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1. 发明申请

WO2022027005A1 ADHESIVE FOR SURGICAL STAPLE LINE REINFORCEMENT 审中-公开
公开(公告)号：WO2022027005A1
公开(公告)日：2022-02-03
申请号：PCT/US2021/070976
申请日：2021-07-27
申请人： COOK BIOTECH INCORPORATED
发明人： SOLORIO, Loran , COHEN, Steven , KLINE, Benjamin, Patrick
IPC分类号： A61L15/58 , A61L24/08 , A61L27/20 , A61L27/34 , A61L27/36
摘要： The present disclosure provides medical products including an adhesive containing a carboxyalkyl cellulose and sorbitol. Such medical products can find use as a bolster material for use in conjunction with a surgical fastening device such as a stapler. Such adhesives may include advantageous properties such as the ability to retain tack while stored under a peelable cover. Related methods of manufacture and use are also described.

2. 发明申请

WO2020242942A1 NASAL SEPTUM CARTILAGE COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：WO2020242942A1
公开(公告)日：2020-12-03
申请号：PCT/US2020/034225
申请日：2020-05-22
申请人： COOK BIOTECH INCORPORATED
发明人： SOLORIO, Loran , FECTEAU, Christopher , HOGGATT, Will , REESE, Cameron
IPC分类号： A61L27/36
摘要： Cartilage derived tissue compositions, methods of making, and methods of using same. The cartilage derived tissue compositions may comprise porcine nasal septal tissue. The cartilage derived tissue compositions also being processed to retain a beneficial component profile, while reducing cellular and DNA content.

3. 发明申请

WO2017180648A1 FIBRIN AND/OR DIALDEHYDE STARCH HYDROLYSATE MATERIALS, AND PREPARATION AND USE THEREOF 审中-公开
标题翻译：纤维素和/或二醛淀粉水解物质及其制备和用途
公开(公告)号：WO2017180648A1
公开(公告)日：2017-10-19
申请号：PCT/US2017/027044
申请日：2017-04-11
申请人： COOK BIOTECH INCORPORATED
发明人： RAMACHANDRAN, Niraj , MAGIERA, Brooke, Lynn
IPC分类号： A61K38/00 , A61L24/10 , A61P7/04
摘要： Various compositions of matter, methods of making compositions of matter, and methods of using compositions of matter, e.g. for inducing hemostasis, are disclosed. In some embodiments, a starting fibrin material is subjected to controlled hydrolysis, desirably base-catalyzed, to prepare a fibrin hydrolysate material with increased water sorption capacity. Such fibrin hydrolysate materials, alone or combined with one or more additional substances, can be used in the preparation of hemostasis promoting foams, powders or gels. In some embodiments, a starting dialdehyde starch material is subjected to controlled hydrolysis to prepare a dialdehyde starch hydrolysate material. Such dialdehyde starch hydrolysate materials, alone or combined with one or more additional substances, in some cases combined with a fibrin hydrolysate material, can be used in the preparation of hemostasis promoting foams, powders or gels.
摘要翻译：物质的各种组合物，制造物质组合物的方法以及使用物质组合物的方法，例如，用于诱导止血。在一些实施方案中，将起始纤维蛋白材料进行受控水解，期望进行碱催化，以制备具有增加的吸水能力的纤维蛋白水解产物材料。这种纤维蛋白水解物材料单独或与一种或多种其他物质组合可用于促进止血泡沫，粉末或凝胶的制备。在一些实施方案中，将起始二醛淀粉材料进行受控水解以制备二醛淀粉水解产物材料。这种二醛淀粉水解物材料单独或与一种或多种附加物质组合，在某些情况下与纤维蛋白水解物材料结合，可用于促进止血泡沫，粉末或凝胶的制备。

