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    • 10. 发明申请
    • POLYMER SYSTEMS FOR LUNG VOLUME REDUCTION THERAPY
    • 用于肺容量减少治疗的聚合物系统
    • WO2008039827A2
    • 2008-04-03
    • PCT/US2007/079504
    • 2007-09-26
    • AERIS THERAPEUTICS, INC.INGENITO, Edward, P.SCHWARZ, AlexanderTSAI, Larry, W.
    • INGENITO, Edward, P.SCHWARZ, AlexanderTSAI, Larry, W.
    • A61K31/736A61K31/74
    • A61K31/736A61K9/007A61K9/06A61K31/74
    • One aspect of the invention relates to a hydrogel comprising a polymer comprising a plurality of pendent hydroxyl groups, a crosslinker, and a sclerosing agent. Another aspect of the invention relates to a method for reducing lung volume in a patient comprising the steps of advancing into a region of a patient's lung via said patient's trachea a multi-lumen catheter lumen through a bronchoscope; and co-administering, through the multi-lumen catheter, a first mixture comprising a first amount of a polymer containing a plurality of pendent hydroxyl groups; a second mixture comprising a second amount of a crosslinker; and a third mixture comprising a third amount of a sclerosing agent; thereby forming a hydrogel in said region. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema of the lung.
    • 本发明的一个方面涉及包含含有多个侧链羟基的聚合物,交联剂和硬化剂的水凝胶。 本发明的另一方面涉及一种用于减轻患者肺容积的方法,包括以下步骤:通过所述病人的气管,通过支气管镜进入多腔导管腔,进入患者肺部区域; 并且通过所述多腔导管共同施用包含第一量含有多个侧链羟基的聚合物的第一混合物; 第二混合物,其包含第二量的交联剂; 和包含第三量的硬化剂的第三混合物; 从而在所述区域中形成水凝胶。 在某些实施方案中,本文所述的组合物和方法旨在用于治疗患有肺气肿的患者。