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1. 发明授权

US09183626B2 Systems and methods for accelerated arterial spin labeling using compressed sensing 有权
标题翻译：使用压缩感应加速动脉自旋标记的系统和方法
公开(公告)号：US09183626B2
公开(公告)日：2015-11-10
申请号：US13867325
申请日：2013-04-22
申请人： Li Zhao , Xiao Chen , Samuel W. Fielden , Frederick H. Epstein , John P. Mugler, III , Manal Nicolas-Jilwan , Max Wintermark , Craig H. Meyer
发明人： Li Zhao , Xiao Chen , Samuel W. Fielden , Frederick H. Epstein , John P. Mugler, III , Manal Nicolas-Jilwan , Max Wintermark , Craig H. Meyer
IPC分类号： G06K9/00 , G06T7/00 , G01R33/563 , A61B5/05 , G01R33/561
CPC分类号： G06T7/0012 , G01R33/4824 , G01R33/5611 , G01R33/56366 , G06K9/6232 , G06T11/005 , G06T2207/10088 , G06T2207/30104 , G06T2211/412 , G06T2211/424
摘要： Systems and methods for accelerated arterial spin labeling (ASL) using compressed sensing are disclosed. In one aspect, in accordance with one example embodiment, a method includes acquiring magnetic resonance data associated with an area of interest of a subject, wherein the area of interest corresponds to one or more physiological activities of the subject. The method also includes performing image reconstruction using temporally constrained compressed sensing reconstruction on at least a portion of the acquired magnetic resonance data, wherein acquiring the magnetic resonance data includes receiving data associated with ASL of the area of interest of the subject.
摘要翻译：公开了使用压缩感测加速动脉自旋标记（ASL）的系统和方法。在一个方面，根据一个示例性实施例，一种方法包括获取与受试者的感兴趣区域相关联的磁共振数据，其中感兴趣区域对应于受试者的一个或多个生理活动。该方法还包括在所获取的磁共振数据的至少一部分上使用时间上受限的压缩感测重构来执行图像重建，其中获取磁共振数据包括接收与被摄体的感兴趣区域的ASL相关联的数据。

2. 发明授权

US08700127B2 Motion-attenuated contrast-enhanced cardiac magnetic resonance imaging system and method 有权
标题翻译：运动衰减对比度增强心脏磁共振成像系统及方法
公开(公告)号：US08700127B2
公开(公告)日：2014-04-15
申请号：US12696433
申请日：2010-01-29
申请人： Michael Salerno , Frederick H. Epstein , Christopher M. Kramer
发明人： Michael Salerno , Frederick H. Epstein , Christopher M. Kramer
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/0402 , A61B5/7257 , A61B5/7285 , G01R33/5601 , G01R33/5602 , G01R33/5607 , G01R33/56366
摘要： A system and method for providing a dark-blood technique for contrast-enhanced cardiac magnetic resonance, improving visualization of subendocardial infarcts or perfusion abnormalities that may otherwise be difficult to distinguish from the bright blood pool. In one technique the dark-blood preparation is performed using a driven-equilibrium fourier transform (DEFT) preparation with motion sensitizing gradients which attenuate the signal in the ventricular cavities related to incoherent phase losses resulting from non-steady flow within the heart. This dark-blood preparation preserves the underlying contrast characteristics of the pulse sequence causing a myocardial infarction to be bright while rendering the blood pool dark. When applied to perfusion imaging, this dark-blood preparation will help eliminate artifacts resulting from the juxtaposition of a bright ventricular cavity and relatively dark myocardium.
摘要翻译：用于提供用于对比度增强的心脏磁共振的深色血液技术的系统和方法，改善心内膜梗死的可视化或可能难以与明亮血液池区分的灌注异常。在一种技术中，使用具有运动敏化梯度的驱动平衡傅里叶变换（DEFT）制备进行暗血制备，所述运动敏化梯度减弱心脏腔内与由心脏内非稳定流动导致的相干相损失相关的信号。这种深色血液制剂保留脉冲序列的潜在对比特征，导致心肌梗死变亮，同时使血液池变暗。当应用于灌注成像时，这种深色血液制剂将有助于消除由于明亮的心室和相对较暗的心肌并置导致的伪像。

