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1. 发明授权

US09079875B2 Method for decarboxylating C—C cross-linking of carboxylic acids with carbon electrophiles 有权
标题翻译：羧酸与碳亲电体的C-C交联脱羧的方法
公开(公告)号：US09079875B2
公开(公告)日：2015-07-14
申请号：US11913626
申请日：2006-05-10
申请人： Lukas Goossen , Guojun Deng
发明人： Lukas Goossen , Guojun Deng
IPC分类号： C07C63/00 , C07C65/00 , C07C61/00 , C07C61/08 , C07C19/00 , C07C2/66 , C07C5/09 , C07C15/40 , C07C2/26 , C07D333/08 , B01J31/18 , B01J31/22 , B01J31/24 , B01J31/26 , C07B37/04 , C07C1/26 , C07C17/263 , C07C17/266 , C07C41/30 , C07C45/68 , C07C45/72 , C07C201/12 , C07C209/68 , C07C231/12 , C07C253/30 , C07C315/04 , C07C319/20 , B01J27/122 , B01J27/232
CPC分类号： C07D333/08 , B01J27/122 , B01J27/232 , B01J31/1815 , B01J31/183 , B01J31/2234 , B01J31/2404 , B01J31/26 , B01J2231/4205 , B01J2531/0241 , B01J2531/16 , B01J2531/17 , B01J2531/824 , C07B37/04 , C07C1/26 , C07C17/263 , C07C17/2637 , C07C17/266 , C07C41/30 , C07C45/68 , C07C45/72 , C07C201/12 , C07C209/68 , C07C231/12 , C07C253/30 , C07C315/04 , C07C319/20 , C07C2527/122 , C07C2531/24 , C07C2531/28 , C07C2531/30 , C07C2603/26 , C07C15/52 , C07C25/18 , C07C25/24 , C07C49/782 , C07C47/546 , C07C49/84 , C07C317/14 , C07C211/55 , C07C233/07 , C07C255/64 , C07C323/09 , C07C205/06 , C07C205/11 , C07C205/35 , C07C205/44 , C07C205/45 , C07C205/57 , C07C43/205
摘要： The invention relates to a method for decarboxylating C—C bond formation by reacting carboxylic salts with carbon electrophiles in the presence of transition metal compounds as catalysts. The method represents a decarboxylating C—C bond formation of carboxylic acid salts with carbon electrophiles, wherein the catalyst contains two transition metals and/or transition metal compounds, from which one is present, preferably, in the oxidation step, which are different from each other by one unit, and catalyzes a radical decarboxylation which is absorbed during the second oxidation steps, which are different from each other by two units and catalyzes the two electron processes of a C—C bond formation reaction.
摘要翻译：本发明涉及通过在过渡金属化合物作为催化剂存在下使羧酸与碳亲电体反应来脱羧C-C键形成的方法。该方法表示与碳亲电体形成羧酸盐的羧基C-C键，其中催化剂含有两种过渡金属和/或过渡金属化合物，优选在氧化步骤中存在一种不同于催化自由基脱羧，其在第二氧化步骤期间被吸收，它们通过两个单元彼此不同并且催化C-C键形成反应的两个电子过程。

2. 发明授权

US08492436B2 Inhibitors of yeast filamentous growth and method of their manufacture 有权
标题翻译：酵母丝状生长抑制剂及其制备方法
公开(公告)号：US08492436B2
公开(公告)日：2013-07-23
申请号：US12965482
申请日：2010-12-10
申请人： Lian-Hui Wang , Lian-Hui Zhang
发明人： Lian-Hui Wang , Lian-Hui Zhang
IPC分类号： A61K31/20 , C07C61/08 , C07C61/00
CPC分类号： C07C57/03 , A61K31/201
摘要： The invention broadly relates to the use of α,β-unsaturated fatty acids to inhibit the filamentous growth of fungi and yeasts and to a method for producing same. In particular the invention relates to the use of optionally substituted C8 to CI5 α,β-unsaturated fatty acids or salts, esters or amides thereof for inhibiting or retarding the yeast-to-mycelium transition of organisms having a dimorphic life cycle.
摘要翻译：本发明广泛涉及α，β-不饱和脂肪酸用于抑制真菌和酵母的丝状生长及其制备方法。特别地，本发明涉及任选取代的C 8至C 5aα，β-不饱和脂肪酸或其盐，酯或酰胺用于抑制或延缓具有二形生命周期的生物的酵母与菌丝体转变的用途。

