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1. 发明授权

US09183626B2 Systems and methods for accelerated arterial spin labeling using compressed sensing 有权
标题翻译：使用压缩感应加速动脉自旋标记的系统和方法
公开(公告)号：US09183626B2
公开(公告)日：2015-11-10
申请号：US13867325
申请日：2013-04-22
申请人： Li Zhao , Xiao Chen , Samuel W. Fielden , Frederick H. Epstein , John P. Mugler, III , Manal Nicolas-Jilwan , Max Wintermark , Craig H. Meyer
发明人： Li Zhao , Xiao Chen , Samuel W. Fielden , Frederick H. Epstein , John P. Mugler, III , Manal Nicolas-Jilwan , Max Wintermark , Craig H. Meyer
IPC分类号： G06K9/00 , G06T7/00 , G01R33/563 , A61B5/05 , G01R33/561
CPC分类号： G06T7/0012 , G01R33/4824 , G01R33/5611 , G01R33/56366 , G06K9/6232 , G06T11/005 , G06T2207/10088 , G06T2207/30104 , G06T2211/412 , G06T2211/424
摘要： Systems and methods for accelerated arterial spin labeling (ASL) using compressed sensing are disclosed. In one aspect, in accordance with one example embodiment, a method includes acquiring magnetic resonance data associated with an area of interest of a subject, wherein the area of interest corresponds to one or more physiological activities of the subject. The method also includes performing image reconstruction using temporally constrained compressed sensing reconstruction on at least a portion of the acquired magnetic resonance data, wherein acquiring the magnetic resonance data includes receiving data associated with ASL of the area of interest of the subject.
摘要翻译：公开了使用压缩感测加速动脉自旋标记（ASL）的系统和方法。在一个方面，根据一个示例性实施例，一种方法包括获取与受试者的感兴趣区域相关联的磁共振数据，其中感兴趣区域对应于受试者的一个或多个生理活动。该方法还包括在所获取的磁共振数据的至少一部分上使用时间上受限的压缩感测重构来执行图像重建，其中获取磁共振数据包括接收与被摄体的感兴趣区域的ASL相关联的数据。

2. 发明授权

US07805176B2 Exchange-weighted xenon-129 nuclear magnetic resonance system and related method 有权
标题翻译：交换加权氙129核磁共振系统及相关方法
公开(公告)号：US07805176B2
公开(公告)日：2010-09-28
申请号：US10592200
申请日：2005-03-09
申请人： Kai Ruppert , John P. Mugler, III , James R. Brookeman
发明人： Kai Ruppert , John P. Mugler, III , James R. Brookeman
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/0515 , A61B5/726
摘要： Method and system that provides, among other things, the capability for using hyperpolarized xenon-129 as a probe to non-invasively and non-destructively characterize important properties of certain structures or materials into which hyperpolarized xenon-129 can be introduced and wherein the xenon exists in two or more chemically-shifted states that are in exchange High-resolution MR images can be generated in a fraction of a second wherein the associated signal intensities reflect material properties that characterize the gas exchange among the different states. For example, in the human or animal lung, the system and related method can exploit the differences in gas-exchange characteristics between healthy and diseased lung tissue to generate high-resolution, high signal-to-noise cross-sectional MR images that permit non-invasive regional detection of variations in lung tissue structure with a combination of spatial and temporal resolution that is unmatched by any current imaging modality.
摘要翻译：除其他外，提供使用超极化氙129作为探针非侵入性地且非破坏性地表征可以引入超极化氙129的某些结构或材料的重要性质的能力的方法和系统，其中氙存在于交换的两个或更多化学位移状态。高分辨率MR图像可以在几分之一秒内生成，其中相关联的信号强度反映表征不同状态之间的气体交换的材料性质。例如，在人或动物肺中，系统和相关方法可以利用健康和患病肺组织之间的气体交换特性的差异，以产生高分辨率，高信噪比横截面MR图像， - 通过任何当前成像模式无法比拟的空间和时间分辨率的组合，对肺组织结构变化的无创区域检测。

