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1. 发明申请

US20120122762A1 186 Human Secreted Proteins 审中-公开
标题翻译： 186人类分泌蛋白
公开(公告)号：US20120122762A1
公开(公告)日：2012-05-17
申请号：US13359199
申请日：2012-01-26
申请人： Steven M. Ruben , Craig A. Rosen , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , D. Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Carrie L. Fischer , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. LaFleur , Yi Li , Zhizhen Zeng , Hla Kyaw
发明人： Steven M. Ruben , Craig A. Rosen , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , D. Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Carrie L. Fischer , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. LaFleur , Yi Li , Zhizhen Zeng , Hla Kyaw
IPC分类号： A61K38/17 , C12N15/63 , C07K14/435 , C07K16/18 , G01N33/53 , C12Q1/68 , C12P21/00 , G01N33/68 , C12N15/85 , C12N15/70 , C12N1/21 , C12N5/10 , A61P7/00 , A61P35/00 , A61P13/12 , A61P9/00 , A61P11/00 , A61P17/02 , A61P25/00 , A61P5/00 , A61P15/00 , A61P31/00 , A61P1/00 , C12N15/12
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , G01N33/566 , G01N2800/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

2. 发明授权

US07816091B2 Method of identifying a binding partner to a cytokine receptor common gamma chain like polypeptide 有权
标题翻译：鉴定细胞因子受体常见的γ链如多肽的结合配偶体的方法
公开(公告)号：US07816091B2
公开(公告)日：2010-10-19
申请号：US12358097
申请日：2009-01-22
申请人： Steven M. Ruben , Craig A. Rosen , Paul A. Moore
发明人： Steven M. Ruben , Craig A. Rosen , Paul A. Moore
IPC分类号： G01N33/53 , C07K14/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/715 , C07K14/7155
摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the Cytokine Receptor family. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named Cytokine Receptor Common Gamma Chain Like, or “CRCGCL.” This invention also relates to CRCGCL polypeptides, as well as vectors, host cells, antibodies directed to CRCGCL polypeptides, and the recombinant methods for producing the same. Also provided are diagnostic methods for detecting disorders related to the immune system, and therapeutic methods for treating diagnosing, detecting, and/or preventing such disorders. The invention further relates to screening methods for identifying agonists and antagonists of CRCGCL activity.
摘要翻译：本发明涉及编码作为细胞因子受体家族成员的多肽的新型人基因。更具体地，本发明涉及编码称为细胞因子受体通用γ链或类似于“CRCGCL”的新型人多肽的多核苷酸。本发明还涉及CRCGCL多肽，以及载体，宿主细胞，针对CRCGCL多肽的抗体，及其制备方法。还提供了用于检测与免疫系统相关的疾病的诊断方法，以及用于治疗诊断，检测和/或预防这种疾病的治疗方法。本发明还涉及用于鉴定CRCGCL活性的激动剂和拮抗剂的筛选方法。

3. 发明申请

US20090011983A1 186 Human Secreted Proteins 失效
标题翻译： 186人类分泌蛋白
公开(公告)号：US20090011983A1
公开(公告)日：2009-01-08
申请号：US11745580
申请日：2007-05-08
申请人： Steven M. Ruben , Craig A. Rosen , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , D. Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Carrie L. Fischer , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. LaFleur , Yi Li , Zhizhen Zeng , Hla Kyaw
发明人： Steven M. Ruben , Craig A. Rosen , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , D. Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Carrie L. Fischer , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. LaFleur , Yi Li , Zhizhen Zeng , Hla Kyaw
IPC分类号： A61K38/00 , C12N15/11 , C12N15/00 , C12N15/63 , C12N5/06 , C12Q1/00 , A61P43/00 , G01N33/566 , C12Q1/68 , C07K14/00 , C07K16/18 , C12P21/04
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , G01N33/566 , G01N2800/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

