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1. 再颁专利

USRE42567E1 Electrochemical cell 有权
标题翻译：电化学电池
公开(公告)号：USRE42567E1
公开(公告)日：2011-07-26
申请号：US12899342
申请日：2010-10-06
申请人： Alastair M. Hodges , Thomas W. Beck , Oddvar Johansen , Ian Andrew Maxwell
发明人： Alastair M. Hodges , Thomas W. Beck , Oddvar Johansen , Ian Andrew Maxwell
IPC分类号： G01N27/327
CPC分类号： C12Q1/006 , C12Q1/004 , G01N27/3272
摘要： A biosensor for use in determining a concentration of a component in an aqueous liquid sample is provided including: an electrochemical cell having a first electrically resistive substrate having a thin layer of electrically conductive material, a second electrically resistive substrate having a thin layer of electrically conductive material, the substrates being disposed with the electrically conductive materials facing each other and being separated by a sheet including an aperture, the wall of which aperture defines a cell wall and a sample introduction aperture whereby the aqueous liquid sample may be introduced into the cell; and a measuring circuit.
摘要翻译：提供了一种用于确定含水液体样品中组分浓度的生物传感器，包括：电化学电池，具有具有导电材料薄层的第一电阻衬底，具有导电薄层的第二电阻衬底材料，所述基板被布置成导电材料相互面对并由包括孔的片分隔开，所述片的壁的孔限定细胞壁和样品引入孔，由此可将水性液体样品引入细胞中; 和测量电路。

2. 再颁专利

USRE44330E1 Electrochemical cell 有权
公开(公告)号：USRE44330E1
公开(公告)日：2013-07-02
申请号：US13100999
申请日：2011-05-04
申请人： Alastair M. Hodges , Thomas W. Beck , Oddvar Johansen
发明人： Alastair M. Hodges , Thomas W. Beck , Oddvar Johansen
IPC分类号： G01N27/327
CPC分类号： G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要： This invention relates to a biosensor and more particularly to an electrochemical biosensor for determining the concentration of an analyte in a carrier. The invention is particularly useful for determining the concentration of glucose in blood and is described herein with reference to that use but it should be understood that the invention is applicable to other analytic determinations.

3. 发明授权

US06454921B1 Electrochemical cell 失效
标题翻译：电化学电池
公开(公告)号：US06454921B1
公开(公告)日：2002-09-24
申请号：US09404119
申请日：1999-09-23
申请人： Alastair M. Hodges , Thomas W. Beck , Ian A. Maxwell
发明人： Alastair M. Hodges , Thomas W. Beck , Ian A. Maxwell
IPC分类号： G01N2726
CPC分类号： G01N27/3272
摘要： The invention relates to an amperometric electrochemical cell having a first insulating substrate carrying a first electrode, a second insulting substrate carrying a second electrode, said electrodes being disposed to face each other and spaced apart by less than 500 &mgr;m, and defining a sample reservoir therebetween, and wherein at least one, and preferably both, insulating substrates and the electrode carried thereon include an electromagnetic radiation transmissive portion in registration with said reservoir. The walls of the electrochemical cell may be formed from a thin metallic portion on a transparent substrate. Such cells are useful in providing visual confirmation of the validity of the electrochemical measurement.
摘要翻译：本发明涉及具有承载第一电极的第一绝缘衬底和承载第二电极的第二绝缘衬底的电流分析电化学电池，所述电极被设置为彼此面对并间隔小于500μm，并在其间限定一个样品容器并且其中至少一个绝缘基板和优选两个绝缘基板和其上承载的电极包括与所述储存器对准的电磁辐射透射部分。电化学电池的壁可以由透明基底上的薄金属部分形成。这样的细胞可用于提供电化学测量的有效性的视觉确认。

4. 发明授权

US07041210B2 Method of filling an amperometric cell 失效
公开(公告)号：US07041210B2
公开(公告)日：2006-05-09
申请号：US10387212
申请日：2003-03-10
申请人： Alastair M. Hodges , Thomas W. Beck , Ian A. Maxwell
发明人： Alastair M. Hodges , Thomas W. Beck , Ian A. Maxwell
IPC分类号： G01N27/327
CPC分类号： G01N27/3272
摘要： The invention relates to an amperometric electrochemical cell having a first insulating substrate carrying a first electrode, a second insulting substrate carrying a second electrode, said electrodes being disposed to face each other and spaced apart by less than 500 μm, and defining a sample reservoir therebetween, and wherein at least one, and preferably both, insulating substrates and the electrode carried thereon include an electromagnetic radiation transmissive portion in registration with said reservoir. The walls of the electrochemical cell may be formed from a thin metallic portion on a transparent substrate. Such cells are useful in providing visual confirmation of the validity of the electrochemical measurement.

