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1. 发明申请

US20090258022A1 ANTIBODIES TO BRAIN SPECIFIC MEMBRANE PROTEIN 有权
标题翻译：脑特异性膜蛋白的抗体
公开(公告)号：US20090258022A1
公开(公告)日：2009-10-15
申请号：US12013346
申请日：2008-01-11
申请人： Shin-ichi Funahashi , Shoji Miyata , Nobuo Nomura , Takahiro Nagase , Osamu Ohara
发明人： Shin-ichi Funahashi , Shoji Miyata , Nobuo Nomura , Takahiro Nagase , Osamu Ohara
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , G01N33/566 , A61P37/02
CPC分类号： C07K14/705
摘要： A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and analyzing the structures of the cDNAs contained within said library by the shotgun method. The novel gene shows brain-specific expression and the protein encoded by said gene has a typical PDZ binding motif.
摘要翻译：通过构建人大脑中表达的mRNA的大小为4kb或以上的cDNA文库，并通过霰弹枪法分析所述文库中所含的cDNA的结构，已经成功地分离了显然编码跨膜糖蛋白的新基因。该新基因显示脑特异性表达，由该基因编码的蛋白具有典型的PDZ结合基序。

2. 发明申请

US20060275302A1 Novel cancer-associated gene 有权
标题翻译：新型癌症相关基因
公开(公告)号：US20060275302A1
公开(公告)日：2006-12-07
申请号：US10535733
申请日：2003-11-20
申请人： Osamu Ohara , Takahiro Nagase , Reiko Kikuno , Shin-ichi Funahashi
发明人： Osamu Ohara , Takahiro Nagase , Reiko Kikuno , Shin-ichi Funahashi
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K14/82 , C07K16/30
CPC分类号： C12N9/1048 , C07K14/4748
摘要： The present invention provides: a novel DNA, a carcinoma-associated gene comprising the DNA, a recombinant protein encoded by the DNA, an antibody binding to the protein, an anti-carcinoma agent comprising the antibody, a low-molecular-weight compound binding to the protein, and a screening system. An example of such a novel DNA is a DNA comprising a nucleotide sequence encoding the following polypeptide (a) or (b): (a) a polypeptide, consisting of an amino acid sequence identical to or substantially identical to the amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide, consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 by deletion, substitution, or addition of one or a plurality of amino acids and having biological activity substantially equivalent to the functions of the polypeptide (a).
摘要翻译：本发明提供：新型DNA，包含DNA的癌相关基因，由DNA编码的重组蛋白，与蛋白结合的抗体，包含抗体的抗癌剂，结合蛋白质和筛选系统。这样的新型DNA的实例是包含编码以下多肽（a）或（b）的核苷酸序列的DNA：（a）多肽，由与氨基酸序列相同或基本相同的氨基酸序列组成， SEQ ID NO：2; 或（b）通过缺失，取代或添加一个或多个氨基酸并具有与功能基本相同的生物学活性的由SEQ ID NO：2所示的氨基酸序列衍生的氨基酸序列组成的多肽的多肽（a）。

3. 发明申请

US20060141517A1 Protein having PDZ domain sequence 审中-公开
标题翻译：具有PDZ结构域序列的蛋白质
公开(公告)号：US20060141517A1
公开(公告)日：2006-06-29
申请号：US11311454
申请日：2005-12-19
申请人： Shin-Ichi Funahashi , Shoji Miyata
发明人： Shin-Ichi Funahashi , Shoji Miyata
IPC分类号： C07K14/705 , C12Q1/68 , C07H21/04 , C12P21/06
CPC分类号： C07K16/18 , A61K38/00 , C07K14/4718
摘要： While analyzing changes in gene expression by TNFα in human umbilical vascular endothelial cells, a gene showing enhanced expression due to stimulation with TNFα was isolated. After screening with this gene as a probe, a gene encoding a protein was isolated. Analysis of the protein encoded by this isolated gene revealed that this novel protein has never been reported and has a PDZ domain in its molecule that plays an important role in protein-protein interactions.
摘要翻译：在分析人脐血管内皮细胞中TNFα的基因表达变化的同时，分离出由TNFα刺激引起的表达增强的基因。用该基因筛选后，分离出编码蛋白质的基因。由该分离基因编码的蛋白质的分析显示，这种新型蛋白质从未被报道，并且在其分子中具有在蛋白质 - 蛋白质相互作用中起重要作用的PDZ结构域。

