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1. 发明授权

US4927565A 5-substituted amino-4-hydroxy-pentenoic acid derivatives and their use 失效
公开(公告)号：US4927565A
公开(公告)日：1990-05-22
申请号：US133642
申请日：1987-12-16
申请人： Seiichi Tanaka , Yutaka Koike , Masato Nakano , Shugo Atsuumi , Hajime Morishima , Kenji Matsuyama
发明人： Seiichi Tanaka , Yutaka Koike , Masato Nakano , Shugo Atsuumi , Hajime Morishima , Kenji Matsuyama
IPC分类号： A61K38/00 , C07K5/02 , C07K5/062 , C07K5/065
CPC分类号： C07K5/06026 , C07K5/0207 , C07K5/06078 , A61K38/00 , Y10S530/86
摘要： A 5-substituted amino-4-hydroxy-pentenoic acid or its salt represented by the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 which may be the same or different is a hydrogen atom, a lower alkyl group, an aralkyl group, a lower alkoxycarbonyl group, an aryloxycarbonyl group, an aralkyloxycarbonyl group or a lower alkanoyl group which may be substituted by from one to three substituents selected from the group consisting of an amino group, a hydroxyl group, a carboxyl group, an aryloxy group, an aralkyloxycarbonylamino group, a lower alkoxycarbonylamino group and a ##STR2## group (wherein each of X.sup.1 and X.sup.2 which may be the same or different is a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group, or X.sup.1 and X.sup.2 form together with the adjacent nitrogen atom a 5- or 6-membered heterocyclic group which may further contain a hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom) and which may further contain a double bond in its carbon chain, each of R.sup.3, R.sup.4 and R.sup.6 which may be the same or different is a hydrogen atom, a lower alkyl group, a cycloalkyl group, a cycloalkylalkyl group, an aryl group, an aralkyl group or a residue of an acidic neutral or basic amino acid, R.sup.5 is a hydrogen atom or a lower alkyl group, R.sup.7 is a hydrogen atom, a lower alkyl, cycloalkyl, cycloalkylalkyl or aralkyl group which may be substituted by one or two hydroxyl groups or a residue of an acidic, neutral or basic amino acid, R.sup.8 is a hydroxymethyl group or a --CO--R.sup.9 group (wherein R.sup.9 is a hydroxyl group, a --OY group (wherein Y is a lower alkyl group, an aryl group, an aralkyl group, a lower alkoxyalkyl group, a lower alkanoyloxyalkyl group, a lower alkoxycarbonyloxyalkyl group, or a 1-phthalidyl group) or ##STR3## group (wherein each of Y.sup.1 and Y.sup.2 which may be the same or different is a hydrogen atom, a lower alkyl group, an aryl group, an aralkyl group or a cycloalkyl group, or Y.sup.1 and Y.sup.2 form together with the adjacent nitrogen atom a 5- or 6-membered heterocyclic group which may further contain a hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom), and each of n and m which may be the same or different is 0 or 1.

