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序号 专利名 申请号 申请日 公开(公告)号 公开(公告)日 发明人
181 Vapor deposited metal catalytic film, process for making the same and liquid container with the film US538570 1990-06-15 US5077258A 1991-12-31 Roger W. Phillips; Lauren R. Wendt
Metal catalytic film comprising a flexible substrate having a surface, a catalytic metal layer adherent to said surface of the substrate and having a thickness ranging from 200 to 1000 Angstroms.Method for forming metal catalytic film on a flexible substrate having a surface in a vacuum chamber comprising the steps of evacuating the vacuum chamber to a predetermined vacuum, introducing a substantially inert heavy gas into the vacuum chamber, creating a vapor stream of molecules of a catalytic metal in the vacuum chamber whereby the molecules of the catalytic metal are scattered by the inert heavy gas and are subsequently deposited upon the surface of the substrate to form a catalytic metal layer to a thickness ranging from 200 to 1000 Angstroms.
182 Method for cleaning dental prosthetic devices US360422 1989-06-02 US4975285A 1990-12-04 Perry A. Ratcliff
The use of stabilized chlorine dioxide or chlorine dioxide in aqueous solution as a composition to reduce or prevent plaque formation and treatment of oral diseases ecologically plaque dependent, such as gingivitis and periodontitis, is disclosed. Preferred concentrations are in the range of 0.005% to 0.2% and the chlorine dioxide may be in the form of a rinse, a wash, a soak or a dentifrice.
183 Method for retarding dental plaque by killing streptococcus sanguis US279360 1988-12-02 US4889714A 1989-12-26 Perry A. Ratcliff
The use of stabilized chlorine dioxide or chlorine dioxide in aqueous solution as a composition to reduce or prevent plaque formation and treatment of oral diseases ecologically plaque dependent, such as gingivitis and periodontitis, is disclosed. Preferred concentrations are in the range of 0.005% to 0.2% and the chlorine dioxide may be in the form of a rinse, a wash, a soak or a dentifrice.
184 Anti-microbial compositions comprising an aqueous solution of a germicidal polymeric nitrogen compound and a potentiating oxidizing agent US700745 1985-02-12 US4654208A 1987-03-31 Richard F. Stockel; Murray Jelling
An anti-microbial composition comprises an aqueous solution of a germicidal polymeric nitrogen compound and an oxidizing agent which potentiates the activity of the compound. The polymeric nitrogen compound includes a germicidal quaternary ammonium compound or a polyguanide compound. The oxidizing agent has a standard reduction potential between 0.85 and 2.0 volts, is soluble in water, non-toxic and enhances the activity germicidal of the nitrogen polymer at low concentrations. Suitable oxidizing agents include halogen oxides, oxyhalogens, halogens, and inorganic and organic peroxides.
185 Anti-microbial compositions and associated methods for preparing the same and for the disinfecting of various objects US471011 1983-03-01 US4499077A 1985-02-12 Richard F. Stockel; Murray Jelling
An anti-microbial composition is provided comprising an aqueous solution of an oxyhalogen compound and a polymeric germicide. The oxyhalogen compound is preferably stabilized chlorine dioxide and the polymeric germicide is preferably a quaternary ammonium compound such as a copolymer of at least one difunctional tertiary amine and a dihalo organic compound such as 1,4-dihalo-2-butene, a copolymer of at least one difunctional tertiary amine, at least one monofunctional tertiary amine and a dihalo organic compound such as 1,4-dihalo-2-butene, or a polyguanide such as hydrochloride salt of poly(hexamethylene biguanide). The anti-microbial composition thus formed is used for the treatment of soft contact lenses to disinfect the same with an optimum effect while minimizing the irritant possibilities thereof and also minimizing absorption of the composition into the porous and hydrophilic surfaces of soft contact lenses such that there is a minimal release of absorbed substances after treatment.
186 Aqueous solution suitable for dissipating available iodine contained in an iodophor US582762 1975-06-02 US4031209A 1977-06-21 Joseph Zenon Krezanoski
An aqueous solution suitable for dissipating, at a controlled rate, available iodine contained in an iodophor is disclosed. The aqueous dissipating solution contains sorbic acid or soluble salts thereof and ethylenediaminetetraacetic acid or soluble salts thereof. Preferably, the dissipating solution also contains an ammonium, alkali metal, or alkaline earth metal salt of a boron oxyacid. Also disclosed are techniques for sterilizing contact lenses and sterile solutions, suitable for maintaining sterility of a previously sterilized object, comprising admixtures of the dissipating solutions with iodophor solutions.
187 Iodine composition and dissipating solution US31579372 1972-12-18 US3911107A 1975-10-07 KREZANOSKI JOSEPH Z
An aqueous, antiseptic, iodophor solution is provided containing iodine, a water soluble iodide salt or hydriotic acid, polyvinyl alcohol and boric acid. The iodophor solution may be employed to sterilize a broad range of animate and inanimate objects, including contact lenses. Additionally, the iodophor solution, or similar iodophor solutions which do not contain boric acid, may be employed in visual temperature sensing devices. The visual temperature sensing devices comprise a transparent vessel containing the iodophor solution. Also disclosed is an aqueous solution for dissipating, at a controlled rate, available iodine contained in an iodophor. The aqueous dissipating solution contains sorbic acid or soluble salts thereof and ethylenediaminetetraacetic acid or soluble salts thereof.
188 Sterilization of soft, hydrophilic acrylate and methacrylate copolymer materials US44664374 1974-02-28 US3876768A 1975-04-08 BLANK IZHAK
Soft, hydrophilic acrylate and methacrylate copolymer materials are sterilized by immersing them in a solution containing small, but effective amounts of a material which releases active halogen in solution, but is non-damaging to the eye in concentrations effective for sterilization. A particularly effective material is chlorinated trisodium phosphate. The concentrataion of the sterilant material should be such that it releases halogen in amounts of from about 2 parts per million to 250 parts per million. The technique is particularly useful for sterilization of soft, hydrophilic acrylate and methacrylate contact lenses.
189 OPHTHALMIC COMPOSITIONS FOR THERAPEUTIC AND PROPHYLACTIC USES PCT/US2018/016696 2018-02-02 WO2018144909A1 2018-08-09 ROY, Chad; METZINGER, Rebecca

