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1. 发明申请

US20100267072A1 Formation/Elongation of Axon by Inhibiting the Expression or Function of Singar and Application to Nerve Regeneration 有权
标题翻译：通过抑制单倍体的表达或功能形成/延伸轴突并应用于神经再生
公开(公告)号：US20100267072A1
公开(公告)日：2010-10-21
申请号：US12084242
申请日：2006-10-26
申请人： Naoyuki Inagaki , Tatsuya Mori , Osamu Ohara , Takahiro Nagase
发明人： Naoyuki Inagaki , Tatsuya Mori , Osamu Ohara , Takahiro Nagase
IPC分类号： C12Q1/02 , C07H21/02 , C12N15/00 , C12N5/02
CPC分类号： G01N33/5058 , C12N15/113 , C12N2310/14 , G01N2500/00
摘要： Singar is identified as a novel molecule, whose expression is varied before and after the polarization of a nerve cell, and occurs in the tip of an elongating axon, called a growth cone, which is important for the formation or elongation of an axon. Singar is expressed specifically in the brain and the amount of Singar expression is largely increased in an individual during periods where the formation of axons is increased. It is observed that Singar is highly enriched in the growth cone at the tip of an axon. When the expression of Singar is inhibited in nerve cells in culture, the formation of multiple axons is induced. Thus, the inhibition of Singar can induce axon formation. Therefore, by inhibiting the expression or activity of Singar, it becomes possible to induce or promote the formation or elongation of an axon in a nerve cell.
摘要翻译： Singar被鉴定为一种新颖的分子，其表达在神经细胞的极化之前和之后是变化的，并且发生在延伸轴突的尖端，称为生长锥，其对于轴突的形成或延伸是重要的。 Singar在脑中特异性表达，并且在轴突形成增加期间个体中Singar表达量大大增加。观察到，Singar在轴突末端的生长锥中高度富集。当培养中神经细胞中Singar的表达被抑制时，诱导多个轴突的形成。因此，Singar的抑制可以诱导轴突形成。因此，通过抑制Singar的表达或活性，可以诱导或促进神经细胞中轴突的形成或延伸。

2. 发明授权

US07790866B2 Cancer-associated gene 有权
标题翻译：癌症相关基因
公开(公告)号：US07790866B2
公开(公告)日：2010-09-07
申请号：US10535733
申请日：2003-11-20
申请人： Osamu Ohara , Takahiro Nagase , Reiko Kikuno , Shin-ichi Funahashi
发明人： Osamu Ohara , Takahiro Nagase , Reiko Kikuno , Shin-ichi Funahashi
IPC分类号： C07H21/02 , C07H21/04 , C07K14/00 , C07K17/00 , C12P21/06 , C12P19/34 , C12N15/64
CPC分类号： C12N9/1048 , C07K14/4748
摘要： The present invention provides: a novel DNA, a carcinoma-associated gene comprising the DNA, a recombinant protein encoded by the DNA, an antibody binding to the protein, an anti-carcinoma agent comprising the antibody, a low-molecular-weight compound binding to the protein, and a screening system. An example of such a novel DNA is a DNA comprising a nucleotide sequence encoding the following polypeptide (a) or (b): (a) a polypeptide, consisting of an amino acid sequence identical to or substantially identical to the amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide, consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 by deletion, substitution, or addition of one or a plurality of amino acids and having biological activity substantially equivalent to the functions of the polypeptide (a).
摘要翻译：本发明提供：新型DNA，包含DNA的癌相关基因，由DNA编码的重组蛋白，与蛋白结合的抗体，包含抗体的抗癌剂，结合蛋白质和筛选系统。这样的新型DNA的实例是包含编码以下多肽（a）或（b）的核苷酸序列的DNA：（a）多肽，由与氨基酸序列相同或基本相同的氨基酸序列组成， SEQ ID NO：2; 或（b）通过缺失，取代或添加一个或多个氨基酸并具有与功能基本相同的生物学活性的由SEQ ID NO：2所示的氨基酸序列衍生的氨基酸序列组成的多肽的多肽（a）。

