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1. 发明专利

JP2016510771A 成長ホルモン分泌促進因子受容体に基づくタンパク質、核酸および方法ならびにその使用审中-公开
标题翻译：基于该生长激素促分泌素受体蛋白质，核酸和方法及其用途
公开(公告)号：JP2016510771A
公开(公告)日：2016-04-11
申请号：JP2015561854
申请日：2014-03-14
申请人：チンファ、ワンQinghua Wang , チンファ、ワンQinghua Wang
发明人：チンファ、ワン , ヨウンズ、アニニ
IPC分类号： C07K19/00 , A61K31/7088 , A61K35/12 , A61K38/00 , A61K39/395 , A61K47/42 , A61K47/48 , A61K48/00 , A61P1/00 , A61P1/18 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/12 , A61P15/00 , A61P35/00 , C07K14/72 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09
CPC分类号： C07K14/723 , A61K48/00 , C07K14/72 , C07K2319/30 , C07K2319/32
摘要：グレリンは、その受容体である成長ホルモン分泌促進因子受容体1a(GHS−R1a、グレリン受容体)と結合して哺乳動物の脂肪過多および肥満を促進するペプチドホルモンである。グレリンおよびその受容体は、肥満関連疾患および癌を治療するための治療介入の標的である。末梢でグレリンと結合し、グレリンが細胞上のGHS−R1と結合しないようにし、それによりグレリンと拮抗して肥満関連病態および癌を治療する可溶性デコイGHS−R1a受容体が開発される。GHS−R1aは、N末端細胞外ドメイン(Nt)、7回膜貫通領域および3つの細胞外ループ(EC1、EC2およびEC3)を含んでなる膜貫通タンパク質である。Nt、EC1およびEC2はともに連結せず、膜貫通領域は存在せず、免疫グロブリン由来のFcと融合されて、デコイGHS−R1a融合タンパク質GHSR−Fcを形成している。GHSR−Fcは、高脂肪食(HFD)のマウスにおいて脂肪過多および体重増加を抑制するが、NtおよびECはそれら自体で有意な作用は持たない。
摘要翻译：生长素释放肽是一种肽激素，其促进其受体生长激素促分泌素受体1A（GHS-R1A，生长素释放肽受体）和结合于哺乳动物肥胖和肥胖。生长激素释放激素及其受体是对于肥胖有关的疾病和癌症的治疗干预治疗的目标。结合在外围生长素释放肽，生长素释放肽，以避免结合GHS-R1上的细胞，它可溶性诱饵GHS-R1A受体拮抗生长素释放肽治疗肥胖相关病症和癌症是由显影。 GHS-R 1a是，N-末端细胞外结构域（NT），七个跨膜区和三个胞外环（EC1，EC2和EC3）并且包括在跨膜蛋白。 NT，EC1和EC2不连接在一起，跨膜区不存在，它被融合至免疫球蛋白衍生的Fc，以形成一个诱饵GHS-R1A融合蛋白GHSR-Fc的。 GHSR-Fc的抑制小鼠肥胖和体重增加高脂肪饮食（HFD）是，NT和EC自己没有显著影响。

3. 发明专利

IES20040252A2 A novel soy bean product and method of producing said product 未知
公开(公告)号：IES20040252A2
公开(公告)日：2007-09-19
申请号：IES20040252
申请日：2004-04-07
申请人： LU WEI , QINGHUA WANG
发明人： LU WEI , WANG QINGHUA
IPC分类号： A23J3/00
摘要： The process listed here is a way of making fast ready-to-eat Soy Protein based product. To achieve this objective the process outlined will show a way of creating a ready-to-eat ToFu rivalling that of Ham/Meat based slices in both taste and texture. In its final form it will be either in slices or block similar to meat. The process also includes other flavours not limited to become vegetarian meat, but also new flavours as well, including but not limited to fruit flavours, herbal flavour etc. Main points in the processing of this include: (1) Extract Soy protein form Soy bean (2) Solidify Soy protein (3) Slice Solid Soy protein (4) Add flavour and combing agent (5) Recombine into Solid Soy product. The end product represents appearance similar to a block of ham, if needed it can be sliced similar to ham slices for easier packaging.

