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    • 9. 发明申请
    • MEDICAL DEVICES HAVING CROSSLINKED POLYMERIC SURFACES
    • 具有交联聚合物表面的医疗装置
    • WO2008141141A2
    • 2008-11-20
    • PCT/US2008063191
    • 2008-05-09
    • BOSTON SCIENT SCIMED INCSUTERMEISTER DEREKRASSAT JAY
    • SUTERMEISTER DEREKRASSAT JAY
    • A61L31/04A61L31/10
    • A61L31/048A61L31/10Y10T428/261Y10T428/2809C08L53/00
    • According to an aspect of the invention, medical devices are provided which contain at least one polymeric region. The polymeric region contains at least one copolymer, which includes at least one high Tg vinyl aromatic monomer and at least one low Tg monomer. Moreover, the polymeric region contains at least one surface sub- region that is crosslinked and at least one bulk sub-region that is substantially non- crosslinked. According to another aspect of the invention, a method is provided which includes exposing a polymeric region of a medical device to energetic species such that at least one surface sub-region of the polymeric region becomes crosslinked and at least one bulk sub-region remains substantially non-crosslinked. The polymeric region contains at least one copolymer, which includes at least one high Tg vinyl aromatic monomer and at least one low Tg monomer.
    • 根据本发明的一个方面,提供了包含至少一个聚合物区域的医疗装置。 聚合物区域含有至少一种共聚物,其包括至少一种高Tg乙烯基芳族单体和至少一种低Tg单体。 此外,聚合物区域含有至少一个交联的表面亚区域和基本上未交联的至少一个整体亚区域。 根据本发明的另一方面,提供了一种方法,其包括将医疗装置的聚合物区域暴露于能量物质,使得聚合物区域的至少一个表面亚区域变得交联,并且至少一个体积亚区域基本上保持 非交联。 聚合物区域含有至少一种共聚物,其包括至少一种高Tg乙烯基芳族单体和至少一种低Tg单体。