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    • 9. 发明授权
    • Dynamically variable separation among nanoparticles for nano-enhanced Raman spectroscopy (NERS) molecular sensing
    • 用于纳米增强拉曼光谱(NERS)分子感测的纳米颗粒之间的动态变化分离
    • US07342656B2
    • 2008-03-11
    • US11252134
    • 2005-10-17
    • M. Saif IslamShih-Yuan WangR. Stanley WilliamsPhilip J. KuekesWei WuZhiyong Li
    • M. Saif IslamShih-Yuan WangR. Stanley WilliamsPhilip J. KuekesWei WuZhiyong Li
    • G01J3/44G01N21/65
    • G01N21/658
    • A NERS-active structure includes a deformable, active nanoparticle support structure for supporting a first nanoparticle and a second nanoparticle that is disposed proximate the first nanoparticle. The nanoparticles each comprise a NERS-active material. The deformable, active nanoparticle support structure is configured to vary the distance between the first nanoparticle and the second nanoparticle while performing NERS. Various active nanoparticle support structures are disclosed. A NERS system includes such a NERS-active structure, a radiation source for generating radiation scatterable by an analyte located proximate the NERS-active structure, and a radiation detector for detecting Raman scattered radiation scattered by the analyte. A method for performing NERS includes providing such a NERS-active structure, providing an analyte at a location proximate the NERS-active structure, irradiating the NERS-active structure and the analyte with radiation, varying the distance between the nanoparticles, and detecting Raman scattered radiation scattered by the analyte.
    • NERS活性结构包括用于支撑第一纳米颗粒的可变形的活性纳米颗粒支撑结构和邻近第一纳米颗粒设置的第二纳米颗粒。 纳米颗粒各自包含NERS-活性材料。 可变形的活性纳米颗粒支撑结构被配置为在执行NERS的同时改变第一纳米颗粒和第二纳米颗粒之间的距离。 公开了各种活性纳米颗粒载体结构。 NERS系统包括这样的NERS-活性结构,用于产生由位于NERS-活性结构附近的分析物可散射的辐射的辐射源,以及用于检测被分析物散射的拉曼散射辐射的辐射检测器。 执行NERS的方法包括提供这样的NERS活性结构,在靠近NERS-活性结构的位置提供分析物,用辐射照射NERS-活性结构和分析物,改变纳米颗粒之间的距离并检测拉曼散射 被分析物散射的辐射。