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1. 发明申请

WO2019099641A1 SYSTEM AND METHOD FOR SINGLE CHANNEL WHOLE CELL SEGMENTATION 审中-公开
公开(公告)号：WO2019099641A1
公开(公告)日：2019-05-23
申请号：PCT/US2018/061242
申请日：2018-11-15
申请人： GENERAL ELECTRIC COMPANY
发明人： AL-KOFAHI, Yousef , RUSU, Mirabela
IPC分类号： G06T7/00 , G06T7/11 , G06T7/143 , G06T7/194 , G06T7/136
CPC分类号： G06K9/0014 , G06K9/00134 , G06T7/0012 , G06T7/0014 , G06T7/11 , G06T7/136 , G06T7/143 , G06T7/194 , G06T2207/10056 , G06T2207/10064 , G06T2207/20021 , G06T2207/20076 , G06T2207/20081 , G06T2207/20152 , G06T2207/20156 , G06T2207/30024
摘要： The present disclosure relates to a computer-implemented system and its associated method for single channel whole cell segmentation of a sample image of a biological sample. The biological sample may be stained with one or more non-nuclear cell marker stains, and the system and the method are configured to transform the sample image of the biological sample stained with the one or more non-nuclear cell marker stains into a segmented image having one or more cells with delineated nuclei and cytoplasm regions.

2. 发明申请

WO2019086800A1 PROCÉDÉ OPTIQUE D'ESTIMATION D'UN VOLUME REPRÉSENTATIF DE PARTICULES PRÉSENTES DANS UN ÉCHANTILLON 审中-公开
公开(公告)号：WO2019086800A1
公开(公告)日：2019-05-09
申请号：PCT/FR2018/052689
申请日：2018-10-30
申请人： COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES , HORIBA ABX SAS
发明人： BLANDIN, Pierre , ALI-CHERIF, Anais , DAYNES, Aurélien , GREMION, Estelle , ISEBE, Damien
IPC分类号： G01N15/02 , G01N33/49 , G01N21/45 , G01N21/47 , G03H1/08 , G01N15/14 , G06T7/62 , G01N15/00 , G03H1/04
CPC分类号： G01N15/1463 , G01N15/0227 , G01N2015/0073 , G01N2015/0233 , G01N2015/1454 , G03H1/0443 , G03H1/0866 , G03H2001/005 , G03H2001/0447 , G03H2001/0883 , G06T7/62 , G06T2207/10056 , G06T2207/30024
摘要： L'invention est un procédé d'estimation d'u n volume représentatif de particules d'intérêt (10 i ) baignant dans un échantillon, l'échantillon s'étendant selon au moins un plan, dit plan de l'échantillon ( P 10 ), l'échantillon comportant un agent sphérisant, apte à modifier la forme des particules, le procédé comportant les étapes suivantes : a) illumination de l'échantillon à l'aide d'une source de lumière (11), la source de lumière émettant une onde lumineuse incidente (12) se propageant vers l'échantillon (10) selon un axe de propagation (Z); b) acquisition, à l'aide d'un capteur d'image (16), d'une image ( I 0 ) de l'échantillon (10), formée dans un plan de détection ( P 0 ), l'échantillon étant disposé entre la source de lumière (11) et le capteur d'image (16), chaque image étant représentative d'une onde lumineuse (14) dite d'exposition, à laquelle est exposé le capteur d'image (16) sous l'effet de l'illumination; c) utilisation de l'image de l'échantillon ( I 0 ), acquise lors de l'étape b), et d 'un opérateur de propagation holographique, pour calculer une expression complexe ( A ( x, y, z )) de l'onde lumineuse d'exposition (14) en différentes positions par rapport a u plan de détection; le procédé comportant une étape d'estimation du volume représentatif (AA) des particules d 'intérêt (10 i ) en fonction des expressions complexes calculées lors de l'étape c)

