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1. 发明申请

WO2012080662A2 METHOD FOR PREDICTING THE RESPONSE TO A TREATMENT AGAINST HEPATITIS C 审中-公开
标题翻译：预防对治疗丙型肝炎的反应的方法C
公开(公告)号：WO2012080662A2
公开(公告)日：2012-06-21
申请号：PCT/FR2011052989
申请日：2011-12-14
申请人： CT HOSPITALIER UNIVERSITAIRE MONTPELLIER , LEHMANN SYLVAIN , ROCHE STEPHANE , DUCOS JACQUES , TIERS LAURENT
发明人： LEHMANN SYLVAIN , ROCHE STEPHANE , DUCOS JACQUES , TIERS LAURENT
IPC分类号： G01N33/576
CPC分类号： G01N33/92 , C12Q1/6883 , G01N33/5767 , G01N2333/76 , G01N2333/775 , G01N2800/52
摘要： The invention relates to a method for predicting the response to an interferon-based treatment in a patient infected with hepatitis C virus. This method consists in determining the presence of apolipoprotein CIII and/or of a multimeric form of human serum albumin in a sample of biological fluid from the patient.
摘要翻译：本发明涉及用于预测感染丙型肝炎病毒的患者对基于干扰素的治疗的应答的方法。该方法在于确定来自患者的生物流体样品中载脂蛋白CIII和/或多聚体形式的人血清白蛋白的存在。

2. 发明申请

WO2010039163A3 CHEMICAL AND BIOCHEMICAL ADDUCTS AS BIOMARKERS FOR ORGANOPHOSPHATE EXPOSURE 审中-公开
标题翻译：化学和生物化学物质作为有机磷酸盐暴露的生物标志物
公开(公告)号：WO2010039163A3
公开(公告)日：2010-08-19
申请号：PCT/US2009002342
申请日：2009-04-14
申请人： HUMAN BIOMOLECULAR RES INST , CASHMAN JOHN R , MACDONALD MARY T
发明人： CASHMAN JOHN R , MACDONALD MARY T
IPC分类号： A61K47/48
CPC分类号： C07K7/06 , A61K47/48284 , A61K47/4833 , A61K47/643 , A61K47/646 , C07K16/18 , C07K16/44 , C12P21/005 , G01N33/6842 , G01N33/6893 , G01N2333/76 , G01N2410/00 , G01N2430/00 , G01N2430/10 , G01N2800/42
摘要： Provided is a method to identify OP-adducted biomarkers of OP exposure as well as compounds containing OPs that can provide OP adducts.
摘要翻译：提供了一种鉴定OP曝光的OP-加合生物标志物的方法以及含有可以提供OP加合物的OP的化合物。

3. 发明申请

WO2007146385A3 ALBUMIN-BOUND PROTEIN/PEPTIDE COMPLEX AS A BIOMARKER FOR DISEASE 审中-公开
标题翻译：白蛋白结合蛋白/肽复合物作为疾病的生物标记物
公开(公告)号：WO2007146385A3
公开(公告)日：2008-11-13
申请号：PCT/US2007013968
申请日：2007-06-14
申请人： UNIV JOHNS HOPKINS , VAN EYK JENNIFER E , GUNDRY REBEKAH LYNN , COTTER ROBERT J
发明人： VAN EYK JENNIFER E , GUNDRY REBEKAH LYNN , COTTER ROBERT J
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N33/6848 , G01N2333/76 , G01N2800/00 , G01N2800/324
摘要： Methods and kits for diagnosis and prognosis using biomarkers comprising albumin-bound protein/peptide complex (ABPPC).
摘要翻译：使用包含白蛋白结合蛋白/肽复合物（ABPPC）的生物标志物进行诊断和预后的方法和试剂盒。

