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1. 发明申请

US20150246867A1 PROCESS FOR HYDROGENATION OF ESTERS OF AROMATIC CARBOXYLIC ACIDS TO YIELD SATURATED HOMOLOGUES THEREOF 有权
标题翻译：将芳香羧酸的酯加氢到其饱和饱和度的方法
公开(公告)号：US20150246867A1
公开(公告)日：2015-09-03
申请号：US14433235
申请日：2013-10-02
申请人： POLYNT S.P.A.
发明人： Gian Luca Castiglioni , Carlotta Cortelli , Leonardo Poletti
IPC分类号： C07C67/303 , C08K5/12 , C08L27/06 , C07C61/08
CPC分类号： C07C67/303 , C07C61/08 , C07C2601/14 , C08K3/26 , C08K5/12 , C08L27/06 , C07C69/75 , C08K5/098
摘要： A process for the hydrogenation of substituted aromatic compounds, with particular reference to esters of aromatic carboxylic acids, for example of aromatic esters used commonly as plasticizers in polymers having wide commercial application (see, in particular, esters of phthalic acid and trimellitic acid).
摘要翻译：取代芳族化合物的氢化方法，特别是涉及芳族羧酸的酯，例如通常作为增塑剂使用的芳族酯，其具有广泛的商业应用的聚合物（特别是邻苯二甲酸和偏苯三酸的酯）。

2. 发明授权

US09079875B2 Method for decarboxylating C—C cross-linking of carboxylic acids with carbon electrophiles 有权
标题翻译：羧酸与碳亲电体的C-C交联脱羧的方法
公开(公告)号：US09079875B2
公开(公告)日：2015-07-14
申请号：US11913626
申请日：2006-05-10
申请人： Lukas Goossen , Guojun Deng
发明人： Lukas Goossen , Guojun Deng
IPC分类号： C07C63/00 , C07C65/00 , C07C61/00 , C07C61/08 , C07C19/00 , C07C2/66 , C07C5/09 , C07C15/40 , C07C2/26 , C07D333/08 , B01J31/18 , B01J31/22 , B01J31/24 , B01J31/26 , C07B37/04 , C07C1/26 , C07C17/263 , C07C17/266 , C07C41/30 , C07C45/68 , C07C45/72 , C07C201/12 , C07C209/68 , C07C231/12 , C07C253/30 , C07C315/04 , C07C319/20 , B01J27/122 , B01J27/232
CPC分类号： C07D333/08 , B01J27/122 , B01J27/232 , B01J31/1815 , B01J31/183 , B01J31/2234 , B01J31/2404 , B01J31/26 , B01J2231/4205 , B01J2531/0241 , B01J2531/16 , B01J2531/17 , B01J2531/824 , C07B37/04 , C07C1/26 , C07C17/263 , C07C17/2637 , C07C17/266 , C07C41/30 , C07C45/68 , C07C45/72 , C07C201/12 , C07C209/68 , C07C231/12 , C07C253/30 , C07C315/04 , C07C319/20 , C07C2527/122 , C07C2531/24 , C07C2531/28 , C07C2531/30 , C07C2603/26 , C07C15/52 , C07C25/18 , C07C25/24 , C07C49/782 , C07C47/546 , C07C49/84 , C07C317/14 , C07C211/55 , C07C233/07 , C07C255/64 , C07C323/09 , C07C205/06 , C07C205/11 , C07C205/35 , C07C205/44 , C07C205/45 , C07C205/57 , C07C43/205
摘要： The invention relates to a method for decarboxylating C—C bond formation by reacting carboxylic salts with carbon electrophiles in the presence of transition metal compounds as catalysts. The method represents a decarboxylating C—C bond formation of carboxylic acid salts with carbon electrophiles, wherein the catalyst contains two transition metals and/or transition metal compounds, from which one is present, preferably, in the oxidation step, which are different from each other by one unit, and catalyzes a radical decarboxylation which is absorbed during the second oxidation steps, which are different from each other by two units and catalyzes the two electron processes of a C—C bond formation reaction.
摘要翻译：本发明涉及通过在过渡金属化合物作为催化剂存在下使羧酸与碳亲电体反应来脱羧C-C键形成的方法。该方法表示与碳亲电体形成羧酸盐的羧基C-C键，其中催化剂含有两种过渡金属和/或过渡金属化合物，优选在氧化步骤中存在一种不同于催化自由基脱羧，其在第二氧化步骤期间被吸收，它们通过两个单元彼此不同并且催化C-C键形成反应的两个电子过程。

