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1. 发明申请

US20100029702A1 Method For Identification of Compound Having Anti-Anxiety Effect 审中-公开
标题翻译：用于鉴定具有抗焦虑作用的化合物的方法
公开(公告)号：US20100029702A1
公开(公告)日：2010-02-04
申请号：US12447979
申请日：2007-11-01
申请人： Daisuke Okajima , Hiroshi Yokota , Osamu Ohara , Takahiro Nagase , Michio Ohishi
发明人： Daisuke Okajima , Hiroshi Yokota , Osamu Ohara , Takahiro Nagase , Michio Ohishi
IPC分类号： C12Q1/68 , A61K31/438 , A61P25/22
CPC分类号： C12Q1/6883 , A01K2267/0356 , C12Q2600/136 , C12Q2600/156 , G01N2800/301
摘要： There are provided a method for identifying a compound having an anti-anxiety effect, an inhibitor of a function of a protein having a function as a G-protein coupled receptor, characterized by finding the protein and a gene encoding the protein and using at least one of a DNA represented by the nucleotide sequence of this gene or a complementary strand thereof, a homologue of the DNA, a protein encoded by the DNA, and a cell expressing the protein encoded by the DNA, an agent and a method for improving an anxiety condition, a method and an agent for prophylactic and/or therapeutic treatment of an anxiety disorder, and a measurement method for diagnosis and a diagnostic method of an anxiety disorder.
摘要翻译：提供了鉴定具有抗焦虑作用的化合物的方法，具有作为G蛋白偶联受体的功能的蛋白质的功能抑制剂，其特征在于找到蛋白质和编码该蛋白质的基因，并至少使用由该基因的核苷酸序列或其互补链所代表的DNA，DNA的同系物，由DNA编码的蛋白质和表达由DNA编码的蛋白质的细胞之一，药剂和改善其的方法焦虑症，焦虑症的预防和/或治疗方法和药剂，以及焦虑障碍的诊断和诊断方法的测定方法。

2. 发明申请

US20080274954A1 Gene Encoding a Guanine Nucleotide Exchange Factor and Its Gene Product 审中-公开
标题翻译：基因编码鸟嘌呤核苷酸交换因子及其基因产物
公开(公告)号：US20080274954A1
公开(公告)日：2008-11-06
申请号：US11578324
申请日：2005-04-14
申请人： Osamu Ohara , Takahiro Nagase , Michio Ohishi , Hiroshi Yokota , Osamu Kamida
发明人： Osamu Ohara , Takahiro Nagase , Michio Ohishi , Hiroshi Yokota , Osamu Kamida
IPC分类号： A61K38/00 , C12N15/11 , C12N15/00 , C12N5/06 , C07K16/18 , A61P31/00 , C12P21/04 , G01N33/00 , C12Q1/68
CPC分类号： G01N33/57446 , A61K38/00 , C07K14/82 , C12Q1/44 , G01N33/57407 , G01N2500/00 , Y10T436/143333
摘要： A gene encoding a novel protein having a guanine nucleotide exchange factor (GEF) activity for a Rho family protein being one group of small GTP binding proteins, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 3, or SEQ ID NO: 5, or the complementary strand, the equivalents of the polynucleotide, a protein encoded by the polynucleotide, a vector containing the polynucleotide, a transformant containing the vector, an antibody against the protein encoded by the polynucleotide, a method of identifying a compound that inhibits the function of the protein encoded by the polynucleotide and/or the expression of the polynucleotide, a method of determining a disease, a pharmaceutical composition, and a reagent kit are provided.
摘要翻译：编码具有Rho家族蛋白质的鸟嘌呤核苷酸交换因子（GEF）活性的新蛋白质的基因是一组小GTP结合蛋白，即由SEQ ID NO：1，SEQ ID NO：1所示的核苷酸序列所示的多核苷酸 SEQ ID NO：3或SEQ ID NO：5，或互补链，多核苷酸的等同物，由多核苷酸编码的蛋白质，含有多核苷酸的载体，含有该载体的转化体，由该多核苷酸编码的蛋白质的抗体提供了鉴定抑制多核苷酸编码的蛋白质的功能和/或多核苷酸表达的化合物的方法，确定疾病的方法，药物组合物和试剂盒的方法。