3. 发明申请

WO2018211418A1 METHOD AND SYSTEM FOR DETERMINING AREA TO BE SCANNED IN PERIPHERAL BLOOD SMEAR FOR ANALYSIS 审中-公开
公开(公告)号：WO2018211418A1
公开(公告)日：2018-11-22
申请号：PCT/IB2018/053388
申请日：2018-05-15
申请人： SIGTUPLE TECHNOLOGIES PRIVATE LIMITED
发明人： POTADAR, Shreepad , MUNDHRA, Dheeraj , SHUKLA, Abhishek , G, Raghu , MURALIDHARAN, Amrutha , KAPOOR, Deepak , MURALIDHARAN, Vijay , MUTHUSUBRAMANIAN, Nivedita , CHELUVARAJU, Bharath , ANAND, Apurv , DASTIDAR, Tathagato, Rai , PANDEY, Rohit, Kumar
IPC分类号： G01N33/72 , G01N15/14
CPC分类号： G01N35/00029 , G01N35/00 , G02B21/244 , G02B21/365 , G06K9/00134 , G06T7/0002 , G06T7/73 , G06T2207/10056 , G06T2207/30024 , G06T2207/30168
摘要： Disclosed subject matter relates to Peripheral Blood Smear (PBS) that determines an area to be scanned in PBS for analysis. A PBS analysing system captures a focused image at each of plurality of positions in the PBS and determines Quality Indicators (QIs) in focused image. Further, a region is identified in PBS where QIs of focused image satisfy predefined QI threshold limits, as a monolayer region of PBS and determines an initiation point in monolayer region based on cell count value and co-ordinates of each of the plurality of positions located in the monolayer region. Finally, the area to be scanned in monolayer region is determined based on the initiation point and a predefined scan pattern. Determining the area to be scanned yields accurate and faster results.

4. 发明申请

WO2018157387A1 ANOMALY DETECTION FOR MEDICAL SAMPLES UNDER MULTIPLE SETTINGS 审中-公开
公开(公告)号：WO2018157387A1
公开(公告)日：2018-09-07
申请号：PCT/CN2017/075587
申请日：2017-03-03
申请人： HONG KONG APPLIED SCIENCE AND TECHNOLOGY RESEARCH INSTITUTE COMPANY LIMITED
发明人： WU, Xiaohua , LAW, Yan Nei
IPC分类号： G06K9/46
CPC分类号： G06K9/00147 , G01N21/64 , G01N33/483 , G06K9/00127 , G06K9/00134 , G06K9/0014 , G06K9/3241 , G06K9/4647 , G06K9/4652 , G06K9/623 , G06K9/6269 , G06K9/6274 , G06K9/6277 , G06K9/6282 , G06K9/6292 , G06K2209/05 , G06T7/0012 , G06T7/0014 , G06T2207/10024 , G06T2207/10056 , G06T2207/10064 , G06T2207/20084 , G06T2207/30024
摘要： Using multiple imaging modes in whole slide image screening is potentially useful to reduce false positives. To use multiple imaging modes, a method for locating anomalies on a medical sample from an image thereof uses an anomaly-detection process that comprises using plural base classifiers individually to classify an object-of-interest suspected to be an anomaly. Each base classifier respectively extracts features of the object-of-interest and generates, according to the extracted features, a score indicating a likelihood of the object-of-interest being anomalous. The anomaly-detection process further comprises using an aggregate classifier to combine the scores generated by the base classifiers to determine whether the object-of-interest is the anomaly. The aggregate classifier determines a dependability measure for each base classifier according to setting-based variables of a setting under which the sample and the image are obtained, and then selectively combines the scores of the base classifiers according to the dependability measures.

5. 发明申请

WO2018017199A1 SYSTEM AND METHOD FOR OPTICAL WHOLE BLOOD HEMOLYSIS DETECTION 审中-公开
标题翻译：用于光学全血溶血检测的系统和方法
公开(公告)号：WO2018017199A1
公开(公告)日：2018-01-25
申请号：PCT/US2017/036338
申请日：2017-06-07
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC.
发明人： JASPERSE, Jeffrey
IPC分类号： G06T7/00 , G06T7/40 , G06K9/00
CPC分类号： G06K9/00543 , G06K9/00127 , G06K9/0053 , G06T7/0016 , G06T2207/10024 , G06T2207/30024
摘要： A method and system is described that includes obtaining a whole blood sample and obtaining a first light absorbance profile of the whole blood sample. Next, the whole blood sample is hemolyzed to generate a hemolyzed sample of blood and a second light absorbance profile of the hemolyzed sample of blood is obtained. The level of hemolysis in the whole blood sample is determined by comparing the first light absorbance profile and the second light absorbance profile.
摘要翻译：描述了一种方法和系统，其包括获得全血样本并获得全血样本的第一吸光度分布图。接下来，全血样品溶血以产生溶血的血液样品，并获得血液溶血样品的第二吸光度分布。通过比较第一吸光度分布图和第二吸光率分布图来确定全血样品中的溶血水平。

