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1. 发明授权

US08114289B2 Method and apparatus for microfiltration to perform cell separation 有权
标题翻译：微滤法进行细胞分离的方法和装置
公开(公告)号：US08114289B2
公开(公告)日：2012-02-14
申请号：US12360067
申请日：2009-01-26
申请人： Siyang Zheng , Richard Cote , Henry Lin , Bo Lu , Yu-Chong Tai
发明人： Siyang Zheng , Richard Cote , Henry Lin , Bo Lu , Yu-Chong Tai
IPC分类号： B01D63/00 , B41J2/175
CPC分类号： B01D69/12 , B01D61/18 , B01D63/082 , B01D67/0034 , B01D71/28 , B01D2325/021
摘要： A microfiltration apparatus and method for separating cells, such as circulating tumor cells, from a sample using a microfiltration device having a top porous membrane and a bottom porous membrane. The porous membranes are formed from parylene and assembled using microfabrication techniques. The porous membranes are arranged so that the pores in the top membrane are offset from the pores in the bottom membrane.
摘要翻译：一种使用具有顶部多孔膜和底部多孔膜的微量过滤装置从样品中分离诸如循环肿瘤细胞的细胞的微滤装置和方法。多孔膜由聚对二甲苯形成并使用微细加工技术组装。多孔膜被布置成使得顶部膜中的孔与底部膜中的孔偏离。

2. 发明申请

US20110294206A1 METHODS AND DESIGN OF MEMBRANE FILTERS 审中-公开
标题翻译：膜过滤器的方法与设计
公开(公告)号：US20110294206A1
公开(公告)日：2011-12-01
申请号：US13078870
申请日：2011-04-01
申请人： YU-CHONG TAI , Bo Lu
发明人： YU-CHONG TAI , Bo Lu
IPC分类号： C12N5/09
CPC分类号： G01N33/5011 , B01D65/10
摘要： The present invention provides methods for designing a filtration systems for capturing viable tumor cells, such as circulating tumor cells at high efficiency and high viability. The methods involve development of a set of “key engineering design parameters” that are crucial to achieve high tumor cell viability. These important design parameters include the filter geometry design, fluid delivery method, drive pressure and filtration time.
摘要翻译：本发明提供了用于设计用于捕获活肿瘤细胞的过滤系统的方法，例如高效率和高活力的循环肿瘤细胞。这些方法涉及开发一组对于实现高肿瘤细胞活力至关重要的“关键工程设计参数”。这些重要的设计参数包括过滤器几何设计，流体输送方法，驱动压力和过滤时间。

3. 发明申请

US20100198464A1 DIAGNOSABLE MAGNETIC SWITCH ASSEMBLY 审中-公开
标题翻译：诊断磁力开关总成
公开(公告)号：US20100198464A1
公开(公告)日：2010-08-05
申请号：US12696086
申请日：2010-01-29
申请人： Randall T. Jones , Bo Lu
发明人： Randall T. Jones , Bo Lu
IPC分类号： A47C7/62 , H01H36/00
CPC分类号： H01H36/0006 , B60N2/002 , B60R21/01524
摘要： A diagnosable magnetic switch assembly and method for determining a seat occupant. A network in the assembly includes a resistor in series with a magnetic switch, and a resistor in parallel with the series combination. Such an arrangement provides distinct assembly resistance values when the magnetic switch is open or closed, and thereby provides a means for diagnosing the operational state of the diagnosable magnetic switch assembly. The diagnosable magnetic switch assembly may be included in a seat occupant indicator system that embeds the seat occupant indicator system and a magnet in a cushion of a seat assembly. When the seat assembly is occupied, the magnet is separated from the seat occupant indicator system by a sufficient distance so the seat occupant indicator system is in an open state. When an occupant sits in the seat assembly, the magnet and the seat occupant indicator system are brought closer together so that the magnetic field operate the seat occupant indicator system to a closed state. A controller measures the assembly resistance values to determine if the seat assembly is empty, occupied, or if an assembly fault state is occurring.
摘要翻译：一种用于确定座椅乘客的可诊断磁开关组件和方法。组件中的网络包括与磁开关串联的电阻器和与串联组合并联的电阻器。这种布置在磁性开关打开或关闭时提供不同的组装电阻值，从而提供用于诊断可诊断磁性开关组件的操作状态的装置。可诊断的磁性开关组件可以包括在将座椅乘员指示器系统和磁体嵌入座椅组件的坐垫中的座椅乘员指示器系统中。当座椅组件被占用时，磁体与座椅乘员指示器系统分离足够的距离，使得座椅乘员指示器系统处于打开状态。当乘员坐在座椅组件中时，磁体和座椅乘员指示器系统被更靠近在一起，使得磁场将座椅乘员指示器系统操作到关闭状态。控制器测量组合电阻值，以确定座椅组件是否为空，占用，或者是否发生装配故障状态。