3. 发明授权

US08703183B2 Metformin glycinate salt for blood glucose control 有权
标题翻译：二甲双胍甘氨酸盐用于血糖控制
公开(公告)号：US08703183B2
公开(公告)日：2014-04-22
申请号：US12928985
申请日：2010-12-24
申请人： Jose Manuel FranciscoOchoa Lara
发明人： Jose Manuel FranciscoOchoa Lara
IPC分类号： A61K9/20 , A61K31/15 , A61K31/131 , A61K31/198 , C07C61/08 , C07C229/00 , C07C251/00
CPC分类号： C07C279/26 , C07C229/08
摘要： The present invention relates to metformin glycinate salt and pharmaceutical compositions thereof for the treatment of diabetes mellitus. The method includes administration of the metformin glycinate salt by various routes selected from oral, intravenous injectable, intramuscular injectable, nasal, intraperitoneal, or sublingual, in order to achieve a reduction in blood glucose levels. The invention further relates to the synthesis of a new 1,1-dimethylbiguanide glycinate salt, called Metformin Glycinate. The resulting salt exhibits advantages over other metformin salts. These advantages are due, in the first place, to the fact that the glycine counterion exhibits hypoglycemic effects by itself. Moreover, the salt exhibits more rapid absorption, reaching higher plasma concentrations than those produced with metformin hydrochloride.
摘要翻译：本发明涉及二甲双胍甘氨酸盐及其药物组合物，用于治疗糖尿病。该方法包括通过选自口服，静脉注射，肌内注射，鼻腔，腹膜内或舌下的各种途径施用二甲双胍甘氨酸盐，以实现血糖水平的降低。本发明还涉及称为二甲双胍甘氨酸的新的1,1-二甲基双胍甘氨酸盐的合成。所得盐显示出优于其他二甲双胍盐的优点。这些优点首先归因于甘氨酸抗衡离子本身表现出低血糖作用。此外，盐显示更快的吸收，达到比盐酸二甲双胍生产的那些更高的血浆浓度。

4. 发明授权

US08669209B2 Process for preparing soluble granules of salts of pyridine containing carboxylic acids 有权
标题翻译：制备含有羧酸的吡啶盐的可溶性颗粒的方法
公开(公告)号：US08669209B2
公开(公告)日：2014-03-11
申请号：US12951100
申请日：2010-11-22
申请人： Franklin N. Keeney , Neil A. Foster , Martin C. Logan , Maria G. Perry
发明人： Franklin N. Keeney , Neil A. Foster , Martin C. Logan , Maria G. Perry
IPC分类号： A01N43/40 , C07D211/72 , C07D211/84 , C07D213/68 , C07D213/72 , C07D213/78 , C07C61/08 , C07C59/56 , C07C59/88 , C07C65/00 , C07C229/00 , C07C62/00
CPC分类号： A01N43/40 , A01N25/12 , A01N2300/00
摘要： Soluble granule formulations of amine salts of pyridine containing carboxylic acids with improved handling properties are provided by an improved process in which the pyridine containing carboxylic acid is partially neutralized with an amine.
摘要翻译：通过改进的方法提供含有羧酸吡啶的胺盐的可溶性颗粒剂，其中含吡啶的羧酸被胺部分中和。

5. 发明授权

US08492436B2 Inhibitors of yeast filamentous growth and method of their manufacture 有权
标题翻译：酵母丝状生长抑制剂及其制备方法
公开(公告)号：US08492436B2
公开(公告)日：2013-07-23
申请号：US12965482
申请日：2010-12-10
申请人： Lian-Hui Wang , Lian-Hui Zhang
发明人： Lian-Hui Wang , Lian-Hui Zhang
IPC分类号： A61K31/20 , C07C61/08 , C07C61/00
CPC分类号： C07C57/03 , A61K31/201
摘要： The invention broadly relates to the use of α,β-unsaturated fatty acids to inhibit the filamentous growth of fungi and yeasts and to a method for producing same. In particular the invention relates to the use of optionally substituted C8 to CI5 α,β-unsaturated fatty acids or salts, esters or amides thereof for inhibiting or retarding the yeast-to-mycelium transition of organisms having a dimorphic life cycle.
摘要翻译：本发明广泛涉及α，β-不饱和脂肪酸用于抑制真菌和酵母的丝状生长及其制备方法。特别地，本发明涉及任选取代的C 8至C 5aα，β-不饱和脂肪酸或其盐，酯或酰胺用于抑制或延缓具有二形生命周期的生物的酵母与菌丝体转变的用途。