6. 发明申请

WO2017217180A1 情報処理装置、観察システム、観察方法及びプログラム审中-公开
标题翻译：信息处理装置，观察系统，观察方法和程序
公开(公告)号：WO2017217180A1
公开(公告)日：2017-12-21
申请号：PCT/JP2017/018654
申请日：2017-05-18
申请人：ソニー株式会社
发明人：青木　卓 , 大橋　武史 , 松井　直史 , 大沼　智也
IPC分类号： G01N21/17 , C12M1/34 , C12N5/075 , C12N5/076 , G06T1/00
CPC分类号： G06T7/0016 , C12M21/06 , C12M41/36 , C12M41/48 , G01J5/025 , G01J2005/0077 , G01N21/17 , G06T1/00 , G06T2207/30024 , H04N13/261
摘要：本技術の一形態に係る情報処理装置は、制御部を具備する。上記制御部は、第１の撮影間隔で撮影した培養中の細胞の光学画像に基づいて細胞の状態変化の有無を検出し、上記状態変化を検出したとき、撮影モードを上記第１の撮影間隔から上記第１の撮影間隔よりも短い第２の撮影間隔に切り替える。
摘要翻译：根据本技术的一个实施例的信息处理设备包括控制单元。控制单元基于以第一成像间隔培养的细胞的光学图像来检测细胞的状态改变的存在或不存在，并且当检测到状态改变时，将成像模式设置为第一成像间隔到第二个拍摄间隔短于第一个拍摄间隔。

7. 发明申请

WO2017216123A1 METHOD OF CHARACTERIZING AND IMAGING MICROSCOPIC OBJECTS 审中-公开
标题翻译：表征和成像微观物体的方法
公开(公告)号：WO2017216123A1
公开(公告)日：2017-12-21
申请号：PCT/EP2017/064328
申请日：2017-06-12
申请人： NANOLIVE SA
发明人： COTTE, Yann , EQUIS, Sebastien , DALLA PIAZZA, Bastian , POP, Sorin , CLARIO, Luca , TREMBLAY, Christopher , COTTE, Pierre-Alain
IPC分类号： G06K9/00
CPC分类号： G06K9/00147 , G01N1/30 , G06F3/04847 , G06K9/00127 , G06K9/0014 , G06T7/0012 , G06T2207/10056 , G06T2207/10064 , G06T2207/30024
摘要： Microscopic object characterization system (1), comprising a computer system (2, 2a, 2b), a microscope (4) with a computing unit (5) connected to the computer system, and an object characterization program (17) executable in the computer system configured to receive refractive index data representing at least a spatial distribution of measured values of refractive index (RI) or values correlated to refractive index of said microscopic object. The object characterization program is operable to execute an algorithm applying a plurality of transformations on said refractive index data. The transformations generate a distribution of two or more parameters used to characterize features of the microscopic object. The computer system further comprises a feedback interface configured for connection to one or more data servers in a network computing system, via a global communications network such as the internet, and configured to receive feedback data from the data servers for processing by the object characterization program to calibrate, refine or enhance a characterization of said features.
摘要翻译：（1），其包括计算机系统（2,2a，2b），具有连接到计算机系统的计算单元（5）的显微镜（4），以及物体表征在计算机系统中可执行的程序（17），其被配置为接收折射率数据，折射率数据至少表示折射率（RI）的测量值的空间分布或与所述微观物体的折射率相关的值。对象表征程序可操作用于执行对所述折射率数据应用多个变换的算法。这些变换产生了用于表征微观物体的特征的两个或多个参数的分布。该计算机系统还包括反馈接口，该反馈接口被配置用于经由诸如因特网的全球通信网络连接到网络计算系统中的一个或多个数据服务器，并且被配置为从数据服务器接收反馈数据以供对象特征化程序处理校准，改进或增强所述特征的表征。

