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1. 发明申请

WO2019081462A1 ELECTROCHEMICAL SENSOR AND METHOD FOR PRODUCING THEREOF 审中-公开
公开(公告)号：WO2019081462A1
公开(公告)日：2019-05-02
申请号：PCT/EP2018/078960
申请日：2018-10-23
申请人： ROCHE DIABETES CARE GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIABETES CARE, INC.
发明人： ACHMANN, Sabine , FREY, Stephan-Michael , PANKALLA, Sebastian
IPC分类号： A61B5/145 , A61B5/1486
CPC分类号： A61B5/14532 , A61B5/14865 , A61B2562/125
摘要： An electrochemical sensor (110) is disclosed, specifically for detecting an analyte in a body fluid, more specifically an electrochemical sensor for insertion of a body tissue of the user. The electrochemical sensor (110) comprises a substrate (112) having a proximal part (114) and an elongated distal part (118). At least one working electrode (124), at least one reference electrode (128) and at least one counter electrode (134)are formed on the distal part (118). The working electrode (124) comprises a conductive trace (174, 198)along which multiple electrode pads (142) are arranged that are connected via the conductive trace (174, 198). The electrode pads (142) include a corrosive conductive layer (144) covered by a non-corrosive conductive layer (146). An insulating layer (138) is disposed on the substrate (112) leaving openings (164) in the area of the electrode pads (142). The electrochemical sensor (110) comprises at least one protective measure for the corrosive conductive layer (144) selected from the group consisting of: a.the insulating layer (138) at least partially overlaps on at least one electrode pad edge (170) of at least one of the electrode pads (142); b.at least one of the electrode pads (142) has an elongated shape along the smaller dimension of the elongated distal part (118).

2. 发明申请

WO2018227006A1 IMPLANTABLE BIOSENSOR 审中-公开
公开(公告)号：WO2018227006A1
公开(公告)日：2018-12-13
申请号：PCT/US2018/036537
申请日：2018-06-07
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： HALL, Drew , KULKARNI, Saurabh
IPC分类号： A61B5/145 , A61B5/05 , C12Q1/00
CPC分类号： A61B5/14532 , A61B5/0031 , A61B5/05 , A61B5/145 , A61B5/14539 , A61B5/14865
摘要： An implantable biosensor may be placed subcutaneously to monitor the concentration of an analyte in a body fluid. The biosensor may include an electrochemical cell and an antenna. The components of the biosensor, including the electrochemical cell and the antenna, may be disposed on a same substrate. The electrochemical cell may include multiple electrodes for performing electrochemical measurements that include a first measurement of the analyte concentration in the body fluid, a second measurement of a background interference present in the body fluid, and a third measurement of a pH level within the body fluid. The antenna may receive, from a transceiver, radio frequency (RF) waves for wirelessly powering the implantable biosensor. The antenna may further transmit, back to the transceiver, a backscatter signal encoding a result of the electrochemical measurements.

3. 发明申请

WO2018178942A1 METHOD AND SYSTEM OF DISPLAYING A REAL-TIME GLUCOSE READING WITH AN ALARM CLOCK 审中-公开
公开(公告)号：WO2018178942A1
公开(公告)日：2018-10-04
申请号：PCT/IB2018/052218
申请日：2018-03-29
申请人： JURIK, Zdenek Frank
发明人： JURIK, Zdenek Frank
IPC分类号： A61B5/145 , A61B5/00 , A61B5/157 , G06F3/048 , G06F3/0484 , G06F19/00
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/743 , G16H10/60 , G16H40/63
摘要： A method and system of displaying a real-time glucose reading includes a computing system, a glucose monitor, and an alarm clock, wherein an acceptable glucose range is stored on the computing system. The method includes the steps of continuously receiving a set of glucose-level readings through the glucose monitor; relaying the set of glucose-level readings from the glucose monitor to the computing system; parsing through the set of glucose-level readings with the computing system in order to identify at least one outlier reading within the set of glucose-level readings, wherein the outlier reading is outside of the acceptable glucose range; relaying the set of glucose-level readings from the computing system to the alarm clock; displaying the set of glucose- level readings with a projector of the alarm clock; outputting an alert with the alarm clock, if the outlier reading is identified by the computing system.