6. 发明申请

US20100311786A1 MONO- OR BICYCLIC CARBOXYLIC ACIDS AS OFF-NOTE BLOCKERS 审中-公开
标题翻译：单酚或双酚类羧酸作为不注意的阻塞剂
公开(公告)号：US20100311786A1
公开(公告)日：2010-12-09
申请号：US12669393
申请日：2008-07-28
申请人： Ioana Maria Ungureanu , Nicole Erna Irene Brune , Jay Patrick Slack , Kimberley Gray , Christopher Todd Simons , Jenny Ellen Evans Pennimpede
发明人： Ioana Maria Ungureanu , Nicole Erna Irene Brune , Jay Patrick Slack , Kimberley Gray , Christopher Todd Simons , Jenny Ellen Evans Pennimpede
IPC分类号： A61K31/4748 , C07C61/06 , C07C61/08 , A61K47/12 , A61K31/445 , A61P11/14 , A61P29/00 , A23L1/226 , A23G4/06 , A23L1/302
CPC分类号： A23L27/84 , A23L27/30 , A23L27/86 , A23V2002/00
摘要： Disclosed are compounds that block off-notes in consumables and methods of blocking off-notes in consumables including off-notes provided by sweeteners such as stevioside, swingle extract, glyccerhizin, perillartine, naringin dihydrochalcone, neohesperidine dihydrochalcone, mogroside V, rubusoside, rubus extract, and rebaudioside A, and artificial sweeteners such as aspartame, saccharin, acesulfame K (Acesulfame potassium), sucralose and cyclamate.
摘要翻译：公开了阻止消耗品中的纸屑的化合物以及阻断消耗品中的纸屑的方法，包括由甜味剂如甜菊糖苷，葡聚糖提取物，甘草酸，perillartine，柚皮苷二氢查耳酮，新月桂哌啶二氢查耳酮，罗汉果苷V，鲁鲁斯苷，罗汉果提取物和莱鲍迪甙A，以及人造甜味剂如阿斯巴甜，糖精，乙酰磺胺酸钾（乙酰磺胺酸钾），三氯蔗糖和环己基氨基磺酸盐。

7. 发明申请

US20100248261A1 METHOD TO DETERMINE PROTEIN INTERACTION SITES 有权
标题翻译：确定蛋白质相互作用位点的方法
公开(公告)号：US20100248261A1
公开(公告)日：2010-09-30
申请号：US12748289
申请日：2010-03-26
申请人： Jeff RANISH , Jie Luo
发明人： Jeff RANISH , Jie Luo
IPC分类号： G01N33/53 , C07D207/40 , C07C211/00 , C07D209/04 , C07C61/08 , C07D495/04
CPC分类号： G01N33/6848 , G01N33/6845
摘要： The invention provides improved crosslinkers which permit more efficient determination of protein interactions in biological samples.
摘要翻译：本发明提供改进的交联剂，其允许更有效地测定生物样品中的蛋白质相互作用。

