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21. 发明授权

US06863801B2 Electrochemical cell 有权
标题翻译：电化学电池
公开(公告)号：US06863801B2
公开(公告)日：2005-03-08
申请号：US09840624
申请日：2001-04-23
申请人： Alastair McIndoe Hodges , Thomas William Beck , Oddvar Johansen , Ian Andrew Maxwell
发明人： Alastair McIndoe Hodges , Thomas William Beck , Oddvar Johansen , Ian Andrew Maxwell
IPC分类号： C12Q1/00 , G01N27/30 , G01N27/403 , G01N27/49 , G01N33/487 , G01N27/327
CPC分类号： C12Q1/004 , C12Q1/006 , G01N27/3272
摘要： A biosensor for use in determining a concentration of a component in an aqueous liquid sample is provided including: an electrochemical cell having a first electrically resistive substrate having a thin layer of electrically conductive material, a second electrically resistive substrate having a thin layer of electrically conductive material, the substrates being disposed with the electrically conductive materials facing each other and being separated by a sheet including an aperture, the wall of which aperture defines a cell wall and a sample introduction aperture whereby the aqueous liquid sample may be introduced into the cell; and a measuring circuit.
摘要翻译：提供了一种用于确定含水液体样品中组分浓度的生物传感器，包括：电化学电池，其具有具有导电材料薄层的第一电阻衬底，具有导电薄层的第二电阻衬底材料，所述基板被布置成导电材料相互面对并由包括孔的片分隔开，所述片的壁的孔限定细胞壁和样品引入孔，由此可将水性液体样品引入细胞中; 和测量电路。

22. 发明授权

US06193865B1 Analytic cell 失效
标题翻译：分析细胞
公开(公告)号：US06193865B1
公开(公告)日：2001-02-27
申请号：US09268250
申请日：1999-03-15
申请人： Alastair McIndoe Hodges , Oddvar Johansen , Ronald Christopher Chatelier , Ian Andrew Maxwell , Thomas William Beck
发明人： Alastair McIndoe Hodges , Oddvar Johansen , Ronald Christopher Chatelier , Ian Andrew Maxwell , Thomas William Beck
IPC分类号： G01N27401
CPC分类号： G01N27/401 , G01N27/4035
摘要： Electrochemical cell having a porous substrate and a first and a second electrodes separated by an ion diffusion inhibiting partition is disclosed. The ion diffusion inhibiting partition between the two electrodes is defined by compressing the substrate and/or blocking pores of the substrate so as to inhibit but not entirely block ion diffusion between the two electrodes.
摘要翻译：公开了具有多孔基底的电化学电池和由离子扩散抑制分隔物隔开的第一和第二电极。通过压缩衬底和/或阻挡衬底的孔来限定两个电极之间的离子扩散抑制分隔，以便抑制但不完全阻止两个电极之间的离子扩散。

23. 发明授权

US08075760B2 Electrochemical cell 有权
标题翻译：电化学电池
公开(公告)号：US08075760B2
公开(公告)日：2011-12-13
申请号：US12560773
申请日：2009-09-16
申请人： Alastair McIndoe Hodges , Thomas William Beck , Oddvar Johansen
发明人： Alastair McIndoe Hodges , Thomas William Beck , Oddvar Johansen
IPC分类号： G01N27/327
CPC分类号： G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要： A method for determining the concentration of a reduced or oxidized form of a redox species is provided. In one exemplary embodiment, an electrochemical apparatus is provided in which the apparatus includes a hollow electrochemical cell for measuring a concentration of glucose in a blood sample, a current of the cell is measured, and a concentration of a redox mediator is determined, at least in part from, a measured current of the cell. The hollow electrochemical cell can include at least one non-metal working electrode, at least one counter electrode or counter/reference electrode, and a spacer interposed between the working electrode and the counter or counter/reference electrode. In one embodiment the working electrode and the counter or counter/reference electrode are not co-planer and are separated by a distance of from about 20 microns to about 200 microns. In another embodiment the working electrode and the counter or counter/reference electrode are not co-planer and the cell has an effective cell volume of less than 1.5 microliters.
摘要翻译：提供了确定还原或氧化形式的氧化还原物质的浓度的方法。在一个示例性实施例中，提供了一种电化学装置，其中所述装置包括用于测量血液样品中葡萄糖浓度的中空电化学电池，测量电池的电流，并且至少确定氧化还原介体的浓度部分来自电池的测量电流。中空电化学电池可以包括至少一个非金属工作电极，至少一个对电极或对置/参考电极，以及插入在工作电极和计数器或反/参比电极之间的间隔物。在一个实施例中，工作电极和计数器或对位/参比电极不是共平面的并且分开约20微米至约200微米的距离。在另一个实施例中，工作电极和计数器或对准/参比电极不是共平面的，并且电池具有小于1.5微升的有效电池容积。