4. 发明申请

US20100093317A1 Targeted Advertisements to Social Contacts 有权
标题翻译：针对社交联系人的广告
公开(公告)号：US20100093317A1
公开(公告)日：2010-04-15
申请号：US12248720
申请日：2008-10-09
申请人： Vishal V. Ghotge , Bo Lu , Karl P. Karlsson
发明人： Vishal V. Ghotge , Bo Lu , Karl P. Karlsson
IPC分类号： H04W4/00
CPC分类号： H04L67/306 , G06Q30/02 , H04L12/1859 , H04L51/38 , H04L67/20 , H04L67/22
摘要： Targeted advertisements to social contacts is described. In embodiment(s), social contacts can be correlated based on messaging interactions between mobile communication devices that are associated with the social contacts. Feedback about an advertisement can be received from mobile communication devices that are associated with the social contacts, and the advertisement can then be targeted to one or more of the social contacts based on the feedback about the advertisement.
摘要翻译：描述了针对社交联系人的目标广告。在实施例中，社交联系人可以基于与社交联系人相关联的移动通信设备之间的消息交互相关联。可以从与社交联系人相关联的移动通信设备接收关于广告的反馈，然后可以基于关于广告的反馈将广告定位到一个或多个社交联系人。

5. 发明申请

US20090188864A1 METHOD AND APPARATUS FOR MICROFILTRATION TO PERFORM CELL SEPARATION 有权
标题翻译：用于微细分离以进行细胞分离的方法和装置
公开(公告)号：US20090188864A1
公开(公告)日：2009-07-30
申请号：US12360067
申请日：2009-01-26
申请人： Siyang Zheng , Richard Cote , Henry Lin , Bo Lu , Yu-Chong Tai
发明人： Siyang Zheng , Richard Cote , Henry Lin , Bo Lu , Yu-Chong Tai
IPC分类号： B01D69/12 , B01D61/14 , B01D65/02 , B44C1/22
CPC分类号： B01D69/12 , B01D61/18 , B01D63/082 , B01D67/0034 , B01D71/28 , B01D2325/021
摘要： A microfiltration apparatus and method for separating cells, such as circulating tumor cells, from a sample using a microfiltration device having a top porous membrane and a bottom porous membrane. The porous membranes are formed from parylene and assembled using microfabrication techniques. The porous membranes are arranged so that the pores in the top membrane are offset from the pores in the bottom membrane.
摘要翻译：一种使用具有顶部多孔膜和底部多孔膜的微量过滤装置从样品中分离诸如循环肿瘤细胞的细胞的微滤装置和方法。多孔膜由聚对二甲苯形成并使用微细加工技术组装。多孔膜被布置成使得顶部膜中的孔与底部膜中的孔偏离。

6. 发明授权

US08899531B2 Clamping device for electrical cables 有权
标题翻译：电缆夹紧装置
公开(公告)号：US08899531B2
公开(公告)日：2014-12-02
申请号：US13968203
申请日：2013-08-15
申请人： Bo Lu
发明人： Bo Lu
IPC分类号： F16L3/22 , F16L3/10
CPC分类号： F16L3/105 , H02G3/32
摘要： A clamping device includes a first clamping member, a second clamping member, and a connecting arrangement providing on the first clamping member and the second clamping member. The connecting arrangement is configured to exert a clamping force between the first clamping member and the second clamping member, in such a manner that when the electrical cable slightly deforms due to thermal expansion and contraction, the first clamping member and the second clamping member are arranged to move with respect to each other so as to allow a slight relative movement between the first clamping member and the second clamping member for preventing unwanted damage to the electrical cable.
摘要翻译：夹紧装置包括第一夹紧构件，第二夹紧构件和设置在第一夹紧构件和第二夹紧构件上的连接装置。连接装置被配置为在第一夹持件和第二夹紧件之间施加夹紧力，使得当电缆由于热膨胀和收缩而稍微变形时，第一夹紧件和第二夹紧件被布置相对于彼此移动，以便允许第一夹紧构件和第二夹紧构件之间的轻微相对移动，以防止对电缆的不必要的损坏。

7. 发明授权

US08877489B2 Ultrathin parylene-C semipermeable membranes for biomedical applications 有权
标题翻译：用于生物医学应用的超薄聚对二甲苯-C半透膜
公开(公告)号：US08877489B2
公开(公告)日：2014-11-04
申请号：US13355426
申请日：2012-01-20
申请人： Yu-Chong Tai , Bo Lu , Mark Humayun
发明人： Yu-Chong Tai , Bo Lu , Mark Humayun
IPC分类号： C12M1/12 , C12M1/00 , C12M3/00 , A01N1/00 , A01N1/02
CPC分类号： A61L27/16 , A61L27/50 , A61L27/56 , A61L2430/16 , B01D71/44 , B01D2325/06 , C12N5/0068 , C12N2533/30 , C12N2535/10 , C12N2539/00
摘要： Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 μm to 5 μm thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The thin regions of parylene are semipermeable to allow for proteins in serum to pass through, and the thick regions give mechanical support for handling by a surgeon. The smooth front side allows for monolayer cell growth, and the rough back side helps prevents cells from attaching there.
摘要翻译：公开了具有较厚区域散布的具有光滑前侧和超薄区域（例如，0.01μm至5μm厚）的薄聚对二甲苯C膜。与光滑的前侧相比，膜的背面可能是粗糙的。膜可以在体外用于在实验室或体内生长细胞的单层，作为外科手术植入的生长层，例如替代眼睛中的Bruch膜。聚对二甲苯的薄区域是半渗透性的，以允许血清中的蛋白质通过，并且厚区域给予外科医生处理的机械支持。光滑的前侧允许单层细胞生长，粗糙的背面有助于防止细胞附着在那里。