8. 发明申请

US20100222609A1 Oxidation of Hydrocarbons 有权
标题翻译：碳氢化合物的氧化
公开(公告)号：US20100222609A1
公开(公告)日：2010-09-02
申请号：US12675342
申请日：2008-10-08
申请人： Jihad M. Dakka , James C. Vartuli , Stephen Zushma
发明人： Jihad M. Dakka , James C. Vartuli , Stephen Zushma
IPC分类号： C07C51/255 , C07C61/08 , C07C49/00 , C07C45/27 , C07C409/00 , C07C27/10 , C07C35/02 , C07C39/12
CPC分类号： C07C409/04 , B01D15/00 , B01J31/0235 , C07C29/50 , C07C37/08 , C07C37/20 , C07C45/33 , C07C45/53 , C07C407/00 , C07C407/003 , C07C409/08 , C07C409/14 , C07C2601/14 , Y02P20/52 , C07C49/403 , C07C35/08 , C07C39/04 , C07C39/16 , C07C409/06 , C07C409/10
摘要： In a process for oxidizing a hydrocarbon to a corresponding hydroperoxide, alcohol, ketone, carboxylic acid or dicarboxylic acid, the hydrocarbon is contacted with an oxygen-containing gas in the presence of a catalyst comprising a cyclic imide of the general formula (I): wherein each of R1 and R2 is independently selected from hydrocarbyl and substituted hydrocarbyl radicals having 1 to 20 carbon atoms, or from the groups SO3H, NH2, OH and NO2, or from the atoms H, F, Cl, Br and I provided that R1 and R2 can be linked to one another via a covalent bond; each of Q1 and Q2 is independently selected from C, CH, N and CR3; each of X and Z is independently selected from C, S, CH2, N, P and elements of Group 4 of the Periodic Table; Y is O or OH; k is 0, 1, or 2; 1 is 0, 1, or 2; m is 1 to 3, and R3 can be any of the entities listed for R1. The contacting produces an effluent comprising an oxidized hydrocarbon product and unreacted imide catalyst of said formula (I) and the effluent is treated with a solid sorbent to remove at least part of the unreacted imide catalyst and produce a treated effluent comprising said oxidized hydrocarbon product. The organic phase can then be recovered.
摘要翻译：在将烃氧化成相应的氢过氧化物，醇，酮，羧酸或二羧酸的方法中，烃在含有通式（I）的环状酰亚胺的催化剂存在下与含氧气体接触：其中R 1和R 2各自独立地选自具有1至20个碳原子的烃基和取代的烃基，或者来自SO 3 H，NH 2，OH和NO 2基团，或者从原子H，F，Cl，Br和I 并且R 2可以通过共价键彼此连接; Q1和Q2中的每一个独立地选自C，CH，N和CR 3; X和Z各自独立地选自C，S，CH 2，N，P和元素周期表第4族的元素; Y为O或OH; k为0,1或2; 1是0,1或2; m为1至3，R3可为R1列出的任何实体。接触产生包含氧化烃产物和所述式（I）的未反应酰亚胺催化剂的流出物，并且用固体吸附剂处理流出物以除去至少部分未反应的酰亚胺催化剂并产生包含所述氧化烃产物的经处理的流出物。然后可以回收有机相。

9. 发明授权

US07786168B2 Phenolic acid salts of gabapentin in solid dosage forms and methods of use 失效
标题翻译：加巴喷丁的酚酸盐在固体剂型和使用方法中的用途
公开(公告)号：US07786168B2
公开(公告)日：2010-08-31
申请号：US12138945
申请日：2008-06-13
申请人： Jeffrey S. Kiel , H. Greg Thomas , Narasimhan Mani
发明人： Jeffrey S. Kiel , H. Greg Thomas , Narasimhan Mani
IPC分类号： A61K31/196 , C07C61/08
CPC分类号： A61K9/2009 , A61K9/2018 , A61K9/2054 , A61K9/485 , A61K9/4858 , A61K31/195 , A61K31/7024
摘要： The present invention relates to pharmaceutical compositions of gabapentin tannate in solid dosage form, processes for production of those compositions and methods of use of those compositions. Tannate salts of active pharmaceutical ingredients are used in sustained release applications and to improve certain organoleptic properties such as taste. The process may utilize either natural or synthetic tannic acid.
摘要翻译：本发明涉及固体剂型中的加巴喷丁鞣酸盐的药物组合物，这些组合物的制备方法和这些组合物的使用方法。活性药物成分的鞣酸盐用于持续释放应用，并改善某些感官特性如味道。该方法可以使用天然或合成的单宁酸。

10. 发明申请

US20100056777A1 ANTIOXIDANT INFLAMMATION MODULATORS: OLEANOLIC ACID DERIVATIVES WITH SATURATION IN THE C-RING 有权
标题翻译：抗氧化剂溶解调节剂：在C环中饱和的油酸衍生物
公开(公告)号：US20100056777A1
公开(公告)日：2010-03-04
申请号：US12426737
申请日：2009-04-20
申请人： Eric Anderson , Xin Jiang , Xiaofeng Liu , Melean Visnick
发明人： Eric Anderson , Xin Jiang , Xiaofeng Liu , Melean Visnick
IPC分类号： C07D223/14 , C07C61/08 , C07C233/57 , C07C49/303 , C07C69/74 , C07C243/12 , C07D257/04 , C07D285/12 , C07D271/10 , C07D313/06
CPC分类号： C07D261/20 , C07C69/757 , C07D207/27 , C07D413/08 , C07J63/008
摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
摘要翻译：本发明提供但不限于具有下式的新型齐墩果酸衍生物：其中变量在本文中定义。还提供了包含这种化合物的药物组合物，试剂盒和制品，用于制备化合物的方法和中间体，以及使用该化合物和组合物的方法。

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