3. 发明授权

US07174200B2 Optimized high-speed magnetic resonance imaging method and system using hyperpolarized noble gases 有权
标题翻译：优化的高速磁共振成像方法和使用超极化惰性气体的系统
公开(公告)号：US07174200B2
公开(公告)日：2007-02-06
申请号：US10474571
申请日：2002-04-12
申请人： Michael Salerno , John P. Mugler, III , James R. Brookeman
发明人： Michael Salerno , John P. Mugler, III , James R. Brookeman
IPC分类号： B61B5/05
CPC分类号： G01R33/5601 , G01R33/56341
摘要： A system and method for using hyperpolarized noble gases together with an appropriately designed and optimized magnetic resonance imaging pulse sequence to rapidly acquire static or dynamic magnetic resonance images. The strong magnetic resonance signal from hyperpolarized gases, combined with the present magnetic resonance imaging technique, presents the opportunity for the imaging of gases with both high spatial and high temporal resolution. One potential application for such a method is the direct, dynamic visualization of gas flow, which would be extremely useful for characterizing a variety of fluid systems. In the medical field, one such system of substantial importance is the lung. The system and method provides for visualizing regional ventilatory patterns throughout the respiratory cycle with high temporal and high spatial resolution. The low sensitivity to susceptibility artifacts permits good image quality to be obtained in various orientations. Depending on the application, temporal resolution can be traded for anatomical coverage. Such application of dynamic imaging of the lung using hyperpolarized gases will provide unique information on the physiology and pathophysiology of the lung, and has the potential for many clinically-relevant applications.
摘要翻译：一种使用超极化惰性气体与适当设计和优化的磁共振成像脉冲序列的系统和方法，以快速获取静态或动态磁共振图像。来自超极化气体的强磁共振信号与目前的磁共振成像技术相结合，为高空间和高时间分辨率的气体成像提供了机会。这种方法的一个潜在应用是气流的直接，动态可视化，这对于表征各种流体系统是非常有用的。在医疗领域，一个这样重要的体系是肺。该系统和方法提供了在整个呼吸周期中具有高时空和高空间分辨率的可视化区域通气模式。对敏感性伪影的低灵敏度允许在各种取向中获得良好的图像质量。根据应用，时间分辨率可以交换用于解剖学覆盖。使用超极化气体对肺的动态成像的这种应用将提供关于肺的生理学和病理生理学的独特信息，并且具有许多临床相关应用的潜力。

4. 发明申请

US20130342202A1 MAGNETIC RESONANCE SYSTEM AND OPERATING METHOD FOR FLOW ARTIFACT REDUCTION IN SLAB SELECTIVE SPACE IMAGING 有权
标题翻译：液体选择性空间成像中的流动减少的磁共振系统和操作方法
公开(公告)号：US20130342202A1
公开(公告)日：2013-12-26
申请号：US13533371
申请日：2012-06-26
申请人： John P. MUGLER, III , Dominik Paul
发明人： John P. MUGLER, III , Dominik Paul
IPC分类号： G01R33/54
CPC分类号： G01R33/5617 , G01R33/56509
摘要： In a SPACE (Sampling Perfection with Application optimized Contrasts using different flip angle Evolutions) or equivalent magnetic resonance imaging pulse sequence, the readout dephasing gradient is generated (activated) so as to occur immediately in front of the second refocusing pulse, thereby eliminating the long time duration that occurs in conventional SPACE or equivalent sequences between excitation and readout. This long time duration has been identified as a source for flow-related artifacts that occur in images reconstructed from data acquired according to conventional SPACE or equivalent sequences. By eliminating this long time duration, such flow-related artifacts are substantially reduced, if not eliminated.
摘要翻译：在空间（使用不同的翻转角度进行应用优化对比度的采样完美）或等效磁共振成像脉冲序列中，产生（激活）读出相位梯度，以便立即在第二重聚焦脉冲之前发生，从而消除长时间在常规SPACE或激发和读出之间的等效序列中发生的持续时间。这个长时间的持续时间已被确定为在根据常规SPACE或等效序列获取的数据重建的图像中发生的流相关伪影的来源。通过消除这个长时间的持续时间，如果不消除这种流量相关的伪影，则显着减少。

