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1. 发明申请

WO2005037987A3 ISOLATED NUCLEOTIDE SEQUENCES RESPONSIBLE FOR THE TOMATO HIGH PIGMENT-1 MUTANT PHENOTYPES (HP-1 AND HP-1W) AND USES THEREOF 审中-公开
标题翻译：用于TOMATO高色素1突变体（HP-1和HP-1W）的分离的核苷酸序列及其用途
公开(公告)号：WO2005037987A3
公开(公告)日：2010-02-11
申请号：PCT/IL2004000956
申请日：2004-10-20
申请人： LEVIN ILAN , LIEBERMAN MICHAL , AMIR SEGEV ORIT , GILBOA NEHAMA , LALAZAR AVRAHAM , VOLCANI CT THE STATE OF ISRAEL
发明人： LEVIN ILAN , LIEBERMAN MICHAL , AMIR SEGEV ORIT , GILBOA NEHAMA , LALAZAR AVRAHAM
IPC分类号： C12N15/12 , A01H1/04 , C07K14/415 , C12N20060101 , C12N15/82
CPC分类号： C12N15/8243 , A01H1/04 , C07K14/415 , C12N15/825
摘要： The present invention provides isolated nucleotide sequences responsible for the tomato high pigment 1 (hp-1) and high pigment 1 w (hp-1 w ) phenotypes, wherein said sequences comprises an altered tomato DDB1 gene sequence or fragment thereof, wherein said the alteration in said altered sequence or fragment comprises an A-to-T transversion at nucleotide 931 of said DDB1 gene sequence in the case of hp-1 and a G-to-A transition at nucleotide 2392 of said DDB1 gene sequence in the case of hp-1 w .
摘要翻译：本发明提供负责番茄高颜料1（hp-1）和高颜料1w（hp-1w）表型的分离的核苷酸序列，其中所述序列包含改变的番茄DDB1基因序列或其片段，其中所述改变在所述改变的序列或片段中包括在hp-1的情况下所述DDB1基因序列的核苷酸931处的A至T逆转，并且在hp情况下包含所述DDB1基因序列的核苷酸2392处的G至A转换 -1 w。

2. 发明申请

WO2005030927A3 METHODS AND COMPOSITIONS FOR IN VIVO INFLAMMATION MONITORING 审中-公开
标题翻译：用于血液透析监测的方法和组合物
公开(公告)号：WO2005030927A3
公开(公告)日：2009-05-28
申请号：PCT/US2004031141
申请日：2004-09-23
申请人： UAB RESEARCH FOUNDATION , ZINN KURT R , CHAUDHURI TANDRA R , WU HONGJU
发明人： ZINN KURT R , CHAUDHURI TANDRA R , WU HONGJU
IPC分类号： A01N47/00 , A01N63/00 , A01N65/00 , A61K31/21 , A61K31/26 , C12N20060101 , C12N9/02 , C12N15/85 , C12N15/861
CPC分类号： C12Q1/6897 , A01K2217/05 , A01K2267/0331 , A01K2267/0368 , A01K2267/0393 , A61K49/0008 , A61K49/0013 , C12N7/00 , C12N9/0083 , C12N15/85 , C12N15/86 , C12N2710/10343 , C12N2710/10345 , C12N2810/6018 , C12N2810/855 , C12N2830/00
摘要： Disclosed are methods and materials for detecting inflammation using in vivo and in vitro monitoring, as well as methods of reducing inflammation. Also disclosed are composition related to in vivo monitoring of inflammation, as well as transgenic animals and cell lines useful for such.
摘要翻译：公开了使用体内和体外监测来检测炎症的方法和材料，以及减少炎症的方法。还公开了与炎症的体内监测相关的组合物，以及用于此的转基因动物和细胞系。