4. 发明申请

WO2015148723A1 EXTRACELLULAR MATRIX GRAFTS LOADED WITH EXOGENOUS FACTORS 审中-公开
标题翻译：细胞外基质与外来因子相结合
公开(公告)号：WO2015148723A1
公开(公告)日：2015-10-01
申请号：PCT/US2015/022569
申请日：2015-03-25
申请人： COOK BIOTECH INCORPORATED
发明人： HILES, Michael, C. , RYAN, Christopher, T.
IPC分类号： C12N5/02 , C12N5/078 , C07K14/745 , C07K14/52 , C07K14/54 , C07K14/555 , C07K14/78 , A61L27/38 , A61L27/54
CPC分类号： A61L27/3616 , A61L27/225 , A61L27/227 , A61L27/24 , A61L27/3633 , A61L27/54 , A61L2300/414 , C12N5/0644 , C12N2533/54
摘要： The present disclosure provides bioactive compositions, methods of making bioactive compositions, and methods of treating a patient using such bioactive compositions. In some forms the bioactive composition of the present disclosure comprises a collagenous biomaterial and a bioactive fraction of mammalian platelets applied to the collagenous biomaterial.
摘要翻译：本公开提供生物活性组合物，制备生物活性组合物的方法，以及使用这种生物活性组合物治疗患者的方法。在一些形式中，本公开的生物活性组合物包含胶原生物材料和应用于胶原生物材料的哺乳动物血小板的生物活性部分。

5. 发明申请

WO2012174234A2 FISTULA CLOSURE DEVICES AND METHODS 审中-公开
标题翻译： FISTULA闭合装置和方法
公开(公告)号：WO2012174234A2
公开(公告)日：2012-12-20
申请号：PCT/US2012/042448
申请日：2012-06-14
申请人： COOK MEDICAL TECHNOLOGIES LLC , COOK BIOTECH INCORPORATED , OBERMILLER, F., Joseph , AGNEW, Charles, W. , CHEN, Steve , HUNT, James, B.
发明人： OBERMILLER, F., Joseph , AGNEW, Charles, W. , CHEN, Steve , HUNT, James, B.
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00588 , A61B2017/00641
摘要： Described are methods and systems for treating fistulae and other passageways and openings in the body. In certain aspects, an anchored suture is provided that extends from at or near a first fistula opening and through a fistula tract toward a second fistula opening. Various modes of anchoring may be used in this regard including, in some modes, having the suture extend from a deployed anchoring member positioned in and/or around the first opening. The anchored suture, which has a more slender cross sectional dimension relative to the fistula tract through which it extends, is capable of receiving an optional fill substance therealong in the tract. A fill substance can be or include a variety of biodegradable and/or non-biodegradable objects and materials including flowable and non-flowable materials.
摘要翻译：描述了用于治疗瘘管和身体其他通道和开口的方法和系统。在某些方面，提供一种锚固缝合线，其从第一瘘开口处或附近延伸并且通过瘘管道朝向第二瘘开口延伸。在这方面可以使用各种锚固模式，包括在一些模式中，缝合线从位于第一开口中和/或周围的展开的锚定构件延伸。相对于其延伸的瘘管具有更细长的横截面尺寸的锚定缝合线能够在管道中接收可选的填充物质。填充物质可以是或包括各种可生物降解和/或不可生物降解的物体和材料，包括可流动和不可流动的材料。