4. 发明申请

US20150073763A1 OIL OR GAS PRODUCTION USING COMPUTER SIMULATION OF OIL OR GAS FIELDS AND PRODUCTION FACILITIES 审中-公开
标题翻译：使用计算机模拟油气田和生产设施进行油气生产
公开(公告)号：US20150073763A1
公开(公告)日：2015-03-12
申请号：US14395738
申请日：2012-05-30
申请人： Qinghua Wang , Graham Christopher Fleming , Qin Lu
发明人： Qinghua Wang , Graham Christopher Fleming , Qin Lu
IPC分类号： E21B43/00
CPC分类号： E21B43/00 , G06Q10/04
摘要： Oil or gas fields and associated facilities are computer simulated by solving linear algebraic equations using a Schwarz method with at least one well node included in the overlap. According to another aspect, equations for the wellbore nodes are processed to eliminate some non-pressure variables, e.g. component compositions. Other features are also provided.
摘要翻译：通过使用包含在重叠中的至少一个井节点的Schwarz方法求解线性代数方程式来计算油气田和相关设施。根据另一方面，对井眼节点的等式进行处理以消除一些非压力变量，例如，组分组成。还提供其他功能。

5. 发明申请

US20140188722A1 SELF-TRANSACTION AUTOMATIC OPTIMIZATION SERVICE CONTROL SYSTEM 审中-公开
标题翻译：自动交易自动优化服务控制系统
公开(公告)号：US20140188722A1
公开(公告)日：2014-07-03
申请号：US13882991
申请日：2012-07-04
申请人： Fei Xie , Qinghua Wang , Yunpei Chen , Xingfeng Xie , Pinde Tao
发明人： Fei Xie , Qinghua Wang , Yunpei Chen , Xingfeng Xie , Pinde Tao
IPC分类号： G06Q20/32
CPC分类号： G06Q20/3223 , G06Q20/18 , G07C11/00 , G07F9/02
摘要： A self-service transaction automatic optimization service control system is provided, which includes a time-slicing service mode generating module, a service interrupting signal generating module and a self-service terminal control module. Wherein, the time-slicing service mode generating module is configured to detect the current user queue of the self-service terminal and identify whether the user queue is in a long queue state, convert the self-service terminal from a general service mode to a time-slicing service mode if the user queue is in a long queue state, otherwise maintain the self-service terminal maintain in the general service mode, wherein the time-slicing service mode provides business service of specific time or specific number of times to the user currently in operation of the self-service terminal.
摘要翻译：提供一种自助交易自动优化服务控制系统，其中包括一个时间分片服务模式生成模块，一个业务中断信号生成模块和一个自助终端控制模块。其中，时分服务模式生成模块被配置为检测自服务终端的当前用户队列，并识别用户队列是否处于长队列状态，将自助终端从一般服务模式转换为如果用户队列处于长队列状态，则维持时间片服务模式，否则维护自助终端维护在一般服务模式，其中时间分片服务模式向特定时间或特定次数提供业务服务用户目前正在运营的自助终端。

6. 发明申请

US20100102219A1 ION GATE FOR DUAL ION MOBILITY SPECTROMETER AND METHOD THEREOF 有权
标题翻译：用于双离子移动光谱仪的离子通道及其方法
公开(公告)号：US20100102219A1
公开(公告)日：2010-04-29
申请号：US12579719
申请日：2009-10-15
申请人： Hua Peng , Qingjun Zhang , Jin Lin , Yuanjing Li , Zhiqiang Chen , Shaoji Mao , Zhude Dai , Shiping Cao , Zhongxia Zhang , Yangtian Zhang , Dexu Lin , Qinghua Wang , Zhang Qing Jun
发明人： Hua Peng , Qingjun Zhang , Jin Lin , Yuanjing Li , Zhiqiang Chen , Shaoji Mao , Zhude Dai , Shiping Cao , Zhongxia Zhang , Yangtian Zhang , Dexu Lin , Qinghua Wang , Zhang Qing Jun
IPC分类号： H01J49/02 , B01D59/44
CPC分类号： H01J3/04 , H01J49/004 , H01J49/061
摘要： Disclosed is an ion gate for a dual IMS and method. The ion gate includes an ion source, a first gate electrode placed on one side of the ion source, a second gate electrode placed on the other side of the ion source, a third gate electrode placed on the side of the first gate electrode away from the ion source, a fourth gate electrode placed on the side of the second gate electrode away from the ion source, wherein during the ion storage, the potential at the position on the tube axis of the ion gate corresponding to the first gate electrode is different from the potentials at the positions on the tube axis corresponding to the ion source and the third gate electrode, and the potential at the position on the tube axis corresponding to the second gate electrode is different from the potentials at the positions on the tube axis corresponding to the ion source and the fourth gate electrode. According to the present invention, after sample gas enters the ion gates, charge exchange with reaction ions occurs between the first gate electrode and the second electrode, and positive and negative ions are continuously stored into the storage regions for the positive and negative ions. This leads to an improvement of utility rate of ions. Then, the ions are educed in a step-wise manner from the storage regions for the positive and negative ions by a simple control of a combination of the electrodes.
摘要翻译：公开了一种用于双重IMS和方法的离子门。离子浇口包括离子源，位于离子源一侧的第一栅电极，位于离子源另一侧的第二栅电极，位于第一栅电极侧的第三栅电极，离子源，第四栅极放置在远离离子源的第二栅电极侧，其中在离子存储期间，对应于第一栅电极的离子门的管轴上的位置的电位不同从对应于离子源和第三栅电极的管轴上的位置的电位和对应于第二栅电极的管轴上的位置的电位与管轴对应的位置的电位不同到离子源和第四栅电极。根据本发明，在样品气体进入离子浇口之后，在第一栅电极和第二电极之间产生与反应离子的电荷交换，正离子和负离子被连续地存储在正离子和负离子的存储区中。这导致了离子的利用率的提高。然后，通过简单地控制电极的组合，从正离子和负离子的存储区域逐步地排出离子。