2. 发明授权

US5319082A N-acylamino acid derivatives 失效
标题翻译： N-酰基氨基酸衍生物
公开(公告)号：US5319082A
公开(公告)日：1994-06-07
申请号：US868140
申请日：1992-04-14
申请人： Hajime Morishima , Yutaka Koike , Masato Nakano , Shugo Atsuumi , Seiichi Tanaka , Kenji Matsuyama
发明人： Hajime Morishima , Yutaka Koike , Masato Nakano , Shugo Atsuumi , Seiichi Tanaka , Kenji Matsuyama
IPC分类号： A61K31/195 , A61K31/535 , C07C59/66 , C07C317/00 , C07C317/44 , C07C323/43 , C07D207/08 , C07D211/14 , C07D215/12 , C07D233/54 , C07D239/38 , C07D257/04 , C07D265/30 , C07D285/12 , C07D285/125 , C07D295/084 , C07D295/12 , C07D295/125 , C07D295/13 , C07D295/24 , C07D307/38 , C07D319/18 , C07D401/12 , C07F7/18 , C07D413/12
CPC分类号： C07D207/08 , C07C323/00 , C07C323/43 , C07C59/66 , C07D211/14 , C07D215/12 , C07D233/64 , C07D239/38 , C07D257/04 , C07D285/125 , C07D295/084 , C07D295/125 , C07D295/13 , C07D295/24 , C07D307/38 , C07D319/18 , C07D401/12 , C07F7/1856
摘要： An N-acylamino acid derivative of the formula: ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.4 and R.sup.6 is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or a monocyclic or bicyclic heterocyclic group containing from 1 to 4 hetero atoms; each of R.sup.3 and R.sup.5 is hydrogen or lower alkyl; A is --CH(OH)--(CH.sub.2).sub.q R.sup.7 wherein R.sup.7 is hydrogen, lower alkyl, cycloalkyl, cyloalkylalkyl, aryl, aralkyl, a-monocyclic or bicyclic heterocyclic group containing from 1 to 4 hetero atoms or --E--R.sup.10 wherein E is --S(O).sub.i -- wherein i is 0, 1 or 2, oxygen, --NR.sup.11 -- wherein R.sup.11 is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl, or ##STR2## wherein each of R.sup.12 and R.sup.13 is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl, and R.sup.10 is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or a monocyclic or bicyclic heterocyclic group containing from 1 to 4 hetero atoms provided that when R.sup.10 is hydrogen, i is 0, and a is an integer of from 0 to 5; or --CH.sub.2 --CHR.sup.8 --CO--R.sup.9 wherein R.sup.8 is hydrogen, lower alkyl, cycloalkyl, cycloalkylakyl, aryl, aralkyl or a monocyclic or bicyclic heterocyclic group containing from 1 to 4 hetero atoms, and R.sup.9 is hydroxyl, --OX wherein, X is alkyl aryl, lower alkoxycarbonyloxyalkyl or 1-phthalidyl, or --N(Y.sup.1)(Y.sup.2 ) wherein each of Y.sup.1 and Y.sup.2 is hydrogen, lower alkyl, aryl, aralkyl or cycloalkyl, or Y.sup.1 and Y.sup.2 form together with the adjacent nitrogen atom a 5- or 6-membered heterocyclic group which may contain a further hetero from; m is 0, 1 or 2; and n is an integer of from 1 to 5, provided that when R.sup.1 is hydrogen, m is 0; or a salt thereof, which is useful as hypotensive drugs.
摘要翻译：下式的N-酰基氨基酸衍生物：其中R 1，R 2，R 4和R 6各自为氢，低级烷基，环烷基，环烷基烷基，芳基，芳烷基或单环或双环杂环基，其含有1至 4个杂原子; R 3和R 5各自为氢或低级烷基; A是-CH（OH） - （CH 2）q R 7，其中R 7是含有1至4个杂原子的氢，低级烷基，环烷基，环烷基烷基，芳基，芳烷基，α-单环或双环杂环基或-E-R 10，其中E是 -S（O）i - 其中i是0,1或2，氧，-NR 11 - ，其中R 11是氢，低级烷基，环烷基，环烷基烷基，芳基或芳烷基，或者其中R 12和R 13各自是氢，低级烷基，环烷基，环烷基烷基，芳基或芳烷基，R 10为含有1至4个杂原子的氢，低级烷基，环烷基，环烷基烷基，芳基，芳烷基或单环或双环杂环基，条件是当R 10为氢时，i为0 a为0〜5的整数，或-CH 2 -CHR 8 -CO-R 9，其中R 8是氢，低级烷基，环烷基，环烷基烷基，芳基，芳烷基或含有1至4个杂原子的单环或双环杂环基，并且R 9是羟基，烷基芳基，低级烷氧基羰氧基烷基或1-邻苯二甲酰基，或-N（Y1）（Y2）其中Y 1和Y 2分别为氢，低级烷基，芳基，芳烷基或环烷基或Y1和Y2各自与相邻的氮原子一起形成5-或可含有另外的杂原子的6元杂环基; m为0,1或2; 且n为1至5的整数，条件是当R 1为氢时，m为0; 或其盐，其可用作降压药物。