4. 发明申请

WO2018152146A1 NEEDLE ALIGNMENT FOR WEARABLE BIOSENSORS 审中-公开
公开(公告)号：WO2018152146A1
公开(公告)日：2018-08-23
申请号：PCT/US2018/018096
申请日：2018-02-14
申请人： VERILY LIFE SCIENCES LLC
发明人： FRICK, Sean
IPC分类号： A61B5/1473
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/6848 , A61B5/688 , A61B2560/063 , A61B2562/12
摘要： Various examples are described for needle alignment for wearable biosensors. One example device includes a housing comprising an upper portion and a lower portion, the housing defining a cavity between the upper portion and the lower portion and configured to be worn on a wearer's skin, wherein: the upper portion defines a first opening extending through the upper portion to the cavity, and the lower portion defines a second opening extending through the lower portion to the cavity, the cavity establishing a substantially unobstructed pathway including the first opening and the second opening to enable an insertion needle to be inserted through the housing; and a needle guide extending into and along a portion of the pathway and aligned with a sensor wire to enable alignment between the insertion needle and the sensor wire.

5. 发明申请

WO2017210377A1 ACUTE KIDNEY INJURY DETECTION SYSTEM AND METHODS 审中-公开
标题翻译：急性肾损伤检测系统与方法
公开(公告)号：WO2017210377A1
公开(公告)日：2017-12-07
申请号：PCT/US2017/035354
申请日：2017-06-01
申请人： CARDIAC PACEMAKERS, INC.
发明人： STAHMANN, Jeffrey E. , KANE, Michael John , THAKUR, Pramodsingh Hirasingh , WARIAR, Ramesh
IPC分类号： A61B5/20 , A61B5/145 , A61B5/00 , G01N27/327 , A61B5/1473 , A61B5/07 , A61B5/1459 , A61B5/1486 , A61B5/0205 , A61B5/08 , A61B5/0245 , A61B5/02
CPC分类号： A61B5/201 , A61B5/0031 , A61B5/02028 , A61B5/0205 , A61B5/021 , A61B5/0245 , A61B5/026 , A61B5/076 , A61B5/0816 , A61B5/14503 , A61B5/14507 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/1473 , A61B5/14865 , A61B5/204 , A61B5/205 , A61B5/208 , A61B5/4848 , A61B5/4875 , A61B5/6861 , A61B5/7264 , A61B5/7275 , A61B5/7282 , A61B5/746 , A61B2505/07 , A61B2560/0475 , G01N27/3273 , G01N33/483 , G01N2800/347 , G06F19/324 , G06F19/3418 , G08B21/0453 , G16H10/60 , G16H50/30
摘要： Embodiments herein include systems and methods for detecting, predicting and/or assessing acute kidney injury. In an embodiment, a monitoring system to detect acute kidney injury is included. The monitoring system can include a sensor circuit configured to collect renal data including at least one of systemic renal data, direct renal data, urinary tract data, and renal-relevant extracorporeal data. The monitoring system can also include a memory circuit to store collected renal data, an evaluation circuit to assess renal status, and a telemetry circuit. The evaluation circuit can determine whether acute kidney injury has occurred or is likely to occur by comparing the renal data to at least one of threshold values, personal historical values, patient population values and patterns indicative of acute kidney injury. The evaluation circuit can initiate a warning notification if acute kidney injury has occurred or is likely to occur. Other embodiments are also included herein.
摘要翻译：这里的实施方式包括用于检测，预测和/或评估急性肾损伤的系统和方法。在一个实施例中，包括检测急性肾损伤的监测系统。该监测系统可以包括传感器电路，该传感器电路被配置为收集肾脏数据，该肾脏数据包括全身肾脏数据，直接肾脏数据，尿道数据和肾脏相关的体外数据中的至少一个。监测系统还可以包括存储收集的肾脏数据的存储电路，评估肾脏状态的评估电路以及遥测电路。评估电路可以通过将肾脏数据与阈值，个人历史值，患者群体值和指示急性肾损伤的模式中的至少一个进行比较来确定急性肾损伤是否已经发生或可能发生。如果急性肾损伤已经发生或可能发生，评估电路可以发出警告通知。其他实施例也包括在本文中。