4. 发明申请

WO2007051069A2 URINARY PROTEOMIC BIOMARKER PATTERNS IN PREECLAMPSIA 审中-公开
标题翻译：早期的尿蛋白生物标志物模式
公开(公告)号：WO2007051069A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/042585
申请日：2006-10-27
申请人： YALE UNIVERSITY , BUHIMSCHI, Irina, A. , BUHIMSCHI, Catalin, S.
发明人： BUHIMSCHI, Irina, A. , BUHIMSCHI, Catalin, S.
IPC分类号： G01N33/50
CPC分类号： G01N33/50 , G01N33/6827 , G01N33/689 , G01N2333/76 , G01N2333/8125 , G01N2800/368
摘要： The invention relates, in part, to methods of using proteomic biomarkers to diagnose preeclampsia. In some aspects the invention, in part, relates to the detection of serpina-1 polypeptide and/or albumin polypeptide in samples from pregnant subjects. Samples from subjects maybe compared to control samples to diagnose preeclampsia and/or to determine the onset, progression, or regression of preeclampsia in a subject. The invention also relates, in part, to screening methods to identify agents that can be used to treat preeclampsia and to determine the efficacy of a preeclampsia treatment. The invention, in part, also includes kits that are useful to diagnose and assess preeclampsia in a subject.
摘要翻译：本发明部分涉及使用蛋白质组生物标志物诊断先兆子痫的方法。在一些方面，本发明部分涉及在怀孕受试者的样品中检测serpina-1多肽和/或白蛋白多肽。可将来自受试者的样品与对照样品进行比较以诊断先兆子痫和/或确定受试者中先兆子痫的发作，进展或消退。本发明还部分涉及筛选鉴定可用于治疗先兆子痫和确定先兆子痫治疗功效的药剂的方法。本发明部分地还包括用于诊断和评估受试者先兆子痫的试剂盒。

5. 发明申请

WO2007028983A1 PROTEIN ASSAY 审中-公开
标题翻译：蛋白质测定
公开(公告)号：WO2007028983A1
公开(公告)日：2007-03-15
申请号：PCT/GB2006/003293
申请日：2006-09-06
申请人： THE NOTTINGHAM TRENT UNIVERSITY , DAVIS, James , CHAHINE, Samir , LIVINGSTONE, Callum
发明人： CHAHINE, Samir , LIVINGSTONE, Callum
IPC分类号： G01N33/68 , C07K14/76
CPC分类号： G01N33/6815 , G01N33/68 , G01N33/6842 , G01N2333/76
摘要： The invention provides a method for determining the relative amount of a sulphydryl-containing protein, such as albumin, compared with lower molecular weight thiol-containing compounds in a sample containing both sulphydryl containing protein and lower molecular weight thiol-containing compounds, comprising the step of contacting the sample with substituted or non-substituted 2.2'-dithio(bis)benzothiazole reagent (the first reagent) or a derivative thereof and determining directly or indirectly an amount of reacted thiol compounds that have reacted with the first reagent (reacted thiols) and/or thiol-containing compounds that have not reacted (unreacted thiol) with the first reagent. The method allows the discrimination between, for example, albumin and low molecular weight species such as glutathione, cysteine and homocysteine. The first reagent may be provided in a column and the sample passed through the column.
摘要翻译：本发明提供了一种用于测定含有含巯基的蛋白质如白蛋白相对于含有含巯基蛋白质和含较低分子量硫醇化合物的样品中含较低分子量硫醇化合物的相对量的方法，该方法包括步骤使样品与取代或未取代的2,2'-二硫代（双）苯并噻唑试剂（第一试剂）或其衍生物接触并直接或间接测定与第一试剂（反应的硫醇）反应的反应的硫醇化合物的量，和/或未与第一试剂反应（未反应的硫醇）的含硫醇化合物。该方法允许区分例如白蛋白和低分子量物质如谷胱甘肽，半胱氨酸和高半胱氨酸。第一试剂可以提供在柱中，样品通过柱。

