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    • 7. 发明授权
    • Mass separation method of magnolol from Magnoliae cortex radix
    • 厚朴从大叶皮质素的质量分离方法
    • US07608741B2
    • 2009-10-27
    • US11915721
    • 2005-06-21
    • Jin Sook KimYun Mi LeeDae Sik Jang
    • Jin Sook KimYun Mi LeeDae Sik Jang
    • C07C39/12
    • C07C37/82C07C37/004C07C37/685C07C37/84C07C39/21
    • The present invention related to method for the mass separation of magnolol from Magnoliae cortex or Magnoliae radix. The method comprises the steps of: 1) crushing Magnoliae cortex or Magnoliae radix, extracting the crushed material with organic solvent, adding n-hexane to the extract so as to obtain a n-hexane layer; 2) concentrating the n-hexane layer in a water bath at a temperature of 30-40° C. and a revolution speed of 40-200 RPM under reduced pressure so as to form a crude crystal; and 3) removing the n-hexane from the crude crystal, completely dissolving the crude crystal in chloroform, adding n-hexane to the n-hexane-containing solution, and leaving the solution to stand at room temperature so as to recrystallize the solution. In the method, a column chromatography step which is necessarily carried out in the general separation process is omitted so that separation process steps are reduced, leading to a saving in separation time. Also, expensive equipment is not required, leading a reduction in separation cost. Accordingly, the method is effective for the mass separation of expensive magnolol.
    • 本发明涉及厚朴与厚朴与木兰质量分离的方法。 该方法包括以下步骤:1)粉碎玉兰大麦或木兰,用有机溶剂萃取粉碎物,向提取液中加入正己烷,得到正己烷层; 2)将正己烷层在30-40℃的温度和40-200RPM的转速下在水浴中浓缩,以形成粗晶体; 3)从粗结晶中除去正己烷,将粗结晶完全溶解在氯仿中,向正己烷溶液中加入正己烷,使溶液在室温下静置,使溶液重结晶。 在该方法中,省略了在一般的分离过程中必须进行的柱色谱步骤,从而减少了分离工艺步骤,从而节省了分离时间。 此外,不需要昂贵的设备,导致分离成本的降低。 因此,该方法对于昂贵的厚朴酚的质量分离是有效的。