3. 发明申请

US20130091760A1 METHOD OF BIOBASED CHEMICAL PRODUCTION FROM CRUDE BIOGLYCERIN OF ANIMAL ORIGIN 审中-公开
标题翻译：生物化学生物化学生物学原理生物学方法
公开(公告)号：US20130091760A1
公开(公告)日：2013-04-18
申请号：US13348785
申请日：2012-01-12
申请人： John R. Peterson , Christopher M. Yost
发明人： John R. Peterson , Christopher M. Yost
IPC分类号： C10L1/00 , C07C69/74 , C07C61/00 , C07C49/00 , C07C31/08 , C07C31/20 , C07C31/22 , C07C31/04 , C07C31/24 , C07C31/18 , C07C53/122 , C07C47/00
CPC分类号： C07C29/60 , C07C29/00 , C07C29/76 , C07C29/80 , C07C31/225 , C07C31/04 , C07C31/08 , C07C31/10 , C07C31/205 , C07C33/03
摘要： A method of production of value-added, biobased chemicals, derivative products, and/or purified glycerin from animal-based bioglycerin is described herein. A method of purification of animal-based bioglycerin is also described herein. The method of purification of animal-based bioglycerin described provides methods for desalinating, decolorizing, and/or concentrating animal-based bioglycerin for the production of biobased chemicals, derivative products, and/or purified glycerin.
摘要翻译：本文描述了从动物基生物甘油生产增值，生物基化学品，衍生产物和/或纯化甘油的方法。本文还描述了基于动物的生物甘油的纯化方法。所述的基于动物的生物甘油的纯化方法提供了用于生产生物基化学品，衍生产物和/或纯化甘油的用于脱盐，脱色和/或浓缩基于动物的生物甘油的方法。

4. 发明授权

US08372944B1 Synthesis of hyperbranched amphiphilic polyester and theranostic nanoparticles thereof 有权
公开(公告)号：US08372944B1
公开(公告)日：2013-02-12
申请号：US12417017
申请日：2009-04-02
申请人： J. Manuel Perez , Santimukul Santra
发明人： J. Manuel Perez , Santimukul Santra
IPC分类号： C08G63/00 , C07C61/00 , C07C27/10
CPC分类号： A61K9/5138 , A61K9/146 , A61K9/1647 , A61K9/5153 , A61K9/5192 , A61K31/337 , A61K31/505 , A61K31/519 , A61K31/7072 , A61K47/48907 , A61K47/6935 , A61K49/0032 , A61K49/0093 , C08G63/06 , C08G63/664 , C08G63/6852 , C08G63/87 , C08G63/90 , C08G63/912 , C08G83/005 , C08G83/006
摘要： A method of making a hyperbranched amphiphilic polyester compound includes drying under vacuum a mixture of 2-(4-hydroxybutyl)-malonic acid and p-toluene sulphonic acid as catalyst. The vacuum is then released with a dry inert gas after drying. The dried mixture is heated under the inert gas at a temperature sufficient for polymerization. The inert gas is evacuated while continuing to heat the mixture. The formed polymer is then dissolved in dimethylformamide and precipitated out by adding methanol. Modifications of the method yield nanoparticles of polyesters having properties suited for coencapsulating fluorescent dyes together with therapeutic drugs, resulting in theranostic nanoparticles, that is, nanoparticles useful in both therapeutic treatments and diagnostic methods.

5. 发明申请

US20110059871A1 Graphene Compositions And Drilling Fluids Derived Therefrom 有权
标题翻译：石墨烯组合物和钻井液
公开(公告)号：US20110059871A1
公开(公告)日：2011-03-10
申请号：US12832797
申请日：2010-07-08
申请人： James M. Tour , Howard K. Schmidt , Jay R. Lomeda , Dmitry V. Kosynkin , Condell D. Doyle
发明人： James M. Tour , Howard K. Schmidt , Jay R. Lomeda , Dmitry V. Kosynkin , Condell D. Doyle
IPC分类号： C09K8/03 , C07C61/00 , C01B31/04 , C07D315/00 , C01B33/26 , B82Y30/00
CPC分类号： C09K8/032 , B82Y30/00 , B82Y40/00 , C01B32/192 , C01B32/194 , C01B32/23 , C01B2204/04 , C01B2204/28 , C09K8/035 , C09K8/62 , Y10S977/734 , Y10S977/737 , Y10S977/738
摘要： Drilling fluids comprising graphenes and nanoplatelet additives and methods for production thereof are disclosed. Graphene includes graphite oxide, graphene oxide, chemically-converted graphene, and functionalized chemically-converted graphene. Derivatized graphenes and methods for production thereof are disclosed. The derivatized graphenes are prepared from a chemically-converted graphene through derivatization with a plurality of functional groups. Derivatization can be accomplished, for example, by reaction of a chemically-converted graphene with a diazonium species. Methods for preparation of graphite oxide are also disclosed.
摘要翻译：公开了包含石墨烯和纳米血小板添加剂的钻井液及其生产方法。石墨烯包括氧化石墨，氧化石墨烯，化学转化的石墨烯和官能化的化学转化的石墨烯。公开了衍生化的石墨烯及其生产方法。衍生的石墨烯通过具有多个官能团的衍生化由化学转化的石墨烯制备。衍生化可以通过例如化学转化的石墨烯与重氮物质的反应来实现。还公开了制备氧化石墨的方法。