3. 发明授权

US07344838B2 Gene encoding brain specific membrane protein 失效
标题翻译：基因编码脑特异性膜蛋白
公开(公告)号：US07344838B2
公开(公告)日：2008-03-18
申请号：US11007517
申请日：2004-12-07
申请人： Shin-Ichi Funahashi , Shoji Miyata , Nobuo Nomura , Takahiro Nagase , Osamu Ohara
发明人： Shin-Ichi Funahashi , Shoji Miyata , Nobuo Nomura , Takahiro Nagase , Osamu Ohara
IPC分类号： C12Q1/68 , C12P21/02 , C12N5/10 , C12N15/63 , C07H21/04
CPC分类号： C07K14/705
摘要： A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and analyzing the structures of the cDNAs contained within said library by the shotgun method. The novel gene shows brain-specific expression and the protein encoded by said gene has a typical PDZ binding motif.
摘要翻译：通过构建人大脑中表达的mRNA的大小为4kb或以上的cDNA文库，并通过霰弹枪法分析所述文库中所含的cDNA的结构，已经成功地分离了显然编码跨膜糖蛋白的新基因。该新基因显示脑特异性表达，由该基因编码的蛋白具有典型的PDZ结合基序。

4. 发明申请

US20070196377A1 Gene encoding a guanmine nucleotide exchange factor and the gene product thereof 失效
标题翻译：基因编码鸟苷核苷酸交换因子及其基因产物
公开(公告)号：US20070196377A1
公开(公告)日：2007-08-23
申请号：US10594707
申请日：2005-03-29
申请人： Osamu Ohara , Takahiro Nagase , Michi Oishi , Hiroshi Yokota , Osamu Kamida
发明人： Osamu Ohara , Takahiro Nagase , Michi Oishi , Hiroshi Yokota , Osamu Kamida
IPC分类号： A61K48/00 , C12Q1/68 , G01N33/574 , C07H21/04 , C07K16/40 , A61K39/395 , C12P21/06 , C12N9/10
CPC分类号： A61K31/7088 , C07K14/4702 , C07K14/82 , G01N33/57446 , G01N33/57484 , G01N2333/4703 , Y10S435/81 , Y10S435/975
摘要： A gene encoding a novel protein that works as a guanine nucleotide exchange factor (GEF) for a Rho family protein being one group of small GTP-binding proteins, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 3, or SEQ ID NO: 5, or the complementary strand, the equivalents of the polynucleotide, a protein encoded by the polynucleotide, a vector containing the polynucleotide, a transformant containing the vector, an antibody against the protein encoded by the polynucleotide, a method of identifying a compound that inhibits the function of the protein encoded by the polynucleotide and/or the expression of the polynucleotide, a method of determining a disease, a pharmaceutical composition, and a reagent kit are provided.
摘要翻译：编码作为Rho家族蛋白质的鸟嘌呤核苷酸交换因子（GEF）的新型蛋白质的基因是一组小的GTP结合蛋白，即由SEQ ID NO：1所示的核苷酸序列显示的多核苷酸， SEQ ID NO：3或SEQ ID NO：5，或互补链，多核苷酸的等同物，由多核苷酸编码的蛋白质，含有多核苷酸的载体，含有该载体的转化体，提供多核苷酸，鉴定抑制多核苷酸编码的蛋白质的功能的化合物的方法和/或多核苷酸的表达，确定疾病的方法，药物组合物和试剂盒的方法。

