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1. 发明申请

WO2013028993A2 DEVICE AND METHODS FOR NERVE MODULATION 审中-公开
标题翻译：神经调制装置及方法
公开(公告)号：WO2013028993A2
公开(公告)日：2013-02-28
申请号：PCT/US2012/052313
申请日：2012-08-24
申请人： BOSTON SCIENTIFIC SCIMED, INC. , SUTERMEISTER, Derek , OSTROOT, Tim A. , ANDERSON, James M.
发明人： SUTERMEISTER, Derek , OSTROOT, Tim A. , ANDERSON, James M.
IPC分类号： A61B18/14 , A61B18/12
CPC分类号： A61B18/1492 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/1435
摘要： The disclosure pertains to an intravascular system for nerve modulation through a wall of a blood vessel and methods of use therefor, wherein the system is capable of nerve modulation by one or more ablations of a blood vessel adjacent to the nerve to be modulated. The intravascular system is suited for modulation of renal nerves.
摘要翻译：本公开涉及通过血管壁进行神经调节的血管内系统及其使用方法，其中所述系统能够通过邻近待调节的神经的血管的一次或多次消融进行神经调节。血管内系统适用于调节肾神经。

2. 发明申请

WO2009088969A2 DETACHMENT MECHANISMS FOR IMPLANTABLE DEVICES 审中-公开
标题翻译：可移植设备的分离机制
公开(公告)号：WO2009088969A2
公开(公告)日：2009-07-16
申请号：PCT/US2009/000017
申请日：2009-01-05
申请人： BOSTON SCIENTIFIC SCIMED, INC. , TEOH, Clifford , WILLIAMS, Michael , MIRIGIAN, Gregory E. , CARROLL, Kirsten , ANDERSON, James M. , RASSAT, Jay , ARCAND, Benjamin , SUTERMEISTER, Derek
发明人： TEOH, Clifford , WILLIAMS, Michael , MIRIGIAN, Gregory E. , CARROLL, Kirsten , ANDERSON, James M. , RASSAT, Jay , ARCAND, Benjamin , SUTERMEISTER, Derek
IPC分类号： A61B17/12
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B2017/12068 , A61B2017/12077 , A61B2017/1209
摘要： Disclosed herein are detachment mechanisms for vaso-occlusive devices that allow for rapid operator-controlled release of the vaso-occlusive device into the selected site. Also disclosed are vaso-occlusive assemblies comprising these detachment mechanisms and methods of using these detachment mechanisms and vaso-occlusive assemblies.
摘要翻译：本文公开了一种用于血管闭塞装置的分离机构，其允许快速操作者控制将血管闭塞装置释放到选定部位。还公开了包括这些分离机构的血管闭塞组件和使用这些分离机构和血管闭塞组件的方法。

3. 发明申请

WO2009111716A1 BALLOON CATHETER DEVICES WITH SHEATH COVERING 审中-公开
标题翻译：带有护罩的气囊导管装置
公开(公告)号：WO2009111716A1
公开(公告)日：2009-09-11
申请号：PCT/US2009/036359
申请日：2009-03-06
申请人： BOSTON SCIENTIFIC SCIMED, INC. , CHEN, John , RIZQ, Raed , HARRISON, Kent , HORN, Daniel , KOCUR, Gordon , EIDENSCHINK, Tracee , ARCAND, Ben , SUTERMEISTER, Derek , RASSAT, Jay , MCGUINESS, Colm , NAIMARK, Wendy , CHENG, Ruth
发明人： CHEN, John , RIZQ, Raed , HARRISON, Kent , HORN, Daniel , KOCUR, Gordon , EIDENSCHINK, Tracee , ARCAND, Ben , SUTERMEISTER, Derek , RASSAT, Jay , MCGUINESS, Colm , NAIMARK, Wendy , CHENG, Ruth
IPC分类号： A61M25/10 , A61L29/00 , A61M25/00
CPC分类号： A61M25/1029 , A61L29/085 , A61L29/16 , A61L2300/416 , A61M25/0045 , A61M25/10 , A61M2025/0056 , A61M2025/1031 , A61M2025/105 , B29L2009/005 , C08L53/02
摘要： Catheter devices (200) having an expandable balloon (204) for delivering a therapeutic agent to a body site. In one aspect, one or more sheaths are disposed around the balloon with the therapeutic agent being disposed within the sheath (206), being disposed over the sheath, being contained in the space between the sheath and the balloon, or being otherwise associated with the sheath. In another aspect, the balloon includes a micro-electromechanical system (MEMS) for drug delivery.
摘要翻译：具有用于将治疗剂递送到身体部位的可膨胀气囊（204）的导管装置（200）。在一个方面，一个或多个护套设置在球囊周围，治疗剂设置在护套（206）内，设置在护套上方，被包含在护套和气囊之间的空间中，或以其它方式与鞘。另一方面，气囊包括用于药物递送的微机电系统（MEMS）。