4. 发明申请

US20090005301A1 207 Human Secreted Proteins 审中-公开
标题翻译： 207人类分泌蛋白
公开(公告)号：US20090005301A1
公开(公告)日：2009-01-01
申请号：US11759448
申请日：2007-06-07
申请人： Jian Ni , Reinhard Ebner , David W. LaFleur , Paul A. Moore , Henrik S. Olsen , Craig A. Rosen , Steven M. Ruben , Daniel R. Soppet , Paul E. Young , Yanggu Shi , Kimberly A. Florence , Ying-Fei Wei , Charles Florence , Jing-Shan Hu , Yi Li , Hla Kyaw , Carrie L. Fischer , Ann M. Ferrie , Ping Fan , Ping Feng , Gregory A. Endress , Patrick J. Dillon , Kenneth C. Carter , Laurie A. Brewer , Guo-Liang Yu , Zhizhen Zeng , John M. Greene
发明人： Jian Ni , Reinhard Ebner , David W. LaFleur , Paul A. Moore , Henrik S. Olsen , Craig A. Rosen , Steven M. Ruben , Daniel R. Soppet , Paul E. Young , Yanggu Shi , Kimberly A. Florence , Ying-Fei Wei , Charles Florence , Jing-Shan Hu , Yi Li , Hla Kyaw , Carrie L. Fischer , Ann M. Ferrie , Ping Fan , Ping Feng , Gregory A. Endress , Patrick J. Dillon , Kenneth C. Carter , Laurie A. Brewer , Guo-Liang Yu , Zhizhen Zeng , John M. Greene
IPC分类号： C07K14/47 , C12N15/12 , C12N15/85 , C07K16/18 , C12Q1/68 , A61K38/14 , A61K31/7088 , G01N33/68 , C12P21/02 , C12N15/00 , C12N5/10
CPC分类号： C07K14/47 , A61K48/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

5. 发明申请

US20080242246A1 Rf Transmitter With Compensation of Differential Path Delay 有权
标题翻译： Rf差分路径延迟补偿的发射机
公开(公告)号：US20080242246A1
公开(公告)日：2008-10-02
申请号：US11996329
申请日：2006-07-26
申请人： Brian Minnis , Paul A. Moore
发明人： Brian Minnis , Paul A. Moore
IPC分类号： H03F1/02
CPC分类号： H03F1/0227 , H03F1/0205 , H03F1/32 , H03F3/24 , H03F2200/102 , H03F2200/336 , H03F2200/462 , H03F2200/504 , H03F2200/99
摘要： A transmitter has a power amplifier (40) to amplify an input signal having amplitude modulation, a supply voltage controller (10) to control a supply voltage of the power amplifier (40) according to the envelope, a sensor (R1) for sensing a modulation of a current drawn by the power amplifier (40), a delay detector (20) for detecting a delay of the controlled supply voltage relative to the sensed current, and a delay adjuster (30) for compensating the relative delay according to the detected delay. By sensing a current drawn, the delay detected can include any delay contributed by the power amplifier (40) up to that point, and yet avoid the more complex circuitry needed to derive the delay from an output of the power amplifier. Thus the distortion and out of band emissions caused by differential delays can be reduced more effectively.
摘要翻译：发射机具有放大具有幅度调制的输入信号的功率放大器（40），用于根据信封控制功率放大器（40）的电源电压的电源电压控制器（10），用于感测的传感器（R 1）由功率放大器（40）所绘制的电流的调制，用于检测受控电源电压相对于感测电流的延迟的延迟检测器（20），以及用于根据所述延迟检测器检测到延迟。通过感测所绘制的电流，检测到的延迟可以包括功率放大器（40）直到那一点所贡献的任何延迟，并且还避免了从功率放大器的输出导出延迟所需的更复杂的电路。因此，可以更有效地降低由差分延迟引起的失真和带外发射。

6. 发明授权

US07390637B2 Keratinocyte derived interferon 失效
标题翻译：角质细胞来源的干扰素
公开(公告)号：US07390637B2
公开(公告)日：2008-06-24
申请号：US10197816
申请日：2002-09-12
申请人： David W. LaFleur , Paul A. Moore , Steven M. Ruben
发明人： David W. LaFleur , Paul A. Moore , Steven M. Ruben
IPC分类号： C12N15/20 , C12N15/00 , C12P21/06 , C07H21/04
CPC分类号： C07K14/555 , A61K38/00 , C10M2209/108 , C10M2209/109
摘要： The present invention relates to a novel KDI protein which is a member of the interferon family. In particular, isolated nucleic acid molecules are provided encoding a human interferon polypeptide, called “KDI”. KDI polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of KDI activity. Also provided are therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及作为干扰素家族成员的新型KDI蛋白。特别地，提供编码人干扰素多肽的分离的核酸分子，称为“KDI”。还提供KDI多肽，载体，宿主细胞以及用于制备其的重组方法。本发明还涉及用于鉴定KDI活性的激动剂和拮抗剂的筛选方法。还提供了治疗免疫系统相关疾病的治疗方法。

