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1. 发明申请

WO2018031675A1 DEVELOPMENT OF A MULTICHANNEL CARBON FIBER MICROELECTRODE ARRAY FOR ELECTROCHEMICAL MEASUREMENTS 审中-公开
标题翻译：用于电化学测量的多通道碳纤维微电极阵列的研制
公开(公告)号：WO2018031675A1
公开(公告)日：2018-02-15
申请号：PCT/US2017/046126
申请日：2017-08-09
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人： HEIEN, Michael, L. , SIEGENTHALER, James, R.
IPC分类号： A61B5/00 , A61B5/1486 , A61B5/04 , C01B31/02 , A61N1/05 , A61B5/145
CPC分类号： A61B5/00 , A61B5/04 , A61B5/145 , A61B5/14546 , A61B5/1468 , A61B5/1486 , A61B5/6868 , A61B2562/046 , A61B2562/125
摘要： Tonic levels of dopamine can be measured with single carbon fiber microelectrodes using fast-scan cyclic voltammetry ("FSCV") and fast-scan controlled-absorption voltammetry ("FSCAV"). A major limitation to these measurement techniques is the regional localization based on the microelectrode placement. In an effort to overcome this challenge, a multi-channel carbon fiber microelectrode array has been developed for both FSCV and FSCAV measurements. The array features a 2x8 microelectrode placement with 300 micron spacing between fibers, providing the ability to span regions of the brain. Characterization of the array includes single channel analysis by slow can voltammetry and FSCAV.
摘要翻译：可以使用快速扫描循环伏安法（“FSCV”）和快速扫描受控吸收伏安法（“FSCAV”），用单碳纤维微电极测量多巴胺的补剂水平。这些测量技术的主要局限性是基于微电极布局的区域定位。为了克服这一挑战，针对FSCV和FSCAV测量开发了多通道碳纤维微电极阵列。该阵列具有2x8微电极放置，纤维之间间距为300微米，提供跨越大脑区域的能力。阵列特性包括通过慢速伏安法和FSCAV进行单通道分析。

2. 发明申请

WO2017173462A1 FLEXIBLE EPIDERMAL MULTIMODAL HEALTH MONITOR 审中-公开
标题翻译：灵活的表面多形式健康监视器
公开(公告)号：WO2017173462A1
公开(公告)日：2017-10-05
申请号：PCT/US2017/025798
申请日：2017-04-03
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： WANG, Joseph , MERCIER, Patrick
IPC分类号： A61B5/04 , A61B5/053
CPC分类号： A61B5/0205 , A61B5/02055 , A61B5/0402 , A61B5/04085 , A61B5/04087 , A61B5/053 , A61B5/0816 , A61B5/14532 , A61B5/1468 , A61B5/1486 , A61B5/6833 , A61B2562/066 , A61B2562/164
摘要： Methods, systems, and devices are disclosed for wearable, real-time multimodal sensing of electrochemical and electrophysiological and/or physical parameters of a user. In some aspects, a multimodal sensor device includes a flexible substrate; an electrochemical sensor disposed on the substrate and including electrochemical sensing electrodes operable to measure an electrical signal corresponding to a reaction including a chemical substance via an electrochemical sensing electrode and an analyte at the electrochemical sensor; and an electrophysiological sensor including two or more electrodes disposed on the substrate to acquire an electrophysiological signal of the user, such that when the multimodal sensor device is electrically coupled to an electronics unit and adhered to the user, the device is operable to simultaneously monitor an electrochemical parameter and an electrophysiological parameter of the user.
摘要翻译：公开了用于可佩戴的实时多模式感测用户的电化学和电生理和/或物理参数的方法，系统和设备。在一些方面，多模态传感器装置包括柔性衬底; 电化学传感器，所述电化学传感器设置在所述衬底上并且包括电化学传感电极，所述电化学传感电极可操作以经由电化学传感电极和所述电化学传感器处的分析物测量对应于包括化学物质的反应的电信号; 以及电生理传感器，其包括布置在所述衬底上的两个或更多个电极以获取所述用户的电生理信号，使得当所述多模式传感器装置电耦合到电子单元并粘附到所述用户时，所述装置可操作以同时监测电化学参数和用户的电生理参数。

