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    • 9. 发明授权
    • Antiviral phosphonate nucleotides
    • 抗病毒膦酸核苷酸
    • US06444656B1
    • 2002-09-03
    • US09534490
    • 2000-03-24
    • Nghe Nguyen-BaRabindra Rej
    • Nghe Nguyen-BaRabindra Rej
    • A61K31525
    • C07H15/04C07H19/04C07H19/06C07H19/16
    • The present invention relates to a novel nucleotide analogue having the general formula (I) and pharmaceutically acceptable salts, esters, or salt of such esters: wherein n, X, Q U R1′, R1, Z and R2 are defined here within. The compounds object of the present invention may be a single enantiomers or as mixtures of said enantiomers, the compounds may have a &agr;D, &agr;-L, &bgr;-D, &bgr;-L, R or S configuration at each chiral center or mixtures thereof. This invention also relates to pharmaceutical compositions containing them, alone or in combination with other therapeutic agents, and their use as antiviral agents, particularly against HIV and/or HBV infections in mammals.
    • 本发明涉及具有通式(I)的新型核苷酸类似物和这些酯的药学上可接受的盐,酯或盐:其中n,X,Q U R1',R1,Z和R2在此定义。 本发明的化合物可以是单一对映异构体或作为所述对映体的混合物,所述化合物可以在每个手性中心具有αD,α-L,β-D,β-L,R或S构型或其混合物。 本发明还涉及含有它们的单独或与其它治疗剂组合的药物组合物,以及它们作为抗病毒剂的用途,特别是用于哺乳动物中的HIV和/或HBV感染。