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1. 发明授权

US06989184B2 Polymeric void-board 失效
标题翻译：聚合物空隙板
公开(公告)号：US06989184B2
公开(公告)日：2006-01-24
申请号：US10803398
申请日：2004-03-18
申请人： David J. Duke , William J. Williams , John M. Kruelle , Tilak R. Varma
发明人： David J. Duke , William J. Williams , John M. Kruelle , Tilak R. Varma
IPC分类号： B65D65/28 , B32B3/28 , A47F1/04
CPC分类号： B65D71/0088 , B65D85/46 , B65D2571/00043 , Y10T428/15 , Y10T428/2457
摘要： An extruded polymeric void-board is configured for placement between adjacent horizontal layers of bricks to maintain an opening in a lower layer of the bricks. The void-board is formed as a relatively thin planar element having first and second surfaces. A plurality of parallel ribs extend from and generally transverse to the first side. The ribs have a predetermined height to width ratio and have a height that is less than a thickness of the planar element. The ribs being formed parallel to one another. A method for forming a bundle of bricks with the void-board is also disclosed.
摘要翻译：挤压的聚合物空隙板被配置为放置在相邻的水平砖块之间，以保持砖的下层中的开口。空隙板形成为具有第一和第二表面的相对薄的平面元件。多个平行肋从第一侧延伸并且大致横向于第一侧。肋具有预定的高宽比，并且具有小于平面元件的厚度的高度。肋形成为彼此平行。还公开了一种用于形成具有空隙板的砖块的方法。

2. 发明授权

US08679610B2 Enhanced void board 失效
标题翻译：增强空白板
公开(公告)号：US08679610B2
公开(公告)日：2014-03-25
申请号：US12125303
申请日：2008-05-22
申请人： John M. Kruelle , Antonio W. Brister , David J. Duke
发明人： John M. Kruelle , Antonio W. Brister , David J. Duke
IPC分类号： B32B3/28 , B65D65/28 , A47F1/04
CPC分类号： B65D71/0088 , B65D2571/00043 , Y10T428/15 , Y10T428/24322 , Y10T428/24479 , Y10T428/2457 , Y10T428/24587 , Y10T428/24942 , Y10T428/2495
摘要： An enhanced polymeric void board for placement between adjacent horizontal layers of masonry materials to maintain an opening in a lower of the layers, the enhanced void board comprising a relatively thin planar element having a plurality of ribs extending along the length of the planar element.
摘要翻译：一种增强的聚合物空隙板，用于放置在相邻的水泥层之间的砖石材料中以保持下层中的开口，增强的空隙板包括相对薄的平面元件，该平面元件具有沿平面元件的长度延伸的多个肋。

3. 发明申请

US20080311335A1 ENHANCED VOID BOARD 失效
标题翻译：增强无线电板
公开(公告)号：US20080311335A1
公开(公告)日：2008-12-18
申请号：US12125303
申请日：2008-05-22
申请人： John M. Kruelle , Antonio W. Brister , David J. Duke
发明人： John M. Kruelle , Antonio W. Brister , David J. Duke
IPC分类号： B65D65/28 , B32B3/30 , B32B3/24
CPC分类号： B65D71/0088 , B65D2571/00043 , Y10T428/15 , Y10T428/24322 , Y10T428/24479 , Y10T428/2457 , Y10T428/24587 , Y10T428/24942 , Y10T428/2495
摘要： An enhanced polymeric void board for placement between adjacent horizontal layers of masonry materials to maintain an opening in a lower of the layers, the enhanced void board comprising a relatively thin planar element having a plurality of ribs extending along the length of the planar element.
摘要翻译：一种增强的聚合物空隙板，用于放置在相邻的水泥层之间的砖石材料中以保持下层中的开口，增强的空隙板包括相对薄的平面元件，该平面元件具有沿平面元件的长度延伸的多个肋。