4. 发明申请

WO2008022168A1 ELECTRICALLY ACTUATED ANNELID 审中-公开
标题翻译：电动执行机构
公开(公告)号：WO2008022168A1
公开(公告)日：2008-02-21
申请号：PCT/US2007/075955
申请日：2007-08-15
申请人： BOSTON SCIENTIFIC SCIMED, INC. , SUTERMEISTER, Derek , RASSAT, Jay , WEFEL, Dan
发明人： SUTERMEISTER, Derek , RASSAT, Jay , WEFEL, Dan
IPC分类号： A61M25/01
CPC分类号： A61M25/0116 , A61M31/00 , A61M2025/0058
摘要： An apparatus for delivery (100) through a vessel (116) including an extensor segment (104) and first (102) and second (106) anchor segments positioned on either side of the extensor segment, wherein each segment has associated with it an individually-addressable electro-active polymer.
摘要翻译：一种用于通过容器（116）输送（100）的装置，包括定位在伸肌部分两侧的伸肌部分（104）和第一（102）和第二（106）锚定段，其中每个部分与其单独地相关联可接地的电活性聚合物。

5. 发明申请

WO2009079574A2 SPIRAL CUT HYPOTUBE 审中-公开
标题翻译：螺旋切割HYPOTUBE
公开(公告)号：WO2009079574A2
公开(公告)日：2009-06-25
申请号：PCT/US2008/087216
申请日：2008-12-17
申请人： BOSTON SCIENTIFIC SCIMED, INC. , SUTERMEISTER, Derek , RASSAT, Jay , EIDENSCHINK, Tracee E. J. , BELTON, Craig
发明人： SUTERMEISTER, Derek , RASSAT, Jay , EIDENSCHINK, Tracee E. J. , BELTON, Craig
IPC分类号： A61L29/08 , A61L29/16
CPC分类号： A61M25/0045 , A61F2/95 , A61L29/085 , A61M25/0054 , A61M25/0138 , A61M25/0158 , A61M2025/0058 , A61M2025/0063
摘要： A medical device such as a catheter may have an elongate shaft that includes a hypotube having a helical cutting formed therein. The elongate shaft may define a lumen that extends within the elongate shaft. An electroactive polymer may be disposed over at least a portion of the hypotube. A medical device may include a spiral cut hypotube having a constant pitch and may be configured to reversibly and temporarily alter the pitch of at least a portion of the spiral cut hypotube. In some cases, the medical device may be configured to reversibly and/or temporarily alter a compressive strength of at least a portion of the spiral cut hypotube.
摘要翻译：诸如导管的医疗装置可以具有细长轴，其包括在其中形成有螺旋切割的海波管。细长轴可以限定在细长轴内延伸的内腔。电活性聚合物可以设置在海波波的至少一部分上。医疗装置可以包括具有恒定节距的螺旋切割海波管，并且可以被配置为可逆地和暂时地改变螺旋切割海波管的至少一部分的俯仰。在一些情况下，医疗装置可以被配置为可逆地和/或暂时地改变至少一部分螺旋切割海波管的抗压强度。