6. 发明申请

WO2017134211A1 MEDICAL DEVICE FOR DETECTING AT LEAST ONE ANALYTE IN A BODY FLUID 审中-公开
标题翻译：用于检测身体流体中至少一种分析物的医疗设备
公开(公告)号：WO2017134211A1
公开(公告)日：2017-08-10
申请号：PCT/EP2017/052360
申请日：2017-02-03
申请人： ROCHE DIABETES CARE GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIABETES CARE, INC.
发明人： WALTER, Helmut
IPC分类号： A61B5/145 , A61B5/1486
CPC分类号： A61B5/14503 , A61B5/14532 , A61B5/14865 , A61B5/6849 , A61B2560/063 , A61B2562/166 , A61B2562/242
摘要： A medical device (110) for detecting at least one analyte in a body fluidis disclosed. The medical device (110) comprises: - at least one analyte sensor (112) having an insertable portion (114) adapted for at least partially being inserted into a body tissue of a user, - at least one insertion cannula (116), wherein the analyte sensor (112) at least partially is placed inside the insertion cannula (116); - at least one housing (118), wherein the housing (118) comprises at least one sensor compartment (120), wherein the sensor compartment (120) forms a sealed compartment (122) receiving at least the insertable portion (114) of the analyte sensor (112), wherein the sealed compartment (122) comprises at least one detachable upper cap (124) and at least one detachable lower cap (126), wherein the detachable lower cap (126) is configured for detachment before insertion, thereby opening the insertable portion (114) for insertion, wherein the insertion cannula (116) is attached to the detachable upper cap (124), wherein the detachable upper cap (124) is configured for detachment after insertion, thereby removing the insertion cannula (116); and - at least one electronics unit (134), wherein the analyte sensor (112) is operably connected to the electronics unit (134), wherein the electronics unit (134) comprises at least one interconnect device (136) with at least one electronic component (142) attached thereto, wherein the interconnect device (136) fully or partially surrounds the housing (118).
摘要翻译：公开了一种用于检测体液中的至少一种分析物的医疗装置（110）。医疗设备（110）包括： - 至少一个分析物传感器（112），其具有适于至少部分地插入使用者的身体组织中的可插入部分（114）; - 至少一个插入套管（116），其中分析物传感器（112）至少部分地放置在插入套管（116）内; - 至少一个壳体（118），其中所述壳体（118）包括至少一个传感器隔室（120），其中所述传感器隔室（120）形成密封隔室（122），所述隔室至少容纳所述可插入部分分析物传感器112，其中所述密封隔室122包括至少一个可拆卸上盖124和至少一个可拆卸下盖126，其中所述可拆卸下盖126被构造用于在插入之前脱离，打开可插入部分（114）以便插入，其中插入套管（116）附接到可拆卸上盖（124），其中可拆卸上盖（124）被构造为在插入后脱离，从而移除插入套管）; 和至少一个电子单元（134），其中分析物传感器（112）可操作地连接到电子单元（134），其中电子单元（134）包括至少一个互连装置（136），其具有至少一个电子（142），其中互连装置（136）完全或部分地围绕壳体（118）。