5. 发明申请

US20070128645A1 Use of KIAA0172 gene in treatment and diagnosis of diseases as well as in pharmaceutical development 审中-公开
标题翻译：使用KIAA0172基因治疗和诊断疾病以及药物开发
公开(公告)号：US20070128645A1
公开(公告)日：2007-06-07
申请号：US11606148
申请日：2006-11-30
申请人： Ryoichi Kiyama , Keisuke Kitajima , Shinobu Oguchi , Michio Oishi , Osamu Ohara , Takahiro Nagase
发明人： Ryoichi Kiyama , Keisuke Kitajima , Shinobu Oguchi , Michio Oishi , Osamu Ohara , Takahiro Nagase
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6886 , C07K14/47 , C12Q2600/154 , C12Q2600/172 , G01N33/505
摘要： An object of the present invention is to provide use of the KIAA0172 gene in treatment and diagnosis of diseases as well as in pharmaceutical development. An agent for treating cancer which comprises as an active ingredient a polypeptide encoded by the KIAA0172 gene, a partial sequence thereof or a variant thereof; an agent for treating cancer which comprises as an active ingredient an oligonucleotide including the KIAA0172 gene sequence; an agent for detecting cancer which comprises an antibody which recognizes polypeptide encoded by the KIAA0172 gene; an agent for detecting cancer which comprises an oligonucleotide including the KIAA0172 gene sequence; a composition for treating cancer which comprises said agent for treating cancer and a pharmaceutically acceptable carrier; and a composition for detecting cancer which comprises said agent for detecting cancer and a pharmaceutically acceptable carrier.
摘要翻译：本发明的目的是提供KIAA0172基因在疾病和药物开发的治疗和诊断中的用途。一种用于治疗癌症的药物，其包含作为活性成分的由KIAA0172基因编码的多肽，其部分序列或其变体; 一种治疗癌症的药物，其包含作为活性成分的包含KIAA0172基因序列的寡核苷酸; 用于检测癌症的试剂，其包含识别由KIAA0172基因编码的多肽的抗体; 用于检测癌症的试剂，其包含含有KIAA0172基因序列的寡核苷酸; 用于治疗癌症的组合物，其包含所述治疗癌症的药物和药学上可接受的载体; 和用于检测癌症的组合物，其包含所述用于检测癌症的药物和药学上可接受的载体。

6. 发明申请

US20050106719A1 Method of efficiently recombining orf encoded by cdna and template vector, trap vector and primer to be used therein 审中-公开
标题翻译：由cdna和模板载体有效重组或编码的方法，其中使用的捕获载体和引物
公开(公告)号：US20050106719A1
公开(公告)日：2005-05-19
申请号：US10491192
申请日：2003-12-04
申请人： Takahiro Nagase , Daisuke Nakajima , Osamu Ohara
发明人： Takahiro Nagase , Daisuke Nakajima , Osamu Ohara
IPC分类号： C12N15/10 , C12N15/64 , C12N15/66 , C12N15/85 , C12N15/74
CPC分类号： C12N15/66 , C12N15/64
摘要： The object of the present invention is to solve the problems in excising a DNA region (or gene) with conventional restriction enzymes, or in amplification of the DNA region by PCR. The present invention provides a method for precisely, quickly and simply cloning a target ORF, for example the target ORF encoding a protein, particularly the target ORF encoding a long-chain ORF comprising bases as many as several thousand bp in cDNA, and means such as various vectors used for the cloning method,
摘要翻译：本发明的目的是解决用常规限制酶切除DNA区域（或基因）或通过PCR扩增DNA区域的问题。本发明提供了精确，快速和简单地克隆靶ORF的方法，例如编码蛋白质的靶ORF，特别是编码包含cDNA多达数千bp的碱基的长链ORF的靶ORF，作为用于克隆方法的各种载体，