4. 发明授权

US06908748B2 Genes associated with the maintenance of differentiation of smooth muscle cells 有权
标题翻译：与维持平滑肌细胞分化相关的基因
公开(公告)号：US06908748B2
公开(公告)日：2005-06-21
申请号：US10058518
申请日：2002-01-28
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
IPC分类号： A61K38/00 , C07K14/47 , C12P21/06
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/4702 , C12N2799/021
摘要： A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
摘要翻译：使用鸡ard平滑肌细胞培养系统，差异显示法和减法杂交法分离参与维持平滑肌分化的cDNA片段。使用获得的cDNA序列作为查询，检索Helix研究所的cDNA序列（日本专利申请2000-118776），从而得到新的基因“C-NT2RP3001495”。由该基因编码的蛋白质具有参与N末端结构域中的蛋白质相互作用的两个WW结构域。证据表明，该蛋白质与其他蛋白质结合，从而调节细胞内信号转导，基因表达等，从而参与维持平滑肌细胞的分化。该蛋白质和调节其表达的化合物在开发用于维持平滑肌细胞分化异常的各种疾病的药物中显着有用。

5. 发明授权

US08110662B2 Antibody directed to protein involved in maintaining differentiation of smooth muscle cells 有权
标题翻译：涉及保持平滑肌细胞分化的蛋白质的抗体
公开(公告)号：US08110662B2
公开(公告)日：2012-02-07
申请号：US11869267
申请日：2007-10-09
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
IPC分类号： C07K16/00 , A61K39/00
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/4702 , C12N2799/021
摘要： A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
摘要翻译：使用鸡ard平滑肌细胞培养系统，差异显示法和减法杂交法分离参与维持平滑肌分化的cDNA片段。使用获得的cDNA序列作为查询，检索Helix研究所的cDNA序列（日本专利申请2000-118776），从而得到新的基因“C-NT2RP3001495”。由该基因编码的蛋白质具有参与N末端结构域中的蛋白质相互作用的两个WW结构域。证据表明，该蛋白质与其他蛋白质结合，从而调节细胞内信号转导，基因表达等，从而参与维持平滑肌细胞的分化。该蛋白质和调节其表达的化合物在开发用于维持平滑肌细胞分化异常的各种疾病的药物中显着有用。

6. 发明授权

US07344838B2 Gene encoding brain specific membrane protein 失效
标题翻译：基因编码脑特异性膜蛋白
公开(公告)号：US07344838B2
公开(公告)日：2008-03-18
申请号：US11007517
申请日：2004-12-07
申请人： Shin-Ichi Funahashi , Shoji Miyata , Nobuo Nomura , Takahiro Nagase , Osamu Ohara
发明人： Shin-Ichi Funahashi , Shoji Miyata , Nobuo Nomura , Takahiro Nagase , Osamu Ohara
IPC分类号： C12Q1/68 , C12P21/02 , C12N5/10 , C12N15/63 , C07H21/04
CPC分类号： C07K14/705
摘要： A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and analyzing the structures of the cDNAs contained within said library by the shotgun method. The novel gene shows brain-specific expression and the protein encoded by said gene has a typical PDZ binding motif.
摘要翻译：通过构建人大脑中表达的mRNA的大小为4kb或以上的cDNA文库，并通过霰弹枪法分析所述文库中所含的cDNA的结构，已经成功地分离了显然编码跨膜糖蛋白的新基因。该新基因显示脑特异性表达，由该基因编码的蛋白具有典型的PDZ结合基序。

7. 发明申请

US20050079539A1 Novel gene encoding brain specific membrane protein 失效
标题翻译：新型基因编码脑特异性膜蛋白
公开(公告)号：US20050079539A1
公开(公告)日：2005-04-14
申请号：US11007517
申请日：2004-12-07
申请人： Shin-Ichi Funahashi , Shoji Miyata , Nobuo Nomura , Takahiro Nagase , Osamu Ohara
发明人： Shin-Ichi Funahashi , Shoji Miyata , Nobuo Nomura , Takahiro Nagase , Osamu Ohara
IPC分类号： C07K14/705 , C12N1/21 , C12N15/12 , C12P21/08 , C12Q1/68 , C07H21/04 , C12N9/10
CPC分类号： C07K14/705
摘要： A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and analyzing the structures of the cDNAs contained within said library by the shotgun method. The novel gene shows brain-specific expression and the protein encoded by said gene has a typical PDZ binding motif.
摘要翻译：通过构建人大脑中表达的mRNA的大小为4kb或以上的cDNA文库，并通过霰弹枪法分析所述文库中所含的cDNA的结构，已经成功地分离了显然编码跨膜糖蛋白的新基因。该新基因显示脑特异性表达，由该基因编码的蛋白具有典型的PDZ结合基序。