6. 发明申请

WO2008141141A3 MEDICAL DEVICES HAVING CROSSLINKED POLYMERIC SURFACES 审中-公开
公开(公告)号：WO2008141141A3
公开(公告)日：2008-11-20
申请号：PCT/US2008/063191
申请日：2008-05-09
申请人： BOSTON SCIENTIFIC SCIMED, INC. , SUTERMEISTER, Derek , RASSAT, Jay
发明人： SUTERMEISTER, Derek , RASSAT, Jay
IPC分类号： A61L31/04 , A61L31/16
摘要： According to an aspect of the invention, medical devices are provided which contain at least one polymeric region. The polymeric region contains at least one copolymer, which includes at least one high Tg vinyl aromatic monomer and at least one low Tg monomer. Moreover, the polymeric region contains at least one surface sub- region that is crosslinked and at least one bulk sub-region that is substantially non- crosslinked. According to another aspect of the invention, a method is provided which includes exposing a polymeric region of a medical device to energetic species such that at least one surface sub-region of the polymeric region becomes crosslinked and at least one bulk sub-region remains substantially non-crosslinked. The polymeric region contains at least one copolymer, which includes at least one high Tg vinyl aromatic monomer and at least one low Tg monomer.

7. 发明申请

WO2008130572A1 DRUG RELEASING STENT HAVING EXTENSION(S) FOR TREATING LONG LESIONS 审中-公开
标题翻译：具有延长治疗长期治疗效果的药物释放手段
公开(公告)号：WO2008130572A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/004909
申请日：2008-04-16
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RASSAT, Jay , SUTERMEISTER, Derek , PETERSEN, Scott
发明人： RASSAT, Jay , SUTERMEISTER, Derek , PETERSEN, Scott
IPC分类号： A61F2/06
CPC分类号： A61F2/856 , A61F2/07 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/828 , A61F2002/91525 , A61F2002/91541 , A61F2002/91575 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2250/0039 , A61F2250/006 , A61F2250/0067
摘要： This invention generally relates to a system (100) for treating body lumens, comprising stents, such as intravascular stents. More particularly, the invention is directed to stents (110, 120) having extensions (115) attached on the ends (112, 121) thereof. The invention is also directed to methods for making and using such stents.
摘要翻译：本发明一般涉及用于治疗体腔的系统（100），其包括支架，例如血管内支架。更具体地，本发明涉及具有附接在其端部（112,121）上的延伸部（115）的支架（110,120）。本发明还涉及制造和使用这种支架的方法。

8. 发明申请

WO2011028419A1 BALLOON CATHETER DEVICES WITH DRUG-COATED SHEATH 审中-公开
标题翻译：具有药物涂层的气囊导管装置
公开(公告)号：WO2011028419A1
公开(公告)日：2011-03-10
申请号：PCT/US2010/045877
申请日：2010-08-18
申请人： BOSTON SCIENTIFIC SCIMED, INC. , KANGAS, Steve , RIZQ, Raed , SUTERMEISTER, Derek
发明人： KANGAS, Steve , RIZQ, Raed , SUTERMEISTER, Derek
IPC分类号： A61L29/08 , A61L29/00 , A61M25/10 , A61M25/00 , A61L27/50
CPC分类号： A61L29/16 , A61L29/14 , A61L2300/608 , A61L2300/63 , A61L2420/08 , A61M25/1027 , A61M2025/105 , A61M2025/1054 , A61M2025/1075 , A61M2025/1081 , A61M2025/1086 , A61M2025/1088
摘要： In one embodiment, an expandable sheath (12) covers the catheter balloon (14), and the expandable sheath is coated with the therapeutic agent. As the balloon is inflated, the sheath expands and causes the coating of therapeutic agent to break apart. In another embodiment, the balloon has a balloon wall comprising an outermost layer and one or more inner layers. The outermost layer is less compliant than the inner layer (s) such that cracks will form in the outermost layer as the balloon is inflated. The coating of therapeutic agent breaks apart when the relatively less compliant outermost layer cracks with the inflation of the balloon. Also disclosed are methods for making a medical device having a balloon.
摘要翻译：在一个实施例中，可扩张护套（12）覆盖导管球囊（14），并且可膨胀护套涂覆有治疗剂。当气囊膨胀时，鞘膨胀并导致治疗剂的涂层分离。在另一个实施例中，球囊具有包括最外层和一个或多个内层的球囊壁。最外层比内层柔顺性较差，使得当球囊膨胀时，最外层形成裂纹。当相对较不顺从的最外层随气囊膨胀而破裂时，治疗剂的涂层分解。还公开了用于制造具有气囊的医疗装置的方法。