7. 发明申请

US20050079539A1 Novel gene encoding brain specific membrane protein 失效
标题翻译：新型基因编码脑特异性膜蛋白
公开(公告)号：US20050079539A1
公开(公告)日：2005-04-14
申请号：US11007517
申请日：2004-12-07
申请人： Shin-Ichi Funahashi , Shoji Miyata , Nobuo Nomura , Takahiro Nagase , Osamu Ohara
发明人： Shin-Ichi Funahashi , Shoji Miyata , Nobuo Nomura , Takahiro Nagase , Osamu Ohara
IPC分类号： C07K14/705 , C12N1/21 , C12N15/12 , C12P21/08 , C12Q1/68 , C07H21/04 , C12N9/10
CPC分类号： C07K14/705
摘要： A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and analyzing the structures of the cDNAs contained within said library by the shotgun method. The novel gene shows brain-specific expression and the protein encoded by said gene has a typical PDZ binding motif.
摘要翻译：通过构建人大脑中表达的mRNA的大小为4kb或以上的cDNA文库，并通过霰弹枪法分析所述文库中所含的cDNA的结构，已经成功地分离了显然编码跨膜糖蛋白的新基因。该新基因显示脑特异性表达，由该基因编码的蛋白具有典型的PDZ结合基序。

8. 发明申请

US20050037347A1 Novel cancer-associated genes 失效
标题翻译：新型癌症相关基因
公开(公告)号：US20050037347A1
公开(公告)日：2005-02-17
申请号：US10451000
申请日：2001-12-21
申请人： Osamu Ohara , Takahiro Nagase , Daisuke Nakajima , Shin-ichi Funahashi
发明人： Osamu Ohara , Takahiro Nagase , Daisuke Nakajima , Shin-ichi Funahashi
IPC分类号： A61P13/08 , A61P15/00 , A61P35/00 , C07K14/47 , C12N15/12 , C12Q1/68 , C07H21/04 , C07K14/72 , C07K16/30 , G01N33/574
CPC分类号： C07K14/47 , A61K2039/505
摘要： The present invention is related to a DNA comprising a nucleotide sequence encoding the following polypeptide (a) or (b): (a) a polypeptide consisting of an amino acid sequence which is identical or substantially identical with an amino acid sequence represented by SEQ ID No. 1 or No. 2, (b) a polypeptide consisting of an amino acid sequence represented by SEQ ID No. 1 or No. 2 in which part of amino acids are deleted, substituted or added, and having substantially the same biological activity as the function of the polypeptide (a). The present invention is further related to an antibody binding to the polypeptide or protein, an anti-cancer agent comprising the antibody, a method of screening a substance that binds to the protein or a peptide fragment thereof, and a polynucleotide having at least 15 bases and hybridizing with the DNA according to the present invention under stringent conditions, and a method of detecting cancer with the use of said polynucleotide. The DNA according to the present invention is a cancer-associated gene, and that it is possible to inhibit cancer by blocking the binding of the present protein to its ligand. Accordingly, the present antibody is used not only in the detection of the present protein, but also as an agent for the treatment or prevention of cancers such as prostatic adenocarcinoma and ovarian carcinoma.
摘要翻译：本发明涉及包含编码以下多肽（a）或（b）的核苷酸序列的DNA：（a）由与SEQ ID NO：1所示氨基酸序列相同或基本相同的氨基酸序列组成的多肽 1或2，（b）由SEQ ID No.1或No.2所示的氨基酸序列组成的多肽，其中部分氨基酸被缺失，取代或添加并且具有基本上相同的生物活性作为多肽（a）的功能。本发明还涉及与多肽或蛋白质结合的抗体，包含抗体的抗癌剂，筛选与蛋白质结合的物质或其肽片段的方法，以及具有至少15个碱基的多核苷酸并且在严格条件下与根据本发明的DNA杂交，以及使用所述多核苷酸检测癌症的方法。根据本发明的DNA是癌相关基因，并且可以通过阻断本发明蛋白质与其配体的结合来抑制癌症。因此，本发明的抗体不仅用于检测本发明的蛋白质，而且用作治疗或预防前列腺腺癌和卵巢癌等癌症的药剂。