3. 发明申请

WO2017116350A1 A CONTACT LENS DESIGN SENSING TEAR GLUCOSE LEVEL 审中-公开
标题翻译：接触式镜片设计感应眼部葡萄糖水平
公开(公告)号：WO2017116350A1
公开(公告)日：2017-07-06
申请号：PCT/TR2016/050413
申请日：2016-11-01
申请人： DOKUZ EYLUL UNIVERSITESI REKTORLUGU
发明人： YILDIRIM, Canan Asli
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1468 , G02C7/04 , B29D11/00
CPC分类号： A61B5/14507 , A61B5/14532 , A61B5/1468 , A61B5/6821 , B29D11/00038 , B29D11/00346 , G02C7/04
摘要： The invention is intended for patients with diabetes, and relates to a type of contact lens by means of which tear glucose level is monitored thanks to a biosensor disposed thereon.
摘要翻译：本发明旨在用于患有糖尿病的患者，并涉及一种隐形眼镜，借助于该隐形眼镜，通过其上设置的生物传感器监测泪液葡萄糖水平。

4. 发明申请

WO2017112688A1 NICKEL ALLOYS FOR BIOSENSORS 审中-公开
标题翻译：用于生物传感器的镍合金
公开(公告)号：WO2017112688A1
公开(公告)日：2017-06-29
申请号：PCT/US2016/067817
申请日：2016-12-20
申请人： MATERION CORPORATION
发明人： GOODWIN, Kevin V. , NEWTON, Robert R. , TRIBICK, Ian S. , FONTAINE, Ethan
IPC分类号： C22C19/00 , A61B5/145
CPC分类号： C12Q1/006 , A61B5/14532 , A61B5/1468 , A61B2562/12 , C22C19/00 , C22C19/007 , C22C19/058 , C23C14/205
摘要： The present disclosure relates to metal alloys for biosensors. An electrode is made from the metal alloy, which more specifically can be a nickel-based alloy. The alloy provides physical and electrical property advantages when compared with existing pure metal electrodes.
摘要翻译：本公开涉及用于生物传感器的金属合金。电极由金属合金制成，更具体地可以是镍基合金。与现有的纯金属电极相比，该合金具有物理和电性能优势。

5. 发明申请

WO2016115608A1 DIAGNOSTIC DEVICES AND METHODS FOR MITIGATING HOOK EFFECT AND USE THEREOF 审中-公开
标题翻译：诊断装置和方法，用于减轻钩效应及其使用
公开(公告)号：WO2016115608A1
公开(公告)日：2016-07-28
申请号：PCT/AU2016/050037
申请日：2016-01-22
申请人： ELLUME PTY LTD
发明人： MCBEAN, Rhiannon , FRY, Scott , PARSONS, Sean
IPC分类号： G01N33/48 , G01N33/50 , G01N33/536 , G01N33/74 , G01N33/558 , A61B10/00
CPC分类号： A61B10/0012 , A61B5/14546 , A61B5/1468 , A61B5/4343 , A61B5/742 , A61B10/007 , A61B2562/0295 , G01N33/54386 , G01N33/558 , G01N33/689 , G01N33/76 , G01N2333/59
摘要： The present disclosure relates to devices and methods for identifying conditions in a human or animal body, such as pregnancy or ovulation. For example, the present disclosure relates to devices and methods for identifying pregnancy or ovulation, which devices and methods are adapted to mitigate the "hook effect", thereby improving accuracy of the devices and methods.
摘要翻译：本公开涉及用于识别人或动物体内的状况的装置和方法，例如怀孕或排卵。例如，本公开涉及用于识别怀孕或排卵的装置和方法，哪些装置和方法适于减轻“钩子效应”，从而提高装置和方法的准确性。