24. 再颁专利

USRE42567E1 Electrochemical cell 有权
标题翻译：电化学电池
公开(公告)号：USRE42567E1
公开(公告)日：2011-07-26
申请号：US12899342
申请日：2010-10-06
申请人： Alastair M. Hodges , Thomas W. Beck , Oddvar Johansen , Ian Andrew Maxwell
发明人： Alastair M. Hodges , Thomas W. Beck , Oddvar Johansen , Ian Andrew Maxwell
IPC分类号： G01N27/327
CPC分类号： C12Q1/006 , C12Q1/004 , G01N27/3272
摘要： A biosensor for use in determining a concentration of a component in an aqueous liquid sample is provided including: an electrochemical cell having a first electrically resistive substrate having a thin layer of electrically conductive material, a second electrically resistive substrate having a thin layer of electrically conductive material, the substrates being disposed with the electrically conductive materials facing each other and being separated by a sheet including an aperture, the wall of which aperture defines a cell wall and a sample introduction aperture whereby the aqueous liquid sample may be introduced into the cell; and a measuring circuit.
摘要翻译：提供了一种用于确定含水液体样品中组分浓度的生物传感器，包括：电化学电池，具有具有导电材料薄层的第一电阻衬底，具有导电薄层的第二电阻衬底材料，所述基板被布置成导电材料相互面对并由包括孔的片分隔开，所述片的壁的孔限定细胞壁和样品引入孔，由此可将水性液体样品引入细胞中; 和测量电路。

25. 发明申请

US20100084288A1 Electrochemical Cell 有权
标题翻译：电化学电池
公开(公告)号：US20100084288A1
公开(公告)日：2010-04-08
申请号：US12560773
申请日：2009-09-16
申请人： Alastair McIndoe Hodges , Thomas William Beck , Oddvar Johansen
发明人： Alastair McIndoe Hodges , Thomas William Beck , Oddvar Johansen
IPC分类号： G01N27/26
CPC分类号： G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要： A method for determining the concentration of a reduced or oxidized form of a redox species is provided. In one exemplary embodiment, an electrochemical apparatus is provided in which the apparatus includes a hollow electrochemical cell for measuring a concentration of glucose in a blood sample, a current of the cell is measured, and a concentration of a redox mediator is determined, at least in part from, a measured current of the cell. The hollow electrochemical cell can include at least one non-metal working electrode, at least one counter electrode or counter/reference electrode, and a spacer interposed between the working electrode and the counter or counter/reference electrode. In one embodiment the working electrode and the counter or counter/reference electrode are not co-planer and are separated by a distance of from about 20 microns to about 200 microns. In another embodiment the working electrode and the counter or counter/reference electrode are not co-planer and the cell has an effective cell volume of less than 1.5 microliters.
摘要翻译：提供了确定还原或氧化形式的氧化还原物质的浓度的方法。在一个示例性实施例中，提供了一种电化学装置，其中所述装置包括用于测量血液样品中葡萄糖浓度的中空电化学电池，测量电池的电流，并且至少确定氧化还原介体的浓度部分来自电池的测量电流。中空电化学电池可以包括至少一个非金属工作电极，至少一个对电极或对置/参考电极，以及插入在工作电极和计数器或反/参比电极之间的间隔物。在一个实施例中，工作电极和计数器或对位/参比电极不是共平面的并且分开约20微米至约200微米的距离。在另一个实施例中，工作电极和计数器或对准/参比电极不是共平面的，并且电池具有小于1.5微升的有效电池容积。