9. 发明授权

US08076307B2 Formation/elongation of axon by inhibiting the expression or function of Singar and application to nerve regeneration 有权
标题翻译：通过抑制Singar的表达或功能并应用于神经再生来形成/延伸轴突
公开(公告)号：US08076307B2
公开(公告)日：2011-12-13
申请号：US12084242
申请日：2006-10-26
申请人： Naoyuki Inagaki , Tatsuya Mori , Osamu Ohara , Takahiro Nagase
发明人： Naoyuki Inagaki , Tatsuya Mori , Osamu Ohara , Takahiro Nagase
IPC分类号： C12N15/11 , C12N15/00 , C07H21/04
CPC分类号： G01N33/5058 , C12N15/113 , C12N2310/14 , G01N2500/00
摘要： Singar is identified as a novel molecule, whose expression is varied before and after the polarization of a nerve cell, and occurs in the tip of an elongating axon, called a growth cone, which is important for the formation or elongation of an axon. Singar is expressed specifically in the brain and the amount of Singar expression is largely increased in an individual during periods where the formation of axons is increased. It is observed that Singar is highly enriched in the growth cone at the tip of an axon. When the expression of Singar is inhibited in nerve cells in culture, the formation of multiple axons is induced. Thus, the inhibition of Singar can induce axon formation. Therefore, by inhibiting the expression or activity of Singar, it becomes possible to induce or promote the formation or elongation of an axon in a nerve cell.
摘要翻译： Singar被鉴定为一种新颖的分子，其表达在神经细胞的极化之前和之后是变化的，并且发生在延伸轴突的尖端，称为生长锥，其对于轴突的形成或延伸是重要的。 Singar在脑中特异性表达，并且在轴突形成增加期间个体中Singar表达量大大增加。观察到，Singar在轴突末端的生长锥中高度富集。当培养中神经细胞中Singar的表达被抑制时，诱导多个轴突的形成。因此，Singar的抑制可以诱导轴突形成。因此，通过抑制Singar的表达或活性，可以诱导或促进神经细胞中轴突的形成或延伸。

10. 发明申请

US20110223175A1 Gene Encoding G-Protein Coupled Receptor And Gene Product Thereof 审中-公开
标题翻译：基因编码G蛋白偶联受体及其基因产物
公开(公告)号：US20110223175A1
公开(公告)日：2011-09-15
申请号：US13113157
申请日：2011-05-23
申请人： Osamu Ohara , Takahiro Nagase , Michio Ohishi , Daisuke Okajima , Hiroshi Yokota
发明人： Osamu Ohara , Takahiro Nagase , Michio Ohishi , Daisuke Okajima , Hiroshi Yokota
IPC分类号： A61K39/395 , C07K16/00 , A61P25/28 , A61P25/24
CPC分类号： G01N33/74 , G01N2333/726
摘要： The present invention, the objects of which are to find out a gene encoding a protein having functions equivalent to those of G-protein-coupled receptor (GPCR) and the protein, and to provide a method for identifying a compound that regulates functions and/or expression of the protein, and to provide a useful mean for preventing and/or treating diseases related to the gene and the protein, provides a DNA comprising base sequence described in SEQ ID NO: 1 or complementary strand thereof, complementary strand of the DNA, a protein encoded by the DNA, a vector containing the DNA, a transformant containing the vector, an antibody against the protein, a method for identifying a compound that regulates functions and/or expression of the protein using aforementioned members, an agent for improving and a method for improving depression state, a pharmaceutical composition, and a reagent kit.
摘要翻译：本发明的目的是找出编码具有与G蛋白偶联受体（GPCR）和蛋白质相同功能的蛋白质的基因，并提供一种鉴定调节功能的化合物和/ 或蛋白质的表达，并且为预防和/或治疗与该基因和蛋白质相关的疾病提供有用的平均值，提供包含SEQ ID NO：1或其互补链中所述的碱基序列的DNA，DNA的互补链，由DNA编码的蛋白质，含有该载体的载体，含有该载体的转化子，针对该蛋白质的抗体，使用上述成员鉴定调节蛋白质的功能和/或表达的化合物的方法，改善剂以及改善抑郁状态的方法，药物组合物和试剂盒。

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