5. 发明授权

US5245282A Three-dimensional magnetic resonance imaging 失效
标题翻译：三维磁共振成像
公开(公告)号：US5245282A
公开(公告)日：1993-09-14
申请号：US723230
申请日：1991-06-28
申请人： John P. Mugler, III , James R. Brookeman
发明人： John P. Mugler, III , James R. Brookeman
IPC分类号： G01R33/54
CPC分类号： G01R33/4822 , G01R33/4835
摘要： A new three-dimensional (3D) MR imaging pulse sequence can produce over 100 high-resolution, high-contrast images in as little as 6 minutes of imaging time. Without additional imaging time, this same image data can be post-processed to yield high-resolution, high-contrast images in any arbitrary orientation. Thus, this new pulse sequence technique provides detailed yet comprehensive coverage. The method of this invention relates to a preparation-acquisition-recovery sequence cycle. The first step is magnetization preparation (MP) period. The MP period can emply a series of RF pulses, gradient field pulses, and/or time delays to encode the desired contrast properties in the form of longitudinal magnetization. A data acquisition period includes at least two repetitions of a gradient echo sequence to acquire data for a fraction of k-space. A magnetization recovery period is provided which allows T1 and T2 relaxation before the start of the next sequence cycle. The MP, data acquisition and magnetization recovery steps are repeated until a predetermined k-space volume is sampled.
摘要翻译：新的三维（3D）MR成像脉冲序列可以在短短6分钟的成像时间内产生超过100个高分辨率，高对比度图像。没有额外的成像时间，可以对相同的图像数据进行后处理，以产生任何方向上的高分辨率，高对比度图像。因此，这种新的脉冲序列技术提供了详细而全面的覆盖。本发明的方法涉及制备 - 获取 - 恢复序列循环。第一步是磁化准备（MP）期间。 MP周期可以产生一系列RF脉冲，梯度场脉冲和/或时间延迟，以纵向磁化的形式对期望的对比度特性进行编码。数据采集周期包括至少两次重复的梯度回波序列，以获取一部分k空间的数据。提供磁化恢复周期，其允许在下一个序列周期开始之前的T1和T2松弛。重复MP，数据采集和磁化恢复步骤，直到对预定的k空间体积进行采样。

6. 发明授权

US07164268B2 Method and apparatus for spin-echo-train MR imaging using prescribed signal evolutions 有权
标题翻译：使用规定的信号进化的自旋回波串MR成像的方法和装置
公开(公告)号：US07164268B2
公开(公告)日：2007-01-16
申请号：US10451124
申请日：2001-12-21
申请人： John P. Mugler, III , James R. Brookeman
发明人： John P. Mugler, III , James R. Brookeman
IPC分类号： G01V3/00 , A61B5/055
CPC分类号： G01R33/5615 , G01R33/50 , G01R33/5617 , G01R33/586
摘要： A magnetic resonance imaging “MRI” method and apparatus for lengthening the usable echo-train duration and reducing the power deposition for imaging is provided. The method explicitly considers the t1 and t2 relaxation times for the tissues of interest, and permits the desired image contrast to be incorporated into the tissue signal evolutions corresponding to the long echo train. The method provides a means to shorten image acquisition times and/or increase spatial resolution for widely-used spin-echo train magnetic resonance techniques, and enables high-field imaging within the safety guidelines established by the Food and Drug Administration for power deposition in human MRI.
摘要翻译：提供了一种用于延长可用回波段持续时间并减少成像功率沉积的磁共振成像“MRI”方法和装置。该方法明确地考虑了感兴趣的组织的t1和t2弛豫时间，并且允许将期望的图像对比度并入到对应于长回波序列的组织信号演化中。该方法提供了缩短图像采集时间和/或增加广泛使用的自旋回波列车磁共振技术的空间分辨率的手段，并且可以在食品和药物管理局为人类进行功率沉积建立的安全准则中实现高场成像 MRI。