6. 发明申请

WO2011150055A2 METHODS, SUBSTRATES, AND SYSTEMS USEFUL FOR CELL SEEDING OF MEDICAL GRAFTS 审中-公开
标题翻译：方法，基质和系统用于细胞接种医疗用品
公开(公告)号：WO2011150055A2
公开(公告)日：2011-12-01
申请号：PCT/US2011/037897
申请日：2011-05-25
申请人： COOK BIOTECH INCORPORATED , MUFFIN INCORPORATED , COOK MEDICAL TECHNOLOGIES LLC , HILES, Michael, C. , JOHNSON, Chad, E. , FEARNOT, Neal, E. , PAYNE, Thomas , JANKOWSKI, Ronald
发明人： HILES, Michael, C. , JOHNSON, Chad, E. , FEARNOT, Neal, E. , PAYNE, Thomas , JANKOWSKI, Ronald
IPC分类号： A61L27/38
CPC分类号： A61L27/50 , A61L27/24 , A61L27/3604 , A61L27/3633 , A61L27/3808 , A61L27/3826 , A61L2430/02 , A61L2430/06 , A61L2430/26 , A61L2430/28 , A61L2430/30 , A61L2430/32 , A61L2430/34 , C12M21/08 , C12M23/06 , C12M23/34 , C12M25/14 , C12N5/0062 , C12N2533/54
摘要： Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
摘要翻译：描述了可用于制备用于给予患者的含细胞的移植材料的方法，细胞生长底物和装置。可以在细胞生长底物中定义管状通道以促进细胞分布到底物中。还描述了用于制备细胞接种组合物的方法和装置，在施用细胞之前预处理细胞生长底物的方法和装置，以及具有新基底的细胞接种移植物及其用途。

7. 发明申请

WO2010056535A1 VASCULAR PLUGS 审中-公开
标题翻译：血管插管
公开(公告)号：WO2010056535A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/062517
申请日：2009-10-29
申请人： COOK BIOTECH INCORPORATED , COOK INCORPORATED , OBERMILLER, F., Joseph , DECKARD, Michael, D. , EVERT, Kathryn , HARDERT, Michael, W.
发明人： OBERMILLER, F., Joseph , DECKARD, Michael, D. , EVERT, Kathryn , HARDERT, Michael, W.
IPC分类号： A61B17/00 , A61B17/12
CPC分类号： A61B17/12109 , A61B17/0057 , A61B17/12022 , A61B17/12031 , A61B17/12159 , A61B17/12172 , A61B17/12177 , A61B17/1219 , A61B2017/12054
摘要： Certain aspects of the present invention provide devices for occluding vascular vessels. In some preferred forms, these devices are able to move from a first condition to a less compact, second condition in a vascular vessel so as to fully or partially prevent fluid from passing through the vessel. One such device includes a frame and a flexible sheet material. The device also includes an occluding material that is located in an interior region of the frame. The flexible sheet material and frame are associated with one another such that when the device is in the second condition in the vascular vessel, the sheet material is positioned in the vessel lumen so as to block fluid flow through the lumen.
摘要翻译：本发明的某些方面提供用于阻塞血管的装置。在一些优选的形式中，这些装置能够在血管容器中从第一状态移动到较不致密的第二状态，以便完全或部分地防止流体通过血管。一种这样的装置包括框架和柔性片材。该装置还包括位于框架的内部区域中的阻塞材料。柔性片材和框架彼此相关联，使得当装置在血管容器中处于第二状态时，片材材料被定位在血管腔中，以阻止流体流过管腔。

8. 发明申请

WO2009155607A2 COMPOSITE EXTRACELLULAR MATRIX MATERIALS AND MEDICAL PRODUCTS FORMED THEREFROM 审中-公开
标题翻译：复合细胞基质材料和形成的医药产品
公开(公告)号：WO2009155607A2
公开(公告)日：2009-12-23
申请号：PCT/US2009/048168
申请日：2009-06-22
申请人： COOK BIOTECH INCORPORATED , JOHNSON, Chad E. , ERNST, David M.J. , OVERBY, Amy
发明人： JOHNSON, Chad E. , ERNST, David M.J. , OVERBY, Amy
IPC分类号： A61L31/12 , A61L31/16 , A61L31/14
CPC分类号： A61L27/56 , A61L27/3633
摘要： Described in certain aspects are composite extracellular matrix material products including expanded collagenous materials in combination with non- expanded collagenous materials. Methods for their preparation and use are also disclosed. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.
摘要翻译：在某些方面描述的是复合细胞外基质材料产品，包括与非扩张胶原材料组合的扩张胶原材料。还公开了其制备和使用方法。某些扩张的胶原材料可以通过在有效扩张第一胶原材料的条件下用碱性物质处理第一胶原材料并回收膨胀的材料来制备。扩展的材料可以在植入时显示出有益的持续性和组织产生特性，并且可以用于形成高度多孔的医用植入物体，其可以被压缩成其原始体积的分数，然后将基本恢复其原始体积。