3. 发明申请

US20130315461A1 SYSTEMS AND METHODS FOR ACCELERATED ARTERIAL SPIN LABELING USING COMPRESSED SENSING 有权
标题翻译：使用压缩感应加速型旋转标签的系统和方法
公开(公告)号：US20130315461A1
公开(公告)日：2013-11-28
申请号：US13867325
申请日：2013-04-22
申请人： Li Zhao , Xiao Chen , Samuel W. Fielden , Frederick H. Epstein , John P. Mugler, III , Manal Nicolas-Jilwan , Max Wintermark , Craig H. Meyer
发明人： Li Zhao , Xiao Chen , Samuel W. Fielden , Frederick H. Epstein , John P. Mugler, III , Manal Nicolas-Jilwan , Max Wintermark , Craig H. Meyer
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G01R33/4824 , G01R33/5611 , G01R33/56366 , G06K9/6232 , G06T11/005 , G06T2207/10088 , G06T2207/30104 , G06T2211/412 , G06T2211/424
摘要： Systems and methods for accelerated arterial spin labeling (ASL) using compressed sensing are disclosed. In one aspect, in accordance with one example embodiment, a method includes acquiring magnetic resonance data associated with an area of interest of a subject, wherein the area of interest corresponds to one or more physiological activities of the subject. The method also includes performing image reconstruction using temporally constrained compressed sensing reconstruction on at least a portion of the acquired magnetic resonance data, wherein acquiring the magnetic resonance data includes receiving data associated with ASL of the area of interest of the subject.
摘要翻译：公开了使用压缩感测加速动脉自旋标记（ASL）的系统和方法。在一个方面，根据一个示例性实施例，一种方法包括获取与受试者的感兴趣区域相关联的磁共振数据，其中感兴趣区域对应于受试者的一个或多个生理活动。该方法还包括在所获取的磁共振数据的至少一部分上使用时间上受限的压缩感测重构来执行图像重建，其中获取磁共振数据包括接收与被摄体的感兴趣区域的ASL相关联的数据。

4. 发明申请

US20140219531A1 SYSTEMS AND METHODS FOR ACCELERATED DYNAMIC MAGNETIC RESONANCE IMAGING 有权
标题翻译：用于加速动态磁共振成像的系统和方法
公开(公告)号：US20140219531A1
公开(公告)日：2014-08-07
申请号：US14174748
申请日：2014-02-06
申请人： Frederick H. Epstein , Xiao Chen , Yang Yang , Michael Salerno
发明人： Frederick H. Epstein , Xiao Chen , Yang Yang , Michael Salerno
IPC分类号： G01R33/565 , G06T7/00 , G06T7/20
CPC分类号： G06T7/20 , G01R33/5608 , G01R33/561 , G01R33/56308 , G01R33/56509 , G06K9/6218 , G06K2209/05 , G06T7/0012 , G06T2207/10096 , G06T2207/30048
摘要： Some aspects of the present disclosure relate to systems and methods for accelerated dynamic magnetic resonance imaging (MRI). In an example embodiment, a method includes acquiring undersampled MRI data corresponding to a set of images associated with an area of interest of a subject, and separating an image of the set of images into image regions. The method also includes performing motion tracking for each of the image regions, grouping the motion-tracked image regions into clusters, and applying a sparsity transform to the clusters, to form sparsity-exploited, transformed image regions. The method further includes forming a set of merged images from the plurality of sparsity-exploited, transformed image regions, and updating the set of merged images based on data fidelity, to form an updated set of estimated images.
摘要翻译：本公开的一些方面涉及用于加速动态磁共振成像（MRI）的系统和方法。在示例性实施例中，一种方法包括获取对应于与被摄体感兴趣的区域相关联的一组图像的欠采样的MRI数据，以及将该组图像分离成图像区域。该方法还包括对每个图像区域执行运动跟踪，将运动跟踪的图像区域分组成群集，以及将稀疏变换应用于群集，以形成稀疏性利用的变换图像区域。所述方法还包括从所述多个经稀疏利用的变换的图像区域形成一组合并的图像，以及基于数据保真度来更新所合并的图像集合，以形成更新的估计图像集。

5. 发明授权

US07813537B2 Motion-guided segmentation for cine DENSE images 有权
标题翻译：电影DENSE图像的运动引导分割
公开(公告)号：US07813537B2
公开(公告)日：2010-10-12
申请号：US11748204
申请日：2007-05-14
申请人： Frederick H Epstein , Ernesta M Meintjes , Bruce S Spottiswoode
发明人： Frederick H Epstein , Ernesta M Meintjes , Bruce S Spottiswoode
IPC分类号： G06K9/00
CPC分类号： G06T7/215 , G06T2207/30048
摘要： Myocardial tissue tracking techniques are used to project or guide a single manually-defined set of myocardial contours through time. Displacement encoding with stimulated echoes (DENSE), harmonic phase (HARP) and speckle tracking is used to encode tissue displacement into the phase of complex MRI images, providing a time series of these images, and facilitating the non-invasive study of myocardial kinematics. Epicardial and endocardial contours need to be defined at each frame on cine DENSE images for the quantification of regional displacement and strain as a function of time. The disclosed method presents a novel and effective two dimensional semi-automated segmentation technique that uses the encoded motion to project a manually defined region of interest through time. Contours can then easily be extracted for each cardiac phase.
摘要翻译：心肌组织跟踪技术用于通过时间来投射或引导单个手动定义的一组心肌轮廓。使用具有刺激回波（DENSE），谐波相位（HARP）和斑点跟踪的位移编码将组织位移编码为复杂MRI图像的相位，提供这些图像的时间序列，并促进对心肌运动学的非侵入性研究。需要在电影DENSE图像的每个帧上定义心外膜和心内膜轮廓，以定量区域位移和应变作为时间的函数。所公开的方法提出了一种新颖有效的二维半自动分割技术，其使用经编码的运动来通过时间投影手动定义的感兴趣区域。然后可以容易地为每个心脏相提取轮廓。