9. 发明申请

WO2009111712A1 BALLOON CATHETER DEVICES WITH FOLDED BALLOONS 审中-公开
标题翻译：具有折叠气球的气缸导管装置
公开(公告)号：WO2009111712A1
公开(公告)日：2009-09-11
申请号：PCT/US2009/036354
申请日：2009-03-06
申请人： BOSTON SCIENTIFIC SCIMED, INC. , KNAPP, David , MICKLEY, Timothy , CHEN, John , SUTERMEISTER, Derek , FREYMAN, Toby , KOCUR, Gordon , HORN, Daniel , ANDERSON, Jim , ARCAND, Ben , RASSAT, Jay , RIZQ, Raed , NAZAROVA, Irina , QUILLIN, Dan , WEBER, Jan , SCHEUERMANN, Torsten
发明人： KNAPP, David , MICKLEY, Timothy , CHEN, John , SUTERMEISTER, Derek , FREYMAN, Toby , KOCUR, Gordon , HORN, Daniel , ANDERSON, Jim , ARCAND, Ben , RASSAT, Jay , RIZQ, Raed , NAZAROVA, Irina , QUILLIN, Dan , WEBER, Jan , SCHEUERMANN, Torsten
IPC分类号： A61M25/10 , A61L29/00
CPC分类号： A61M25/1029 , A61L29/085 , A61L29/16 , A61L2300/416 , A61M25/0045 , A61M25/10 , A61M2025/0056 , A61M2025/1031 , A61M2025/105 , B29L2009/005 , C08L53/02
摘要： Catheter devices (10) having an expandable balloon (14) for delivering a therapeutic agent to a body site. The balloon has one or more folds (16) which serve as a reservoir for containing the therapeutic agent. The fold may have any of various configurations to hold the therapeutic agent. In some cases, the balloon comprises one or more lobes that forms the fold(s). The therapeutic agent may be provided in various ways. For example, the therapeutic agent may be contained in packets that rupture upon expansion of the balloon, or as a plurality of discrete bulk masses, or sealed within compartments.
摘要翻译：具有用于将治疗剂递送到身体部位的可膨胀气囊（14）的导管装置（10）。气囊具有一个或多个褶皱（16），其用作容纳治疗剂的储存器。折叠可以具有保持治疗剂的各种构造中的任何一种。在一些情况下，气囊包括形成褶皱的一个或多个凸起。治疗剂可以以各种方式提供。例如，治疗剂可以包含在囊膨胀时破裂的包装中，或者作为多个离散的体积块，或者密封在隔室内。

10. 发明申请

WO2009099935A2 DRUG-COATED MEDICAL DEVICES FOR DIFFERENTIAL DRUG RELEASE 审中-公开
标题翻译：用于不同药物释放的药物包装医疗器械
公开(公告)号：WO2009099935A2
公开(公告)日：2009-08-13
申请号：PCT/US2009/032604
申请日：2009-01-30
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： SUTERMEISTER, Derek , ARCAND, Benjamin , RIZQ, Raed , WENTLAND, Adam , RASSAT, Jay
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/61
摘要： The embodiments described herein relate generally to medical devices that are useful for delivering one or more therapeutic agents to a body tissue of a subject, and methods for making and using such devices. In particular, the embodiments relate to a medical device such as a stent having a sidewall structure comprising a plurality of struts, in which one or more therapeutic agents are released from different surfaces of the struts at different release profiles. More particularly, the embodiments relate to a stent having a sidewall structure comprising a plurality of struts, in which the two side surfaces of each strut are coated with a coating composition that is different from the coating composition used to coat the outer surface and/or inner surface of the strut.
摘要翻译：本文所述的实施方案一般涉及可用于将一种或多种治疗剂递送至受试者的身体组织的医疗装置，以及用于制造和使用这些装置的方法。具体地，实施例涉及医疗装置，例如具有侧壁结构的支架，其包括多个支柱，其中一个或多个治疗剂在不同释放曲线下从支柱的不同表面释放。更具体地，实施例涉及一种具有侧壁结构的支架，该侧壁结构包括多个支柱，其中每个支柱的两个侧表面涂覆有与用于涂覆外表面的涂料组合物不同的涂料组合物和/或支柱的内表面。

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