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1. 发明申请

WO2015059690A8 POLYNUCLEOTIDES ENCODING BREX SYSTEM POLYPEPTIDES AND METHODS OF USING SAME 审中-公开
标题翻译：编织BREX系统聚合物的多核苷酸及其使用方法
公开(公告)号：WO2015059690A8
公开(公告)日：2015-07-23
申请号：PCT/IL2014050902
申请日：2014-10-14
申请人： YEDA RES & DEV
发明人： SOREK ROTEM , SBERRO HILA , GOLDFARB TAMARA
IPC分类号： C12N9/10 , C07K14/195
CPC分类号： C12N1/20 , A23C9/1234 , A23C2220/202 , C07K14/195 , C07K14/245 , C07K14/32 , C12N9/0051 , C12N9/1007 , C12N9/12 , C12N9/14 , C12N9/16 , C12N9/48 , C12N15/52 , C12Y108/04008 , C12Y201/01072 , C12Y207/11001 , C12Y301/03001 , C12Y304/00 , C12Y306/04012 , C12Y306/04013
摘要： Isolated polynucleotides encoding a BREX system are provided. Accordingly there is provided an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ and at least one of pglX, pglXI, brxP, brxHI, brxHII, brxL, brxD, brxA, brxB, brxF, and brxE, with the proviso that said BREX system does not comprise pglW, and wherein said BREX system confers phage resistance to a bacteria recombinantly expressing same; Also provided is an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ, pglX, pglW and at least one of brxD and brxHI, and wherein said BREX system confers phage resistance to a bacteria recombinantly expressing same. Also provided are compositions and methods for conferring phage resistance to bacteria or for conferring bacterial susceptibility to phages.
摘要翻译：提供编码BREX系统的分离的多核苷酸。因此，提供了编码BREX系统的分离的多核苷酸，其包含编码包含brxC / pglY，pglZ和pglX，pglXI，brxP，brxHI，brxHII，brxL，brxD，brxA，brxB，brxD，brxA，brxB，brxF中的至少一种的BREX系统的核酸序列和brxE，条件是所述BREX系统不包含pglW，并且其中所述BREX系统赋予对重组表达的细菌的噬菌体抗性; 还提供了编码BREX系统的分离的多核苷酸，其包含编码包含brxC / pglY，pglZ，pglX，pglW和至少一种brxD和brxHI的BREX系统的核酸序列，并且其中所述BREX系统将重组的噬菌体抗性赋予细菌表达相同。还提供了赋予细菌噬菌体抗性或赋予细菌对噬菌体易感性的组合物和方法。

2. 发明申请

WO2008108989A3 CULTURES WITH IMPROVED PHAGE RESISTANCE 审中-公开
标题翻译：具有改善抗药性的文化
公开(公告)号：WO2008108989A3
公开(公告)日：2009-03-05
申请号：PCT/US2008002714
申请日：2008-02-29
申请人： DANISCO , BARRANGOU RODOLPHE , FREMAUX CHRISTOPHE , HORVATH PHILIPPE , ROMERO DENNIS , BOYAVAL PATRICK
发明人： BARRANGOU RODOLPHE , FREMAUX CHRISTOPHE , HORVATH PHILIPPE , ROMERO DENNIS , BOYAVAL PATRICK
IPC分类号： C12Q1/68
CPC分类号： C12N15/746 , A23C9/123 , A23C9/1238 , A23C2220/202 , A23Y2240/75 , C12N1/20 , C12N2795/00011 , C12Q1/70 , C12Q2525/151
摘要： The present invention provides methods and compositions related to modulating the resistance of a cell against a target nucleic acid or a transcription product thereof. In some preferred embodiments, the present invention provides compositions and methods for the use of one or more cas genes or proteins for modulating the resistance of a cell against a target nucleic acid or a transcription product thereof. In some embodiments, the present invention provides methods and compositions that find use in the development and use of strain combinations and starter culture rotations. In additional embodiments, the present invention provides methods for labelling and/or identifying bacteria. In some preferred embodiments, the present invention provides methods for the use of CRISPR loci to determine the potential virulence of a phage against a cell and the use of CRISPR-cas to modulate the genetic sequence of a phage for increased virulence level. In still further embodiments, the present invention provides means and compositions for the development and use of phages as biocontrol agents.
摘要翻译：本发明提供了与调节细胞对靶核酸或其转录产物的抗性相关的方法和组合物。在一些优选实施方案中，本发明提供了使用一种或多种cas基因或蛋白质调节细胞对靶核酸或其转录产物的抗性的组合物和方法。在一些实施方案中，本发明提供了用于开发和使用菌株组合和起始培养旋转的方法和组合物。在另外的实施方案中，本发明提供用于标记和/或鉴定细菌的方法。在一些优选的实施方案中，本发明提供了使用CRISPR基因座确定噬菌体对细胞的潜在毒力的方法，以及使用CRISPR-cas调节噬菌体的遗传序列以增加毒力水平。在另外的实施方案中，本发明提供用于开发和使用噬菌体作为生物防治剂的方法和组合物。