3. 发明申请

WO2005042720A3 KAHALALIDE-PRODUCING BACTERIA 审中-公开
标题翻译：海藻酸生产细菌
公开(公告)号：WO2005042720A3
公开(公告)日：2009-04-16
申请号：PCT/US2004036201
申请日：2004-11-01
申请人： UNIV MARYLAND BIOTECH INST , UNIV MISSISSIPPI , HILL RUSSELL T , HAMANN MARK T , ENTICKNAP JULIE , RAO KARUMANCHI V
发明人： HILL RUSSELL T , HAMANN MARK T , ENTICKNAP JULIE , RAO KARUMANCHI V
IPC分类号： C12N1/00 , C12N20060101 , C12N1/21 , C12P17/00 , C12P17/16 , C12P21/02 , C12R1/63
CPC分类号： C12P17/00 , C12P17/16 , C12P21/02 , C12R1/63
摘要： Disclosed are strains of Vibrio sp bacteria that produce kahalalides or derivatives thereof, methods of isolating said strains, and 16S rRNA sequences useful in identifying kahalalides producing bacteria.
摘要翻译：公开了产生辣椒碱或其衍生物的弧菌菌株，分离所述菌株的方法，以及可用于鉴定产生kahalalides的细菌的16S rRNA序列。

4. 发明申请

WO2005035714A3 VACCINES FOR CANCER, AUTOIMMUNE DISEASE AND INFECTIONS 审中-公开
标题翻译：癌症疫苗，自发性疾病和感染的疫苗
公开(公告)号：WO2005035714A3
公开(公告)日：2009-04-16
申请号：PCT/US2004027792
申请日：2004-08-26
申请人： UNIV TEXAS , MOLLDREM JEFFREY
发明人： MOLLDREM JEFFREY
IPC分类号： C07K1/00 , A61K38/02 , A61K38/03 , A61K38/04 , A61K39/00 , C07K2/00 , C07K4/00 , C07K7/00 , C07K14/00 , C12N20060101
CPC分类号： A61K39/0011 , C07K14/4748
摘要： The present invention provides tumor-associated HLA-restricted antigens, and in particular HLA-A2 restricted antigens, as vaccines for treating or preventing cancers in a patient. In specific aspects, neutrophil elastase peptides other than PR1, cyclin E1 peptides, cyclin D peptides, or cyclin E2 peptides are provided. Such peptides can be used to elicit specific CTLs that preferentially attack tumor cells. The present invention also provides HLA-restricted antigens as vaccines for treating or preventing autoimmune diseases or conditions, transplant rejection or vasculitis in a patient. In particular aspects, there is provided Pr3, a myeloid tissue-restricted protein and a HLA-A2.1-restricted self-peptide, PRl, derived from Pr3, which can be used to elicit PR1-specific CTLs. The present invention also provides a HLA-restricted-peptide myeloperoxidases-based methods.
摘要翻译：本发明提供肿瘤相关的HLA限制性抗原，特别是HLA-A2限制性抗原，作为用于治疗或预防患者癌症的疫苗。在具体方面，提供除PR1以外的嗜中性粒细胞弹性蛋白酶肽，细胞周期蛋白E1肽，细胞周期蛋白D肽或细胞周期蛋白E2肽。这样的肽可以用于引发优先攻击肿瘤细胞的特异性CTL。本发明还提供HLA限制性抗原作为用于治疗或预防患者自身免疫性疾病或病症，移植排斥或血管炎的疫苗。在特定方面，提供了可用于引发PR1特异性CTL的Pr3，来自Pr3的髓系组织限制蛋白和HLA-A2.1限制性自身肽PR1。本发明还提供了基于HLA限制肽的髓过氧化物酶的方法。