9. 发明申请

WO2009155600A2 COMPRESSIBLE/EXPANDABLE MEDICAL GRAFT PRODUCTS, AND METHODS FOR APPLYING HEMOSTASIS 审中-公开
标题翻译：可压缩/可扩展的医用产品，以及应用HEMOSTASIS的方法
公开(公告)号：WO2009155600A2
公开(公告)日：2009-12-23
申请号：PCT/US2009/048152
申请日：2009-06-22
申请人： COOK BIOTECH INCORPORATED , JOHNSON, Chad, E. , ERNST, David, M. J. , OVERBY, Amy
发明人： JOHNSON, Chad, E. , ERNST, David, M. J. , OVERBY, Amy
IPC分类号： A61L27/36 , A61L27/56
CPC分类号： A61L27/56 , A61L27/3633
摘要： Described are expanded collagenous materials useful in hemostatic applications. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, recovering the expanded material, processing the expanded material to provide a foam, and chemically crosslinking the foam. Expanded materials can exhibit beneficial resilience, persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.
摘要翻译：描述了可用于止血应用的扩张胶原材料。某些扩张的胶原材料可以通过在有效扩张第一胶原材料的条件下处理具有碱性物质的第一胶原材料，回收膨胀的材料，加工膨胀的材料以提供泡沫和化学交联泡沫来制备。膨胀的材料可以在植入时显示出有益的弹性，持续性和组织生成特性，并且可以用于形成高度多孔的医用植入物体，其可以被压缩成其原始体积的分数，然后将基本恢复其原始体积。

10. 发明申请

WO2009111306A2 COATED EMBOLIZATION DEVICE 审中-公开
标题翻译：涂层加固装置
公开(公告)号：WO2009111306A2
公开(公告)日：2009-09-11
申请号：PCT/US2009/035466
申请日：2009-02-27
申请人： COOK BIOTECH INCORPORATED , VIRKLER, Joel, A. , NINAN, Lal
发明人： VIRKLER, Joel, A. , NINAN, Lal
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/236 , A61L2300/252 , A61L2300/414 , A61L2300/45 , A61L2430/36 , C08L89/06
摘要： Described are embolization devices having unique bioactive coatings, as well as methods for their manufacture and use. An illustrative embolization device of the invention comprises an embolic body and a coating material comprising biotropic extracellular matrix material immobilized on a surface of the embolic body. The biotropic extracellular matrix material comprises a network of self-assembled collagen fibrils, and comprises at least one bioactive agent retained in the extracellular matrix material, wherein the bioactive agent is selected from the group consisting of a proteoglycan, a growth factor, a glycoprotein, and a glycosaminoglycan. In certain forms, such an extracellular matrix material comprises a remodelable, angiogenic extracellular matrix material, for example, a submucosa material such as but not limited to porcine small intestinal submucosa.
摘要翻译：描述了具有独特生物活性涂层的栓塞装置，以及其制造和使用的方法。本发明的说明性栓塞装置包括栓塞体和包含固定在栓塞体表面上的生物型细胞外基质材料的涂层材料。该生物活性剂选自蛋白多糖，生长因子，糖蛋白，蛋白多糖，蛋白多糖，糖蛋白，和糖胺聚糖。在某些形式中，这种细胞外基质材料包括可重塑的血管生成细胞外基质材料，例如粘膜下层材料，例如但不限于猪小肠粘膜下层。

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