3. 发明申请

US20090203073A1 Gene Encoding G-Protein Coupled Receptor and Gene Product Thereof 有权
标题翻译：基因编码G蛋白偶联受体及其基因产物
公开(公告)号：US20090203073A1
公开(公告)日：2009-08-13
申请号：US12409847
申请日：2009-03-24
申请人： Osamu Ohara , Takahiro Nagase , Michio Ohishi , Daisuke Okajima , Hiroshi Yokota
发明人： Osamu Ohara , Takahiro Nagase , Michio Ohishi , Daisuke Okajima , Hiroshi Yokota
IPC分类号： C12P21/00 , C12N15/11 , C12N15/00 , C12N5/06
CPC分类号： G01N33/74 , G01N2333/726
摘要： The present invention, the objects of which are to find out a gene encoding a protein having functions equivalent to those of G-protein-coupled receptor (GPCR) and the protein, and to provide a method for identifying a compound that regulates functions and/or expression of the protein, and to provide a useful mean for preventing and/or treating diseases related to the gene and the protein, provides a DNA comprising base sequence described in SEQ ID NO: 1 or complementary strand thereof, complementary strand of the DNA, a protein encoded by the DNA, a vector containing the DNA, a transformant containing the vector, an antibody against the protein, a method for identifying a compound that regulates functions and/or expression of the protein using aforementioned members, an agent for improving and a method for improving depression state, a pharmaceutical composition, and a reagent kit.
摘要翻译：本发明的目的是找出编码具有与G蛋白偶联受体（GPCR）和蛋白质相同功能的蛋白质的基因，并提供一种鉴定调节功能的化合物和/ 或蛋白质的表达，并且为预防和/或治疗与该基因和蛋白质相关的疾病提供有用的平均值，提供包含SEQ ID NO：1或其互补链中所述的碱基序列的DNA，DNA的互补链，由DNA编码的蛋白质，含有该载体的载体，含有该载体的转化子，针对该蛋白质的抗体，使用上述成员鉴定调节蛋白质的功能和/或表达的化合物的方法，改善剂以及改善抑郁状态的方法，药物组合物和试剂盒。

4. 发明授权

US07527937B2 Assay employing a g-protein coupled receptor that is activated by CCK-8S 有权
标题翻译：测定采用由CCK-8S激活的g-蛋白偶联受体
公开(公告)号：US07527937B2
公开(公告)日：2009-05-05
申请号：US11436904
申请日：2006-05-18
申请人： Osamu Ohara , Takahiro Nagase , Michio Ohishi , Daisuke Okajima , Hiroshi Yokota
发明人： Osamu Ohara , Takahiro Nagase , Michio Ohishi , Daisuke Okajima , Hiroshi Yokota
IPC分类号： G01N33/566 , C07K14/705
CPC分类号： G01N33/74 , G01N2333/726
摘要： Methods of providing a protein having a function as a G-protein coupled receptor and methods of identifying a compound that inhibits or promotes a function of the protein and/or expression of a DNA encoding the protein are provided. Methods for identifying an anti-depressant drug or a compound That has an anti-depressant action and methods for diagnosing depression are also provided.
摘要翻译：提供了具有作为G蛋白偶联受体的功能的蛋白质的方法和鉴定抑制或促进蛋白质的功能和/或表达编码该蛋白质的DNA的化合物的方法。还提供了用于鉴定抗抑郁药物或具有抗抑郁作用的化合物和用于诊断抑郁症的方法。

5. 发明申请

US20080262202A1 NOVEL CANCER-ASSOCIATED GENES 失效
标题翻译：新癌症相关基因
公开(公告)号：US20080262202A1
公开(公告)日：2008-10-23
申请号：US12099513
申请日：2008-04-08
申请人： Osamu Ohara , Takahiro Nagase , Daisuke Nakajima , Shin-ichi Funahashi
发明人： Osamu Ohara , Takahiro Nagase , Daisuke Nakajima , Shin-ichi Funahashi
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , A61K2039/505
摘要： The present invention is related to a DNA comprising a nucleotide sequence encoding a polypeptide represented by SEQ ID NO:1 or SEQ ID NO:2. The DNA according to the present invention is highly expressed in prostatic adenocarcinoma and ovarian carcinoma, and is a cancer-associated gene, so that it is possible to inhibit cancer by blocking the binding of the present protein to its ligand. Accordingly, the present antibody is used not only in the detection of the present protein, but also as an agent for the treatment or prevention of cancers such as prostatic adenocarcinoma and ovarian carcinoma.
摘要翻译：本发明涉及包含编码由SEQ ID NO：1或SEQ ID NO：2表示的多肽的核苷酸序列的DNA。根据本发明的DNA在前列腺腺癌和卵巢癌中高度表达，并且是癌相关基因，使得可以通过阻断本发明蛋白质与其配体的结合来抑制癌症。因此，本发明的抗体不仅用于检测本发明的蛋白质，而且用作治疗或预防前列腺腺癌和卵巢癌等癌症的药剂。