3. 发明授权

US5240924A N-acylamino acid derivatives and their use 失效
标题翻译： N-酰基氨基酸衍生物及其用途
公开(公告)号：US5240924A
公开(公告)日：1993-08-31
申请号：US815412
申请日：1991-12-31
申请人： Hajime Morishima , Yutaka Koike , Masato Nakano , Shugo Atsuumi , Seiichi Tanaka , Kenji Matsuyama
发明人： Hajime Morishima , Yutaka Koike , Masato Nakano , Shugo Atsuumi , Seiichi Tanaka , Kenji Matsuyama
IPC分类号： A61K38/00 , C07C59/66 , C07C323/43 , C07D207/08 , C07D211/14 , C07D215/12 , C07D233/54 , C07D239/38 , C07D257/04 , C07D285/12 , C07D285/125 , C07D295/084 , C07D295/125 , C07D295/13 , C07D295/24 , C07D307/38 , C07D319/18 , C07D401/12 , C07F7/18
CPC分类号： C07D207/08 , C07C323/00 , C07C323/43 , C07C59/66 , C07D211/14 , C07D215/12 , C07D233/64 , C07D239/38 , C07D257/04 , C07D285/125 , C07D295/084 , C07D295/125 , C07D295/13 , C07D295/24 , C07D307/38 , C07D319/18 , C07D401/12 , C07F7/1856
摘要： An N-acylamino acid derivative of the formula: ##STR1## wherein the substituents are herein defined, or a salt thereof, which is useful as hypotensive drugs.
摘要翻译：下式的N-酰基氨基酸衍生物：其中本文定义的取代基或其盐，其可用作降压药物。

4. 发明授权

US5481036A N-acylamino acid derivatives and their use 失效
标题翻译： N-酰基氨基酸衍生物及其用途
公开(公告)号：US5481036A
公开(公告)日：1996-01-02
申请号：US179195
申请日：1994-01-10
申请人： Hajime Morishima , Yutaka Koike , Masato Nakano , Shugo Atsuumi , Seiichi Tanaka , Kenji Matsuyama
发明人： Hajime Morishima , Yutaka Koike , Masato Nakano , Shugo Atsuumi , Seiichi Tanaka , Kenji Matsuyama
IPC分类号： A61K31/195 , A61K31/535 , C07C59/66 , C07C317/00 , C07C317/44 , C07C323/43 , C07D207/08 , C07D211/14 , C07D215/12 , C07D233/54 , C07D239/38 , C07D257/04 , C07D265/30 , C07D285/12 , C07D285/125 , C07D295/084 , C07D295/12 , C07D295/125 , C07D295/13 , C07D295/24 , C07D307/38 , C07D319/18 , C07D401/12 , C07F7/18 , C07C321/00
CPC分类号： C07D207/08 , C07C323/00 , C07C323/43 , C07C59/66 , C07D211/14 , C07D215/12 , C07D233/64 , C07D239/38 , C07D257/04 , C07D285/125 , C07D295/084 , C07D295/125 , C07D295/13 , C07D295/24 , C07D307/38 , C07D319/18 , C07D401/12 , C07F7/1856
摘要： An N-acylamino acid derivative of the formula: ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.4 and R.sup.6 is hydrogen lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or a monocyclic or bicyclic heterocyclic group containing from to 4 hetero atoms; each of R.sup.3 and R.sup.5 is hydrogen or lower alkyl; A is --CH(OH)--(CH.sub.2).sub.q R.sup.7 wherein R.sup.7 is hydrogen, lower alkyl, cycloalkyl, cyloalkylalkyl, aryl, aralkyl, a monocyclic or bicyclic heterocyclic group containing from to 4 hereto atoms or --E--R.sup.10 wherein E is --S(O).sub.i -- wherein i is 0, 1 or 2, oxygen, --NR.sup.11 -- wherein R.sup.11 is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl, or ##STR2## wherein each of R.sup.12 and R.sup.13 is hydrogen, lower alkyl cycloalkyl, cycloalkylalkyl, aryl or aralkyl, and R.sup.10 is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or a monocyclic or bicyclic heterocyclic group containing from 1 to 4 hetero atoms provided that when R.sup.10 is hydrogen, i is 0, and a is an integer of from 0 to 5; or --CH.sub.2 --CHR.sup.8 --CO--R.sup.9 wherein R.sup.8 is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or a monocyclic or bicyclic heterocyclic group containing from 1 to 4 hetero atoms, and R.sup.9 is hydroxyl, --OX wherein X is alkyl, aryl, lower alkoxycarbonyloxyalkyl or 1-phthalidyl, or --N(Y.sup.1) (Y.sup.2) wherein each of Y.sup.1 and Y.sup.2 is hydrogen, lower alkyl, aryl, aralkyl or cycloalkyl, or Y and.sup.1 and Y.sup.2 form together with the adjacent nitrogen atom a 5- or 6-membered heterocyclic group which may contain a further hereto atom; m is 0, 1 or 2; and n is an integer of from 1 to 5, provided that when R.sup.1 is hydrogen, m is 0; or a salt thereof, which is useful as hypotensive drugs.
摘要翻译：下式的N-酰基氨基酸衍生物：其中R 1，R 2，R 4和R 6各自为氢低级烷基，环烷基，环烷基烷基，芳基，芳烷基或含有4个杂原子的单环或双环杂环基原子 R 3和R 5各自为氢或低级烷基; A是-CH（OH） - （CH 2）q R 7，其中R 7是氢，低级烷基，环烷基，环烷基烷基，芳基，芳烷基，含有至4原子的单环或双环杂环基或-E-R 10，其中E是-S （O）i-其中i是0,1或2，氧，-NR 11 - ，其中R 11是氢，低级烷基，环烷基，环烷基烷基，芳基或芳烷基，或者其中R 12和R 13各自是氢，环烷基，环烷基烷基，芳基或芳烷基，R 10为含有1至4个杂原子的氢，低级烷基，环烷基，环烷基烷基，芳基，芳烷基或单环或双环杂环基，条件是当R 10为氢时，i为0，是从0到5的整数; 或-CH 2 -CHR 8 -CO-R 9，其中R 8是氢，低级烷基，环烷基，环烷基烷基，芳基，芳烷基或含有1至4个杂原子的单环或双环杂环基，并且R 9是羟基，，芳基，低级烷氧基羰氧基烷基或1-苯酞基，或-N（Y1）（Y2），其中Y1和Y2各自为氢，低级烷基，芳基，芳烷基或环烷基，或Y和1和Y2与相邻的氮原子一起形成可含有其它原子的5-或6-元杂环基; m为0,1或2; 且n为1至5的整数，条件是当R 1为氢时，m为0; 或其盐，其可用作降压药物。