6. 发明申请

WO2016081075A1 WEARABLE ELECTRONIC PATCH WITH ANTENNA ENHANCEMENT 审中-公开
标题翻译：具有天线增强功能的电子护具
公开(公告)号：WO2016081075A1
公开(公告)日：2016-05-26
申请号：PCT/US2015/053723
申请日：2015-10-02
申请人： QUALCOMM INCORPORATED
发明人： GANTON, Robert Bruce , BALLAM, Robert Scott
IPC分类号： G06K19/077 , H01Q1/27 , G06K19/07 , A61B5/00 , A61B5/145 , A61B5/0478 , A61B5/053 , A61B5/021 , A61B5/1455 , A61B5/1468
CPC分类号： H01Q1/273 , A61B5/0022 , A61B5/01 , A61B5/02141 , A61B5/02438 , A61B5/0402 , A61B5/0478 , A61B5/0531 , A61B5/14532 , A61B5/1455 , A61B5/1468 , A61B5/4839 , A61B5/6832 , A61B5/6833 , A61B5/6844 , A61B2503/10 , A61B2503/40 , A61B2560/0412 , A61B2562/0257 , A61B2562/12 , A61B2562/166 , A61B2562/182 , A61B2562/187 , A61B2562/242 , A61B2562/247 , G06F19/00 , G06K19/0716 , G06K19/0718 , G06K19/0723 , G06K19/07771 , G06K19/07773 , G16H40/67 , H01Q9/04 , H01Q9/26 , H05K3/30
摘要： A wearable electronic patch with an enhanced radio antenna includes an antenna, radio circuitry, a base portion, a distal portion, and intermediate portion, and a spacer, configured to raise the antenna away from the base portion, and thus away from a wearer to improve radiation properties of the antenna. The spacer may be sized and shaped to expand from a compressed state, as it may be when the patch is packaged, to an expanded state that raises the antenna when it is applied to a wearer. Other aspects, embodiments, and features are also claimed and disclosed.
摘要翻译：具有增强型无线电天线的可穿戴电子贴片包括天线，无线电电路，基座部分，远端部分和中间部分，以及间隔件，其构造成将天线从基部部分升高，从而远离佩戴者到改善天线的辐射特性。间隔件的尺寸和形状可以从压缩状态膨胀，这可能是当贴片被包装时的状态，使之在将天线施加到穿着者时升高的状态。还要求和公开其他方面，实施例和特征。

7. 发明申请

WO2016038529A1 DEVICE AND METHOD FOR NON-ENZYMATIC AND ELECTROCHEMICAL DETECTION OF GLUCOSE BIOANALYTE 审中-公开
标题翻译：葡萄糖生物质的非酶化和电化学检测的装置和方法
公开(公告)号：WO2016038529A1
公开(公告)日：2016-03-17
申请号：PCT/IB2015/056854
申请日：2015-09-08
申请人： INDIAN INSTITUTE OF SCIENCE
发明人： KUMAR, Vinay , BHAT, Navakant
IPC分类号： A61B5/1468
CPC分类号： A61B5/1468 , A61B2562/0295
摘要： An electrochemically active device is provided for collecting and retaining a biological sample with electrodes connected to conductive tracks arranged on a substrate. The device is provided with a non- enzymatic and an electrochemically active receptor and the receptor is in chemical contact with the electrodes and a biological sample with a bioanalyte. The present invention also provides a holder and a point-of-care biosensor for the device of the present invention and a method for measuring glucose bioanalyte in a reduce volume of the biological sample. The device, point-of-care biosensor and the method of the present invention facilitate accurate measurements concentrations of glucose bioanalytes by determining redox current values in the biological samples.
摘要翻译：提供了一种电化学活性器件，用于收集和保留具有连接到布置在衬底上的导电轨迹的电极的生物样品。该装置设置有非酶和电化学活性受体，并且受体与电极化学接触，并具有生物分析物的生物样品。本发明还提供了用于本发明的装置的保持器和点护理生物传感器以及在生物样品的减少体积中测量葡萄糖生物分析物的方法。本发明的装置，保护点生物传感器和方法通过确定生物样品中的氧化还原电流值来促进葡萄糖生物分析物的精确测量浓度。

8. 发明申请

WO2016033686A1 METHOD AND SYSTEM FOR BRAIN ACTIVITY SIGNAL-BASED TREATMENT AND/OR CONTROL OF USER DEVICES 审中-公开
标题翻译：用于基于信号的基于信号处理和/或用户设备的控制的方法和系统
公开(公告)号：WO2016033686A1
公开(公告)日：2016-03-10
申请号：PCT/CA2015/050839
申请日：2015-09-02
申请人： UNIVERSITY HEALTH NETWORK
发明人： MARQUEZ CHIN, César , ATWELL, Kathryn , POPOVIC, Milos R.
IPC分类号： A61B5/048 , A61B5/0476 , G06F19/00 , G06F19/10 , G06F3/01
CPC分类号： A61B5/4851 , A61B5/04001 , A61B5/04008 , A61B5/0476 , A61B5/0478 , A61B5/048 , A61B5/1468 , A61B5/4836 , A61B5/7246 , A61B5/7264 , A61F2/72 , A61F5/01 , A61H2230/105 , A61N1/36003 , A63B2230/105 , G06F3/015 , G06F3/038 , G06F19/00 , G06F19/3481 , G16H50/20
摘要： A method for characterizing a brain electrical signal comprising forming a temporo-spectral decomposition of the signal to form a plurality of time resolved frequency signal values, associating each instance of the signal value with a predetermined function approximating a neurological signal to form a table of coefficients collectively representative of the brain electrical signal.
摘要翻译：一种用于表征脑电信号的方法，包括形成信号的时间频谱分解以形成多个时间分辨频率信号值，将信号值的每个实例与接近神经信号的预定函数相关联，以形成系数表统称为脑电信号。