6. 发明申请

WO2005041895A8 ALBUMIN BINDING SITES FOR EVALUATING DRUG INTERACTIONS AND METHODS OF EVALUATING OR DESIGNING DRUGS BASED ON THEIR ALBUMIN BINDING PROPERTIES 审中-公开
标题翻译：用于评估药物相互作用的ALBUMIN结合位点和基于其ALBUMIN结合特性的评估或设计药物的方法
公开(公告)号：WO2005041895A8
公开(公告)日：2006-08-24
申请号：PCT/US2004036437
申请日：2004-11-03
申请人： NEW CENTURY PHARMACEUTICALS , CARTER DANIEL C , HO JOSEPH , WANG ZHONGMIN
发明人： CARTER DANIEL C , HO JOSEPH , WANG ZHONGMIN
IPC分类号： G06F17/11 , A61K20060101 , G06F19/00 , G06F19/16 , G06F19/18
CPC分类号： G01N33/6803 , G01N2333/76 , G01N2333/765 , G01N2500/04 , G06F19/16 , G06F19/706
摘要： A method is provided for evaluating drug compounds based on their binding properties to human serum albumin wherein structural information at particular albumin binding regions is entered into a computer database and assessed with regard to particular contacting binding residues located in accordance with the invention. The information obtained through the computer database is thus useful in assessing and predicting drug interactions at albumin binding sites. Further, protein fragments including one or more albumin binding sites are provided which can be used in methods of assessing and designing drugs.

7. 发明申请

WO2002096266A2 METHOD AND SYSTEM FOR OPTICALLY PERFORMING AN ASSAY TO DETERMINE A MEDICAL CONDITION 审中-公开
标题翻译：用于光学执行测定以确定医疗条件的方法和系统
公开(公告)号：WO2002096266A2
公开(公告)日：2002-12-05
申请号：PCT/US2002/016860
申请日：2002-05-30
申请人： ISCHEMIA TECHNOLOGY, INC. , BAR-OR, Raphael , BAR-OR, David , CURTIS, C., Gerald
发明人： BAR-OR, Raphael , BAR-OR, David , CURTIS, C., Gerald
IPC分类号： A61B
CPC分类号： G01N21/31 , A61B5/0071 , A61B5/0075 , A61B5/0084 , G01N21/6428 , G01N33/683 , G01N33/84 , G01N2021/6423 , G01N2201/129 , G01N2333/76 , G01N2800/2871 , G01N2800/32
摘要： A method and system are disclosed for detecting a medical condition wherein a blood or plasma sample is combined with a metal such a cobalt and optically analyzed for an optical distinction that identifies the medical condition. The invention is useful for diagnosing medical conditions such as ischemia. Moreover, the diagnoses of patient samples according to the invention may be enhanced by developing a mathematical model based on signal processing techniques such as principal component analysis on the spectral data obtained in patient studies.
摘要翻译：公开了一种用于检测医疗状况的方法和系统，其中血液或血浆样品与诸如钴的金属组合并且被光学分析以识别医学状况。本发明可用于诊断诸如缺血的医学病症。此外，根据本发明的患者样品的诊断可以通过开发基于信号处理技术的数学模型来增强，例如在患者研究中获得的光谱数据的主成分分析。

8. 发明申请

WO2016181229A1 DEVICE AND METHOD FOR DETECTING CREATININE AND ALBUMIN TO CREATININE RATIO 审中-公开
标题翻译：用于检测葡萄糖和阿尔伯糖以产生比例的装置和方法
公开(公告)号：WO2016181229A1
公开(公告)日：2016-11-17
申请号：PCT/IB2016/050311
申请日：2016-01-22
申请人： INDIAN INSITUTE OF SCIENCE
发明人： KUMAR, Vinay , BHAT, Navakant , KASHYAP DHANVANTARI MADHURESH, Nikhila
IPC分类号： A61B5/05 , C07K14/76 , G01N27/327 , G01N27/447 , G01N33/48 , G01N33/493
CPC分类号： G01N27/3277 , A61B5/14507 , A61B5/14546 , A61B5/1468 , A61B5/207 , A61B10/007 , C07K14/76 , G01N27/327 , G01N27/48 , G01N33/493 , G01N33/5438 , G01N33/68 , G01N33/70 , G01N2333/76 , G01N2333/765
摘要： An electrochemically active, creatinine-binding device is provided to detect and measure quantitatively, creatinine in biological samples. The device of the present invention is also provided with a device to detect and measure quantitatively creatinine and albumin bioanalytes, simultaneously and to determine albumin to creatinine ratio (ACR). The present invention also provides an electrochemically active, creatinine-binding and albumin-binding device, for collection and retention of biological samples, having creatinine and albumin bioanalytes. In the present invention, a device holder is provided to receive the electrochemically active, creatinine-binding and albumin-binding device. The device, point-of-care biosensor and the method of the present invention, facilitate quantitative measurement of creatinine and albumin bioanalytes in urine and blood samples, and albumin to creatinine ratio (ACR), in urine samples, electrochemically, by determining redox current values.
摘要翻译：提供电化学活性的肌酸酐结合装置，用于在生物样品中检测和测量肌酐。本发明的装置还具有同时检测和测量肌酐和白蛋白生物分析物并测定白蛋白与肌酐比（ACR）的装置。本发明还提供用于收集和保留具有肌酸酐和白蛋白生物分析物的生物样品的电化学活性肌酸酐结合和白蛋白结合装置。在本发明中，提供了一种装置保持器来接收电化学活性的肌酸酐结合和白蛋白结合装置。本发明的装置，保护点生物传感器和方法，有助于通过测定氧化还原电流来电化学测定尿液和血液样品中的肌酐和白蛋白生物分析物以及尿样中的白蛋白与肌酐比（ACR）值。