8. 发明申请

WO2017106272A1 METHODS AND SYSTEMS FOR ASSESSING HISTOLOGICAL STAINS 审中-公开
标题翻译：用于评估组织污染的方法和系统
公开(公告)号：WO2017106272A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/066541
申请日：2016-12-14
申请人： ABBOTT LABORATORIES , BEREZHNA, Svitlana Y. , NIEVES ALICEA, Rene , COLEMAN, Marilou L. , STONAS, Walter G. , COWART, Willie J. , LI, Wenjing , CIUCUREL, Ema C.
发明人： BEREZHNA, Svitlana Y. , NIEVES ALICEA, Rene , COLEMAN, Marilou L. , STONAS, Walter G. , COWART, Willie J. , LI, Wenjing , CIUCUREL, Ema C.
IPC分类号： G06K9/18
CPC分类号： G06T7/0014 , G01N33/52 , G06K9/0014 , G06K9/00147 , G06K9/3241 , G06K9/4642 , G06K9/4652 , G06K9/6212 , G06T7/11 , G06T7/136 , G06T7/90 , G06T2207/10024 , G06T2207/30024
摘要： The present disclosure includes methods of assessing a histologically stained specimen based on a determined color signature of a region of interest of the specimen. Such assessments may be performed for a variety of purposes including but not limited to assessing the quality of the histological stain, as part of identifying one or more biologically relevant features of the image, as part of differentiating one feature of the image from other features of the image, identifying an anomalous area of the stained specimen, classifying cells of the specimen, etc. Also provided are systems configured for performing the disclosed methods and computer readable medium storing instructions for performing steps of the disclosed methods.
摘要翻译：本公开包括基于样本的感兴趣区域的确定的颜色标记来评估组织学染色的标本的方法。作为鉴别图像的一个或多个生物相关特征的一部分，作为区分图像的一个特征与其他特征的一部分，可以出于各种目的（包括但不限于评估组织学染色的质量）图像，识别染色样本的异常区域，分类样本的细胞等。还提供了配置用于执行所公开的方法的系统和存储用于执行所公开的方法的步骤的指令的计算机可读介质。