9. 发明申请

WO2016025468A2 DEVICES AND RELATED METHODS FOR EPIDERMAL CHARACTERIZATION OF BIOFLUIDS 审中-公开
标题翻译：用于生物流体表皮特征的装置和相关方法
公开(公告)号：WO2016025468A2
公开(公告)日：2016-02-18
申请号：PCT/US2015/044638
申请日：2015-08-11
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： ROGERS, John A. , KOH, Ahyeon , KANG, Daeshik , LIU, YuHao , HUANG, Xian
IPC分类号： A61B5/145
CPC分类号： A61B5/6833 , A61B5/002 , A61B5/0059 , A61B5/0075 , A61B5/01 , A61B5/053 , A61B5/1032 , A61B5/14514 , A61B5/14517 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1455 , A61B5/1468 , A61B5/1477 , A61B5/4266 , A61B5/6898 , A61B2562/12 , A61B2576/00 , B01L3/502707 , B01L3/505
摘要： Skin-mounted or epidermal devices and methods for monitoring biofluids are disclosed. The devices comprise a functional substrate that is mechanically and/or thermally matched to skin to provide durable adhesion for long-term wear. The functional substrates allow for the microfluidic transport of biofluids from the skin to one or more sensors that measure and/or detect biological parameters, such as rate of biofluid production, biofluid volume, and biomarker concentration. Sensors within the devices may be mechanical, electrical or chemical, with colorimetric indicators being observable by the naked eye or with a portable electronic device (e.g., a smartphone). By monitoring changes in an individual's health state over time, the disclosed devices may provide early indications of abnormal conditions.
摘要翻译：公开了用于监测生物流体的皮肤安装或表皮装置和方法。这些装置包括与皮肤机械和/或热匹配的功能性基底，以提供持久的粘合剂用于长期磨损。功能性底物允许将生物流体从皮肤的微流体传输到测量和/或检测生物参数（例如生物流体生成速率，生物流体体积和生物标志物浓度）的一个或多个传感器。装置内的传感器可以是机械的，电的或化学的，其中比色指示器可以通过肉眼或便携式电子设备（例如，智能电话）来观察。通过监视个人健康状态随时间的变化，所公开的设备可以提供异常状况的早期指示。

10. 发明申请

WO2015156876A9 INTEGRATED ELECTRICAL PROFILING SYSTEM FOR MEASURING LEUKOCYTES ACTIVATION FROM WHOLE BLOOD 审中-公开
标题翻译：用于测量全血白细胞介素激活的综合电气剖面系统
公开(公告)号：WO2015156876A9
公开(公告)日：2016-01-21
申请号：PCT/US2015011801
申请日：2015-01-16
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： VOLDMAN JOEL , SU HAO-WEI , PRIETO JAVIER LOPEZ , HAN JONGYOON , WU LIDAN
IPC分类号： G01N33/53 , B03C5/00 , B03C5/02 , C12Q1/04
CPC分类号： A61B5/412 , A61B5/14546 , A61B5/1468 , A61B5/1486 , B01L3/502715 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0605 , B01L2200/0647 , B01L2200/0652 , B01L2300/0645 , B01L2300/0816 , B01L2300/088 , G01N15/1031 , G01N15/1404 , G01N15/1459 , G01N15/1463 , G01N15/1484 , G01N33/48735 , G01N2015/0073 , G01N2015/008 , G01N2015/1006 , G01N2015/1486 , G01N2015/149 , G01N2800/7095
摘要： A system includes a microfluidic device configured to isolate one or more particles from a mixture, a flow rate matching device configured to match flow rate of the microfluidic device with flow rate of an electrical measurement device configured to measure an electrical property of the isolated particles, and an electrical measurement device configured to measure an electrical property of the isolated particles.
摘要翻译：一种系统包括配置成从混合物中分离一个或多个颗粒的微流体装置，配置成使微流体装置的流速与配置成测量孤立颗粒的电性能的电测量装置的流速相匹配的流速匹配装置，以及被配置为测量所述孤立颗粒的电特性的电测量装置。

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