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1. 发明申请

WO2011080631A2 HIGH INTENSITY FOCUSED ULTRASOUND TRANSDUCER OPTIMIZATION 审中-公开
标题翻译：高强度聚焦超声换能器优化
公开(公告)号：WO2011080631A2
公开(公告)日：2011-07-07
申请号：PCT/IB2010/055640
申请日：2010-12-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , RADULESCU, Emil, G. , EHNHOLM, Gosta, Jakob , ERKAMP, Ramon, Q. , KOSKELA, I., A., Julius , SOKKA, Shunmugavelu, D. , VAHALA, Erkki, T. , KOHLER, Max, Oskar
发明人： RADULESCU, Emil, G. , EHNHOLM, Gosta, Jakob , ERKAMP, Ramon, Q. , KOSKELA, I., A., Julius , SOKKA, Shunmugavelu, D. , VAHALA, Erkki, T. , KOHLER, Max, Oskar
IPC分类号： A61N7/00 , A61N7/02 , A61B19/00
CPC分类号： A61N7/02 , A61B2034/104 , A61B2034/105 , A61B2090/374 , A61N2007/0065 , A61N2007/0078 , A61N2007/0095
摘要： When planning magnetic resonance (MR) guided high intensity focused ultrasonic (HIFU) therapy, HIFU transducer element parameters are optimized as a function of 3D MR data describing a size, shape, and position of a region of interest (ROI) (146) and any obstructions (144) between the HIFU transducer elements and the ROI (146). Transducer element phases and amplitudes are adjusted to maximize HIFU radiation delivery to the ROI (146) while minimizing delivery to the obstruction (144). Additionally or alternatively, transducer elements are selectively deactivated if the obstruction (144) is positioned between the ROI (146) and a given transducer element.
摘要翻译：当规划磁共振（MR）引导的高强度聚焦超声波（HIFU）疗法时，HIFU换能器元件参数根据3D MR数据进行优化，所述3D MR数据描述区域的大小，形状和位置兴趣（ROI）（146）以及HIFU换能器元件和ROI（146）之间的任何障碍物（144）。传感器元件的相位和幅度被调整以最大化HIFU辐射传送到ROI（146），同时最小化传送到障碍物（144）。另外或可选地，如果障碍物（144）位于ROI（146）和给定换能器元件之间，则选择性地停用换能器元件。

2. 发明申请

WO2010140086A1 MR IMAGING GUIDED THERAPY 审中-公开
标题翻译：成像指导治疗
公开(公告)号：WO2010140086A1
公开(公告)日：2010-12-09
申请号：PCT/IB2010/052357
申请日：2010-05-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , RAJU, Balasundara, I. , ANAND, Ajay , EHNHOLM, Gosta, Jakob
发明人： RAJU, Balasundara, I. , ANAND, Ajay , EHNHOLM, Gosta, Jakob
IPC分类号： A61N7/02 , A61N5/067 , A61N1/40
CPC分类号： A61N7/02 , A61B2017/00084 , A61B2090/374
摘要： The invention relates to a therapeutic system comprising: a MR imaging unit arranged to acquire MR signals from a body (10) of a patient positioned in an examination volume, a thermal treatment unit (19, 20) for the deposition of thermal energy within tissue of the body (10). It is an object of the invention to enable continuous temperature monitoring based on MR thermometry even in a situation in which the focus of the thermal treatment is moved. To this end, the invention proposes that the system is arranged to perform the steps of: a) initiating thermal treatment by heating the tissue of the body (10) at the position of a focus within the examination volume, b) selective acquisition of MR signals from a first image plane (24), the position of the focus of the thermal treatment being located within the first image plane (24), c) reconstruction of a thermographic MR image from the MR signals acquired from the first image plane (24), d) computing a baseline thermographic MR image from the temperature distribution within at least one second image plane (25, 26, 27) being different from the first image plane (24), e) moving the focus of the thermal treatment to a new position within the examination volume, f) changing the position and/or orientation of the first image plane (24) corresponding to the new position of the focus of the thermal treatment, g) repeating steps b) and c), wherein the baseline thermographic MR image computed in step d) is used for thermographic image reconstruction in subsequent step c).
摘要翻译：本发明涉及一种治疗系统，包括：MR成像单元，其布置成从位于检查体积中的患者的身体（10）获取MR信号;热处理单元（19,20），用于在组织内沉积热能的身体（10）。本发明的目的是即使在热处理的焦点移动的情况下也能够基于MR测温进行连续温度监测。为此，本发明提出，该系统被设置为执行以下步骤：a）通过在检查体积内的焦点位置加热身体（10）的组织来启动热处理，b）选择性地获取MR 来自第一图像平面（24）的信号，热处理的焦点的位置位于第一图像平面（24）内，c）从从第一图像平面（24）获取的MR信号重建热成像MR图像），d）从与第一图像平面（24）不同的至少一个第二图像平面（25,26,27）内的温度分布计算基线热成像MR图像，e）将热处理的焦点移动到在检查体积内的新位置，f）改变对应于热处理焦点的新位置的第一图像平面（24）的位置和/或取向，g）重复步骤b）和c），其中基线热成像MR图像计算步骤d）中的d用于后续步骤c）中的热成像图像重建。

3. 发明申请

WO2010076685A1 SUSCEPTIBILITY-BASED LOCAL FLOW DETECTION TO CONTROL MR-GUIDED ABLATION USING BALLOON DEVICES 审中-公开
标题翻译：基于可靠性的局部流量检测来控制使用气球装置的MR导向
公开(公告)号：WO2010076685A1
公开(公告)日：2010-07-08
申请号：PCT/IB2009/055301
申请日：2009-11-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KRUEGER, Sascha , EHNHOLM, Gosta, Jakob
发明人： KRUEGER, Sascha , EHNHOLM, Gosta, Jakob
IPC分类号： A61B18/14 , A61B19/00 , G01R33/28
CPC分类号： A61B18/1492 , A61B90/06 , A61B90/36 , A61B2017/00084 , A61B2017/00243 , A61B2017/22067 , A61B2090/374 , A61B2090/3954 , A61N7/022
摘要： An interventional instrument (24) for use in performing an interventional procedure includes: a balloon (30) disposed proximate to a tip of the interventional instrument that inflates and anchors in a lumen of a fluid conduit during the interventional procedure; and one or more susceptibility markers (34) disposed proximate to the tip of the interventional instrument. A magnetic resonance scanner (10) is configured to image at least the tip of the interventional instrument during the interventional procedure using a magnetic resonance imaging sequence in which fluid flow (40) through the fluid conduit past the inflated balloon produces an extended magnetic resonance image artifact (42).
摘要翻译：用于执行介入手术的介入器械（24）包括：靠近介入器械的尖端布置的球囊（30），其在介入手术过程中使流体导管的内腔膨胀并锚固; 以及设置在介入器械的尖端附近的一个或多个敏感性标记（34）。磁共振扫描器（10）被配置为使用磁共振成像序列在介入手术过程中至少对介入器械的尖端进行成像，其中通过流体导管的经过充气气囊的流体流（40）产生延伸的磁共振图像神器（42）。

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