6. 发明授权

US07507856B2 Method of oxidising hydrocarbons to acids 失效
标题翻译：将烃氧化成酸的方法
公开(公告)号：US07507856B2
公开(公告)日：2009-03-24
申请号：US10485468
申请日：2002-07-15
申请人： Didier Bonnet , Eric Fache , Jean-Pierre Simonato
发明人： Didier Bonnet , Eric Fache , Jean-Pierre Simonato
IPC分类号： C07C51/16 , C07C61/00 , C07C51/31
CPC分类号： C07C51/313 , C07C55/14 , C07C55/21
摘要： The present invention relates to a process for the oxidation of hydrocarbons, in particular of branched or unbranched saturated aliphatic hydrocarbons, of cycloaliphatic or alkylaromatic hydrocarbons or of alcohols and/or ketones, to acid or polyacid compounds.It relates more particularly to the oxidation, by an oxidizing agent comprising molecular oxygen, of cyclohexane and/or of cyclohexanol and/or cyclohexanone to adipic acid, in the presence of an aromatic organic acid and a manganese-based catalyst. The yield and selectivity for adipic acid are of a high level with respect to those obtained with other solvents and catalysts.
摘要翻译：本发明涉及一种将脂环族或烷基芳烃或醇和/或酮的烃类，特别是支链或非支链饱和脂族烃氧化成酸或多元酸化合物的方法。其更具体地涉及在芳族有机酸和锰基催化剂存在下，通过包含分子氧的环己烷和/或环己醇和/或环己酮与己二酸的氧化反应。对于己二酸的产率和选择性与使用其它溶剂和催化剂得到的产率和选择性相当。

7. 发明授权

US07507817B2 Prostaglandin prodrugs 有权
标题翻译：前列腺素前药
公开(公告)号：US07507817B2
公开(公告)日：2009-03-24
申请号：US11938902
申请日：2007-11-13
申请人： David W. Old , Vinh X. Ngo , Wha-Bin Im
发明人： David W. Old , Vinh X. Ngo , Wha-Bin Im
IPC分类号： C07D265/30 , C07D333/02 , C07D321/00 , C07D333/32 , C07D307/00 , C07D213/04 , C07D265/28 , A61K31/535 , A61K31/335 , C07C61/00 , C07C63/36
CPC分类号： C07D295/088
摘要： Novel compounds, and therapeutic methods, compositions and medicament related thereto are disclosed herein.
摘要翻译：本文公开了新颖的化合物及其相关的治疗方法，组合物和药物。

8. 发明授权

US07468389B2 Carboxylic acid compound having cyclopropane ring 有权
标题翻译：具有环丙烷环的羧酸化合物
公开(公告)号：US07468389B2
公开(公告)日：2008-12-23
申请号：US10450816
申请日：2001-12-18
申请人： Tomoyuki Nishizaki , Akito Tanaka
发明人： Tomoyuki Nishizaki , Akito Tanaka
IPC分类号： A61K31/215 , C07C61/00 , C07C61/04
CPC分类号： C07C61/04 , C07C53/134 , C07C57/26 , C07C61/12 , C07C61/28 , C07C61/35
摘要： A carboxylic acid compound having cyclopropane ring(s) of the formula (I): wherein R is alkyl or alkenyl optionally having one or more 1,2-cyclopropylene in a carbon chain and/or optionally having cyclopropyl at the end of a chain,X is a single bond or alkylene, wherein the total number of carbon less the number of cyclopropane ring is 10-25, and a pharmaceutically acceptable salt thereof are provided. The compound (I) shows an LTP-like potentiation of synaptic transmission, allows slow metabolism in the living body, show a stable LTP-like potentiation of synaptic transmission, and is useful as an agent for LTP-like potentiation of synaptic transmission, a cognition-enhancing drug or an agent for the prophylaxis and treatment of dementia, a learning and memory disorder and a neurotransmitter release disorder.
摘要翻译：具有式（I）的环丙烷环的羧酸化合物：其中R是在碳链中任选具有一个或多个1,2-亚丙基的烷基或链烯基和/或在链末端任选具有环丙基的羧酸化合物， X是单键或亚烷基，其中提供环丙烷环数少于10-25的碳总数及其药学上可接受的盐。化合物（I）显示突触传递的LTP样增强，允许活体中的代谢缓慢，表现出稳定的LTP样增强突触传递，并且可用作LTP样增强突触传递的药剂，a 认知增强药物或预防和治疗痴呆，学习和记忆障碍和神经递质释放障碍的药剂。