7. 发明申请

WO2017117472A1 BIOINTERFACE LAYER FOR ANALYTE SENSORS 审中-公开
标题翻译：用于分析传感器的生物界面层
公开(公告)号：WO2017117472A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/069348
申请日：2016-12-29
申请人： DEXCOM, INC.
发明人： LEE, Ted, Tang , DENNIS, Andrew, Trinin , WANG, Shanger , ZOU, Jiong
IPC分类号： B05C9/12 , C12Q1/58 , G01N27/26
CPC分类号： G01N27/3273 , A61B5/0004 , A61B5/002 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B2562/12 , A61K31/045 , A61K31/137 , A61K31/46 , A61K31/465 , A61K31/485 , A61K31/515 , A61K31/56 , A61K33/00 , A61K36/185 , A61K38/28 , C08G18/0828 , C08G18/12 , C08G18/3857 , C08G18/4018 , C08G18/44 , C08G18/4833 , C08G18/755 , C08L39/06 , C08L69/00 , C08L75/04 , C12N11/08 , C12Q1/002 , C12Q1/006 , G01N27/3275 , G01N33/66 , C08G18/3234
摘要： Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The biointerface layer increases sensor longevity and decrease sensor inaccuracy by inhibiting accumulation of cells, proteins, and other biological species on the outermost layers of the sensor.
摘要翻译：公开了用于确定分析物浓度的装置（例如葡萄糖）。这些装置包括配置为产生与分析物浓度相关的信号的传感器和位于传感器上的传感膜。传感膜包括生物界面层，其与包含待测分析物的生物流体相接。生物界面层包含生物界面聚合物，其中生物界面聚合物包含聚氨酯和/或聚脲区段和一个或多个两性离子重复单元。生物界面层通过抑制传感器最外层的细胞，蛋白质和其他生物物种的积累，增加传感器的寿命并降低传感器的不准确性。

8. 发明申请

WO2017117468A1 ENZYME IMMOBILIZED ADHESIVE LAYER FOR ANALYTE SENSORS 审中-公开
标题翻译：用于分析传感器的酶固定粘合剂层
公开(公告)号：WO2017117468A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/069341
申请日：2016-12-29
申请人： DEXCOM, INC.
发明人： WANG, Shanger , LEE, Ted, Tang , ZOU, Jiong
IPC分类号： B05C9/12 , C12Q1/58 , G01N27/26
CPC分类号： G01N27/3273 , A61B5/0004 , A61B5/002 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B2562/12 , A61K31/045 , A61K31/137 , A61K31/46 , A61K31/465 , A61K31/485 , A61K31/515 , A61K31/56 , A61K33/00 , A61K36/185 , A61K38/28 , C08G18/0828 , C08G18/12 , C08G18/3857 , C08G18/4018 , C08G18/44 , C08G18/4833 , C08G18/755 , C08L39/06 , C08L69/00 , C08L75/04 , C12N11/08 , C12Q1/002 , C12Q1/006 , G01N27/3275 , G01N33/66 , C08G18/3234
摘要： Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.
摘要翻译：公开了用于确定分析物浓度的装置（例如葡萄糖）。这些装置包括配置为产生与分析物浓度相关的信号的传感器和位于传感器上的传感膜。传感膜包含酶层，其中酶层包含酶和包含聚氨酯和/或聚脲段和一个或多个两性离子重复单元的聚合物。酶层保护酶并防止其从传感膜渗入宿主或失活。

9. 发明申请

WO2017116915A1 TRANSCUTANEOUS ANALYTE SENSOR SYSTEMS AND METHODS 审中-公开
标题翻译：经皮分析传感器系统和方法
公开(公告)号：WO2017116915A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/068102
申请日：2016-12-21
申请人： DEXCOM, INC.
发明人： HALAC, Jason , GRAY, John, Michael , JOHNSTON, Neal, Davis , ENGLAND, Justen, Deering , SIMPSON, Peter, C. , NEALE, Paul, V. , BLACKWELL, Jennifer , WELLS, Maria Noel, Brown , PIRONDINI, Kenneth , REINHARDT, Andrew, Michael , KEMPKEY, Mark, Douglas
IPC分类号： A61B5/00
CPC分类号： A61B5/14503 , A61B5/0004 , A61B5/14532 , A61B5/14865 , A61B5/6832 , A61B5/6848 , A61B5/6849 , A61B5/742 , A61B2560/063
摘要： Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.
摘要翻译：用于将经皮监视器应用于人的系统可以包括伸缩组件，传感器和具有粘合剂的基座以将传感器耦合到皮肤。当底座从系统的远端突出时，传感器可以位于伸缩组件内。系统可以配置为通过压缩伸缩组件将传感器连接到基座上。