8. 发明申请

US20050037347A1 Novel cancer-associated genes 失效
标题翻译：新型癌症相关基因
公开(公告)号：US20050037347A1
公开(公告)日：2005-02-17
申请号：US10451000
申请日：2001-12-21
申请人： Osamu Ohara , Takahiro Nagase , Daisuke Nakajima , Shin-ichi Funahashi
发明人： Osamu Ohara , Takahiro Nagase , Daisuke Nakajima , Shin-ichi Funahashi
IPC分类号： A61P13/08 , A61P15/00 , A61P35/00 , C07K14/47 , C12N15/12 , C12Q1/68 , C07H21/04 , C07K14/72 , C07K16/30 , G01N33/574
CPC分类号： C07K14/47 , A61K2039/505
摘要： The present invention is related to a DNA comprising a nucleotide sequence encoding the following polypeptide (a) or (b): (a) a polypeptide consisting of an amino acid sequence which is identical or substantially identical with an amino acid sequence represented by SEQ ID No. 1 or No. 2, (b) a polypeptide consisting of an amino acid sequence represented by SEQ ID No. 1 or No. 2 in which part of amino acids are deleted, substituted or added, and having substantially the same biological activity as the function of the polypeptide (a). The present invention is further related to an antibody binding to the polypeptide or protein, an anti-cancer agent comprising the antibody, a method of screening a substance that binds to the protein or a peptide fragment thereof, and a polynucleotide having at least 15 bases and hybridizing with the DNA according to the present invention under stringent conditions, and a method of detecting cancer with the use of said polynucleotide. The DNA according to the present invention is a cancer-associated gene, and that it is possible to inhibit cancer by blocking the binding of the present protein to its ligand. Accordingly, the present antibody is used not only in the detection of the present protein, but also as an agent for the treatment or prevention of cancers such as prostatic adenocarcinoma and ovarian carcinoma.
摘要翻译：本发明涉及包含编码以下多肽（a）或（b）的核苷酸序列的DNA：（a）由与SEQ ID NO：1所示氨基酸序列相同或基本相同的氨基酸序列组成的多肽 1或2，（b）由SEQ ID No.1或No.2所示的氨基酸序列组成的多肽，其中部分氨基酸被缺失，取代或添加并且具有基本上相同的生物活性作为多肽（a）的功能。本发明还涉及与多肽或蛋白质结合的抗体，包含抗体的抗癌剂，筛选与蛋白质结合的物质或其肽片段的方法，以及具有至少15个碱基的多核苷酸并且在严格条件下与根据本发明的DNA杂交，以及使用所述多核苷酸检测癌症的方法。根据本发明的DNA是癌相关基因，并且可以通过阻断本发明蛋白质与其配体的结合来抑制癌症。因此，本发明的抗体不仅用于检测本发明的蛋白质，而且用作治疗或预防前列腺腺癌和卵巢癌等癌症的药剂。

9. 发明授权

US08008437B2 Cancer-associated genes 失效
标题翻译：癌症相关基因
公开(公告)号：US08008437B2
公开(公告)日：2011-08-30
申请号：US12099513
申请日：2008-04-08
申请人： Osamu Ohara , Takahiro Nagase , Daisuke Nakajima , Shin-ichi Funahashi
发明人： Osamu Ohara , Takahiro Nagase , Daisuke Nakajima , Shin-ichi Funahashi
IPC分类号： C07K5/00
CPC分类号： C07K14/47 , A61K2039/505
摘要： The present invention is related to a DNA comprising a nucleotide sequence encoding a polypeptide represented by SEQ ID NO:1 or SEQ ID NO:2. The DNA according to the present invention is highly expressed in prostatic adenocarcinoma and ovarian carcinoma, and is a cancer-associated gene, so that it is possible to inhibit cancer by blocking the binding of the present protein to its ligand. Accordingly, the present antibody is used not only in the detection of the present protein, but also as an agent for the treatment or prevention of cancers such as prostatic adenocarcinoma and ovarian carcinoma.
摘要翻译：本发明涉及包含编码由SEQ ID NO：1或SEQ ID NO：2表示的多肽的核苷酸序列的DNA。根据本发明的DNA在前列腺腺癌和卵巢癌中高度表达，并且是癌相关基因，使得可以通过阻断本发明蛋白质与其配体的结合来抑制癌症。因此，本发明的抗体不仅用于检测本发明的蛋白质，而且用作治疗或预防前列腺腺癌和卵巢癌等癌症的药剂。

10. 发明授权

US07829083B2 Antibodies to brain specific membrane protein 有权
标题翻译：脑特异性膜蛋白抗体
公开(公告)号：US07829083B2
公开(公告)日：2010-11-09
申请号：US12013346
申请日：2008-01-11
申请人： Takahiro Nagase , Shoji Miyata , Nobuo Nomura , Osamu Ohara , Shin-ichi Funahashi
发明人： Takahiro Nagase , Shoji Miyata , Nobuo Nomura , Osamu Ohara , Shin-ichi Funahashi
IPC分类号： A61K39/395 , C12N5/10 , C12N5/12 , G01N33/53
CPC分类号： C07K14/705
摘要： A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and analyzing the structures of the cDNAs contained within said library by the shotgun method. The novel gene shows brain-specific expression and the protein encoded by said gene has a typical PDZ binding motif.
摘要翻译：通过构建人大脑中表达的mRNA的大小为4kb或以上的cDNA文库，并通过霰弹枪法分析所述文库中所含的cDNA的结构，已经成功地分离了显然编码跨膜糖蛋白的新基因。该新基因显示脑特异性表达，由该基因编码的蛋白具有典型的PDZ结合基序。

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