6. 发明授权

US6144200A Acquisition of segmented MRI cardiac data using an EPI pulse sequence 失效
标题翻译：采用EPI脉冲序列获取分割的MRI心脏数据
公开(公告)号：US6144200A
公开(公告)日：2000-11-07
申请号：US27519
申请日：1998-02-20
申请人： Frederick H. Epstein , Steven D. Wolff
发明人： Frederick H. Epstein , Steven D. Wolff
IPC分类号： A61B5/055 , G01R33/32 , G01R33/48 , G01R33/561 , G01V3/00
CPC分类号： G01R33/5615 , G01R33/5616
摘要： A method is disclosed to reconstruct multiphase MR images that accurately depict the entire cardiac cycle. A segmented, echo-planar imaging (EPI) pulse sequence is used to acquire data continuously during each cardiac cycle. Images are retrospectively reconstructed by selecting views from each heartbeat based on cardiac phase.
摘要翻译：公开了一种重建准确描绘整个心动周期的多相MR图像的方法。使用分段回波平面成像（EPI）脉冲序列在每个心动周期期间连续获取数据。通过基于心脏相位选择来自每个心跳的视图来回顾性地重建图像。

7. 发明授权

US6031374A Method for extracting deformations from velocity-encoded magnetic resonance images of the heart 失效
标题翻译：从心脏的速度编码磁共振图像中提取变形的方法
公开(公告)号：US6031374A
公开(公告)日：2000-02-29
申请号：US937725
申请日：1997-09-25
申请人： Frederick H. Epstein , Andrew E. Arai , Carl C. Gaither , Steven D. Wolff
发明人： Frederick H. Epstein , Andrew E. Arai , Carl C. Gaither , Steven D. Wolff
IPC分类号： G01R33/48 , A61B5/055 , G01R33/563 , G01R33/567 , G01V3/00
CPC分类号： A61B5/7207 , A61B5/055 , G01R33/56308 , G01R33/5673
摘要： An MRI scan is conducted in which velocity encoded NMR data is acquired for a slice through the heart. Velocity images and magnitude images are reconstructed at multiple cardiac phases and masks are formed using the magnitude images. The masks are applied to the velocity images to isolate the left ventricle, and rigid body motion is calculated and subtracted from the masked velocity images to indicate deformation of the left ventricle.
摘要翻译：进行MRI扫描，其中通过心脏获取速度编码的NMR数据。在多个心脏相位处重建速度图像和幅度图像，并且使用幅度图像形成掩模。将掩模应用于速度图像以分离左心室，并且计算刚体运动并从掩蔽的速度图像中减去以指示左心室的变形。

8. 发明授权

US05997883A Retrospective ordering of segmented MRI cardiac data using cardiac phase 失效
标题翻译：使用心脏相的分段MRI心脏数据的回顾性排序
公开(公告)号：US05997883A
公开(公告)日：1999-12-07
申请号：US886487
申请日：1997-07-01
申请人： Frederick H. Epstein , Andrew E. Arai , Jeffrey A. Feinstein , Thomas K. Foo , Steven D. Wolff
发明人： Frederick H. Epstein , Andrew E. Arai , Jeffrey A. Feinstein , Thomas K. Foo , Steven D. Wolff
IPC分类号： A61B5/0456 , G01R33/567 , G01V3/00
CPC分类号： A61B5/7292 , G01R33/5673 , A61B5/0456 , A61B5/7289
摘要： A method is disclosed to reconstruct multiphase MR images that accurately depict the entire cardiac cycle. A segmented, gradient-recalled-echo sequence is modified to acquire data continuously. Images are retrospectively reconstructed by selecting views from each heartbeat based on cardiac phase rather than the time elapsed from the QRS complex. Cardiac phase is calculated using a model that compensates for beat-to-beat heart rate changes.
摘要翻译：公开了一种重建准确描绘整个心动周期的多相MR图像的方法。修改分段渐变回波序列以连续采集数据。通过基于心脏相位而不是从QRS复合体经过的时间选择来自每个心跳的视图来回顾性地重建图像。使用补偿搏动心跳变化的模型计算心脏相。