5. 发明授权

US09739745B2 System and method for measuring an analyte in a sample 有权
公开(公告)号：US09739745B2
公开(公告)日：2017-08-22
申请号：US13620448
申请日：2012-09-14
申请人： Alastair M. Hodges , Ronald C. Chatelier
发明人： Alastair M. Hodges , Ronald C. Chatelier
IPC分类号： G01N27/327
摘要： Methods for calculating an analyte concentration of a sample are provided. In one exemplary embodiment the method includes steps that are directed toward accounting for inaccuracies that occur as a result of temperature variations in a sample, a meter, or the surrounding environment. In another exemplary embodiment the method includes steps that are directed toward determining whether an adequate sample is provided in a meter because insufficient samples can result in inaccuracies. The methods that are provided can be incorporated into a variety of mechanisms, but they are primarily directed toward glucose meters for blood samples and toward meters for controls solutions.

6. 发明授权

US08877034B2 Systems, devices, and methods for measuring whole blood hematocrit based on initial fill velocity 有权
标题翻译：基于初始填充速度测量全血血细胞比容的系统，装置和方法
公开(公告)号：US08877034B2
公开(公告)日：2014-11-04
申请号：US12649509
申请日：2009-12-30
申请人： Ronald C. Chatelier , Dennis Rylatt , Linda Raineri , Alastair M. Hodges
发明人： Ronald C. Chatelier , Dennis Rylatt , Linda Raineri , Alastair M. Hodges
IPC分类号： G01N33/49 , G01N33/80 , G01N33/48 , G01N27/48
CPC分类号： G01N27/3272 , G01N27/3273 , G01N27/3274 , G01N27/48 , G01N33/49 , G01N33/80 , G01N2333/4737
摘要： Methods for determining the hematocrit of a blood sample, and devices and systems used in conjunction with the same. The hematocrit value can be determined on its own, and further, it can be further used to determine a concentration of an analyte in a sample. In one exemplary embodiment of a method for determining the hematocrit value in a blood sample, a volume of blood is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and an initial fill velocity of the sample into the device is calculated. The hematocrit of the blood, as well as a concentration of an analyte in view of the initial fill velocity can then be determined. Systems and devices that take advantage of the use of an initial fill velocity to determine hematocrit levels and make analyte concentration determinations are also provided.
摘要翻译：用于确定血液样本的血细胞比容的方法，以及与之一起使用的装置和系统。血细胞比容值可以单独测定，而且还可以用于确定样品中分析物的浓度。在用于确定血液样品中的血细胞比容值的方法的一个示例性实施方案中，在具有工作和对电极的样品分析装置中提供体积的血液。在电极之间施加电位，并计算样品进入器件的初始填充速度。然后可以确定血液的血细胞比容，以及考虑到初始填充速度的分析物的浓度。还提供利用初始填充速度来确定血细胞比容水平并进行分析物浓度测定的系统和装置。

7. 发明申请

US20130306493A1 SYSTEMS AND METHODS FOR HIGH ACCURACY ANALYTE MEASUREMENT 有权
标题翻译：用于高精度分析测量的系统和方法
公开(公告)号：US20130306493A1
公开(公告)日：2013-11-21
申请号：US13824308
申请日：2010-12-31
申请人： Ronald C. Chatelier , Alastair M. Hodges
发明人： Ronald C. Chatelier , Alastair M. Hodges
IPC分类号： G01N27/327
CPC分类号： G01N27/4163 , C12Q1/006 , C12Q1/025 , G01N27/30 , G01N27/327 , G01N27/3272 , G01N27/3274 , G01N27/413 , G01N33/49
摘要： Methods for determining a concentration of an analyte in a sample, and the devices and systems used in conjunction with the same, are provided herein. In one exemplary embodiment of a method for determining a concentration of an analyte in a sample, a sample including an analyte is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and a first analyte concentration is determined. A second analyte concentration value is calculated from the first analyte concentration value and corrected for temperature effects, fill time and capacitance to provide for a final analyte concentration value.
摘要翻译：本文提供了用于确定样品中分析物浓度的方法以及与其一起使用的装置和系统。在用于确定样品中分析物浓度的方法的一个示例性实施方案中，在具有工作电极和对电极的样品分析装置中提供包括分析物的样品。在电极之间施加电位，并确定第一分析物浓度。根据第一分析物浓度值计算第二分析物浓度值，并对温度影响，填充时间和电容进行校正以提供最终分析物浓度值。

