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1. 发明公开

US20240003890A1 PARTICLE-BASED DETECTION OF ANALYTES 审中-公开
公开(公告)号：US20240003890A1
公开(公告)日：2024-01-04
申请号：US18037279
申请日：2021-11-17
申请人： Xibus Syetems, Inc.
发明人： Timothy Manning Swager , Kent Harvey , Matthias Oberli
IPC分类号： G01N33/58 , G01N33/543 , G01N33/545
CPC分类号： G01N33/582 , G01N33/54386 , G01N33/545
摘要： Particle-based detection of analytes including, for example, systems, kits, and methods for growth, isolation, and/or monitoring of analytes are generally disclosed. In some embodiments, the systems and methods described herein are generally directed to the capture and/or concentrating of a target species (e.g., analyte) to be detected and/or monitored. In some embodiments, the materials, systems, and methods described herein may be used to create luminescent signals in response to the presence of selected analytes such as bacteria, viruses, and parasites. In some cases, the target analyte is a pathogenic bacteria, a pathogenic virus, a pathogenic parasite, or toxin.

2. 发明公开

US20230228769A1 METHOD OF ASSISTING DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE 审中-公开
公开(公告)号：US20230228769A1
公开(公告)日：2023-07-20
申请号：US18157250
申请日：2023-01-20
申请人： FUJIFILM Corporation , OSAKA UNIVERSITY
发明人： Eiji MIYOSHI , Koichi MORISHITA , Shinichiro SHINZAKI , Kei MOTOOKA , Kayoko KIDOWAKI , Ikumi TAMURA , Mutsuhiro DATE
IPC分类号： G01N33/68 , G01N33/545
CPC分类号： G01N33/6893 , G01N33/545 , G01N2800/065 , G01N2470/04
摘要： An object of the present invention is to provide a method of assisting diagnosis of inflammatory bowel disease, which can specifically determine inflammatory bowel disease.
The present invention relates to “a method of assisting diagnosis of inflammatory bowel disease, the method including subjecting a subject-derived specimen to a reduction treatment and subsequently measuring a human prohaptoglobin amount in the specimen by using an antibody 1 which is an antibody that specifically binds to an amino acid sequence set forth in SEQ ID NO: 1, and determining that a subject has inflammatory bowel disease by using the human prohaptoglobin amount as an indicator, and relates to an examination kit for assisting diagnosis of inflammatory bowel disease, including the antibody 1 a reducing agent”.

3. 发明公开

US20230192943A1 POLYMER DYE MODIFICATION AND APPLICATIONS 审中-公开
公开(公告)号：US20230192943A1
公开(公告)日：2023-06-22
申请号：US18094270
申请日：2023-01-06
申请人： Beckman Coulter, Inc.
发明人： Arunkumar Easwaran , Sergei Gulnik , Massimiliano Tomasulo
IPC分类号： C08G61/10 , C09B69/10 , G01N33/533 , G01N33/542 , G01N33/545 , G01N33/58
CPC分类号： C08G61/10 , C09B69/105 , G01N33/533 , G01N33/542 , G01N33/545 , G01N33/582 , C08G2261/11 , C08G2261/18 , C08G2261/78 , C08G2261/94 , C08G2261/145 , C08G2261/228 , C08G2261/314 , C08G2261/1424 , C08G2261/1432 , C08G2261/1644
摘要： Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.

4. 发明申请

US20230023831A1 IN-SITU GENERATED MICROFLUIDIC ASSAY STRUCTURES, RELATED KITS, AND METHODS OF USE THEREOF 有权
公开(公告)号：US20230023831A1
公开(公告)日：2023-01-26
申请号：US17930649
申请日：2022-09-08
申请人： BERKELEY LIGHTS, INC
发明人： Kristin G. BEAUMONT , Peter J. BEEMILLER , Volker L.S. KURZ , Gregory G. LAVIEU , Xiaohua WANG , Aathavan KARUNAKARAN
IPC分类号： G01N33/543 , B01L3/00 , G01N33/545 , G01N33/58
摘要： In situ-generated microfluidic capture structures incorporating a solidified polymer network, methods of preparation and use, compositions and kits therefor are described. Microfluidic capture structures may be advantageously used for assays performed within the microfluidic environment, providing flexibility in assaying micro-objects such as biological cells. Assay reagents and analytes may be incorporated within the microfluidic capture structures.

5. 发明授权

US11378577B2 Reagent and method for measuring thrombin-antithrombin complex 有权
公开(公告)号：US11378577B2
公开(公告)日：2022-07-05
申请号：US15772037
申请日：2016-10-31
申请人： LSI MEDIENCE CORPORATION
发明人： Tatsuya Yoshida , Yuhang Yang
IPC分类号： G01N33/52 , G01N33/543 , G01N33/545
摘要： Provided is a reagent for assaying a thrombin-antithrombin complex (TAT) in a blood sample from a subject by latex agglutination assay. The reagent includes a polycation. As a result, TAT complexes can be precisely assayed while circumventing the effect of heparin. The polycation is, for example, hexadimethrine bromide, chitosans, modified dextran, aminodextran, hydroxymethyl cellulose trimethylamine, lysozyme, spermine, spermidine, polylysine, polyarginine, polyornithine, protamine sulfate, hydroxyethyl cellulose trimethylamine, heparin-binding protein, polyallylamine, polyallylamine hydrochloride, poly(diallyl dialkyl amine), polyamideamine, polyamine, polyvinylbenzyltrimethylammonium chloride, polydiallyldimethylammonium chloride, polyethyleneimine, polypropyleneimine, polypropylethyleneimine, polyimidazoline, polyvinylamine, polyvinyl pyridine, poly(acrylamide/methacryloxypropyltrimethylammonium bromide), poly(diaryldimethylammonium chloride/N-isopropylacrylamide), poly(dimethylaminoethyl acrylate/acrylamide), poly(dimethylaminoethyl methacrylate), polydimethylaminoepichlorohydrin, polyethyleneiminoepichlorohydrin, polymethacryloxyethyl-trimethylammonium bromide, hydroxypropylmethacryloyloxyethyl dimethyl ammonium chloride, poly(methyldiethylaminoethylmethacrylate/acrylamide), poly(methyl/guanidine), polymethylvinylpyridinium bromide, poly(vinylpyrrolidone-dimethylaminoethyl methacrylate), or polyvinylmethylpyridinium bromide.