8. 发明授权

US08265606B2 Targeted advertisements to social contacts 有权
标题翻译：针对广告的社会接触
公开(公告)号：US08265606B2
公开(公告)日：2012-09-11
申请号：US12248720
申请日：2008-10-09
申请人： Vishal V. Ghotge , Bo Lu , Karl P. Karlsson
发明人： Vishal V. Ghotge , Bo Lu , Karl P. Karlsson
IPC分类号： H04M3/42
CPC分类号： H04L67/306 , G06Q30/02 , H04L12/1859 , H04L51/38 , H04L67/20 , H04L67/22
摘要： Targeted advertisements to social contacts is described. In embodiment(s), social contacts can be correlated based on messaging interactions between mobile communication devices that are associated with the social contacts. Feedback about an advertisement can be received from mobile communication devices that are associated with the social contacts, and the advertisement can then be targeted to one or more of the social contacts based on the feedback about the advertisement.
摘要翻译：描述了针对社交联系人的目标广告。在实施例中，社交联系人可以基于与社交联系人相关联的移动通信设备之间的消息交互相关联。可以从与社交联系人相关联的移动通信设备接收关于广告的反馈，然后可以基于关于广告的反馈将广告定位到一个或多个社交联系人。

9. 发明申请

US20120178097A1 METHODS AND DESIGN OF MEMBRANE FILTERS 有权
标题翻译：膜过滤器的方法与设计
公开(公告)号：US20120178097A1
公开(公告)日：2012-07-12
申请号：US13118332
申请日：2011-05-27
申请人： Yu-Chong Tai , Bo Lu
发明人： Yu-Chong Tai , Bo Lu
IPC分类号： C12N5/071 , C12N5/078 , G01N21/64 , C12M1/12 , C12Q1/02 , C12N5/04 , C12N5/09
CPC分类号： G01N33/5011 , B01D63/087 , B01D65/10 , B01D67/0034 , B01D2325/021 , C12M47/04
摘要： The present invention provides methods for designing a filtration systems for capturing viable tumor cells, such as circulating tumor cells at high efficiency and high viability. The methods involve development of a set of “key engineering design parameters” that are crucial to achieve high tumor cell viability. These important design parameters include the filter geometry design, fluid delivery method, transfilter pressure and total filtration time.
摘要翻译：本发明提供了用于设计用于捕获活肿瘤细胞的过滤系统的方法，例如高效率和高活力的循环肿瘤细胞。这些方法涉及开发一组对于实现高肿瘤细胞活力至关重要的“关键工程设计参数”。这些重要的设计参数包括过滤器几何设计，流体输送方法，输送机压力和总过滤时间。

10. 发明申请

US20110087842A1 PRE-FETCHING CONTENT ITEMS BASED ON SOCIAL DISTANCE 有权
标题翻译：基于社会距离的预制内容项目
公开(公告)号：US20110087842A1
公开(公告)日：2011-04-14
申请号：US12577464
申请日：2009-10-12
申请人： Bo Lu , Raghavendra Malpani , Joseph A. Porkka , Bartosz Henryk Paliswiat , Christian Bøgh Jensen , Sushil Kumar
发明人： Bo Lu , Raghavendra Malpani , Joseph A. Porkka , Bartosz Henryk Paliswiat , Christian Bøgh Jensen , Sushil Kumar
IPC分类号： G06F15/16 , G06F12/08
CPC分类号： G06F17/30867 , G06F17/30902
摘要： Retrieving content items based on a social distance between a user and content providers. The social distance is determined based on, for example, user interaction with the content providers. The content providers are ranked, for the user, based on the determined social distance. Prior to a request from the user, the content items are pre-fetched based on the ranked content providers and constraints such as storage space, bandwidth, and battery power level of a computing device of the user. In some embodiments, additional content items are retrieved, or retrieved content items are deleted, as a variable-size cache on the computing device fills or changes size.
摘要翻译：基于用户和内容提供商之间的社交距离检索内容项。基于例如用户与内容提供商的交互来确定社交距离。内容提供商根据确定的社交距离对用户进行排名。在来自用户的请求之前，基于排名内容提供商和诸如用户的计算设备的存储空间，带宽和电池功率级别的约束来预取内容项。在一些实施例中，随着计算设备上的可变大小的高速缓存填充或改变大小，检索附加内容项目或检索到的内容项目。

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