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1. 发明申请

WO2004102492A2 SECURED DISPENSING CABINET AND METHODS 审中-公开
标题翻译：安全分配柜和方法
公开(公告)号：WO2004102492A2
公开(公告)日：2004-11-25
申请号：PCT/US2004/014210
申请日：2004-05-07
申请人： OMNICELL, INC. , DUNCAN, Mark, Kevin , KIDNEY, Scott, L. , ARNOLD, Brian, R.
发明人： DUNCAN, Mark, Kevin , KIDNEY, Scott, L. , ARNOLD, Brian, R.
IPC分类号： G07F
CPC分类号： G07F11/62 , G06F19/00 , G06F19/3462 , G07F11/60 , G07F17/0092
摘要： A device for dispensing items comprises a cabinet having an interior for storing items. A dispenser frame is coupled to the cabinet and is configured to be accessed, such as by pulling the dispenser frame from the cabinet. The dispenser frame includes a plurality of dividers that are configured to hold the plurality of dispensing mechanisms that each hold multiple items within the storage area. Further, the dividers are reconfigurable to permit the arrangement of the dispensing mechanisms to be adjusted. A lockable door is coupled to the front of the cabinet in front of the dispenser frame. The door may be opened to provide access to the interior of the cabinet and to the dispenser frame. A dispense drawer is positioned below the storage area so that items dispensed from the dispensing mechanisms
摘要翻译：用于分配物品的装置包括具有用于存储物品的内部的柜。分配器框架联接到机柜并且被配置为被访问，例如通过从机柜拉动分配器框架。分配器框架包括多个分隔件，其被构造成保持多个分配机构，每个分配机构保持在存储区域内的多个物品。此外，分配器是可重新配置的，以允许调整分配机构的布置。可锁定的门在分配器框架的前面联接到机柜的前部。门可以打开以提供进入橱柜内部和分配器框架的通路。分配抽屉位于存储区域下方，使得从分配机构分配的物品

2. 发明申请

WO2004042072A9 QUANTITATIVE ANALYSIS OF PROTEIN ISOFORMS USING MATRIX-ASSISTED LASER DESORPTION/IONIZATION TIME OF FLIGHT MASS SPECTROMETRY 审中-公开
标题翻译：使用矩阵辅助激光解吸/飞行质谱分析时间的蛋白质质量的定量分析
公开(公告)号：WO2004042072A9
公开(公告)日：2004-08-26
申请号：PCT/US0334386
申请日：2003-10-30
申请人： UNIV COLORADO A BODY , PERRYMAN BENJAMIN M , HELMKE STEVE M , DUNCAN MARK W
发明人： PERRYMAN BENJAMIN M , HELMKE STEVE M , DUNCAN MARK W
IPC分类号： C12Q20060101 , G01N24/00 , G01N33/00 , G01N33/68 , H01J49/00 , C12Q
CPC分类号： G01N33/6848 , G01N33/6851
摘要： The present invention provides for methods of quantitating the amounts of proteins or peptides, including those that are closely related isoforms, using matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS). Measurement of protein concentrations in vivo has been extremely difficult and problematic, and protein concentrations have not been shown to correlate well with mRNA levels, the standard used in the past. The present invention overcomes the deficiencies of prior methodologies by taking advantage of MALDI-TOF-MS technology and applying it to proteins and peptides in a way that allows for accurate, quantitative measurement in vivo of protein or peptide concentrations.
摘要翻译：本发明提供了使用基质辅助激光解吸/离子化飞行时间质谱（MALDI-TOF-MS）定量蛋白质或肽的量的方法，包括具有密切相关同种型的那些。蛋白质浓度在体内的测量是非常困难和有问题的，并且蛋白质浓度尚未显示与mRNA水平（以往使用的标准）相关性良好。本发明通过利用MALDI-TOF-MS技术克服现有方法的缺陷，并以允许蛋白质或肽浓度的体内准确，定量测量的方式将其应用于蛋白质和肽。

