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    • 5. 发明授权
    • Glucagon antagonists
    • 胰高血糖素拮抗剂
    • US08981047B2
    • 2015-03-17
    • US12739342
    • 2008-10-23
    • Richard D. DimarchiBin Yang
    • Richard D. DimarchiBin Yang
    • A61K38/26C07K14/605C07K14/00A61K38/00
    • C07K14/605A61K38/00
    • Glucagon antagonists are provided which comprise amino acid substitutions and/or chemical modifications to glucagon sequence. In one embodiment, the glucagon antagonists comprise a native glucagon peptide that has been modified by the deletion of the first two to five amino acid residues from the N-terminus and (i) an amino acid substitution at position 9 (according to the numbering of native glucagon) or (ii) substitution of the Phe at position 6 (according to the numbering of native glucagon) with phenyl lactic acid (PLA). In another embodiment, the glucagon antagonists comprise the structure A-B-C as described herein, wherein A is PLA, an oxy derivative thereof, or a peptide of 2-6 amino acids in which two consecutive amino acids of the peptide are linked via an ester or ether bond.
    • 提供了包含对胰高血糖素序列的氨基酸取代和/或化学修饰的胰高血糖素拮抗剂。 在一个实施方案中,胰高血糖素拮抗剂包含通过从N-末端缺失前两个至五个氨基酸残基而修饰的天然胰高血糖素肽,以及(i)在第9位的氨基酸取代(根据 天然胰高血糖素)或(ii)用苯基乳酸(PLA)取代第6位的Phe(根据天然胰高血糖素的编号)。 在另一个实施方案中,胰高血糖素拮抗剂包含如本文所述的结构ABC,其中A是PLA,其氧衍生物或2-6个氨基酸的肽,其中肽的两个连续氨基酸经由酯或醚连接 键。
    • 10. 发明申请
    • WATERMARKING IMAGE BLOCK DIVISION METHOD AND DEVICE FOR WESTERN LANGUAGE WATERMARKING PROCESSING
    • WATERMARKING图像块分割方法和西语言水印处理装置
    • US20140003649A1
    • 2014-01-02
    • US13997258
    • 2011-12-23
    • Gaoyang WangWenfa QiLidong WangBin Yang
    • Gaoyang WangWenfa QiLidong WangBin Yang
    • G06T1/00
    • G06T1/0021G06K9/348G06K2209/01G06T2201/0051G06T2201/0062G06T2201/0083
    • The application provides a method for partitioning a watermark image with western language characters, comprising: partitioning a western language characters image along rows and columns to form a plurality of character image blocks; identifying valid character image blocks from the formed character image blocks; counting sizes of the valid character image blocks to determine if the image corresponds to a document with a large font size or a document with a small font size; dividing words in the image into a plurality of groups, wherein each divided group in the document with large font size has different numbers of words from that with small font size; and dividing equally the divided word groups into multiple portions corresponding to watermark image blocks. The application further provides a device for partitioning a watermark image with western language characters. The operability of watermark embedding process can be ensured through the above technical solution.
    • 该应用程序提供了一种用于用西方语言字符分割水印图像的方法,包括:沿着行和列划分西方语言字符图像以形成多个字符图像块; 从形成的字符图像块中识别有效的字符图像块; 计算有效字符图像块的大小,以确定图像是否对应于具有较大字体大小的文档或具有小字体大小的文档; 将图像中的单词划分成多个组,其中具有大字体大小的文档中的每个划分组具有与具有小字体尺寸的单词不同的字数; 并将划分的字组分成相当于水印图像块的多个部分。 该应用还提供了一种用于用西语字符分割水印图像的设备。 通过上述技术方案可以确保水印嵌入过程的可操作性。