26. 发明授权

US06960289B2 Electrochemical cell 有权
标题翻译：电化学电池
公开(公告)号：US06960289B2
公开(公告)日：2005-11-01
申请号：US10035924
申请日：2001-12-21
申请人： Alastair Mcindoe Hodges , Thomas William Beck , Oddvar Johansen
发明人： Alastair Mcindoe Hodges , Thomas William Beck , Oddvar Johansen
IPC分类号： C12Q1/00 , G01N27/327 , G01N27/49
CPC分类号： G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要： This invention relates to a biosensor and more particularly to an electrochemical biosensor for determining the concentration of an analyte in a carrier. The invention is particularly useful for determining the concentration of glucose in blood and is described herein with reference to that use but it should be understood that the invention is applicable to other analytic determinations.
摘要翻译：本发明涉及一种生物传感器，更具体地说，涉及用于确定载体中分析物浓度的电化学生物传感器。本发明对于确定血液中葡萄糖的浓度特别有用，并且在此参考该用途进行了描述，但是应当理解，本发明可应用于其它分析测定。

27. 发明申请

US20050077176A1 Electrochemical cell 失效
公开(公告)号：US20050077176A1
公开(公告)日：2005-04-14
申请号：US10624795
申请日：2003-07-22
申请人： Alastair Hodges , Thomas Beck , Oddvar Johansen
发明人： Alastair Hodges , Thomas Beck , Oddvar Johansen
IPC分类号： C12Q1/00 , G01N27/327 , G01N27/49 , G01N27/26
CPC分类号： G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要： This invention relates to a biosensor and more particularly to an electrochemical biosensor for determining the concentration of an analyte in a carrier. The invention is particularly useful for determining the concentration of glucose in blood and is described herein with reference to that use but it should be understood that the invention is applicable to other analytic determinations.

28. 发明授权

US5980709A Method of defining an electrode area 失效
标题翻译：定义电极面积的方法
公开(公告)号：US5980709A
公开(公告)日：1999-11-09
申请号：US973086
申请日：1997-10-10
申请人： Alastair McIndoe Hodges , Oddvar Johansen , Thomas William Beck
发明人： Alastair McIndoe Hodges , Oddvar Johansen , Thomas William Beck
IPC分类号： G01N27/28 , B01D61/38 , B01D65/00 , B01D67/00 , B01D69/00 , C25B9/10 , G01N27/30 , G01N27/40 , G01N27/403 , G01N27/26 , C25B11/00
CPC分类号： B01D67/0086 , G01N27/30
摘要： The present invention relates to a method for defining an area (4) of a layer on a porous substrate comprising compressing a volume of the substrate to produce a compressed region (8) which defines, or which in combination with an edge (7) of the substrate or of the layer defines, a boundary of the area and which substantially prevents the transport of material through or across its surface. The present invention also relates to an electrochemical sensing device comprising: a porous substrate; and an electrode (1) on one side of the substrate; wherein a region of the substrate is compressed to an extent which forms a barrier to migration of electrolyte within the substrate, the compressedregion defining, or in combination with an edge of the substrate or the electrode defining, a zone on the electrode of predetermined area.
摘要翻译： PCT No.PCT / AU96 / 00210 Sec。 371日期：1997年10月10日 102（e）1997年10月10日PCT PCT 1996年4月11日PCT公布。公开号WO96 / 32635 PCT 日期：1996年10月17日本发明涉及一种用于限定多孔基底上的层的区域（4）的方法，包括压缩一定体积的基底以产生压缩区域（8），所述压缩区域（8）定义或与衬底或层的边缘（7）限定了该区域的边界，并且基本上防止了材料通过其或穿过其表面的传送。本发明还涉及一种电化学感测装置，包括：多孔基材; 以及在所述基板的一侧上的电极（1）其中所述衬底的区域被压缩到对所述衬底内的电解质迁移的阻挡的程度，所述压缩区限定或者与所述衬底或所述电极的边缘组合以限定所述预定区域的电极上的区域。