3. 发明申请

WO2011103687A1 SEALING SYSTEM FOR THE OUTLET OF A PLASTIC-LINED COMPRESSED GAS CYLINDER 审中-公开
标题翻译：用于塑料压缩气瓶的出口的密封系统
公开(公告)号：WO2011103687A1
公开(公告)日：2011-09-01
申请号：PCT/CA2011/050118
申请日：2011-02-28
申请人： DYNETEK INDUSTRIES LTD. , SHARP, Jeffrey, J. , DUNCAN, Mark
发明人： SHARP, Jeffrey, J. , DUNCAN, Mark
IPC分类号： F17C13/00 , F16J12/00 , F16J15/02 , F17C1/06
CPC分类号： F17C1/16 , F17C2201/0109 , F17C2201/018 , F17C2203/0604 , F17C2203/0619 , F17C2203/0621 , F17C2203/066 , F17C2203/0663 , F17C2205/0305 , F17C2205/0323 , F17C2209/227 , F17C2209/234 , F17C2221/012 , F17C2221/017 , F17C2221/033 , F17C2223/0123 , F17C2223/036 , F17C2260/036 , Y02E60/321 , Y10T29/49719 , Y10T29/4973
摘要： A sealing system for an outlet of a plastic-lined cylinder has a plastic liner outlet extending into a bore of a boss. An insert is engageable with the bore, forming a primary seal between the insert and portion of the liner outlet. A tapered compression surface of the insert engages a tapered bore portion of the liner outlet adjacent the primary seal forming a tapered interface and a secondary seal. An axial position in the boss, and dimensional integrity, of the liner outlet is maintained by engaging an annular distal end of the liner outlet in the bore by a stop. The stop can be formed on the insert.
摘要翻译：用于塑料衬里圆筒的出口的密封系统具有延伸到凸台的孔中的塑料衬里出口。插入件可与孔接合，在插入件和衬套出口的一部分之间形成主密封。插入件的锥形压缩表面接合邻近主密封件的衬套出口的锥形孔部分，形成锥形界面和次级密封。通过将衬套出口的环形远端通过止动件接合在内孔出口的凸台中的轴向位置和尺寸完整性来维持。止动件可以在插入件上形成。

4. 发明申请

WO2010053816A3 BIOMARKERS FOR DIAGNOSIS OF BREAST CANCER 审中-公开
标题翻译：用于诊断乳腺癌的生物标志物
公开(公告)号：WO2010053816A3
公开(公告)日：2010-09-02
申请号：PCT/US2009062455
申请日：2009-10-29
申请人： UNIV COLORADO REGENTS , DUNCAN MARK W , WEITZEL LINDSAY , ELIAS ANTHONY , BYERS TIMOTHY
发明人： DUNCAN MARK W , WEITZEL LINDSAY , ELIAS ANTHONY , BYERS TIMOTHY
IPC分类号： G01N33/68 , C07K14/47
CPC分类号： G01N33/57415 , G01N2800/60
摘要： The present invention provides methods and kits for determining breast cancer. The invention includes the identification and use of biomarkers that are present in different amount or differentially expressed in breast cancer versus normal controls.
摘要翻译：本发明提供了用于确定乳腺癌的方法和试剂盒。本发明包括在乳腺癌中与正常对照相比以不同量存在或差异表达的生物标志物的鉴定和使用。

5. 发明申请

WO2007070809A2 BIOMARKERS FOR BABESIA 审中-公开
标题翻译： BABESIA生物标志
公开(公告)号：WO2007070809A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/061954
申请日：2006-12-12
申请人： MCGILL UNIVERSITY , CONNECTICUT CHILDREN'S MEDICAL CENTER , THE REGENTS OF THE UNIVERSITY OF COLORADO , NDAO, Momar , WARD, Brian , KRAUSE, Peter , DUNCAN, Mark W. , EDWARDS, Mike , SPITHILL, Terence William
发明人： NDAO, Momar , WARD, Brian , KRAUSE, Peter , DUNCAN, Mark W. , EDWARDS, Mike , SPITHILL, Terence William
IPC分类号： G01N33/569
CPC分类号： G01N33/56905 , Y02A50/58
摘要： The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying babesia status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as infected with babesia or not infected with babesia. The biomarkers can be detected by SELDI mass spectrometry.
摘要翻译：本发明提供了可用于限定患者中的婴儿状态的基于蛋白质的生物标志物和生物标志物组合。特别地，本发明的生物标志物可用于将受感染的婴儿或未感染巴贝的受试者样品分类。生物标志物可以通过SELDI质谱检测。