5. 发明授权

US5122523A N-acylamino acid derivatives and their pharmaceutical compositions 失效
标题翻译： N-亚氨基酸衍生物及其药物组合物
公开(公告)号：US5122523A
公开(公告)日：1992-06-16
申请号：US240725
申请日：1988-09-06
申请人： Hajime Morishima , Yutaka Koike , Masato Nakano , Shugo Atsuumi , Seiichi Tanaka , Kenji Matsuyama
发明人： Hajime Morishima , Yutaka Koike , Masato Nakano , Shugo Atsuumi , Seiichi Tanaka , Kenji Matsuyama
IPC分类号： A61K31/195 , A61K31/535 , C07C59/66 , C07C317/00 , C07C317/44 , C07C323/43 , C07D207/08 , C07D211/14 , C07D215/12 , C07D233/54 , C07D239/38 , C07D257/04 , C07D265/30 , C07D285/12 , C07D285/125 , C07D295/084 , C07D295/12 , C07D295/125 , C07D295/13 , C07D295/24 , C07D307/38 , C07D319/18 , C07D401/12 , C07F7/18
CPC分类号： C07D207/08 , C07C323/00 , C07C323/43 , C07C59/66 , C07D211/14 , C07D215/12 , C07D233/64 , C07D239/38 , C07D257/04 , C07D285/125 , C07D295/084 , C07D295/125 , C07D295/13 , C07D295/24 , C07D307/38 , C07D319/18 , C07D401/12 , C07F7/1856
摘要： An N-acylamino acid derivative of the formula: ##STR1## wherein the substituents are herein defined or a salt thereof, which is useful as hypotensive drugs.