29. 发明授权

US5942102A Electrochemical method 失效
标题翻译：电化学方法
公开(公告)号：US5942102A
公开(公告)日：1999-08-24
申请号：US852804
申请日：1997-05-07
申请人： Alastair McIndoe Hodges , Thomas William Beck , Oddvar Johansen , Ian Andrew Maxwell
发明人： Alastair McIndoe Hodges , Thomas William Beck , Oddvar Johansen , Ian Andrew Maxwell
IPC分类号： G01N27/28 , C12Q1/00 , C12Q1/54 , G01N20060101 , G01N27/30 , G01N27/327 , G01N27/403 , G01N27/416 , G01N27/42 , G01N27/49 , G01N33/487 , G01N27/26
CPC分类号： C12Q1/006 , C12Q1/004 , G01N27/3272
摘要： A method for determining the concentration of a reduced or oxidized form of a redox species in an electrochemical cell (FIG. 10) of the kind comprising a working electrode (2) and a counter electrode (16) spaced from the working electrode such that reaction products from the counter electrode arrive at the working electrode, the method comprising the steps (FIG. 5) of applying (21) an electric potential between the electrodes, such that the electro-oxidation of the redox species is diffusion controlled, determining the current as a function of time, estimating the magnitude of the steady state current (23), reversing the potential, again determining current as a function of time and estimating the reverse potential steady state (25).
摘要翻译：一种用于确定电化学电池（图10）中还原或氧化形式的还原或氧化形式的浓度的方法，其包括与工作电极间隔开的工作电极（2）和对电极（16），使得反应来自对电极的产品到达工作电极，该方法包括在电极之间施加（21）电位的步骤（图5），使得氧化还原物质的电氧化被扩散控制，确定电流作为时间的函数，估计稳态电流（23）的大小，反转电位，再次确定电流作为时间的函数，并估计反向电位稳态（25）。

30. 发明授权

US5010009A Material for cell attachment and growth 失效
标题翻译：用于细胞附着和生长的材料
公开(公告)号：US5010009A
公开(公告)日：1991-04-23
申请号：US477884
申请日：1990-05-09
申请人： John Steele , Oddvar Johansen , Graham Johnson , Johnathon Hodgkin
发明人： John Steele , Oddvar Johansen , Graham Johnson , Johnathon Hodgkin
IPC分类号： C12M3/00 , C08F8/36 , C08F259/00 , C08F259/08 , C12N5/00 , C12N5/02 , C12N5/06
CPC分类号： C12N5/0068 , C08F259/08 , C08F8/36 , C08J7/12 , C12N2533/30 , C12N2533/52 , Y10S623/915 , Y10S623/921
摘要： A surface for the attachment and growth of cells is prepared by first grafting polyacrylic acid chains to a fluorocarbon polymer substrate so that its weight increases by between 0.1 % and 20%. The surface is then treated with concentrated sulphuric acid under such conditions that will separately decarboxylate, aromatize and sulphonate an effective proportion of the grafted polyacrylic acid chains before being dried, soaked in a concentrated acid and brought to a substantially neutral pH for cell attachment and growth thereupon. The surface may also be used as a human tissue implant.
摘要翻译： PCT No.PCT / AU89 / 00356 Sec。 371日期1990年5月9日 102（e）日期1990年5月9日PCT提交1989年8月22日PCT公布。出版物WO90 / 02145 1990年3月8日。用于附着和生长细胞的表面是通过首先将聚丙烯酸链接枝到氟碳聚合物基底上制成的，使其重量增加0.1％至20％。然后将表面用浓硫酸处理，在这样的条件下，其将在干燥之前分别脱羧，芳构化和磺化有效比例的接枝聚丙烯酸链，浸在浓酸中并使其达到基本上中性的pH以使细胞附着和生长于是。该表面也可以用作人体组织植入物。

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