7. 发明授权

US07295630B2 Receiver having a variable threshold slicer stage and a method of updating the threshold levels of the slicer stage 有权
标题翻译：具有可变阈值限幅器级的接收器和更新限幅器级的阈值电平的方法
公开(公告)号：US07295630B2
公开(公告)日：2007-11-13
申请号：US10015848
申请日：2001-12-10
申请人： Adrian W. Payne , Paul A. Moore , Brian J. Minnis
发明人： Adrian W. Payne , Paul A. Moore , Brian J. Minnis
IPC分类号： H03K9/00 , H03D1/04
CPC分类号： H04L25/061
摘要： A receiver having a variable bit slicer for detecting bits in a demodulated signal, comprises a demodulator (14) for deriving a demodulated bit rate signal, means (36) for storing a plurality of threshold values, each of the threshold values being selectively adjustable, means (28, 38) for selecting the threshold value for comparison with the current bit signal (Sn) in response to a sequence of N bits (where N is at least 2) (Bn-1, Bn-2) received prior to the current bit (Bn) and means (38, 40) for using the current bit to update the selected threshold value.Also disclosed is a method of dc offset correction.
摘要翻译：具有用于检测解调信号中的比特的可变比特限制器的接收机包括用于导出解调比特率信号的解调器（14），用于存储多个阈值的装置（36），每个阈值可选择性地调整，用于响应于N位序列（其中N至少为2），选择用于与当前位信号（S SUB n N）进行比较的阈值的装置（28,38）（B＆lt; 在当前位（B SUB）之前接收的n-1，b-n-2）和用于使用当前位的装置（38,40）更新所选择的阈值。还公开了一种直流偏移校正的方法。

8. 发明授权

US07092461B1 Polyphase receivers 有权
标题翻译：多相接收器
公开(公告)号：US07092461B1
公开(公告)日：2006-08-15
申请号：US09710830
申请日：2000-11-13
申请人： Brian J. Minnis , Paul A. Moore
发明人： Brian J. Minnis , Paul A. Moore
IPC分类号： H03D3/22 , H04L27/22
CPC分类号： H03D3/008 , H03D7/165 , H03G7/001 , H04B1/30
摘要： A polyphase receiver comprises an RF front end (10 to 28) for receiving a wanted data signal modulated on a carrier signal and for producing quadrature related low IF signals, an image rejection filter formed by a polyphase filter (30) for filtering the quadrature related low IF signals, soft limiting means (36,38) for compressing the dynamic range of the filtered quadrature related IF signals and a signal demodulator (41) for recovering the data signal. The soft limiting means (36,38) has a characteristic which is substantially linear at signal levels 10 dB below a predetermined minimum wanted signal level, moves into compression for higher signal levels and hard limits at substantially 10 dB above the desired receiver sensitivity which avoids degrading the sensitivity of the receiver.
摘要翻译：多相接收机包括用于接收在载波信号上调制的有用数据信号并用于产生正交相关低IF信号的RF前端（10至28），由多相滤波器（30）形成的用于滤波正交相关低IF信号，用于压缩滤波正交相关IF信号的动态范围的软限幅装置（36,38）和用于恢复数据信号的信号解调器（41）。软限制装置（36,38）具有在预定的最小有用信号电平以下10dB的信号电平处基本上线性的特性，进入压缩以达到高于期望接收机灵敏度的基本上10dB的较高信号电平和硬限制，这避免了降低接收机的灵敏度。

9. 发明授权

US06844170B1 Cytokine receptor common gamma chain like 有权
标题翻译：细胞因子受体常见γ链
公开(公告)号：US06844170B1
公开(公告)日：2005-01-18
申请号：US09263626
申请日：1999-03-05
申请人： Paul A. Moore , Craig A. Rosen , Steven M. Ruben
发明人： Paul A. Moore , Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K14/715 , C07K1/00 , C07H21/04 , C12N1/20 , C12P21/06
CPC分类号： C07K14/715
摘要： The present invention relates to a novel human protein called Cytokine Receptor Common Gamma Chain Like, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
摘要翻译：本发明涉及称为细胞因子受体通用γ链的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。还提供了用于产生该人蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与该新型人蛋白相关的疾病的诊断和治疗方法。

10. 发明授权

US06569992B1 Protein HLQDR48 失效
标题翻译：蛋白HLQDR48
公开(公告)号：US06569992B1
公开(公告)日：2003-05-27
申请号：US09369247
申请日：1999-08-05
申请人： David W. LaFleur , Steven M. Ruben , Craig A. Rosen , Paul A. Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
发明人： David W. LaFleur , Steven M. Ruben , Craig A. Rosen , Paul A. Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
IPC分类号： A61K3800
CPC分类号： C12Q1/6883 , A61K35/13 , A61K38/00 , C07K14/47 , G01N33/6893 , Y02A50/465
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

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