Disclosed herein are topical ophthalmic compositions comprising ammonium chloride, a quaternary ammonium salt, and stabilized chlorine dioxide. Also disclosed herein are methods of treating or preventing active infections of the tissues comprising the eye and surrounding parenchyma from bacterial, fungal, mycobacterial, mycoplasmal, viral, and protozoan amoeba microorganisms.

190 眼科組成物 PCT/JP2016/083944 2016-11-16 WO2017094508A1 2017-06-08 林 紗衣子; 辻 和宏; 清宮 暁

本発明は、(A)アルギニン、2-アミノ-2-メチル-1,3-プロパンジオール、トリス(ヒドロキシメチル)アミノメタン、2-アミノエタノール及びこれらの塩からなる群より選択される1種以上と、(B)多糖類と、を含有する、眼科組成物に関する。

191 ELECTROCHEMICAL SYSTEM FOR DISINFECTING AND CLEANING CONTACT LENSES PCT/US2015/021950 2015-03-23 WO2015153161A1 2015-10-08 TUCKER, Robert, Carey

The present invention is generally related to a lens care system and method for disinfecting and cleaning contact lenses. A lens care system or method of the invention is based on electrolysis of an aqueous chloride solution for generating germicide species (e.g., chlorine, hypochlorous acid, hypochlorite, or combinations thereof) and subsequent in-situ electrolysis of hypochlorous acid or hypochlorite in the aqueous solution for neutralizing the generated germicide species.

192 PHARMACEUTICAL COMPOSITION CONTAINING AN ELECTROCHEMICALLY ACTIVATED SALT SOLUTION PCT/EP2011004470 2011-09-06 WO2012034659A3 2012-06-07 MATHE HANS-GEORG
The aim of the invention is to provide a pharmaceutical composition containing an active ingredient and a carrier substance, wherein the carrier substance comprises an electrochemically activated aqueous sodium chloride solution and is present in a phase separated from the active ingredient, wherein said pharmaceutical composition guarantees an especially long storage life and especially high long-term stability of the composition without unacceptable impairment of the effectiveness of the active ingredient. For this purpose, the carrier substance has a content of free chlorine of more than 500 mg/l, preferably of more than 600 mg/l, according to the invention.
193 L-HISTIDINE IN OPHTHALMIC SOLUTIONS PCT/US0146762 2001-11-08 WO0238077A2 2002-05-16 SMITH FRANCIS XAVIER
The invention relates to an aqueous ophthalmic solution comprising 0.01 to about 1.0 percent by weight L-histidine; 0.01 to 0.0001 percent by weight hydrogen peroxide; 0.1 to 500 parts per million of a cationic polymeric preservative that provides superior preservative efficacy especially as against fungal microbes. These solutions may be employed in various ways including cleaning contact lenses, rinsing lenses while in the eye, storing lenses and in delivering active pharmaceutical agents to the eye.
194 MICROBIAL INHIBITORY COMPOSITIONS PCT/AU2001/000295 2001-03-16 WO01068090A1 2001-09-20
The present invention provides an antimicrobial composition. The composition comprises a cell-permeabilising agent and at least one compound of general formula (I) wherein R1 and R2 are independently H, halogen, alkyl, alkoxy, oxoalkyl, alkenyl, aryl or arylalkyl whether unsubstituted or substituted, optionally interrupted by one or more heteroatoms, straight chain or branched chain, hydrophilic or fluorophilic; R3 and R4 are independently H, halogen, alkyl, aryl or arylalkyl, alkoxy; R3 or R4 + R2 can be a saturated or an unsaturated cycloalkane; and "-----" represents a single bond or a double bond provided that at least one of R1, R2, R3 and R4 is halogen.
195 CONTACT LENS CLEANER, AND PROTEIN REMOVAL AND STERILIZATION METHOD BY MEANS OF ELECTROPHORESIS DISSOCIATION EP21851272.1 2021-07-29 EP4187312A1 2023-05-31 SUN, Bixia