7. 发明授权

US07034533B2 Method and system for rapid magnetic resonance imaging of gases with reduced diffusion-induced signal loss 失效
标题翻译：快速磁共振成像方法和系统，减少扩散诱导的信号损失
公开(公告)号：US07034533B2
公开(公告)日：2006-04-25
申请号：US10514272
申请日：2003-05-14
申请人： John P. Mugler, III , James R. Brookeman
发明人： John P. Mugler, III , James R. Brookeman
IPC分类号： G01V3/00
CPC分类号： G01R33/5615 , G01R33/281 , G01R33/5613 , G01R33/565 , G01R33/56509
摘要： A methodology, system and computer program product for designing and optimizing a rapid magnetic resonance imaging pulse sequence for creating images of a gas or gas-filled structure with substantially reduced diffusion-induced signal attenuation during the course of data acquisition compared to that for currently available magnetic resonance imaging techniques is disclosed. The methodology and system allows desirable combinations of image signal-to-noise ration, spatial resolution and temporal resolution to be achieved that were heretofore not possible. For example, magnetic resonance imaging of hyperpolarized noble gases, which recently has shown significant promise for several medical imaging applications, particularly imaging of the human lung, can be improved. Pulse sequences designed according to the subject methods permit signal levels to be achieved that are up to ten times higher than those possible with the gradient-echo methods now commonly used for hyperpolarized-gas imaging. This signal increase can be traded for substantially lower does, and hence much lower cost, of the hyperpolarized-gas agent. The methodology and system will also be useful for non-biological applications of hyperpolarized gases for example material science studies, as well as for magnetic resonance imaging of any other gas for biological or non-biological applications. Pulse sequences designed according to the subject methods can also serve as the foundation for a variety of specialized gas-imaging pulse sequences, such as those for apparent-diffusion-coefficient, dynamic or oxygen-concentration imaging.
摘要翻译：一种用于设计和优化快速磁共振成像脉冲序列的方法学，系统和计算机程序产品，用于在数据采集过程中与当前可用的数据采集相比，在气体或气体填充结构中形成显着降低的扩散诱发信号衰减的图像公开了磁共振成像技术。该方法和系统允许实现迄今为止不可能实现的图像信噪比，空间分辨率和时间分辨率的期望组合。例如，最近已经显示出许多医学成像应用，特别是人肺成像的超极化惰性气体的磁共振成像可以得到改善。根据本方法设计的脉冲序列允许实现比现在通常用于超极化气体成像的梯度回波方法可能达到的高达十倍的信号水平。这种信号增加可以以极低的价格进行交易，因此成本更低，这是超极化气体的。该方法和系统也可用于超极化气体的非生物应用，例如材料科学研究，以及任何其他气体用于生物或非生物应用的磁共振成像。根据本方法设计的脉冲序列还可以作为各种特定气体成像脉冲序列的基础，例如用于表观扩散系数，动态或氧浓度成像的脉冲序列。

8. 发明授权

US09360545B2 Magnetic resonance system and operating method for flow artifact reduction in slab selective space imaging 有权
标题翻译：平板选择性空间成像中的磁共振系统和流动伪影减少的操作方法
公开(公告)号：US09360545B2
公开(公告)日：2016-06-07
申请号：US13533371
申请日：2012-06-26
申请人： John P. Mugler, III , Dominik Paul
发明人： John P. Mugler, III , Dominik Paul
IPC分类号： G01R33/561 , G01R33/565
CPC分类号： G01R33/5617 , G01R33/56509
摘要： In a SPACE (Sampling Perfection with Application optimized Contrasts using different flip angle Evolutions) or equivalent magnetic resonance imaging pulse sequence, the dephasing gradient is generated (activated) so as to occur immediately in front of the second refocusing pulse, thereby eliminating the long time duration that occurs in conventional SPACE or equivalent sequences between excitation and readout. This long time duration has been identified as a source for flow-related artifacts that occur in images reconstructed from data acquired according to conventional SPACE or equivalent sequences. By eliminating this long time duration, such flow-related artifacts are substantially reduced, if not eliminated.
摘要翻译：在空间（使用不同的翻转角度的应用优化对比度的采样完美）或等效磁共振成像脉冲序列中，产生（激活）去相位梯度，以便立即在第二重聚焦脉冲之前发生，从而消除长时间在常规SPACE或激发和读出之间的等效序列中发生的持续时间。这个长时间的持续时间已被确定为在根据常规SPACE或等效序列获取的数据重建的图像中发生的流相关伪影的来源。通过消除这个长时间的持续时间，如果不消除这种流量相关的伪影，则显着减少。