6. 发明授权

US5506356A N-acylamino acid derivatives and their use 失效
标题翻译： N-酰基氨基酸衍生物及其用途
公开(公告)号：US5506356A
公开(公告)日：1996-04-09
申请号：US375738
申请日：1995-01-20
申请人： Hajime Morishima , Yutaka Koike , Masato Nakano , Shugo Atsuumi , Seiichi Tanaka , Kenji Matsuyama
发明人： Hajime Morishima , Yutaka Koike , Masato Nakano , Shugo Atsuumi , Seiichi Tanaka , Kenji Matsuyama
IPC分类号： A61K31/195 , A61K31/535 , C07C59/66 , C07C317/00 , C07C317/44 , C07C323/43 , C07D207/08 , C07D211/14 , C07D215/12 , C07D233/54 , C07D239/38 , C07D257/04 , C07D265/30 , C07D285/12 , C07D285/125 , C07D295/084 , C07D295/12 , C07D295/125 , C07D295/13 , C07D295/24 , C07D307/38 , C07D319/18 , C07D401/12 , C07F7/18
CPC分类号： C07D207/08 , C07C323/00 , C07C323/43 , C07C59/66 , C07D211/14 , C07D215/12 , C07D233/64 , C07D239/38 , C07D257/04 , C07D285/125 , C07D295/084 , C07D295/125 , C07D295/13 , C07D295/24 , C07D307/38 , C07D319/18 , C07D401/12 , C07F7/1856
摘要： An N-acylamino acid derivative of the formula: ##STR1##
摘要翻译：下式的N-酰基氨基酸衍生物：（I）

7. 发明授权

US4851387A 5-substituted amino-4-hydroxy-pentanoic acid derivatives and their use 失效
标题翻译： 5-取代的氨基-4-羟基 - 戊酸衍生物及其用途
公开(公告)号：US4851387A
公开(公告)日：1989-07-25
申请号：US106804
申请日：1987-10-13
申请人： Yutaka Koike , Masato Nakano , Shugo Atsuumi , Seiichi Tanaka , Hajime Morishima , Kenji Matsuyama
发明人： Yutaka Koike , Masato Nakano , Shugo Atsuumi , Seiichi Tanaka , Hajime Morishima , Kenji Matsuyama
IPC分类号： A61K38/00 , C07D263/04 , C07D263/06 , C07D413/14 , C07K5/02
CPC分类号： C07D263/04 , C07D263/06 , C07D413/14 , C07K5/0207 , C07K5/0227 , A61K38/00 , Y02P20/55 , Y10S530/86
摘要： A 5-substituted amino-4-hydroxy-pentanoic acid derivative having the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or an N-protecting group, R.sup.2, R.sup.3 and R.sup.5 may be any of a variety of groups including the side chains of amino acid residues, R.sup.4 is a hydrogen atom or a lower alkyl group, R.sup.6 is a group which is substituted by one or two hydroxyl groups, and R.sup.7 is any of a variety of groups, including a hydroxyl group, which compounds are renin inhibitors useful as hypotensive drugs, are disclosed.
摘要翻译：具有下式的5-取代的氨基-4-羟基 - 戊酸衍生物：其中R 1是氢原子或N-保护基，R 2，R 3和R 5可以是任何一种的包括氨基酸残基的侧链的基团，R4是氢原子或低级烷基，R6是被一个或两个羟基取代的基团，并且R7是包括羟基的任何基团，这些化合物是可用作降压药物的肾素抑制剂。

8. 发明授权

US5424309A N-substituted acylamino acid compounds, process for their production and their use 失效
标题翻译： N-取代的酰基氨基酸化合物，其制备及其用途
公开(公告)号：US5424309A
公开(公告)日：1995-06-13
申请号：US200536
申请日：1994-02-22
申请人： Hajime Morishima , Yutaka Kokie , Masato Nakano , Shugo Atsuumi , Seiichi Tanaka , Kenji Matsuyama
发明人： Hajime Morishima , Yutaka Kokie , Masato Nakano , Shugo Atsuumi , Seiichi Tanaka , Kenji Matsuyama
IPC分类号： A61K38/55 , A61K31/22 , A61K31/221 , A61K31/223 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61P9/12 , C07C59/48 , C07C317/44 , C07C323/41 , C07C323/60 , C07D233/54 , C07D277/30 , C07D295/12 , C07D295/125 , C07D401/12 , C07H15/14 , C07H15/26 , C07K5/06 , C07D265/30
CPC分类号： C07D233/64 , C07C317/44 , C07C323/41 , C07C323/60 , C07C59/48 , C07D277/30 , C07D295/125 , C07D401/12 , C07H15/14 , C07H15/26
摘要： The present invention provides an N-substituted acylamino acid compound of the formula: ##STR1## a process for their production and pharmaceutical uses, and intermediates useful for their production.
摘要翻译：本发明提供下式的N-取代的酰基氨基酸化合物：其制备方法和药物用途，以及可用于其生产的中间体。