10. 发明申请

WO2016193444A1 MEASUREMENT SYSTEM FOR MEASURING THE CONCENTRATION OF AN ANALYTE WITH A SUBCUTANEOUS ANALYTE SENSOR 审中-公开
标题翻译：用于测量分析仪与分析仪分析仪传感器浓度的测量系统
公开(公告)号：WO2016193444A1
公开(公告)日：2016-12-08
申请号：PCT/EP2016/062673
申请日：2016-06-03
申请人： ROCHE DIABETES CARE GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIABETES CARE, INC.
发明人： RIEBEL, Stefan , SCHWENKER, Kai-Oliver , SCHMITZ, Ralf , MUEGLITZ, Carsten , EISSENLOEFFEL, Thomas
IPC分类号： G06F19/00 , A61B5/1495 , A61B5/1486 , A61B5/145 , A61M5/142 , A61M5/172 , A61M5/168 , G01N33/487
CPC分类号： A61B5/0022 , A61B5/002 , A61B5/1451 , A61B5/14532 , A61B5/14865 , A61B5/1495 , A61B2560/0214 , A61B2560/0475 , A61M5/14248 , A61M5/16827 , A61M5/1723 , A61M2005/1726 , A61M2205/3561 , A61M2205/3569 , A61M2205/52 , A61M2205/8206 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H10/60 , G16H40/40 , G16H40/63 , G16H50/20
摘要： The invention provides for a a medical system comprising a control unit (102) and a medical appliance (104). The medical appliance is a body-worn medical appliance with a subcutaneous portion powered by a first battery. The medical appliance comprises a first wireless communication module and a sensor for measuring an analyte concentration. The control unit comprises a second wireless communication module and a second memory comprising an application partition (138) and a persistent partition (140). The application partition contains a medical application (142) and application data (144). The persistent partition contains archived data (146). The archived data comprises a copy of at least a portion of the application data. The medical application is configured for modifying the application data in the application partition and storing the portion of the application data comprised in the archived data in the persistent partition. The medical data entry comprises the analyte concentration, wherein execution of the medical appliance instructions cause the first processor to: record the analyte concentration using the monitoring system, generate a medical data entry at least partially using the analyte concentration, and transfer the medical data entry to the control unit using the wireless communication channel, wherein the application data comprises the medical data entry. The second memory further contains an operating system, wherein the operating system is operable for de-installing the medical application. The de-installation deletes the application data and preserves the archived data on the persistent partition.
摘要翻译：本发明提供一种包括控制单元（102）和医疗器具（104）的医疗系统。医疗器具是具有由第一电池供电的皮下部分的身体佩戴的医疗器具。医疗器具包括第一无线通信模块和用于测量分析物浓度的传感器。控制单元包括第二无线通信模块和包括应用分区（138）和持久分区（140）的第二存储器。应用程序分区包含医疗应用程序（142）和应用程序数据（144）。持久分区包含归档数据（146）。归档数据包括应用数据的至少一部分的副本。医疗应用被配置用于修改应用程序分区中的应用程序数据，并将包含在归档数据中的应用程序数据的部分存储在永久分区中。医疗数据输入包括分析物浓度，其中医疗器具指令的执行使得第一处理器使用监测系统记录分析物浓度，至少部分地使用分析物浓度产生医学数据输入，并传送医疗数据项使用所述无线通信信道发送到所述控制单元，其中所述应用数据包括所述医疗数据条目。第二存储器还包括操作系统，其中操作系统可操作用于解除医疗应用的安装。解除安装会删除应用程序数据并保留持久分区上的归档数据。

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