7. 发明申请

US20090309013A1 Electrode structure for drift tube in ion mobility spectrometer 有权
标题翻译：离子迁移谱仪中漂移管的电极结构
公开(公告)号：US20090309013A1
公开(公告)日：2009-12-17
申请号：US12455029
申请日：2009-05-27
申请人： Zhiqiang Chen , Yuanjing Li , Hua Peng , Qingjun Zhang , Jin Lin , Shaoji Mao , Zhude Dai , Shiping Cao , Zhongxia Zhang , Yangtian Zhang , Dexu Lin , Qinghua Wang , Shaofeng Wang , Hui Li
发明人： Zhiqiang Chen , Yuanjing Li , Hua Peng , Qingjun Zhang , Jin Lin , Shaoji Mao , Zhude Dai , Shiping Cao , Zhongxia Zhang , Yangtian Zhang , Dexu Lin , Qinghua Wang , Shaofeng Wang , Hui Li
IPC分类号： H01J49/00
CPC分类号： G01N27/622
摘要： Disclosed is an electrode structure for a drift tube in IMS comprising a ring electrode, for each of two surfaces of the ring electrode, at least a part adjacent to the inner radius is formed into a cone, and the angles formed between the cones and the axis of the ring electrode are different from each other. The electrode structure of the present invention can alleviate, even eliminate, the accumulation of space charges in the drift tube. Such structure is particularly suitable when the electric field in the drift tube is low in strength or a great number of ions pass through. Meanwhile, the structure allows a significant decrease in the size of the outer radius of the electrode, while the inner radius remains constant. In this way, it is possible to effectively reduce the outline size of the drift tube and thus make the IMS compact.
摘要翻译：公开了一种用于IMS中的漂移管的电极结构，包括环形电极，对于环形电极的两个表面中的每一个，至少与内半径相邻的部分形成为锥体，并且在锥体和环电极的轴线彼此不同。本发明的电极结构可以减轻甚至消除漂移管中空间电荷的累积。当漂移管中的电场强度低或大量离子通过时，这种结构特别合适。同时，结构允许电极的外半径的大小显着减小，而内半径保持恒定。以这种方式，可以有效地减小漂移管的轮廓尺寸，从而使得IMS紧凑。

8. 发明授权

US09463174B2 Pharmaceutical composition for the treatment of type-1 diabetes 有权
标题翻译：用于治疗1型糖尿病的药物组合物
公开(公告)号：US09463174B2
公开(公告)日：2016-10-11
申请号：US14223602
申请日：2014-03-24
申请人： Qinghua Wang
发明人： Qinghua Wang , Nepton Soltani
IPC分类号： C07H15/02 , A61K38/26 , A61K31/197 , A61K38/38 , A61K39/395 , G06F9/45 , G06F9/44
CPC分类号： A61K31/197 , A61K38/26 , A61K38/38 , A61K39/39533 , G06F8/51 , G06F8/76
摘要： A composition for the prevention or treatment of type I diabetes in a subject, said composition comprising a GABAergic and incretin exemplified by GABA and GLP-1/Ex4. These are optionally provided together in a single composition to promote beta-cell regeneration prevent beta-cell apoptosis and control autoimmunity for the prevention and treatment of T1D in mammals.
摘要翻译：用于预防或治疗受试者的I型糖尿病的组合物，所述组合物包含由GABA和GLP-1 / Ex4示例的GABA能和肠促胰岛素。这些可选地一起提供在单一组合物中以促进β-细胞再生，预防β-细胞凋亡并控制用于预防和治疗哺乳动物中T1D的自身免疫。