3. 发明申请

WO2004089097A1 COMPOSITION WITH HEART RATE REDUCING PROPERTIES 审中-公开
标题翻译：具有心率降低特性的组合物
公开(公告)号：WO2004089097A1
公开(公告)日：2004-10-21
申请号：PCT/DK2004/000239
申请日：2004-04-05
申请人： CHR. HANSEN A/S , FLAMBARD, Bénédicte
发明人： FLAMBARD, Bénédicte
IPC分类号： A23C9/123
CPC分类号： A61K38/018 , A23C9/1234 , A23C11/106 , A23C2220/202 , A23K20/147 , A23L33/18 , A23L33/19 , A23Y2220/39 , A61K35/20 , A61K36/00 , A61K38/02 , C12N9/52 , C12P21/00 , C12P21/06 , C12R1/225 , A61K2300/00
摘要： Use of a composition obtainable by a process comprising fermenting a food material, comprising animal milk or vegetable proteins, with a lactic acid bacterium to obtain a fermented food material which comprises active components with heart rate reducing properties for the manufacture of a product for reducing the heart rate and/or the fluctuations in the heart rate of a mammalian.
摘要翻译：使用通过包括发酵包含动物乳或植物蛋白质的食物材料与乳酸菌的方法获得的组合物，以获得发酵食品材料，其包含具有降低心率的活性成分，用于制造用于减少心率和/或哺乳动物心率的波动。

4. 发明申请

WO02024883A2 LACTIC ACID BACTERIA CAPABLE OF REDUCING AN INDIVIDUAL'S TENDENCY TO DEVELOP ALLERGIC REACTIONS 审中-公开
标题翻译：能够减少个体倾向发展过敏反应的酸性细菌
公开(公告)号：WO02024883A2
公开(公告)日：2002-03-28
申请号：PCT/EP2001/010956
申请日：2001-09-21
IPC分类号： A23C9/13 , A23C9/123 , A23J3/34 , A23L1/03 , A23L1/30 , A23L1/305 , A61K35/74 , A61K38/17 , A61K39/07 , A61P37/08 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/18 , C12N1/20 , C12N1/21 , C12N9/52 , C12N15/09 , C12N15/62
CPC分类号： A23C9/1234 , A23C9/1236 , A23C2220/202 , A23L29/065 , A23L33/10 , A23Y2220/43 , A23Y2240/41 , A23Y2300/00 , A61K35/745 , A61K35/747 , A61K2039/52 , C12N1/20
摘要： The present invention pertains to novel strains of lactic acid bacteria that are capable to reduce an individual's tendency to mount allergic reactions. In particular, the present invention relates to the generation of lactic acid bacteria strains that express proteins including tolerogenic peptides and the use thereof in reducing an individual's tendency to mount allergic reactions. The invention also pertains to food or pharmaceutical compositions containing said micro-organisms or active fractions thereof.
摘要翻译：本发明涉及能够降低个体倾向于过敏反应的新型乳酸菌菌株。特别地，本发明涉及表达包括耐受性肽的蛋白质的乳酸菌菌株的产生及其在减少个体倾向于过敏反应的用途中的用途。本发明还涉及含有所述微生物或其活性级分的食品或药物组合物。