A contact lens cleaner and a method for protein removal and sterilization by electrophoresis dissociation are disclosed. The contact lens cleaner comprises a lens cleaning tank (10), two electrophoresis dissociation probes (20) are arranged in the lens cleaning tank (10) opposite each other, and the electrophoresis dissociation probes (20) are electrically connected to a circuit power supply. The lens cleaning tank (10) is filled with an electrolyte solution; a lens to be cleaned is placed in the lens cleaning tank (10); and a switch is turned on, and the two electrophoresis dissociation probes (20) in the lens cleaning tank (10) form an anode and a cathode. There are lacrimal proteins on the surface of the lens to be cleaned, the lacrimal proteins are charged in the solution, and the charged lacrimal proteins move to the electrode opposite to the electrical property thereof in the cleaning tank (10) according to the phenomenon of electrophoresis. The electrolyte solution reacts chemically in the cleaning tank (10) to produce hypochlorite having a strong oxidizing property, and the hypochlorite can degrade the lacrimal proteins, and also can sterilize and disinfect.

196 Improved ophthalmic and contact lens solution EP08014693.9 2001-11-08 EP1992340B1 2016-05-11 Smith, Francis, Xavier
197 Improved ophthalmic and contact lens solution EP08014693.9 2001-11-08 EP1992340A1 2008-11-19 Smith, Francis, Xavier

The present invention relates to improved ophthalmic solutions that employ a preservative enhancer chosen from the group consisting of dexpanthenol and panthenol; and at least 0.00001 weight percent of a preservative, in order to more effectively preserve solutions and to reduce the degree to which cationic preservatives will deposit on contact lenses. Ophthalmic solutions are here understood to include contact lens treatment solutions, such as cleaners, soaking solutions, conditioning solutions and lens storage solutions, as well as wetting solutions and in-eye solutions for treatment of eye conditions. More particularly, a preferred ophthalmic solution comprises dexpanthenol, 0.2% of a phosphate buffer or Bis-Tris propane, and 0.00001 % of polyhexamethylene biguanide, wherein the solution is made isotonic with sodium chloride.

198 Contact lens care composition EP06704705.0 2006-02-20 EP1850888B1 2008-09-17 Obwaller, Andreas
The present invention relates to ophthalmic compositions such as contact lens care solutions, containing miltefosine. The present invention further relates to ophthalmic compositions or contact lens care systems containing miltefosine in combination with additional other active microbiocidal substances or proteases. Furthermore, the invention relates to the use of the compositions for the removal and eradication of protozoan parasites such as Acanthamoeba from contact lenses.
199 Verwendung von Taurolidin und seiner Metaboliten als antimikrobieller Zusatz in Zubereitungen zur Behandlung, Reinigung, Aufbewahrung und zum Konditionieren von Kontaktlinsen EP04010102.4 2004-04-28 EP1495772A1 2005-01-12 HERDEIS, Claus; Weis, Christian Edwin

Die Erfindung betrifft die Verwendung von Taurolidin und seinen Metaboliten wie insbesondere Taurultam als antimikrobieller Zusatz zu Lösungen zur Behandlung, Reinigung, Aufbewahrung und zum Conditioning von Kontaktlinsen.

200 MICROBIAL INHIBITORY COMPOSITIONS EP01911289.5 2001-03-16 EP1274420A1 2003-01-15 HOLMSTROM, Gerd, Pia, Carola; KJELLEBERG, Staffan
The present invention provides an antimicrobial composition. The composition comprises a cell-permeabilising agent and at least one compound of general formula (I) wherein R1 and R2 are independently H, halogen, alkyl, alkoxy, oxoalkyl, alkenyl, aryl or arylalkyl whether unsubstituted or substituted, optionally interrupted by one or more heteroatoms, straight chain or branched chain, hydrophilic or fluorophilic; R3 and R4 are independently H, halogen, alkyl, aryl or arylalkyl, alkoxy; R3 or R4 + R2 can be a saturated or an unsaturated cycloalkane; and '-----' represents a single bond or a double bond provided that at least one of R1, R2, R3 and R4 is halogen.