6. 发明申请

US20080206775A1 Method of Amplifying Nucleic Acids, Reagent Kit for Amplifying Nucleic Acids, Method of Detecting Single Nucleotide Polymorphism, and Reagent Kit for Detecting Single Nucleotide Polymorphism 失效
标题翻译：扩增核酸的方法，扩增核酸的试剂盒，检测单核苷酸多态性的方法和用于检测单核苷酸多态性的试剂盒
公开(公告)号：US20080206775A1
公开(公告)日：2008-08-28
申请号：US12062215
申请日：2008-04-03
申请人： Yasushi SHIGEMORI , Takehiko SHIBATA , Tsutomu MIKAWA , Michio OISHI , Osamu OHARA
发明人： Yasushi SHIGEMORI , Takehiko SHIBATA , Tsutomu MIKAWA , Michio OISHI , Osamu OHARA
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6848 , C12Q1/6858 , C12Q2521/507
摘要： An object of the present invention is to provide a nucleic acid amplification method for amplifying a desired nucleic acid while suppressing amplification of byproducts in a PCR reaction, a reagent kit used for nucleic acid amplification, a method of detecting single nucleotide polymorphism to detect single nucleotide polymorphism by utilizing that amplification of byproducts is suppressed in a PCR reaction, and a reagent kit used for detecting single nucleotide polymorphism. The method of amplifying nucleic acids by PCR is characterized by admixing in a reaction solution, a homologous recombinant protein which contains at least one of a RecA protein derived from Thermus thermophilus, and a modified RecA protein obtained by modification of the RecA protein and having a function similar to that of the RecA protein, and carrying out PCR.
摘要翻译：本发明的目的是提供用于扩增所需核酸同时抑制PCR反应中副产物扩增的核酸扩增方法，用于核酸扩增的试剂盒，检测单核苷酸多态性以检测单核苷酸的方法在PCR反应中抑制副产物扩增的多态性，以及用于检测单核苷酸多态性的试剂盒。通过PCR扩增核酸的方法的特征在于在反应溶液中混合含有至少一种源自Thermus thermophilus的RecA蛋白的同源重组蛋白，以及通过修饰RecA蛋白获得的经修饰的RecA蛋白，并且具有功能类似于RecA蛋白，并进行PCR。

7. 发明申请

US20060160082A1 Novel genes and proteins encoded thereby 审中-公开
标题翻译：由此编码的新型基因和蛋白质
公开(公告)号：US20060160082A1
公开(公告)日：2006-07-20
申请号：US10530880
申请日：2003-10-16
申请人： Osamu Ohara , Takahiro Nagase , Reiko Kikuno
发明人： Osamu Ohara , Takahiro Nagase , Reiko Kikuno
IPC分类号： C12Q1/68 , C07H21/02 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： C07K14/47
摘要： A novel DNA comprising a protein-encoding region is directly cloned from cDNA library originating from human adult whole brain and human fetal whole brain, the base sequence thereof is determined, and the functions thereof are identified. A DNA comprising a base sequence encoding the following polypeptide (a) or (b): (a) a polypeptide consisting of an amino acid sequence which is identical or substantially identical with the amino acid sequence represented by SEQ ID No.1, (b) a polypeptide consisting of an amino acid sequence represented by SEQ ID No.1 in which part of amino acids are deleted, substituted or added, and having substantially the same biological activity as the function of the polypeptide (a), recombinant polypeptide encoded by the above DNAs, and protein comprising the polypeptide.
摘要翻译：从源自人成人全脑和人胎儿全脑的cDNA文库直接克隆包含蛋白质编码区的新型DNA，确定其碱基序列，鉴定其功能。包含编码以下多肽（a）或（b）的碱基序列的DNA：（a）由与SEQ ID No.1所代表的氨基酸序列相同或基本相同的氨基酸序列组成的多肽）由SEQ ID No.1所示的氨基酸序列组成的多肽，其中部分氨基酸缺失，取代或添加，并且具有与多肽（a）的功能基本上相同的生物学活性，由上述DNA和包含该多肽的蛋白质。