5. 发明申请

WO2005059099A3 HUMAN IPLA2T 审中-公开
标题翻译：人类IPLA2T
公开(公告)号：WO2005059099A3
公开(公告)日：2009-04-09
申请号：PCT/US2004041619
申请日：2004-12-13
申请人： UNIV ST LOUIS , GROSS RICHARD , JENKINS CHRISTOPHER M
发明人： GROSS RICHARD , JENKINS CHRISTOPHER M
IPC分类号： C12P21/06 , A01N29/04 , A01N61/00 , A61K38/00 , A61K49/00 , C07H21/04 , C07K1/00 , C12N20060101 , C12N9/20
CPC分类号： C12N9/20 , A61K38/00
摘要： A novel function phospholipase A2, referred to herein as calciumindependent phospholipase A2? (iPLA2?) having SEQ ID NO: 1 and SEQ ID NO: 2, and nucleic acid sequences (SEQ ID NO: 3 and SEQ ID NO: 4) encoding and expressing iPLA2?. This novel enzyme has been isolated and characterized and is involved in the catalysis and hydrolysis of lipids cycling in a living cell biosystem. In an embodiment, the compromises to an isolated nucleic acid molecule comprising a set of iPLA2? polynucleotides. In an aspect of this embodiment, the iPLA2? polynucleotides encode and express an iPLA2? polypeptide. In one aspect, an isolated and characterized gene comprises a polynucleotide having a sequence shown in SEQ ID NO: 3 and SEQ ID NO: 4.
摘要翻译：一种新型功能磷脂酶A2，本文称为钙依赖性磷脂酶A2？具有SEQ ID NO：1和SEQ ID NO：2的核酸序列（iPLA2β）和编码并表达iPLA2β的核酸序列（SEQ ID NO：3和SEQ ID NO：4）。这种新型酶已经被分离和表征，并参与活细胞生物系统中脂质循环的催化和水解。在一个实施方案中，对分离的核酸分子的折衷包括一组iPLA2？多核苷酸。在本实施例的一个方面，iPLA2？多核苷酸编码并表达iPLA2？多肽。一方面，分离和表征的基因包含具有SEQ ID NO：3和SEQ ID NO：4所示序列的多核苷酸。

6. 发明申请

WO2005054433A3 A NOVEL "CLEAVE-N-READ" SYSTEM FOR PROTEASE ACTIVITY ASSAY AND METHODS OF USE THEREOF 审中-公开
标题翻译：一种用于蛋白酶活性测定的新型“CLEAVE-N-READ”系统及其使用方法
公开(公告)号：WO2005054433A3
公开(公告)日：2009-04-02
申请号：PCT/US2004039578
申请日：2004-11-24
申请人： BIOSCION LLC , TAN ZHIQUN , BI XIAONING , BAUDRY MICHEL , SCHREIBER STEVEN S
发明人： TAN ZHIQUN , BI XIAONING , BAUDRY MICHEL , SCHREIBER STEVEN S
IPC分类号： C07K1/00 , A61K39/00 , A61K39/29 , C07H21/04 , C07K14/435 , C12N20060101 , C12P21/04 , C12Q1/37
CPC分类号： C12Q1/37 , G01N2333/005 , G01N2333/16 , G01N2333/165 , G01N2333/445
摘要： The present invention provides a reliable protease activity assay system for determination of cleavage of more than one recognition/cleavage site in a single assay. The assay relies on use of a fluorescent fusion substrate which comprises a purification module (PM), a first fluorescent protein (FP1), a specific protease recognition/scission site (SPSS), a second fluorescent protein (FP2) and a matrix binding module (BM).
摘要翻译：本发明提供了用于在单次测定中测定多于一个识别/切割位点的切割的可靠的蛋白酶活性测定系统。该测定依赖于使用荧光融合底物，其包含纯化模块（PM），第一荧光蛋白（FP1），特异性蛋白酶识别/切断位点（SPSS），第二荧光蛋白（FP2）和基质结合模块（BM）。