5. 发明申请

WO01016329A2 PHAGE RESISTANT BACTERIA 审中-公开
标题翻译：抗菌细菌
公开(公告)号：WO01016329A2
公开(公告)日：2001-03-08
申请号：PCT/EP2000/007696
申请日：2000-08-08
IPC分类号： A23C9/123 , A23C19/032 , C12N1/20 , C12N1/21 , C12N15/31 , A23C9/12
CPC分类号： C12R1/46 , A23C9/1238 , A23C19/0323 , A23C2220/202 , C12N1/20
摘要： The invention relates to an S thermophilus bacterium which is restant to attack by at least one bacteriophage, a method of production of the bacterium and a composition which comprises the bacterium. The bacterium comprises a modification of the Sfi21 prophage or the bacterial genome which disrupts expression of a gene which is essential to a bacteriophage, but not essential to the bacteria.
摘要翻译：本发明涉及一种嗜热菌嗜热菌细菌，其是由至少一种噬菌体进行复原的方法，该细菌的生产方法和包含该细菌的组合物。该细菌包含Sfi21原噬菌体或细菌基因组的修饰，其破坏对噬菌体必需但对细菌不是必需的基因的表达。

6. 发明申请

WO2015059690A1 POLYNUCLEOTIDES ENCODING BREX SYSTEM POLYPEPTIDES AND METHODS OF USING S AME 审中-公开
标题翻译：编码BREX系统聚合物的多核苷酸和使用SME的方法
公开(公告)号：WO2015059690A1
公开(公告)日：2015-04-30
申请号：PCT/IL2014/050902
申请日：2014-10-14
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.
发明人： SOREK, Rotem , SBERRO, Hila , GOLDFARB, Tamara
IPC分类号： C12N9/10 , C07K14/195
CPC分类号： C12N1/20 , A23C9/1234 , A23C2220/202 , C07K14/195 , C07K14/245 , C07K14/32 , C12N9/0051 , C12N9/1007 , C12N9/12 , C12N9/14 , C12N9/16 , C12N9/48 , C12N15/52 , C12Y108/04008 , C12Y201/01072 , C12Y207/11001 , C12Y301/03001 , C12Y304/00 , C12Y306/04012 , C12Y306/04013
摘要： Isolated polynucleotides encoding a BREX system are provided. Accordingly there is provided an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ and at least one of pglX, pglXI, brxP, brxHI, brxHH, brxL, brxD, brxA, brxB, brxF , and brxE , with the proviso that said BREX system does not comprise pglW , and wherein said BREX system confers phage resistance to a bacteria recombinantiy expressing same; Also provided is an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ, pglX, pglW and at least one of brxD and brxHI , and wherein said BREX system confers phage resistance to a bacteria recombinantiy expressing same. Also provided are compositions and methods for conferring phage resistance to bacteria or for conferring bacterial susceptibility to phages.
摘要翻译：提供编码BREX系统的分离的多核苷酸。因此，提供了编码BREX系统的分离的多核苷酸，其包含编码BREX系统的核酸序列，其包含brxC / pglY，pglZ和pglX，pglXI，brxP，brxHI，brxHH，brxL，brxD，brxA，brxB，brxF中的至少一种和brxE，条件是所述BREX系统不包含pglW，并且其中所述BREX系统赋予对表达其的重组细菌的噬菌体抗性; 还提供了编码BREX系统的分离的多核苷酸，其包含编码包含brxC / pglY，pglZ，pglX，pglW和至少一种brxD和brxHI的BREX系统的核酸序列，并且其中所述BREX系统赋予对重组细菌的噬菌体抗性表达相同。还提供了赋予细菌噬菌体抗性或赋予细菌对噬菌体易感性的组合物和方法。