8. 发明授权

US06849410B2 Method for detecting DNA polymorphism applying triple strand DNA formation technique 失效
标题翻译：检测应用三链DNA形成技术的DNA多态性的方法
公开(公告)号：US06849410B2
公开(公告)日：2005-02-01
申请号：US09989526
申请日：2001-11-21
申请人： Yasushi Shigemori , Michio Oishi , Osamu Ohara
发明人： Yasushi Shigemori , Michio Oishi , Osamu Ohara
IPC分类号： C12N15/09 , C07H21/02 , C07H21/04 , C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6839 , C12Q2537/119 , C12Q2527/107 , C12Q2521/507
摘要： An objective of this invention is to provide a method for detecting DNA polymorphism that has high sensitivity and efficiency and does not need long DNA searching region.A homologous recombination protein RecA makes partial triple strand DNA from target double DNA and oligonucleotide probe complementary to the DNA. The triple strand DNA maintains stable triple strand DNA after RecA protein is removed. The present inventors found that the thermostability of triple strand DNA changes greatly when there is a mismatch between target DNA and oligonucleotide probe because of the existence of polymorphism in the target DNA. Utilizing this change of thermostability, efficient detection of polymorphism in labeled DNA is possible by examining whether oligonucleotide probe is released and the triple strand DNA is solved after heat treatment of triple strand DNA formed using homologous recombination protein.
摘要翻译：本发明的目的是提供一种检测DNA多态性的方法，其具有高灵敏度和高效性并且不需要长的DNA搜索区。同源重组蛋白RecA使得来自靶双重DNA的部分三链DNA和与DNA互补的寡核苷酸探针。在除去RecA蛋白后，三链DNA保持稳定的三链DNA。本发明人发现，由于目标DNA中存在多态性，当靶DNA和寡核苷酸探针之间存在错配时，三链DNA的热稳定性变化很大。利用这种热稳定性的变化，可以通过检查寡核苷酸探针是否被释放并且在使用同源重组蛋白形成的三链DNA热处理后求解三链DNA来有效地检测标记的DNA中的多态性。

9. 发明授权

US5107770A Conveyor drive system 失效
标题翻译：输送机驱动系统
公开(公告)号：US5107770A
公开(公告)日：1992-04-28
申请号：US695086
申请日：1991-05-03
申请人： Osamu Ohara
发明人： Osamu Ohara
IPC分类号： B61B13/04 , B60L15/20 , B61C13/04 , B65G43/00
CPC分类号： B61C13/04 , Y02T10/7258
摘要： A drive controller for a rail supported conveyor device made up of a plurality of wheel driven support carriages linked together includes a revolution sensor on one of the drive wheels of one of the support carriages, individual torque controllers on each of the carriages, and a device for providing a common torque signal to the various torque controllers based on the difference between the measured speed of the one speed sensor and the desired speed of the carriages.
摘要翻译：用于由连接在一起的多个轮驱动支撑滑架构成的轨道支撑的传送装置的驱动控制器包括在支撑滑架之一的驱动轮之一上的旋转传感器，每个滑架上的各个扭矩控制器，以及装置用于基于所述一个速度传感器的所测量的速度与所述滑架的期望速度之间的差异，向所述各种扭矩控制器提供公共扭矩信号。

10. 发明授权

US4968549A Laminated material made of annual lignocellulosic stalks 失效
标题翻译：由年木质纤维素秸秆制成的层压材料
公开(公告)号：US4968549A
公开(公告)日：1990-11-06
申请号：US269958
申请日：1988-11-10
申请人： Shin Smimizu , Tsugane Tanaka , Osamu Ohara , Taisei Inoue
发明人： Shin Smimizu , Tsugane Tanaka , Osamu Ohara , Taisei Inoue
IPC分类号： B27N3/02 , B27N3/00 , B27N3/04 , B27N3/14 , B32B5/12 , B32B9/02 , B32B21/10 , B32B21/13
CPC分类号： B32B21/13 , Y10T156/1059 , Y10T156/1062 , Y10T156/1075 , Y10T428/24066 , Y10T428/24124 , Y10T428/24132 , Y10T428/24182 , Y10T428/249942 , Y10T428/31982 , Y10T428/31989
摘要： A laminated material in board form made by the steps of cutting open a lignocellulosic stalk in the fiber direction with a knife; flattening the lignocellulosic stalk by means of a roller press to form a compressed stalk, one face of which consists of its epidermis; arranging a plurality of the compressed stalks in parallel with each other to form a sheet; coating the sheet with a resin adhesive; stacking a plurality of the sheets coated with the adhesive; and then bonding with heat and pressure by means of a hot press. The laminated material has an equal to or higher flexural strength than conventional plywood or also has excellent sound absorbing and heat insulating properties in comparison with conventional particleboard or fiberboard.
摘要翻译：一种制备层压材料的方法，包括以下步骤：用刀切割纤维方向上的年木质纤维素秸秆; 通过辊压机使木质纤维素秆平坦化以形成压制茎，其一面由其表皮组成; 将多个压缩的杆彼此平行地布置以形成片材; 用树脂粘合剂涂覆片材; 堆叠涂覆有粘合剂的多个薄片; 然后通过热压机进行加热和加压粘合。板材形式的层压材料具有等于或高于常规胶合板的弯曲强度，或者与传统的刨花板或纤维板相比具有优异的吸音和绝热性能。

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