9. 发明申请

WO2016038505A3 ELECTROCHEMICAL BIOSENSOR AND A METHOD OF SENSING ALBUMIN AND ITS COMPLEXES 审中-公开
标题翻译：电化学生物传感器及其检测白蛋白及其复合物的方法
公开(公告)号：WO2016038505A3
公开(公告)日：2016-05-19
申请号：PCT/IB2015056619
申请日：2015-09-01
申请人： INDIAN INST SCIENT
发明人： KUMAR VINAY , BHAT NAVAKANT
IPC分类号： G01N33/566
CPC分类号： G01N33/5438 , G01N27/327 , G01N27/3277 , G01N33/6827 , G01N2333/76 , G01N2333/765
摘要： An electrochemically active device for collecting and retaining a biological sample with a bioanalyte, the device provided with at least a two-electrode member and an albumin-binding and an electrochemically active receptor in chemical contact with the two-electrode members and the biological sample. The present invention also provides a point-of-care biosensor with the device of the present invention and a method for measuring a bioanalyte in a biological sample. The device, point-of-care biosensor and the method of the present invention facilitate accurate measurements concentrations of urine albumin, human serum albumin (HSA), glycated albumin (GA) and methemalbumin (MHA) by determining redox current values in reduced volumes of biological samples.
摘要翻译：一种用生物分析物收集和保留生物样品的电化学活性装置，该装置具有至少一个双电极构件以及与双电极构件和生物样品化学接触的白蛋白结合和电化学活性受体。本发明还提供了具有本发明装置的即时生物传感器和用于测量生物样品中的生物分析物的方法。该设备，即时护理生物传感器和本发明的方法通过确定氧化还原电流值以减少的体积来准确测量尿白蛋白，人血清白蛋白（HSA），糖化白蛋白（GA）和高铁白蛋白（MHA）生物样品。

10. 发明申请

WO2015193552A2 MEANS AND METHODS FOR DETERMINING RISK OF TYPE-1 DIABETES BY SERUM PROTEIN BIOMARKERS 审中-公开
标题翻译：用于测定血清蛋白生物标志物的1型糖尿病风险的方法和方法
公开(公告)号：WO2015193552A2
公开(公告)日：2015-12-23
申请号：PCT/FI2015/050448
申请日：2015-06-18
申请人： TURUN YLIOPISTO
发明人： MOULDER, Robert , BHOSALE, Santosh , GOODLETT, David , LÄHDESMÄKI, Harri , SIMELL, Olli , LAHESMAA, Riitta
IPC分类号： G01N33/564
CPC分类号： G01N33/564 , G01N33/92 , G01N2333/47 , G01N2333/4713 , G01N2333/4716 , G01N2333/76 , G01N2333/775 , G01N2560/00 , G01N2570/00 , G01N2800/042 , G01N2800/50 , G01N2800/60
摘要： The present invention relates to methods for predicting a risk of a subject for Type 1 diabetes (T1D) on the basis of expression levels of protein markers in a sample obtained from the subject. The present invention also relates to in vitro kits for use in said methods.
摘要翻译：本发明涉及基于从受试者获得的样品中的蛋白质标记物的表达水平来预测1型糖尿病（T1D）受试者风险的方法。本发明还涉及用于所述方法的体外试剂盒。

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