6. 发明申请

US20220146502A1 HIGH-SENSITIVITY ASSAY 有权
公开(公告)号：US20220146502A1
公开(公告)日：2022-05-12
申请号：US17427799
申请日：2020-01-31
申请人： SENTILUS HOLDCO, LLC
发明人： Reiner BABIEL , Tom FRAME , Sukanta BANERJEE , Tiruneh HAILEMARIAM , Hui HUANG , Efstathia MARINAKOS , Angus HUCKNALL , Vinalia TJONG
IPC分类号： G01N33/545 , G01N33/569 , G01N33/80 , G01N33/543
摘要： Disclosed herein are biological assays, screening formats, detection devices, and related methods of use. More specifically, disclosed herein are assay formats, microarrays, devices, methods of making the same, and methods of screening, detecting a target analyte, and methods of diagnosing an individual with a disease or condition when a target analyte associated with the disease or condition is detected.

7. 发明申请

US20220065848A1 SUBSTRATE FOR AMPLIFYING THE CHEMILUMINESCENCE 有权
公开(公告)号：US20220065848A1
公开(公告)日：2022-03-03
申请号：US17421119
申请日：2020-03-18
申请人： Fianostics GmbH
发明人： Albert Missbichler , Gerhard Hawa
IPC分类号： G01N33/533 , G01N33/58 , G01N33/553 , G01N33/545 , C12N9/08 , C12N9/02 , C12N9/16
摘要： The present invention relates to the use of a substrate for enhancing the chemiluminescence of one or more luminophores produced in a chemiluminescence reaction, wherein the substrate comprises a solid polymeric carrier with a plurality of depressions separated from one another and that the solid carrier is at least partially coated with a metal.

8. 发明申请

US20220026421A1 METHOD, SURFACE, PARTICLE AND KIT FOR THE DETECTION OF ANALYTES IN SAMPLES 有权
公开(公告)号：US20220026421A1
公开(公告)日：2022-01-27
申请号：US17297150
申请日：2019-11-18
申请人： TECHNISCHE UNIVERSITÄT DRESDEN , UNIVERSITÄT LEIPZIG
发明人： Gerhard RÖDEL , Kai OSTERMANN , Julia DÖRING , Christian DAHMANN , Tilo POMPE , David RETTKE , Steve MARTIN
IPC分类号： G01N33/53 , G01N33/543 , G01N33/545 , C07K14/37 , C12N9/10
摘要： The invention relates to a method, to a surface, to a particle, and to a kit for the detection of low molecular weight analytes such as crop protection agents in samples. In particular, the invention relates to a method for the detection of glyphosate through protein-functionalised surfaces and functionalised particles by means of reflection interference contrast microscopy (RICM).

9. 发明申请

US20210318309A1 ASSAYS WITH INDUCED AGGREGATION FOR ENHANCED SENSITIVITY 有权
公开(公告)号：US20210318309A1
公开(公告)日：2021-10-14
申请号：US17226989
申请日：2021-04-09
申请人： ILYTICA LLC
发明人： Jay T. GROVES
IPC分类号： G01N33/569 , G01N33/545 , G01N33/53 , G01N15/14 , G01N21/64
摘要： Provided herein are systems, devices and methods for the rapid and accurate measurement of analyte particles binding-induced aggregation of reporter particles. In the presence of analyte particles of interest, reporter particles form aggregates which increase in mean particle size as the concentration of analyte increases. From analysis of the mean particle size, determined from sample frames, the presence and/or concentration of analyte can be determined.

10. 发明授权

US11078254B2 Method for immobilizing lectin 有权
公开(公告)号：US11078254B2
公开(公告)日：2021-08-03
申请号：US16604565
申请日：2018-04-11
申请人： National Institute of Advanced Industrial Science and Technology , Nissan Chemical Corporation , National University Corporation Kyoto Institute of Technology
发明人： Hiroaki Tateno , Junko Katayama , Kazutaka Matoba , Yoichi Kumada
IPC分类号： C07K7/06 , C07K14/195 , C07K17/08 , C07K17/14 , C07K19/00 , G01N33/545 , G01N33/551 , G01N33/566 , C07K14/705 , C07K17/00 , C12N15/62 , G01N33/543
摘要： Provided is a highly sensitive and less expensive lectin-immobilized base material (for example, a lectin plate), such as lectin-immobilized base material having stable qualities and being able to be sufficiently washed after a target sugar chain-containing antigen binds thereto. Further provided is a method for immobilizing lectin to a base material therefor. Particularly provided are: a method whereby a lectin-peptide fusion, in which a peptide capable of adsorbing to a base material surface such as a polystyrene (PS) tag is fused with the N-terminal side or C-terminal side of lectin capable of recognizing a target sugar chain, is immobilized on the peptide side to a base material; and a lectin-immobilized base material produced by this method. By using the lectin-immobilized base material, a target sugar chain-containing antigen can be highly sensitively and evenly measured and, moreover, target sugar chain-containing cells, etc. can be separated (concentrated and harvested).

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