhesive layer. A second photo-definable hydrogel membrane with an immobilized bio-recognition element is positioned over the first hydrogel membrane in contact with the electrode layer through an opening in the first hydrogel membrane.

6. 发明授权

US09709519B2 Measuring device and methods for use therewith 有权
公开(公告)号：US09709519B2
公开(公告)日：2017-07-18
申请号：US14816786
申请日：2015-08-03
申请人： AGAMATRIX, INC.
发明人： Ian Harding , Sridhar G. Iyengar , Baoguo Wei , Steven Diamond , Martin Forest
IPC分类号： G01N33/49 , G01N27/403 , G01N27/28 , G01N27/327 , G01N33/50
CPC分类号： G01N27/28 , G01N27/3271 , G01N27/3272 , G01N27/3273 , G01N27/403 , G01N33/50
摘要： The ability to switch at will between amperometric measurements and potentiometric measurements provides great flexibility in performing analyses of unknowns. Apparatus and methods can provide such switching to collect data from an electrochemical cell. The cell may contain a reagent disposed to measure glucose in human blood.

7. 发明申请

US20160370314A1 PROTECTED SENSOR FIELD EFFECT TRANSISTORS 有权
标题翻译：保护传感器场效应晶体管
公开(公告)号：US20160370314A1
公开(公告)日：2016-12-22
申请号：US15251141
申请日：2016-08-30
申请人： Patrice M. Parris , Weize Chen , Richard J. de Souza , Jose Fernandez Villasenor , Md M. Hoque , David E. Niewolny , Raymond M. Roop
发明人： Patrice M. Parris , Weize Chen , Richard J. de Souza , Jose Fernandez Villasenor , Md M. Hoque , David E. Niewolny , Raymond M. Roop
IPC分类号： G01N27/414 , G01N27/28 , B01L3/00
CPC分类号： G01N27/4148 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2200/10 , B01L2200/12 , B01L2300/04 , B01L2300/041 , B01L2300/0645 , B01L2300/0887 , B01L2400/0415 , B01L2400/0418 , G01N27/28 , G01N27/414 , H01L21/67259 , H01L29/4933 , H01L29/66431 , H01L29/66462 , H01L29/7833 , H01L31/119
摘要： Protected sensor field effect transistors (SFETs). The SFETs include a semiconductor substrate, a field effect transistor, and a sense electrode. The SFETs further include an analyte-receiving region that is supported by the semiconductor substrate, is in contact with the sense electrode, and is configured to receive an analyte fluid. The analyte-receiving region is at least partially enclosed. In some embodiments, the analyte-receiving region can be an enclosed analyte channel that extends between an analyte inlet and an analyte outlet. In these embodiments, the enclosed analyte channel extends such that the analyte inlet and the analyte outlet are spaced apart from the sense electrode. In some embodiments, the SFETs include a cover structure that at least partially encloses the analyte-receiving region and is formed from a cover material that is soluble within the analyte fluid. The methods include methods of manufacturing the SFETs.
摘要翻译：保护传感器场效应晶体管（SFET）。 SFET包括半导体衬底，场效应晶体管和感测电极。 SFET还包括由半导体衬底支撑的分析物接收区域，与感测电极接触，并被配置为接收分析物流体。分析物接收区域至少部分封闭。在一些实施方案中，分析物接收区域可以是在分析物入口和分析物出口之间延伸的封闭分析物通道。在这些实施例中，封闭的分析物通道延伸使得分析物入口和分析物出口与感测电极间隔开。在一些实施例中，SFET包括至少部分地包围分析物接收区并由可溶于分析物流体内的覆盖材料形成的覆盖结构。这些方法包括制造SFET的方法。