9. 发明授权

US5288898A N-methylphenylserine alkyl ester derivatives and uses thereof 失效
标题翻译： N-甲基苯基丝氨酸烷基酯衍生物及其用途
公开(公告)号：US5288898A
公开(公告)日：1994-02-22
申请号：US56619
申请日：1993-05-04
申请人： Hamao Umezawa , Toshiharu Nagatsu , Tomio Takeuchi , Hajime Morishima , Yoshio Sawasaki , Hiroshi Takezawa , Fujinori Sasaki
发明人： Hamao Umezawa , Toshiharu Nagatsu , Tomio Takeuchi , Hajime Morishima , Yoshio Sawasaki , Hiroshi Takezawa , Fujinori Sasaki
IPC分类号： A61K31/195 , C07C229/36 , A61K31/24
CPC分类号： A61K31/195
摘要： As new compounds are now provided N-methyl-3-(3,4-dihydroxyphenyl)serine alkyl esters which are effective as an .alpha.-adrenergic and .beta.-adrenergic agent to stimulate the .alpha.-adrenergic and .beta.-adrenergic functions of the central nervous system of mammalian animals and are expectable to be useful for therapeutic treatment of disorders as invoked by reduced biological activities or functions of the .alpha.- and/or .beta.-adrenergic neurons. N-methyl-L-threo-3-(3,4-dihydroxyphenyl)serine (C.sub.1 -C.sub.6) alkyl esters are preferred amongst the new compounds of this invention.
摘要翻译：由于新化合物现在提供作为（α） - 肾上腺素能和（β） - 肾上腺素能药物有效的N-甲基-3-（3,4-二羟基苯基）丝氨酸烷基酯，以刺激（α） - 肾上腺素能和（β ） - 哺乳动物中枢神经系统的肾上腺素能功能，并且预期可用于通过减少（α） - 和/或（β） - 肾上腺素能神经元的生物活性或功能引起的病症的治疗性治疗。 N-甲基-L-苏式-3-（3,4-二羟基苯基）丝氨酸（C1-C6）烷基酯在本发明的新化合物中是优选的。

10. 发明授权

US4335250A Compound with immunopotentiating activity and production and uses thereof 失效
标题翻译：具有免疫增强活性的化合物及其制备及其应用
公开(公告)号：US4335250A
公开(公告)日：1982-06-15
申请号：US57014
申请日：1979-07-12
申请人： Hamao Umezawa , Tomio Takeuchi , Takaaki Aoyagi , Masaaki Ishizuka , Hajime Morishima , Takuzo Yamamoto , Junji Yoshizawa , Masaaki Hosoi , Ikuo Matsumoto
发明人： Hamao Umezawa , Tomio Takeuchi , Takaaki Aoyagi , Masaaki Ishizuka , Hajime Morishima , Takuzo Yamamoto , Junji Yoshizawa , Masaaki Hosoi , Ikuo Matsumoto
IPC分类号： C07C69/88 , A61K31/19 , A61K31/235 , A61P37/04 , C07C51/00 , C07C51/09 , C07C65/01 , C07C65/03 , C07C67/00 , C07C69/84
CPC分类号： C07C65/03 , C07C65/01 , Y10S514/885
摘要： A new compound is produced which has the general formula: ##STR1## wherein R represents hydrogen atom or a lower alkyl group and which exhibits an immunopotentiating activity. This new compound as well as its pharmaceutically acceptable salts and hydrates are useful for immunotherapy and treatment of immune diseases and disorders in living animals including human beings. The new compound can be produced by reduction of a hydroxyterephthalic acid alkyl ester or by esterification of the corresponding 3-hydroxy-4-(hydroxymethyl)-benzoic acid.
摘要翻译：制备了具有以下通式的新化合物：其中R表示氢原子或低级烷基，并表现出免疫增强活性。该新化合物及其药学上可接受的盐和水合物可用于免疫治疗和治疗包括人在内的活动物中的免疫疾病和病症。新化合物可以通过还原羟基对苯二甲酸烷基酯或通过相应的3-羟基-4-（羟甲基） - 苯甲酸的酯化来制备。

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