9. 发明申请

US20080234499A1 Synthesising Method and Benzoxathiepine Intermediates 有权
标题翻译：合成方法和苯并噻肟中间体
公开(公告)号：US20080234499A1
公开(公告)日：2008-09-25
申请号：US11547708
申请日：2005-04-08
申请人： Bernard Vacher , Yves Brunel , Florence Castan-Cuisiat
发明人： Bernard Vacher , Yves Brunel , Florence Castan-Cuisiat
IPC分类号： C07D327/00 , C07C69/00 , C07C61/00
CPC分类号： C07D327/02 , C07C323/52
摘要： The invention relates to preparing derivatives of formula (1), wherein, in particular R1 and R2, identical or different, represent a hydrogen, flourine or chlorine atom, a hydroxy group, an alkyl radical and an alkoxy radical, R3 is an alkyl radical, a hydroxy group, or a methoxy radical, R4 is a hydrogen atom or a methyl radical and R5 and R6, identical or different, represent a hydrogen atom, an alkyl radical, an alkoxy radical, an alkylthio radical, and an alkylamino radical. The inventive method consists in reducing an amid of formula (9).
摘要翻译：本发明涉及制备式（1）的衍生物，其中特别是R 1和R 2相同或不同，表示氢，氟或氯原子，羟基，烷基和烷氧基，R 3是烷基，羟基或甲氧基，R 4是氢原子或甲基基团和R 5和R 6相同或不同，表示氢原子，烷基，烷氧基，烷硫基和烷基氨基。本发明的方法在于减少式（9）中的化合物。

10. 发明授权

US07420086B2 Process for producing trans-1,4-cyclohexanedicarboxylic acid 有权
标题翻译：反式-1,4-环己烷二羧酸的制备方法
公开(公告)号：US07420086B2
公开(公告)日：2008-09-02
申请号：US10831156
申请日：2004-04-26
申请人： Koetsu Endou , Hirofumi Nakamura , Shinichi Tanaka
发明人： Koetsu Endou , Hirofumi Nakamura , Shinichi Tanaka
IPC分类号： C07C61/00
CPC分类号： C07C51/353 , C07C51/363 , C07C2601/14 , C07C61/09
摘要： A subject for the invention is to obtain trans-1,4-cyclohexanedicarboxylic acid (t-CHDA) in a high concentration by efficiently isomerizing cis-1,4-cyclohexanedicarboxylic acid (c-CHDA) by a simple method. The invention provides: (1) a process for producing t-CHDA which comprises heating crude CHDA to 180° C. or higher in an inert atmosphere and causing the t-CHDA formed by isomerization to precipitate in the molten c-CHDA while holding the crude CHDA at a temperature in the range of not lower than 180° C. and less than the melting point of t-CHDA; (2) a process for producing t-CHDA, wherein crude CHDA which is powdery or granular is heat-treated at a temperature of not lower than the melting point of c-CHDA and lower than the melting point of t-CHDA to thereby isomerize the cis isomer to the trans isomer while maintaining the powdery or granular state; (3) a process for producing t-CHDA, wherein crude CHDA is held at a temperature of not lower than the melting point of c-CHDA and lower than the melting point of t-CHDA in an inert atmosphere while maintaining flowing to thereby obtain powdery or granular t-CHDA; and (4) a process for purifying crude CHDA in which crude CHDA obtained through the step of hydrogenating TPA or the like is heated in an atmosphere of an inert gas to volatilize and remove impurities.
摘要翻译：本发明的目的是通过简单的方法有效地使顺式-1,4-环己烷二羧酸（c-CHDA）异构化，以高浓度获得反式-1,4-环己烷二羧酸（t-CHDA）。本发明提供：（1）一种生产t-CHDA的方法，其包括在惰性气氛中将粗CHDA加热至180℃或更高，并使通过异构化形成的t-CHDA在熔融的c-CHDA中沉淀，同时保持原料CHDA在不低于180℃且小于t-CHDA的熔点的温度范围内; （2）生产t-CHDA的方法，其中将粉末状或粒状的粗CHDA在不低于c-CHDA的熔点并低于t-CHDA的熔点的温度下进行热处理，从而异构化顺式异构体反式异构体，同时保持粉状或颗粒状态; （3）生产t-CHDA的方法，其中将粗CHDA保持在不低于c-CHDA的熔点并低于在惰性气氛中的t-CHDA的熔点的温度，同时保持流动，从而获得粉状或颗粒状t-CHDA; （4）一种纯化粗制CHDA的方法，其中通过氢化TPA等步骤得到的粗CHDA在惰性气体气氛中加热，挥发除去杂质。

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