7. 发明申请

WO2013164479A3 IMPROVED CHYMOSINE ENZYME VARIANTS 审中-公开
标题翻译：改善CHYMOSINE酶变异
公开(公告)号：WO2013164479A3
公开(公告)日：2013-12-19
申请号：PCT/EP2013059315
申请日：2013-05-03
申请人： DSM IP ASSETS BV
发明人： DEKKER PETRUS JACOBUS THEODORUS , JONG DE RENE MARCEL , MUIJLWIJK CORNELIS MARINUS
IPC分类号： C12N9/64 , A23C19/04 , C12N1/19 , C12N15/59
CPC分类号： C12N9/6483 , A23C19/032 , A23C19/0326 , A23C19/0684 , A23C19/072 , A23C2220/202 , A23C2250/15 , C12Y304/23004
摘要： A variant polypeptide having chymosin activity, wherein the variant has an amino acid sequence which, when aligned with the chymosin comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue corresponding to any of amino acids 2, 22, 40, 48, 50, 51, 53, 61, 62, 76, 88, 98, 99, 109, 112, 117, 125, 126, 135, 144, 160, 161, 163, 187, 189, 194, 200, 201, 202, 203, 221, 223, 240, 242, 244, 254, 267, 271, 273, 278, 280, 284, 289, 292, 294 or 295 said positions being defined with reference to SEQ ID NO: 2 and wherein the variant has one or more altered properties as compared with a reference polypeptide having chymosin activity. Such a variant polypeptide may be used in the preparation of a cheese.
摘要翻译：具有凝乳酶活性的变体多肽，其中所述变体具有当与包含SEQ ID NO：2所示的序列的凝乳酶比对时的氨基酸序列包含对应于任何氨基酸的氨基酸残基的至少一个取代 2，22，40，48，50，51，53，61，62，76，88，98，99，109，112，117，125，126，135，144，160，161，163，187， 194,2200,201,202,203,221,223,240,242,244,254,267,271,273,278,280,284,289,292,294或295表示所述位置是参照SEQ ID NO：2，其中与具有凝乳酶活性的参照多肽相比，变体具有一个或多个改变的特性。这种变体多肽可用于制备奶酪。

8. 发明申请

WO2006128864A3 MUTANT STRAINS OF LACTIC ACID BACTERIA HAVING A NON-PHOSPORYLABLE LACTOSE PERMEASE 审中-公开
标题翻译：具有不可溶性乳糖皮肤的乳酸菌的突变菌株
公开(公告)号：WO2006128864A3
公开(公告)日：2007-03-29
申请号：PCT/EP2006062715
申请日：2006-05-30
申请人： GERVAIS DANONE SA , DRUESNE ANNE , GARAULT PEGGY , FAURIE JEAN-MICHEL , LICAU NADINE
发明人： DRUESNE ANNE , GARAULT PEGGY , FAURIE JEAN-MICHEL , LICAU NADINE
IPC分类号： A23C9/123 , C07K14/315
CPC分类号： A23C9/1238 , A23C19/0323 , A23C2220/202 , C12N1/20 , C12N9/00 , C12R1/46
摘要： The invention concerns lactic acid bacteria strains wherein the phosphorylable histidine of the IIA domain of lactose permease is replaced by a non-phosphorylable amino acid. Said strains have a reduced post-acidification and are useful in particular for preparing fermented dairy products.
摘要翻译：本发明涉及乳酸菌菌株，其中乳糖通透酶的IIA结构域的可磷酸化组氨酸被不可磷酸化的氨基酸替代。所述菌株具有减少的后酸化，并且特别用于制备发酵乳制品。