7. 发明申请

WO2005033291A3 HORMONE RESPONSE ELEMENT BINDING TRANSREGULATORS 审中-公开
标题翻译：霍尔曼响应元件绑定传感器
公开(公告)号：WO2005033291A3
公开(公告)日：2009-04-02
申请号：PCT/US2004032561
申请日：2004-10-04
申请人： UNIV ROCHESTER , MUYAN MESUT , HUANG JING
发明人： MUYAN MESUT , HUANG JING
IPC分类号： A61K39/00 , A61K38/04 , C07K14/72 , C12N20060101 , C12N15/62 , C12N15/85
CPC分类号： C12N15/85 , C07K2319/71 , C07K2319/80 , C12N15/62 , C12N2830/001
摘要： Disclosed are compositions and methods for ERE-binding transregulators that specifically and potently regulate ERE-containing genes. To accomplish this, we took advantage of the modular nature of ER and initially designed a monomeric ERE binding module by co-joining two DNA binding domains with the hinge domain. Integration of strong activation or repressor domains from other transcription factors into this module generated constitutively active ERE-binding activators (EBAs) and ERE-binding repressors (EBRs) respectively. These novel transregulators are the basis for the targeted regulation of ERE containing genes, the identification of estrogen responsive gene networks, and the development of alternative/complementary therapeutic approaches for estrogen target tissue cancers.
摘要翻译：公开了特异性和有效调节含ERE的基因的ERE结合跨越调节因子的组合物和方法。为了实现这一点，我们利用了ER的模块化特性，并最初通过将两个DNA结合结构域与铰链域共同连接来设计单体ERE结合模块。将来自其他转录因子的强激活或阻抑物结构域整合到该模块中分别产生组成型活性ERE结合激活子（EBAs）和ERE结合阻遏物（EBR）。这些新型跨越调控因子是靶向调控含ERE基因，雌激素反应基因网络鉴定以及雌激素靶组织癌替代/补充治疗方法发展的基础。

8. 发明申请

WO2004094591A3 THREE-DIMENSIONAL STRUCTURES OF HDAC9 AND CABIN1 AND COMPOUND STRUCTURES AND METHODS RELATED THERETO 审中-公开
标题翻译： HDAC9和CABIN1的三维结构及其相关的化合物结构与方法
公开(公告)号：WO2004094591A3
公开(公告)日：2009-04-02
申请号：PCT/US2004011744
申请日：2004-04-16
申请人： UNIV COLORADO , HAN AIDONG , CHEN LIN
发明人： HAN AIDONG , CHEN LIN
IPC分类号： G06F19/00 , C12N20060101 , G06G7/58
CPC分类号： C07K14/4716 , C07K14/4702 , C07K2299/00 , C12N9/16
摘要： Disclosed are the three-dimensional structures of two complexes: a Cabin 1/MEF2B/DNA complex and a MITR/MEF2B/DNA complex. Also disclosed are methods of using such structures and models derived therefrom in structure-based design methods to identify regulators of the interaction of MEF2 with its cognate ligands/corepressors, to compounds that can be designed or identified based on the knowledge of such structures and models, and to methods of using such compounds in therapeutic methods.
摘要翻译：公开了两种配合物的三维结构：一个宿舍1 / MEF2B / DNA复合物和MITR / MEF2B / DNA复合物。还公开了在基于结构的设计方法中使用这种结构和衍生的模型的方法，以基于这种结构和模型的知识来鉴定MEF2与其同源配体/共抑制因子的相互作用的调节剂可以被设计或鉴定的化合物，以及在治疗方法中使用这些化合物的方法。

9. 发明申请

WO2005071059A3 METHODS OF IDENTIFYING PUTATIVE GENE PRODUCTS BY INTERSPECIES SEQUENCE COMPARISON AND BIOMOLECULAR SEQUENCES UNCOVERED THEREBY 审中-公开
标题翻译：通过观察序列比较和未知的生物分子序列鉴定引物基因产物的方法
公开(公告)号：WO2005071059A3
公开(公告)日：2009-02-12
申请号：PCT/IL2005000107
申请日：2005-01-27
申请人： COMPUGEN LTD , SOREK ROTEM , POLLOCK SARAH , DIBER ALEX , LEVINE ZURIT , NEMZER SERGEY , KOL GUY , WOOL ASSAF , HAVIV AMI , COHEN YUVAL , COHEN YOSSI , SHEMESH RONEN , SAVITSKY KINNERET
发明人： SOREK ROTEM , POLLOCK SARAH , DIBER ALEX , LEVINE ZURIT , NEMZER SERGEY , KOL GUY , WOOL ASSAF , HAVIV AMI , COHEN YUVAL , COHEN YOSSI , SHEMESH RONEN , SAVITSKY KINNERET
IPC分类号： G01N33/48 , C12N20060101 , C12Q1/00 , G06F19/00
CPC分类号： G06F19/22
摘要： A method of identifying alternatively spliced exons is provided. The method comprising, scoring each of a plurality of exon sequences derived from genes of a species according to at least one sequence parameter, wherein exon sequences of the plurality of exon sequences scoring above a predetermined threshold represent alternatively spliced exons, thereby identifying the alternatively spliced exons.
摘要翻译：提供了一种识别可变剪接外显子的方法。所述方法包括：根据至少一个序列参数对来自物种基因的多个外显子序列中的每一个进行评分，其中得分高于预定阈值的多个外显子序列的外显子序列代表可变剪接的外显子，由此鉴定可变剪接外显子。

