专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2019030542A1 IMMUNOMODULATORY AGENT 审中-公开
公开(公告)号：WO2019030542A1
公开(公告)日：2019-02-14
申请号：PCT/GB2018/052298
申请日：2018-08-13
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
发明人： MAIZELS, Richard Michael , MCSORLEY, Henry John
IPC分类号： C07K14/715 , A61K38/58 , A61K35/62
CPC分类号： C07K14/4354 , A61K35/62 , A61K38/00 , C07K2319/21 , C07K2319/41 , C07K2319/80
摘要： The present invention relates to a polypeptide comprising HpARI domain 2 and: -a. a DNA-binding domain, and/or b. HpARI domain 3, the polypeptide having an inhibitory effect on IL-33 activity. The invention relates further to a related nucleic acid, expression vector, host cell, pharmaceutical composition use in method of treatment, for example for use in treating allergic or inflammatory disorders. The invention also relates to a method of treating allergic or inflammatory disorder, and a ex vivo method of inhibiting IL-33, wherein these methods involve the use of the polypeptide.

2. 发明申请

WO2018049287A2 METHODS AND COMPOUNDS FOR GENE INSERTION INTO REPEATED CHROMOSOME REGIONS FOR MULTI-LOCUS ASSORTMENT AND DAISYFIELD DRIVES 审中-公开
标题翻译：将基因插入重复染色体区域的方法和化合物用于多位点分布和DAISYFIELD驱动
公开(公告)号：WO2018049287A2
公开(公告)日：2018-03-15
申请号：PCT/US2017/050857
申请日：2017-09-09
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： ESVELT, Kevin , MIN, Jianghong , NOBLE, Charleston
IPC分类号： C12N15/10
CPC分类号： C12N9/22 , A01K67/0275 , A01K67/0336 , A01K67/0339 , A01K2217/15 , A01K2227/105 , A01K2227/706 , A01K2267/01 , C07K2319/80 , C12N15/10 , C12N15/102 , C12N15/90 , C12N15/902 , C12N2310/20 , C12N2800/80
摘要： The invention relates, in part, to methods to design and construct gene drives such as daisy chain gene drives, suppression gene drives, and other types of gene drives that may be included in cell lines and organisms.
摘要翻译：本发明部分涉及设计和构建基因驱动的方法，例如菊花链基因驱动，抑制基因驱动以及可以包括在细胞系和生物体中的其他类型的基因驱动。

3. 发明申请

WO2017121836A1 THERMOPHILIC DNA POLYMERASE MUTANTS 审中-公开
标题翻译：热亲和DNA聚合酶突变体
公开(公告)号：WO2017121836A1
公开(公告)日：2017-07-20
申请号：PCT/EP2017/050631
申请日：2017-01-13
申请人： THERMO FISHER SCIENTIFIC BALTICS UAB
发明人： SKIRGAILA, Remigijus , RIMSELIENE, Renata , SUKACKAITE, Rasa , SIMUTYTE, Martyna , VALINSKYTE, Skaiste , MATJOSAITIS, Karolis , UKANIS, Mindaugas
IPC分类号： C12N9/12
CPC分类号： C12N9/1252 , C07K2319/80 , C12P19/34 , C12Q1/686 , C12Y207/07007
摘要： This disclosure relates to thermophilic family B DNA polymerases comprising a neutral amino acid residue at a certain position near the C-terminus of the catalytic domain, which corresponds to a position occupied by a basic amino acid residue in wild-type Pfu polymerase. Related uses, methods, and compositions are also provided. In some embodiments, the polymerases comprise a 3'-5' exonuclease domain and/or a sequence non-specific dsDNA binding domain.
摘要翻译：本公开涉及嗜热家族B DNA聚合酶，其包含在催化结构域的C端附近的特定位置处的中性氨基酸残基，所述中性氨基酸残基对应于被碱性氨基酸残基野生型Pfu聚合酶。还提供了相关的用途，方法和组成。在一些实施方案中，聚合酶包含3'-5'外切核酸酶结构域和/或序列非特异性dsDNA结合结构域。

4. 发明申请

WO2017066497A3 GENOME ENGINEERING WITH TYPE I CRISPR SYSTEMS IN EUKARYOTIC CELLS 审中-公开
标题翻译：基因工程与I型CRISPR系统在真核细胞中的应用
公开(公告)号：WO2017066497A3
公开(公告)日：2017-06-29
申请号：PCT/US2016056925
申请日：2016-10-13
申请人： UNIV DUKE , UNIV NORTH CAROLINA STATE
发明人： GERSBACH CHARLES A , PICKAR ADRIAN , BEISEL CHASE
IPC分类号： C12N15/867 , A61K48/00 , C12N5/10 , C12N9/22 , C12N15/09 , C12N15/86
CPC分类号： C12N15/907 , C07K2319/00 , C07K2319/09 , C07K2319/21 , C07K2319/41 , C07K2319/43 , C07K2319/80 , C12N9/22 , C12N15/102 , C12N2740/15043 , C12N2740/16043
摘要： Disclosed herein are Type I Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) system related compositions and methods of using said Type I CRISPR/Cas system related compositions for altering gene expression and genome engineering. The invention relates to compositions comprising Type I CRISPR-Cas polypeptides and CRISPR array nucleic acids designed for genome modification in eukaryotic cells and for targeted killing of eukaryotic cells.
摘要翻译：本文公开了用于改变基因表达和基因组工程的I型成簇常规间隔短回文重复（CRISPR）/ CRISPR相关（Cas）系统相关组合物和使用所述I型CRISPR / Cas系统相关组合物的方法。本发明涉及包含I型CRISPR-Cas多肽和CRISPR阵列核酸的组合物，其设计用于在真核细胞中进行基因组修饰并用于靶向杀死真核细胞。