9. 发明申请

WO2005003354A2 METHODS AND MEANS FOR REGULATING GENE EXPRESSION 审中-公开
标题翻译：调节基因表达的方法和手段
公开(公告)号：WO2005003354A2
公开(公告)日：2005-01-13
申请号：PCT/NL2004/000474
申请日：2004-07-02
申请人： FRIESLAND BRANDS B.V. , DEN HENGST, Christiaan, Daniël , GAJIC, Olivera , KUIPERS, Oscar, Paul , KOK, Jan , SIKKEMA, Jan , GEURTS, Johannes, Marie, Wilhelmus , NAUTA, Arjen
发明人： DEN HENGST, Christiaan, Daniël , GAJIC, Olivera , KUIPERS, Oscar, Paul , KOK, Jan , SIKKEMA, Jan , GEURTS, Johannes, Marie, Wilhelmus , NAUTA, Arjen
IPC分类号： C12N15/31
CPC分类号： C12N15/746 , A23C9/12 , A23C19/032 , A23C2220/202
摘要： The invention relates to the field of biochemistry, molecular biology and food production. More in particular, the invention relates to methods and means for regulating gene expression. Even more in particular, the invention relates to CodY target sequences. Herein we show that CodY represses its target genes by binding to specific DNA sequences upstream of the respective genes. A conserved target site was identified by analyzing upstream sequences of derepressed genes in a delta codY L. lactis MG1363 derivative, as identified in a DNA micro-array study. The present application furthermore discloses CodY target sequences from other gram-positive bacteria, like B. subtilis and Streptococcus. Hence, the invention provides CodY target sequences that may be used in different applications to repress or derepress gene expression.
摘要翻译：本发明涉及生物化学，分子生物学和食品生产领域。更具体地，本发明涉及用于调节基因表达的方法和手段。更具体地，本发明涉及CodY靶序列。这里我们显示CodY通过与相应基因上游的特定DNA序列结合来抑制其靶基因。通过分析在DNA微阵列研究中鉴定的δ编码乳酸乳球菌MG1363衍生物中的去甲基化基因的上游序列来鉴定保守的靶位点。本申请还公开了来自其它革兰氏阳性菌如枯草芽孢杆菌和链球菌的CodY靶序列。因此，本发明提供可用于不同应用中的抑制或解除基因表达的CodY靶序列。

10. 发明申请

WO2004031389A1 POLYNUCLEOTIDES AND POLYPEPTIDES DERIVED FROM LACTOBACILLUS RHAMNOSUS HN001 审中-公开
标题翻译：从乳酸杆菌RHAMNOSUS HN001衍生的多核苷酸和多肽
公开(公告)号：WO2004031389A1
公开(公告)日：2004-04-15
申请号：PCT/NZ2003/000221
申请日：2003-10-03
申请人： GENESIS RESEARCH AND DEVELOPMENT CORPORATION LIMITED , FONTERRA CO-OPERATIVE GROUP LTD. , GLENN, Matthew , HAVUKKALA, Ikka, J. , LUBBERS, Mark, William , DEKKER, James
发明人： GLENN, Matthew , HAVUKKALA, Ikka, J. , LUBBERS, Mark, William , DEKKER, James
IPC分类号： C12N15/31
CPC分类号： A23C19/0323 , A23C2220/202 , A61K38/00 , A61K2039/52 , C07K14/335 , C07K2319/00
摘要： Novel polynucleotides isolated from Lactobacillus rhamnosus , as well as oligonucleotide probes and primers, genetic constructs comprising the polynucleotides, biological materials, including plants, microorganisms and multicellular organisms incorporating the polynucleotides, polypeptides expressed by the polynucleotides, and methods for using the polynucleotides and polypeptides are disclosed.
摘要翻译：从鼠李糖杆菌分离的新型多核苷酸以及寡核苷酸探针和引物，包含多核苷酸的遗传构建体，生物材料，包括植物，包含多核苷酸的微生物和多细胞生物，由多核苷酸表达的多肽，以及使用多核苷酸和多肽的方法，披露。

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