8. 发明申请

US20160305901A1 METHOD FOR MEASURING TEMPERATURE OF BIOLOGICAL SAMPLE, MEASURING DEVICE, AND BIOSENSOR SYSTEM 审中-公开
公开(公告)号：US20160305901A1
公开(公告)日：2016-10-20
申请号：US15182836
申请日：2016-06-15
申请人： Panasonic Healthcare Holdings Co., Ltd.
发明人： Masaki FUJIWARA
IPC分类号： G01N27/327 , C12Q1/54 , G01K7/00
CPC分类号： G01N27/3274 , B01L3/502 , B01L2200/147 , B01L2300/0645 , B01L2400/0406 , C12Q1/004 , C12Q1/006 , C12Q1/54 , G01K7/00 , G01N27/26 , G01N27/28 , G01N27/327 , G01N27/3272 , G01N27/3273 , G01N27/416 , Y10T436/144444
摘要： The concentration measurement method includes: introducing a predetermined amount of the biological sample into the capillary; measuring a temperature of the biological sample by applying a first voltage to the electrode unit when the temperature of the biological sample is measured, the first voltage allowing the temperature measurement to be less affected by increase and reduction in an amount of the analyte contained in the biological sample; measuring the concentration of the analyte contained in the biological sample by applying a second voltage to the electrode unit; measuring an environmental temperature in a surrounding of the biological sample; and correcting the concentration of the measured analyte based on the measured temperature of the biological sample and the measured environmental temperature.

9. 发明申请

US20160279635A1 SYSTEMS AND METHODS FOR DETECTION AND QUANTIFICATION OF ANALYTES 有权
公开(公告)号：US20160279635A1
公开(公告)日：2016-09-29
申请号：US15172077
申请日：2016-06-02
申请人： CUE INC.
发明人： Clinton Sever , Ayub Khattak
IPC分类号： B01L3/00 , G01N33/543
CPC分类号： B01L3/502715 , B01L3/5027 , B01L3/502723 , B01L3/502738 , B01L3/5029 , B01L2200/025 , B01L2200/026 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/0668 , B01L2200/0684 , B01L2200/0689 , B01L2200/087 , B01L2200/10 , B01L2200/16 , B01L2300/023 , B01L2300/025 , B01L2300/04 , B01L2300/044 , B01L2300/06 , B01L2300/0627 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/12 , B01L2300/161 , B01L2300/1827 , B01L2400/0406 , B01L2400/0487 , B01L2400/0677 , B01L2400/0683 , B05D3/002 , B05D2518/00 , C12Q1/6825 , F16K99/0032 , F16K99/0036 , F16K2099/0084 , G01N1/02 , G01N21/78 , G01N27/28 , G01N27/3271 , G01N27/3272 , G01N27/3273 , G01N33/54306 , G01N33/54326 , G01N33/54333 , G01N33/54366 , G01N33/54373 , G01N33/5438 , G01N33/581 , G01N35/00029 , G01N35/0098 , G01N35/08 , G01N35/1095 , G01N2001/027 , G01N2001/028 , G01N2035/00277 , G01N2035/00564 , G01N2458/30 , H04M1/72527 , H04M1/7253 , Y10T137/1797
摘要： Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

10. 发明授权

US09377429B2 Calibration liquid 有权
标题翻译：校准液
公开(公告)号：US09377429B2
公开(公告)日：2016-06-28
申请号：US13727378
申请日：2012-12-26
申请人： HORIBA, Ltd.
发明人： Yasukazu Iwamoto
IPC分类号： G01N27/28 , G01N27/416 , G01N33/493 , G01N27/333
CPC分类号： G01N27/28 , G01N27/333 , G01N27/4163 , G01N33/493
摘要： This invention relates to a correction liquid for a liquid membrane type ion-selective electrode that makes it possible to measure a ratio between a sodium ion concentration and a potassium ion concentration in urine by correcting for an influence from an ionic strength of the urine. The correction liquid comprises a sodium ion-sensitive part that selectively reacts with the sodium ion and a potassium ion-sensitive part that selectively reacts with the potassium ion, and measures a ratio between a sodium ion concentration and a potassium ion concentration in urine, and comprises the sodium ion, the potassium ion, and an electrolytic ionic strength modifier.
摘要翻译：本发明涉及一种用于液膜型离子选择电极的校正液，其可以通过校正尿液的离子强度的影响来测量尿中的钠离子浓度与钾离子浓度的比例。校正液包括选择性地与钠离子反应的钠离子敏感部分和选择性地与钾离子反应的钾离子敏感部分，并且测量尿中钠离子浓度与钾离子浓度之比，以及包括钠离子，钾离子和电解离子强度改性剂。

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