9. 发明申请

US20100191099A1 MOTION-ATTENUATED CONTRAST-ENHANCED CARDIAC MAGNETIC RESONANCE IMAGING AND RELATED METHOD THEREOF 有权
标题翻译：运动减弱对比增强心脏磁共振成像及其相关方法
公开(公告)号：US20100191099A1
公开(公告)日：2010-07-29
申请号：US12696433
申请日：2010-01-29
申请人： Michael Salerno , Frederick H. Epstein , Christopher M. Kramer
发明人： Michael Salerno , Frederick H. Epstein , Christopher M. Kramer
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/0402 , A61B5/7257 , A61B5/7285 , G01R33/5601 , G01R33/5602 , G01R33/5607 , G01R33/56366
摘要： A system and method for providing a dark-blood technique for contrast-enhanced cardiac magnetic resonance, improving visualization of subendocardial infarcts or perfusion abnormalities that may otherwise be difficult to distinguish from the bright blood pool. In one technique the dark-blood preparation is performed using a driven-equilibrium fourier transform (DEFT) preparation with motion sensitizing gradients which attenuate the signal in the ventricular cavities related to incoherent phase losses resulting from non-steady flow within the heart. This dark-blood preparation preserves the underlying contrast characteristics of the pulse sequence causing a myocardial infarction to be bright while rendering the blood pool dark. When applied to perfusion imaging, this dark-blood preparation will help eliminate artifacts resulting from the juxtaposition of a bright ventricular cavity and relatively dark myocardium.
摘要翻译：用于提供用于对比度增强的心脏磁共振的深色血液技术的系统和方法，改善心内膜梗死的可视化或可能难以与明亮血液池区分的灌注异常。在一种技术中，使用具有运动敏化梯度的驱动平衡傅里叶变换（DEFT）制备进行暗血制备，所述运动敏化梯度减弱心脏腔内与由心脏内非稳定流动导致的相干相损失相关的信号。这种深色血液制剂保留脉冲序列的潜在对比特征，导致心肌梗死变亮，同时使血液池变暗。当应用于灌注成像时，这种深色血液制剂将有助于消除由于明亮的心室和相对较暗的心肌并置导致的伪像。

10. 发明授权

US5672969A Reduction of Nyquist ghost artifacts in oblique echo planar imaging 失效
标题翻译：在倾斜回波平面成像中减少奈奎斯特幻影
公开(公告)号：US5672969A
公开(公告)日：1997-09-30
申请号：US637879
申请日：1996-04-25
申请人： Xiaohong Zhou , Joseph K. Maier , Frederick H. Epstein
发明人： Xiaohong Zhou , Joseph K. Maier , Frederick H. Epstein
IPC分类号： G01R33/54 , A61B5/055 , G01R33/561 , G01R33/565 , G01R33/20
CPC分类号： G01R33/56572 , G01R33/5616
摘要： In a magnetic resonance imaging (MRI) system, a method is provided for reducing oblique Nyquist ghost artifact in an image produced by an oblique EPI scan. Prior to commencing the EPI scan, referencing pre-scans are conducted to generate pre-scan echo trains respectively corresponding to the physical gradient axes. Distortion compensating parameters are derived from the pre-scan echo trains for reducing Nyquist ghost by alternatively modifying the data acquisitions stage of the oblique EPI scan, or the post-data acquisition image processing stage thereof. In one mode of operation, the pre-scan echo trains are generated while a subject is in the MRI system. In another mode of operation, pre-scan echo trains are generated while no subject is present in the MR system, so that the distortion compensating parameters represent characteristics of the MR system only, and thus may be used for EPI scans of different protocols. For such mode of operation the distortion compensating parameters may be computed as a function of readout gradient pulse spacing.
摘要翻译：在磁共振成像（MRI）系统中，提供了一种用于减少由倾斜EPI扫描产生的图像中的倾斜奈奎斯特幻影伪像的方法。在开始EPI扫描之前，进行参考预扫描以产生分别对应于物理梯度轴的预扫描回波列。通过交替地修改倾斜EPI扫描的数据采集阶段或其后数据采集图像处理阶段，从预扫描回波列导出失真补偿参数，以减少奈奎斯特重影。在一种操作模式中，当受检者在MRI系统中时，产生预扫描回波列。在另一种操作模式中，在MR系统中不存在主体的情况下产生预扫描回波串，使得失真补偿参数仅表示MR系统的特性，因此可用于不同协议的EPI扫描。对于这种操作模式，失真补偿参数可以作为读出梯度脉冲间隔的函数来计算。

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