6. 发明申请

WO2004102492A3 SECURED DISPENSING CABINET AND METHODS 审中-公开
标题翻译：安全分配柜和方法
公开(公告)号：WO2004102492A3
公开(公告)日：2005-08-18
申请号：PCT/US2004014210
申请日：2004-05-07
申请人： OMNICELL INC , DUNCAN MARK KEVIN , KIDNEY SCOTT L , ARNOLD BRIAN R
发明人： DUNCAN MARK KEVIN , KIDNEY SCOTT L , ARNOLD BRIAN R
IPC分类号： A61J7/00 , G06F17/00 , G07F20060101 , G07F11/60 , G07F11/62
CPC分类号： G07F11/62 , G06F19/3462 , G07F11/60 , G07F17/0092
摘要： A device for dispensing items comprises a cabinet (10) having an interior for storing items. A dispenser frame (44) is coupled to the cabinet and is configured to be accessed, such as by pulling the dispenser frame from the cabinet. The dispenser frame includes a plurality of dividers (22) that are configured to hold the plurality of dispensing mechanisms that each hold multiple items within the storage area. Further, the dividers are reconfigurable to permit the arrangement of the dispensing mechanisms to be adjusted. A lockable door (46) is coupled to the front of the cabinet in front of the dispenser frame. The door may be opened to provide access to the interior of the cabinet and to the dispenser frame. A dispenser drawer (38) is positioned below the storage area so that items dispensed from the dispensing mechanisms may be retrieved
摘要翻译：用于分配物品的装置包括具有用于存储物品的内部的柜（10）。分配器框架（44）联接到机柜并且被配置为被访问，例如通过从机柜拉动分配器框架。分配器框架包括多个分隔件（22），其被构造成保持多个分配机构，每个分配机构各自容纳存储区域内的多个物品。此外，分配器是可重新配置的，以允许调整分配机构的布置。可锁定门（46）在分配器框架前面联接到机柜的前部。门可以打开以提供进入橱柜内部和分配器框架的通路。分配器抽屉（38）位于存储区域下方，从而可以取回从分配机构分配的物品

7. 发明申请

WO2012050836A1 DEVICES AND METHODS FOR TREATING FISTULAE AND OTHER BODILY OPENINGS AND PASSAGEWAYS 审中-公开
标题翻译：用于处理假肢和其他身体开放和穿刺的装置和方法
公开(公告)号：WO2012050836A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/053483
申请日：2011-09-27
申请人： COOK BIOTECH INCORPORATED , AGNEW, Charles, W. , DUNCAN, Mark , JOHNSON, Chad, E.
发明人： AGNEW, Charles, W. , DUNCAN, Mark , JOHNSON, Chad, E.
IPC分类号： A61L31/14 , A61B17/00
CPC分类号： A61B17/0057 , A61B17/12099 , A61B17/12159 , A61B17/12181 , A61B17/1219 , A61B2017/00004 , A61B2017/00579 , A61B2017/00601 , A61B2017/00628 , A61B2017/00641 , A61B2017/0065 , A61B2017/00884
摘要： Some aspects of the present invention are directed to unique products and methods for treating fistulae and other passageways and openings in the body. In some preferred forms, an inventive construct will include an elongate graft body that incorporates a plurality of sheet or sheet- like segments. The plurality of sheet or sheet-like segments, in some arrangements, will be stacked in a generally longitudinal direction along the length of the plug body, and optionally, the segments will be received over one or more elongate elements. Elongate elements of this sort can take a variety of forms including a suture, wire, filament, or other relatively thin-bodied elongate member, although in some forms, an elongate element will be or include a somewhat heftier structure such as a biodegradable or non-biodegradable three-dimensional body.
摘要翻译：本发明的一些方面涉及用于治疗瘘管和身体其它通道和开口的独特产品和方法。在一些优选形式中，本发明的构造将包括结合有多个片状或片状段的细长移植体。在一些布置中，多个片状或片状片段将沿着插塞体的长度沿大致纵向的方向堆叠，并且可选地，片段将被接收在一个或多个细长元件上。这种细长的元件可以采取各种形式，包括缝合线，丝线，细丝或其他相对细长的细长构件，尽管在某些形式中，细长元件将是或包括一些较高的结构，例如可生物降解的或不可生物降解的可生物降解的三维体。