8. 发明申请

US20130098763A1 SYSTEM AND METHOD FOR MEASURING AN ANALYTE IN A SAMPLE 有权
公开(公告)号：US20130098763A1
公开(公告)日：2013-04-25
申请号：US13619241
申请日：2012-09-14
申请人： Ronald C. Chatelier , Alastair M. Hodges , Santhanagopalan Nandagopalan
发明人： Ronald C. Chatelier , Alastair M. Hodges , Santhanagopalan Nandagopalan
IPC分类号： C12Q1/00
CPC分类号： G01N27/4163 , C12Q1/006 , G01N27/3274
摘要： Methods of determining a corrected analyte concentration in view of some error source are provided herein. The methods can be utilized for the determination of various analytes and/or various sources of error. In one example, the method can be configured to determine a corrected glucose concentration in view of an extreme level of hematocrit found within the sample. In other embodiments, methods are provided for identifying various system errors and/or defects. For example, such errors can include partial-fill or double-fill situations, high track resistance, and/or sample leakage. Systems are also provided for determining a corrected analyte concentration and/or detecting some system error.

9. 发明申请

US20130008804A1 SYSTEM AND METHOD FOR MEASURING AN ANALYTE IN A SAMPLE 有权
公开(公告)号：US20130008804A1
公开(公告)日：2013-01-10
申请号：US13620448
申请日：2012-09-14
申请人： Alastair M. Hodges , Ronald C. Chatelier
发明人： Alastair M. Hodges , Ronald C. Chatelier
IPC分类号： G01N27/26
CPC分类号： G01N27/3274
摘要： Methods for calculating an analyte concentration of a sample are provided. In one exemplary embodiment the method includes steps that are directed toward accounting for inaccuracies that occur as a result of temperature variations in a sample, a meter, or the surrounding environment. In another exemplary embodiment the method includes steps that are directed toward determining whether an adequate sample is provided in a meter because insufficient samples can result in inaccuracies. The methods that are provided can be incorporated into a variety of mechanisms, but they are primarily directed toward glucose meters for blood samples and toward meters for controls solutions.

10. 发明申请

US20110155584A1 Systems, Devices, and Methods for Measuring Whole Blood Hematocrit Based on Initial Fill Velocity 有权
标题翻译：基于初始填充速度测量全血血细胞比容的系统，设备和方法
公开(公告)号：US20110155584A1
公开(公告)日：2011-06-30
申请号：US12649509
申请日：2009-12-30
申请人： Ronald C. Chatelier , Dennis Rylatt , Linda Raineri , Alastair M. Hodges
发明人： Ronald C. Chatelier , Dennis Rylatt , Linda Raineri , Alastair M. Hodges
IPC分类号： G01N27/26
CPC分类号： G01N27/3272 , G01N27/3273 , G01N27/3274 , G01N27/48 , G01N33/49 , G01N33/80 , G01N2333/4737
摘要： Methods for determining the hematocrit of a blood sample, and devices and systems used in conjunction with the same. The hematocrit value can be determined on its own, and further, it can be further used to determine a concentration of an analyte in a sample. In one exemplary embodiment of a method for determining the hematocrit value in a blood sample, a volume of blood is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and an initial fill velocity of the sample into the device is calculated. The hematocrit of the blood, as well as a concentration of an analyte in view of the initial fill velocity can then be determined. Systems and devices that take advantage of the use of an initial fill velocity to determine hematocrit levels and make analyte concentration determinations are also provided.
摘要翻译：用于确定血液样本的血细胞比容的方法，以及与之一起使用的装置和系统。血细胞比容值可以单独测定，而且还可以用于确定样品中分析物的浓度。在用于确定血液样品中的血细胞比容值的方法的一个示例性实施方案中，在具有工作和对电极的样品分析装置中提供体积的血液。在电极之间施加电位，并计算样品进入器件的初始填充速度。然后可以确定血液的血细胞比容，以及考虑到初始填充速度的分析物的浓度。还提供利用初始填充速度来确定血细胞比容水平并进行分析物浓度测定的系统和装置。

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