5. 发明申请

WO2017070632A3 NUCLEOBASE EDITORS AND USES THEREOF 审中-公开
标题翻译：核编辑器及其用途
公开(公告)号：WO2017070632A3
公开(公告)日：2017-06-08
申请号：PCT/US2016058344
申请日：2016-10-22
申请人： HARVARD COLLEGE
发明人： LIU DAVID R , KOMOR ALEXIS CHRISTINE , REES HOLLY A , KIM YONGJOO
IPC分类号： C07K14/32 , C12N9/22 , C12N9/78 , C12N15/10 , C12N15/90
CPC分类号： C12N9/22 , C07K14/32 , C07K2319/00 , C07K2319/09 , C07K2319/80 , C12N9/2497 , C12N9/78 , C12N15/907 , C12Y305/04005
摘要： Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of Cas9 and nucleic acid editing proteins or protein domains, e.g., deaminase domains, are provided. In some embodiments, methods for targeted nucleic acid editing are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of Cas9 and nucleic acid editing proteins or domains, are provided.
摘要翻译：本公开的一些方面提供可用于核酸的定向编辑的策略，系统，试剂，方法和试剂盒，包括编辑例如人基因组内的细胞或受试者基因组内的单个位点。在一些实施方案中，提供了Cas9的融合蛋白和核酸编辑蛋白或蛋白结构域，例如脱氨酶结构域。在一些实施方案中，提供了用于靶向核酸编辑的方法。在一些实施方案中，提供用于产生靶向核酸编辑蛋白的试剂和试剂盒，例如Cas9的融合蛋白和核酸编辑蛋白或结构域。

6. 发明申请

WO2017066497A2 GENOME ENGINEERING WITH TYPE I CRISPR SYSTEMS IN EUKARYOTIC CELLS 审中-公开
标题翻译：基因工程与I型CRISPR系统在真核细胞中的应用
公开(公告)号：WO2017066497A2
公开(公告)日：2017-04-20
申请号：PCT/US2016/056925
申请日：2016-10-13
申请人： DUKE UNIVERSITY , NORTH CAROLINA STATE UNIVERSITY
发明人： GERSBACH, Charles, A. , PICKAR, Adrian , BEISEL, Chase
IPC分类号： A61K48/00 , C07H21/04
CPC分类号： C12N15/907 , C07K2319/00 , C07K2319/09 , C07K2319/21 , C07K2319/41 , C07K2319/43 , C07K2319/80 , C12N9/22 , C12N15/102 , C12N2740/15043 , C12N2740/16043
摘要： Disclosed herein are Type I Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) system related compositions and methods of using said Type I CRISPR/Cas system related compositions for altering gene expression and genome engineering. The invention relates to compositions comprising Type I CRISPR-Cas polypeptides and CRISPR array nucleic acids designed for genome modification in eukaryotic cells and for targeted killing of eukaryotic cells.
摘要翻译：本文公开了I型聚簇规则间隔短回文重复序列（CRISPR）/ CRISPR相关（Cas）系统相关组合物和使用所述I型CRISPR / Cas系统相关组合物改变基因表达的方法和基因组工程。本发明涉及包含I型CRISPR-Cas多肽和CRISPR阵列核酸的组合物，其设计用于在真核细胞中进行基因组修饰并用于靶向杀死真核细胞。