8. 发明申请

WO2011103688A1 ANTI-EXTRUSION SEALING SYSTEM FOR THE OUTLET OF A PLASTIC-LINED COMPRESSED GAS CYLINDER 审中-公开
标题翻译：塑料压缩气瓶筒出口的防挤压密封系统
公开(公告)号：WO2011103688A1
公开(公告)日：2011-09-01
申请号：PCT/CA2011/050119
申请日：2011-02-28
申请人： DYNETEK INDUSTRIES LTD. , SHARP, Jeffrey J. , DUNCAN, Mark
发明人： SHARP, Jeffrey J. , DUNCAN, Mark
IPC分类号： F17C13/00 , F16J12/00 , F16J15/02 , F17C1/06
CPC分类号： F17C1/16 , F17C2201/0109 , F17C2201/018 , F17C2203/0604 , F17C2203/0619 , F17C2203/0621 , F17C2203/066 , F17C2203/0663 , F17C2205/0305 , F17C2205/0323 , F17C2209/227 , F17C2209/234 , F17C2221/012 , F17C2221/017 , F17C2221/033 , F17C2223/0123 , F17C2223/036 , F17C2260/036 , Y02E60/321 , Y10T29/49719 , Y10T29/4973
摘要： A sealing system for an outlet of a plastic-lined cylinder has a plastic liner outlet extending into a bore of a boss. An insert is engageable with the bore, forming a primary seal between the insert and portion of the liner outlet. Further, a tapered compression surface of the insert engages a tapered bore portion of the liner outlet adjacent the primary seal for compressing the liner outlet and closing any annular assembly clearance at the primary seal for obviating opportunity for seal extrusion under pressure. An axial position in the boss and dimensional integrity of the liner outlet is maintained by engaging an annular distal end of the liner outlet in the bore by a stop. The stop can be integral with the boss. Reverse extrusion of the primary seal due to trapped gas and rapid decompression of the cylinder can be defeated by providing a leak path.
摘要翻译：用于塑料衬里缸的出口的密封系统具有延伸到凸台的孔中的塑料衬套出口。插入件可与孔接合，在插入件和衬套出口的一部分之间形成主密封。此外，插入件的锥形压缩表面接合邻近主密封件的衬套出口的锥形孔部分，用于压缩衬套出口并在主密封件处封闭任何环形组件间隙，以避免在压力下进行密封挤压的机会。通过将衬套出口的环形远端通过止动件接合在孔中，来保持衬套中的轴向位置和衬套出口的尺寸完整性。停止可以与老板一体化。通过提供泄漏路径可以消除由于捕获的气体和气缸的快速减压而导致的主密封件的反向挤压。

9. 发明申请

WO2004042072A2 QUANTITATIVE ANALYSIS OF PROTEIN ISOFORMS USING MATRIX-ASSISTED LASER DESORPTION/IONIZATION TIME OF FLIGHT MASS SPECTROMETRY 审中-公开
标题翻译：基质辅助激光解吸/飞行时间质谱法定量分析蛋白质异构体
公开(公告)号：WO2004042072A2
公开(公告)日：2004-05-21
申请号：PCT/US2003/034386
申请日：2003-10-30
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , PERRYMAN, M., Benjamin , HELMKE, Steve, M , DUNCAN, Mark, W.
发明人： PERRYMAN, M., Benjamin , HELMKE, Steve, M , DUNCAN, Mark, W.
IPC分类号： C12Q
CPC分类号： G01N33/6848 , G01N33/6851
摘要： The present invention provides for methods of quantitating the amounts of proteins or peptides, including those that are closely related isoforms, using matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS). Measurement of protein concentrations in vivo has been extremely difficult and problematic, and protein concentrations have not been shown to correlate well with mRNA levels, the standard used in the past. The present invention overcomes the deficiencies of prior methodologies by taking advantage of MALDI-TOF-MS technology and applying it to proteins and peptides in a way that allows for accurate, quantitative measurement in vivo of protein or peptide concentrations.
摘要翻译：本发明提供了使用基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF-MS）定量蛋白质或肽（包括那些密切相关的同种型的那些）的量的方法）。体内蛋白质浓度的测量是非常困难和有问题的，并且蛋白质浓度未显示与mRNA水平（过去使用的标准）很好地相关。本发明通过利用MALDI-TOF-MS技术并且以允许蛋白质或肽浓度的体内精确定量测量的方式将其应用于蛋白质和肽，克服了现有方法的缺陷

10. 发明申请

WO2004042072A3 QUANTITATIVE ANALYSIS OF PROTEIN ISOFORMS USING MATRIX-ASSISTED LASER DESORPTION/IONIZATION TIME OF FLIGHT MASS SPECTROMETRY 审中-公开
标题翻译：使用矩阵辅助激光解吸/飞行质谱分析时间的蛋白质质量的定量分析
公开(公告)号：WO2004042072A3
公开(公告)日：2004-12-29
申请号：PCT/US0334386
申请日：2003-10-30
申请人： UNIV COLORADO A BODY , PERRYMAN BENJAMIN M , HELMKE STEVE M , DUNCAN MARK W
发明人： PERRYMAN BENJAMIN M , HELMKE STEVE M , DUNCAN MARK W
IPC分类号： C12Q20060101 , G01N24/00 , G01N33/00 , G01N33/68 , H01J49/00
CPC分类号： G01N33/6848 , G01N33/6851
摘要： The present invention provides for methods of quantitating the amounts of proteins or peptides, including those that are closely related isoforms, using matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS). Measurement of protein concentrations in vivo has been extremely difficult and problematic, and protein concentrations have not been shown to correlate well with mRNA levels, the standard used in the past. The present invention overcomes the deficiencies of prior methodologies by taking advantage of MALDI-TOF-MS technology and applying it to proteins and peptides in a way that allows for accurate, quantitative measurement in vivo of protein or peptide concentrations.

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