9. 再颁专利

USRE44644E1 Method and apparatus for spin-echo-train MR imaging using prescribed signal evolutions 有权
标题翻译：使用规定的信号进化的自旋回波串MR成像的方法和装置
公开(公告)号：USRE44644E1
公开(公告)日：2013-12-17
申请号：US12354471
申请日：2009-01-15
申请人： John P. Mugler, III , James R. Brookeman
发明人： John P. Mugler, III , James R. Brookeman
IPC分类号： G01R33/50 , A61B5/055 , G01V3/00
摘要： A magnetic resonance imaging “MRI” method and apparatus for lengthening the usable echo-train duration and reducing the power deposition for imaging is provided. The method explicitly considers the t1 and t2 relaxation times for the tissues of interest, and permits the desired image contrast to be incorporated into the tissue signal evolutions corresponding to the long echo train. The method provides a means to shorten image acquisition times and/or increase spatial resolution for widely-used spin-echo train magnetic resonance techniques, and enables high-field imaging within the safety guidelines established by the Food and Drug Administration for power deposition in human MRI.
摘要翻译：提供了一种用于延长可用回波段持续时间并减少成像功率沉积的磁共振成像“MRI”方法和装置。该方法明确地考虑了感兴趣的组织的t1和t2弛豫时间，并且允许将期望的图像对比度并入到对应于长回波序列的组织信号演化中。该方法提供了缩短图像采集时间和/或增加广泛使用的自旋回波列车磁共振技术的空间分辨率的手段，并且可以在食品和药物管理局为人类进行功率沉积建立的安全准则中实现高场成像 MRI。

10. 发明申请

US20130315461A1 SYSTEMS AND METHODS FOR ACCELERATED ARTERIAL SPIN LABELING USING COMPRESSED SENSING 有权
标题翻译：使用压缩感应加速型旋转标签的系统和方法
公开(公告)号：US20130315461A1
公开(公告)日：2013-11-28
申请号：US13867325
申请日：2013-04-22
申请人： Li Zhao , Xiao Chen , Samuel W. Fielden , Frederick H. Epstein , John P. Mugler, III , Manal Nicolas-Jilwan , Max Wintermark , Craig H. Meyer
发明人： Li Zhao , Xiao Chen , Samuel W. Fielden , Frederick H. Epstein , John P. Mugler, III , Manal Nicolas-Jilwan , Max Wintermark , Craig H. Meyer
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G01R33/4824 , G01R33/5611 , G01R33/56366 , G06K9/6232 , G06T11/005 , G06T2207/10088 , G06T2207/30104 , G06T2211/412 , G06T2211/424
摘要： Systems and methods for accelerated arterial spin labeling (ASL) using compressed sensing are disclosed. In one aspect, in accordance with one example embodiment, a method includes acquiring magnetic resonance data associated with an area of interest of a subject, wherein the area of interest corresponds to one or more physiological activities of the subject. The method also includes performing image reconstruction using temporally constrained compressed sensing reconstruction on at least a portion of the acquired magnetic resonance data, wherein acquiring the magnetic resonance data includes receiving data associated with ASL of the area of interest of the subject.
摘要翻译：公开了使用压缩感测加速动脉自旋标记（ASL）的系统和方法。在一个方面，根据一个示例性实施例，一种方法包括获取与受试者的感兴趣区域相关联的磁共振数据，其中感兴趣区域对应于受试者的一个或多个生理活动。该方法还包括在所获取的磁共振数据的至少一部分上使用时间上受限的压缩感测重构来执行图像重建，其中获取磁共振数据包括接收与被摄体的感兴趣区域的ASL相关联的数据。

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