7. 发明申请

WO2016156033A1 ISOLATION OF NUCLEOSOMES HAVING MULTIPLE-MODIFIED HISTONE PROTEIN OCTAMERS 审中-公开
标题翻译：具有多个修饰的HISTONE蛋白OCTAMERS的核酸分离
公开(公告)号：WO2016156033A1
公开(公告)日：2016-10-06
申请号：PCT/EP2016/055605
申请日：2016-03-15
申请人： UNIVERSITÄT STUTTGART
发明人： JELTSCH, Albert , KUNGULOVSKI, Goran , MAUSER, Rebekka
IPC分类号： C07K14/435
CPC分类号： C07K14/4702 , C07K14/435 , C07K2319/20 , C07K2319/80 , G01N33/573 , G01N33/6842 , G01N2440/12
摘要： The invention discloses the use of an artificial protein for isolating a nucleosome, the nucleosome comprising a multiple-modified histone protein octamer, wherein the artificial protein comprises a first histone modification binding domain of 50 to 200 amino acids binding to a first histone modification, a second histone modification binding domain of 50 to 200 amino acids binding to a second histone modification, a linker of 5 to 50 amino acids connecting the first and the second histone modification binding domain, and an affinity tag. Further disclosed are a nucleic acid encoding the artificial protein, a host cell comprising the nucleic acid and a kit for isolating a nucleosome, the nucleosome comprising a multiple-modified histone protein octamer. Further disclosed is an in-vitro method for isolating a nucleosome having a first and a second histone modification.
摘要翻译：本发明公开了人造蛋白用于分离核小体的用途，所述核小体包含多重修饰的组蛋白八聚体，其中所述人造蛋白包含与第一组蛋白修饰结合的50-200个氨基酸的第一组蛋白修饰结合结构域，与第二组蛋白修饰结合的50至200个氨基酸的第二组蛋白修饰结合结构域，连接第一和第二组蛋白修饰结合结构域的5至50个氨基酸的接头和亲和标签。还公开了编码人造蛋白的核酸，包含核酸的宿主细胞和用于分离核小体的试剂盒，所述核小体包含多重修饰的组蛋白八聚体。进一步公开的是用于分离具有第一和第二组蛋白修饰的核小体的体外方法。

8. 发明申请

WO2016141224A1 ENGINEERED CRISPR-CAS9 NUCLEASES WITH ALTERED PAM SPECIFICITY 审中-公开
标题翻译：工程CRISPR-CAS9核与更改的PAM特性
公开(公告)号：WO2016141224A1
公开(公告)日：2016-09-09
申请号：PCT/US2016/020756
申请日：2016-03-03
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： JOUNG, J. Keith , KLEINSTIVER, Benjamin
IPC分类号： C12N15/00 , C12N15/63 , C12N9/14
CPC分类号： C12N9/22 , A01K2227/40 , A61K38/00 , C07K2319/71 , C07K2319/80 , C12N15/102 , C12N15/63 , C12N15/90 , C12N2800/22 , C12N2800/80 , C12Y301/00
摘要： Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
摘要翻译：具有改变和改善的PAM特异性的CRISPR-Cas9工程化核酸酶及其在基因工程，表观遗传学工程和基因组靶向中的应用。

9. 发明申请

WO2016077273A1 ENGINEERING MESENCHYMAL STEM CELLS USING HOMOLOGOUS RECOMBINATION 审中-公开
标题翻译：使用同源重建的工程化骨髓干细胞
公开(公告)号：WO2016077273A1
公开(公告)日：2016-05-19
申请号：PCT/US2015/059833
申请日：2015-11-10
申请人： Q THERAPEUTICS, INC.
发明人： RAO, Mahendra, S. , ZENG, Xianmin
IPC分类号： C12N5/00 , C12N5/071 , C12N15/00 , C12N15/07 , C12N15/79
CPC分类号： C12N5/0663 , C07K2319/80 , C12N5/00 , C12N9/22 , C12N15/79 , C12N2510/00
摘要： Methods are provided herein for genetically modifying a mesenchymal stem cell, differentiating these cells and using these cells in screening and in treating diseases and disorders.
摘要翻译：本文提供了用于遗传修饰间充质干细胞，区分这些细胞并在筛选和治疗疾病和病症中使用这些细胞的方法。

10. 发明申请

WO2015188094A1 METHODS FOR TARGETED MODIFICATION OF GENOMIC DNA 审中-公开
标题翻译：用于基因组DNA修饰的方法
公开(公告)号：WO2015188094A1
公开(公告)日：2015-12-10
申请号：PCT/US2015/034471
申请日：2015-06-05
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , COLLIER, R. John , MCCLUSKEY, Andrew J.
发明人： COLLIER, R. John , MCCLUSKEY, Andrew J. , MARSISCHKY, Gerald , PENTELUTE, Bradley L.
IPC分类号： C12P21/04 , C12P19/34 , C12Q1/34 , C12N9/96 , C07K14/00 , C07H21/04
CPC分类号： C12N15/907 , C07K14/195 , C07K2319/09 , C07K2319/70 , C07K2319/80 , C07K2319/81 , C12N9/22 , C12N9/54 , C12N15/102 , C12N15/90 , C12Y301/21004 , C12Y304/24083
摘要： Provided herein are methods of integrating one or more exogenous nucleic acids into one or more selected target sites of a host cell genome. In certain embodiments, the methods comprise contacting the host cell genome with one or more nucleic acid constructs fused with a pore-forming toxin, which may further be targeted to a particular cell type, wherein the nucleic acid constructs comprise an exogenous nucleic acid to be integrated into a genomic target site, and an enzyme, such as a nuclease or recombinase or a combination thereof capable of targeted introduction of the nucleic acid into the genome.
摘要翻译：本文提供将一种或多种外源核酸整合到宿主细胞基因组的一个或多个选定靶位点的方法。在某些实施方案中，所述方法包括使宿主细胞基因组与一个或多个与成孔毒素融合的核酸构建体接触，所述核酸构建体可进一步靶向特定细胞类型，其中所述核酸构建体包含外源核酸整合到基因组靶位点，以及能够将核酸靶向引入基因组的酶，例如核酸酶或重组酶或其组合。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式