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    • 3. 发明授权
    • Preparation of porous particles with multiple markers
    • 多标记多孔颗粒的制备
    • US08110628B1
    • 2012-02-07
    • US12984044
    • 2011-01-04
    • Mridula NairTamara K. JonesDaniel L. Kapp
    • Mridula NairTamara K. JonesDaniel L. Kapp
    • C08F253/00C08J9/00C08J3/05C08J3/11
    • C08J9/283C08F2/12C08F2/32C08J9/0061C08J2201/05C08J2205/048Y10T428/1376
    • Porous particles are prepared using a first water-in-oil emulsion comprising a first marker material in a first aqueous phase that is dispersed in a first oil phase containing a polymer and a first organic solvent, and a second water-in-oil emulsion comprising a second marker material in a second aqueous phase that is dispersed in a second oil phase. The first and second marker materials are detectably different. The two water-in-oil emulsions can be used to form a third water-in-oil emulsion containing distinct droplets of the first and second aqueous phases. This third water-in-oil emulsion is dispersed in a third aqueous phase containing a surface stabilizing agent to form a water-in-oil-in-water emulsion containing droplets of the third water-in-oil emulsion. The organic solvents are removed from the water-in-oil-in-water emulsion to form porous particles comprising first and second discrete pores that are isolated from each other. The first marker material is present within the first discrete pores, and the second marker material is present within the second discrete pores.
    • 使用第一种油包水乳液制备多孔颗粒,所述第一油包水乳液包含分散在含有聚合物和第一有机溶剂的第一油相中的第一水相中的第一标记物质和第二油包水乳液,其包含 分散在第二油相中的第二水相中的第二标记物质。 第一和第二标记材料是可检测的不同。 两种油包水乳液可用于形成含有第一和第二水相的不同液滴的第三种油包水乳液。 该第三种油包水乳液分散在含有表面稳定剂的第三水相中以形成包含第三种油包水乳液的液滴的水包油包水乳液。 从水包油包水乳液中除去有机溶剂以形成包含彼此分离的第一和第二离散孔的多孔颗粒。 第一标记材料存在于第一离散孔内,第二标记材料存在于第二离散孔内。