9. 发明申请

WO2017098011A1 METHOD FOR ALIGNING AT LEAST ONE PART OF ONE DIGITAL IMAGE TO AT LEAST ONE PART OF ANOTHER DIGITAL IMAGE 审中-公开
标题翻译：将一个数字图像的至少一部分对准至另一个数字图像的至少一部分的方法
公开(公告)号：WO2017098011A1
公开(公告)日：2017-06-15
申请号：PCT/EP2016/080509
申请日：2016-12-09
申请人： QIAGEN GMBH
发明人： SCHUSTER, Guido , ZERFASS, Thorsten , UNTERER, Thomas , HAUTH, Jan , LOHEL, Maiko
IPC分类号： G06T7/32
CPC分类号： G06T7/32 , G06T2207/10056 , G06T2207/10064 , G06T2207/20016 , G06T2207/20021 , G06T2207/30024
摘要： The present invention relates to a method and a system for aligning at least one part of one digital image to another digital image. In particular, the present invention relates to a method for aligning at least one part of a second digital image with at least one part of a first digital image comprising the following steps, preferably in the following order: dividing the at least one part of the first digital image into a plurality of tiles t_fi={t_fi1,t_fi2,...,t_fin} with n being a positive integer; dividing the at least one part of the second digital image into a plurality of tiles t_si={t_si1,t_si2,...,t_sin}, wherein each tile t_siv with v ∊ {1,2,...n} of the plurality of tiles t_si corresponds to one respective tile t_fiv of the plurality of tiles t_fi; creating a plurality of correlation images fci = { fci_1, fci_2,... fci_n'} by computing the correlation between each tile t_fiv' and the corresponding tile t_siv' with v' ∊ {1,2,...n'≤n}; determining the position of a global maximum correlation value p_ν' for each of the plurality of correlation images fci_v'; and calculating a plurality of first offset vectors fov = {fov_1, fov_2,..., fov_ n"}, the offset vector fov_v" with v"∊ {1,2,...n"≤n'} representing the offset between the tile t_siv" and the corresponding tile t_fiv" being calculated by considering the center position of the corresponding correlation image fci_v" and the position of the global maximum correlation value p_v of the respective correlation image fci_v" with v"∊ {1,2,...n"≤n'}. The method also comprises aligning the at least one part of the second digital image with the at least one part of the first digital image by applying the corresponding first offset vectors fov.
摘要翻译：本发明涉及用于将一个数字图像的至少一部分与另一个数字图像对齐的方法和系统。特别地，本发明涉及一种用于将第二数字图像的至少一部分与第一数字图像的至少一部分对准的方法，该方法包括以下步骤，优选地按以下顺序进行：将所述至少一部分第一数字图像转换为多个瓦片t_fi = {t_fi1，t_fi2，...，t_fin}，其中n是正整数; 将所述第二数字图像的所述至少一部分划分成多个瓦片t_si = {t_si1，t_si2，...，t_sin}，其中所述多个瓦片中的每个瓦片t_siv具有v∈{1,2，...，n} 瓦片t_si对应于多个瓦片t_fi中的一个相应瓦片t_fiv; 通过计算每个图块t_fiv'与相应图块t_siv'之间的相关性来创建多个相关图像fci = {fci_1，fci_2，... fci_n'}，其中v'ε{1,2，...，n'≤n }; 确定多个相关图像fci_v'中的每一个的全局最大相关值p_v'的位置; 并计算多个第一偏移矢量fov = {fov_1，fov_2，...，fov_n“}，偏移矢量fov_v” 其中v“ε{1,2，... n”≤n'}表示瓦片t_siv“ 并且相应的瓦片t_fiv“ 通过考虑对应的相关图像的中心位置fci_v“ 以及各个相关图像的全局最大相关值p_v的位置fci_v“ 其中v“ε{1,2，... n”≤n'}。该方法还包括通过应用对应的第一偏移矢量fov来将第二数字图像的至少一部分与第一数字图像的至少一部分对齐。

10. 发明申请

WO2017070584A1 COMPUTER PROCESSES BEHIND AN ENHANCED VERSION OF AQUA 审中-公开
标题翻译：计算机进程是AQUA增强版本的后续版本
公开(公告)号：WO2017070584A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/058280
申请日：2016-10-21
申请人： NOVARTIS AG , BORDEAUX, Jennifer
发明人： BORDEAUX, Jennifer , LITTLE, Brian
IPC分类号： G01N33/483 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/533 , G01N33/574 , G01N33/487 , G06T7/40 , G06F19/10 , G06F19/16 , G06T7/00 , G06T7/10 , G06T7/136 , G06T7/155 , G06T7/174 , G06T7/187 , G06T7/507 , G06T7/55 , G06T7/60 , G06T7/90
CPC分类号： G06T7/0012 , G01N21/6456 , G01N33/574 , G06F19/10 , G06F19/16 , G06K9/00147 , G06T2207/10056 , G06T2207/30024
摘要： The invention relates, in part, to systems and methods for scoring a sample containing tumor tissue from a cancer patient. The score obtained from these methods can be indicative of a likelihood that a patient may respond positively to immunotherapy. The invention also relates, in part, to methods of deriving a value for % biomarker positivity (PBP) for all cells or optionally, one or more subsets thereof, present in a field of view of a tissue sample from a cancer patient. The values for PBP can be indicative of a patient's response to immunotherapy.
摘要翻译：本发明部分涉及用于对包含来自癌症患者的肿瘤组织的样品进行评分的系统和方法。从这些方法获得的分数可以指示患者可能对免疫疗法有积极响应的可能性。本发明还部分涉及导出存在于来自癌症患者的组织样品的视野中的所有细胞或任选地其一个或多个亚组的％生物标志物阳性（PBP）的值的方法。 PBP的值可以指示患者对免疫疗法的反应。

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