10. 发明申请

WO2005003319A3 GLUCANASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：葡萄糖，编码它们的核酸及其制备和使用它们的方法
公开(公告)号：WO2005003319A3
公开(公告)日：2008-10-16
申请号：PCT/US2004021492
申请日：2004-07-02
申请人： DIVERSA CORP , STEER BRIAN , CALLEN WALTER , HEALEY SHAUN , PULLIAM DERRICK
发明人： STEER BRIAN , CALLEN WALTER , HEALEY SHAUN , PULLIAM DERRICK
IPC分类号： C07H21/04 , A23K1/00 , A23K1/165 , A23K1/18 , C12N20060101 , C12N9/24 , C12N9/42 , C12P21/06
CPC分类号： C12N9/2405 , A23C9/1322 , A23C19/04 , A23K10/14 , A23K20/189 , A23K40/10 , A23K50/10 , A23L2/52 , A23L29/10 , A23L33/18 , A23V2002/00 , A61K9/0056 , A61K38/47 , C09K8/62 , C11D3/38636 , C12N9/2437 , C12N11/02 , C12N11/14 , C12N11/16 , C12P7/10 , C12P19/02 , C12P19/18 , C12Y302/01004 , D21C1/00 , D21C5/005 , G01N33/53 , G01N33/573 , G01N2333/924 , G01N2500/00 , Y02E50/16 , Y02E50/17
摘要： The invention relates to polypeptides having glucanase, e.g., endoglucanase, mannanase, xylanase activity or a combination of these activities, and polynucleotides encoding them. In one aspect, the glucanase activity is an endoglucanase activity (e.g., endo-1,4-beta-D-glucan 4-glucano hydrolase activity) and comprises hydrolysis of 1,4-beta-D-glycosidic linkages in cellulose, cellulose derivatives (e.g., carboxy methyl cellulose and hydroxy ethyl cellulose) lichenin, beta-1,4 bonds in mixed beta-1,3 glucans, such as cereal beta-D-glucans or xyloglucans and other plant material containing cellulosic parts. In addition, methods of designing new enzymes and methods of use thereof are also provided. In alternative aspects, the new glucanases e.g., endoglucanases, mannanases, xylanases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及具有葡聚糖酶的多肽，例如内切葡聚糖酶，甘露聚糖酶，木聚糖酶活性或这些活性的组合，以及编码它们的多核苷酸。一方面，葡聚糖酶活性是内切葡聚糖酶活性（例如内切-1,4-β-D-葡聚糖4-葡聚糖水解酶活性），并且包括在纤维素，纤维素衍生物中水解1,4-β-D-糖苷键（例如，羧甲基纤维素和羟乙基纤维素）地衣淀粉，混合的β-1,3葡聚糖中的β-1,4键，例如谷类β-D-葡聚糖或木葡聚糖和含有纤维素部分的其它植物材料。此外，还提供了设计新酶的方法及其使用方法。在替代方面，新葡聚糖酶例如内切葡聚糖酶，甘露聚糖酶，木聚糖酶在增加的pH和温度下具有增加的活性和稳定性。

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