9. 发明申请

US20160054052A1 DEVICE FOR RAPID COOLING DRINKS 审中-公开
标题翻译：快速冷却饮料的设备
公开(公告)号：US20160054052A1
公开(公告)日：2016-02-25
申请号：US14792407
申请日：2015-07-06
申请人： QINGHUA WANG
发明人： QINGHUA WANG
IPC分类号： F25D31/00
CPC分类号： F25D3/08 , F25D2331/803
摘要： A device for rapidly cooling drinks, at least comprises a casing, a cooling component and a silica gel ring. The casing is arranged on the outermost end of the whole cooling device. Said cooling component is arranged in the casing, and is composed of a plurality of the same modules surrounded by the silica gel ring.The device is very convenient for use, since it is available only after being put into a freezing chamber of a refrigerator for a few hours and taken out of the refrigerator, and a red wine bottle filled with red wine is then inserted into the internal cooling component that is flexible to contain the red wine bottle with certain specification. A few minutes later, red wine is cooled down, having suitable temperature and mouthfeel. The technology can prevent the waste of water, meanwhile it is very environmentally friendly, easy to use, and reusable.
摘要翻译：用于快速冷却饮料的装置至少包括壳体，冷却部件和硅胶环。壳体布置在整个冷却装置的最外端。所述冷却部件布置在壳体中，并且由被硅胶环包围的多个相同的模块组成。该装置使用非常方便，因为它只有在放入冰箱的冷冻室几小时后才能从冰箱中取出，然后将装满红葡萄酒的红酒瓶插入内部冷却灵活地包含具有一定规格的红酒瓶的组件。几分钟后，红酒被冷却，具有适当的温度和口感。该技术可以防止水的浪费，同时环保，易于使用，可重复使用。

10. 发明授权

US08217365B2 Double-faced ion source 有权
标题翻译：双面离子源
公开(公告)号：US08217365B2
公开(公告)日：2012-07-10
申请号：US12437044
申请日：2009-05-07
申请人： Zhiqiang Chen , Yuanjing Li , Hua Peng , Qingjun Zhang , Jin Lin , Shaoji Mao , Zhude Dai , Shiping Cao , Zhongxia Zhang , Yangtian Zhang , Dexu Lin , Qinghua Wang , Shaofeng Wang , Hui Li
发明人： Zhiqiang Chen , Yuanjing Li , Hua Peng , Qingjun Zhang , Jin Lin , Shaoji Mao , Zhude Dai , Shiping Cao , Zhongxia Zhang , Yangtian Zhang , Dexu Lin , Qinghua Wang , Shaofeng Wang , Hui Li
IPC分类号： H01J27/20 , H01J49/14
CPC分类号： H01J49/14 , H01J27/20
摘要： Disclosed is an ion source comprising a plate-shaped source body which has radioactivity on its both sides and allows positive and negative ions to penetrate through the source body. The present invention gives beneficial effects. First, the ion source structure can improve the ionization efficiency of sample molecules, and the generated sample ions have a centralized distribution within a flat space on both sides of the source body. Such distribution of ion cloud facilitates to improve the IMS sensitivity. Meanwhile, the source body of the present invention has a transmittance in itself. Thus, positive and negative ions generated on both sides of the source body can penetrate through the source body and be separated to the both sides of the source body. In this way, it is possible to improve the utilization efficiency of ions.
摘要翻译：公开了一种离子源，其包括在其两侧具有放射性并允许正离子和负离子穿过源体的板状源体。本发明具有有益效果。首先，离子源结构可以提高样品分子的电离效率，并且所产生的样品离子在源体的两侧的平坦空间内具有集中分布。这种离子云的分布有助于提高IMS灵敏度。同时，本发明的源体本身具有透光性。因此，源体两侧产生的正离子和负离子可以穿透源体并分离到源体的两侧。以这种方式，可以提高离子的利用效率。

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