4. 发明授权

US5693622A Expression of exogenous polynucleotide sequences cardiac muscle of a mammal 失效
标题翻译：外源多核苷酸序列在哺乳动物心肌中的表达
公开(公告)号：US5693622A
公开(公告)日：1997-12-02
申请号：US480039
申请日：1995-06-07
申请人： Jon A. Wolff , David J. Duke , Philip L. Felgner
发明人： Jon A. Wolff , David J. Duke , Philip L. Felgner
IPC分类号： A61K48/00 , C12N15/87 , C12N15/00
CPC分类号： B82Y5/00 , A61K48/00 , C12N15/87
摘要： The present invention provides a method for delivering a pharmaceutical polypeptide to the interior of a cardiac cell of a vertebrate in vivo, comprising the step of introducing a preparation comprising a pharmaceutically acceptable injectable carrier and naked polynucleotide operatively coding for the polypeptide into the interstitial space of the heart, whereby the naked polynucleotide is taken up into the interior of the cell and has a pharmacological effect on the vertebrate. In a preferred embodiment wherein the polynucleotide encodes polypeptide immunologically foreign to the vertebrate, the delivery method preferably comprises delivering an immunosuppressive agent to the vertebrate to limit immune responses directed to the polypeptide.
摘要翻译：本发明提供了一种用于在体内将药物多肽递送至脊椎动物心脏细胞内部的方法，其包括将包含药学上可接受的可注射载体的制剂和可操作地编码多肽的裸核苷酸引入到心脏，其中裸多核苷酸被吸收到细胞内部并且对脊椎动物具有药理作用。在其中多核苷酸编码对脊椎动物免疫外源的多肽的优选实施方案中，递送方法优选包括将免疫抑制剂递送至脊椎动物以限制针对多肽的免疫应答。

5. 发明授权

US06228844B1 Stimulating vascular growth by administration of DNA sequences encoding VEGF 失效
标题翻译：通过施用编码VEGF的DNA序列刺激血管生长
公开(公告)号：US06228844B1
公开(公告)日：2001-05-08
申请号：US08979686
申请日：1997-11-26
申请人： Jon A. Wolff , David J. Duke , Philip L. Felgner
发明人： Jon A. Wolff , David J. Duke , Philip L. Felgner
IPC分类号： A61K3800
CPC分类号： A61K48/00 , C12N15/87
摘要： The present invention provides a method for delivering a pharmaceutical polypeptide to the interior of a cardiac cell of a vertebrate in vivo, comprising the step of introducing a preparation comprising a pharmaceutically acceptable injectable carrier and naked polynucleotide operatively coding for the polypeptide into the interstitial space of the heart, whereby the naked polynucleotide is taken up into the interior of the cell and has a pharmacological effect on the vertebrate such as inducing vascular growth. In a preferred embodiment wherein the polynucleotide encodes polypeptide immunologically foreign to the vertebrate, the delivery method preferably comprises delivering an immunosuppressive agent to the vertebrate to limit immune responses directed to the polypeptide.
摘要翻译：本发明提供了一种用于在体内将药物多肽递送至脊椎动物心脏细胞内部的方法，其包括将包含药学上可接受的可注射载体的制剂和可操作地编码多肽的裸核苷酸引入到心脏，由此裸露的多核苷酸被吸收到细胞的内部并且对脊椎动物具有药理作用，例如诱导血管生长。在其中多核苷酸编码对脊椎动物免疫外源的多肽的优选实施方案中，递送方法优选包括将免疫抑制剂递送至脊椎动物以限制针对多肽的免疫应答。

6. 发明授权

US06706694B1 Expression of exogenous polynucleotide sequences in a vertebrate 失效
标题翻译：外源多核苷酸序列在脊椎动物中的表达
公开(公告)号：US06706694B1
公开(公告)日：2004-03-16
申请号：US09588655
申请日：2000-06-06
申请人： Jon A. Wolff , David J. Duke , Philip L. Felgner
发明人： Jon A. Wolff , David J. Duke , Philip L. Felgner
IPC分类号： A61K4800
CPC分类号： B82Y5/00 , A61K48/00 , C12N15/87
摘要： The present invention provides a method for delivering a pharmaceutical polypeptide to the interior of a cardiac cell of a vertebrate in vivo, comprising the step of introducing a preparation comprising a pharmaceutically acceptable injectable carrier and naked polynucleotide operatively coding for the polypeptide into the interstitial space of the heart, whereby the naked polynucleotide is taken up into the interior of the cell and has a pharmacological effect on the vertebrate. In a preferred embodiment wherein the polynucleotide encodes polypeptide immunologically foreign to the vertebrate, the delivery method preferably comprises delivering an immunosuppressive agent to the vertebrate to limit immune responses directed to the polypeptide.
摘要翻译：本发明提供了一种用于在体内将药物多肽递送至脊椎动物心脏细胞内部的方法，其包括将包含药学上可接受的可注射载体的制剂和可操作地编码多肽的裸核苷酸引入到心脏，其中裸多核苷酸被吸收到细胞内部并且对脊椎动物具有药理作用。在其中多核苷酸编码对脊椎动物免疫外源的多肽的优选实施方案中，递送方法优选包括将免疫抑制剂递送至脊椎动物以限制针对多肽的免疫应答。

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