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1. 发明申请

US20070048345A1 Antimicrobial composition 审中-公开
标题翻译：抗微生物组成
公开(公告)号：US20070048345A1
公开(公告)日：2007-03-01
申请号：US11364799
申请日：2006-02-28
申请人： Lei Huang , Shu-Ping Yang , Ali Yahiaoui , Anthony Spencer
发明人： Lei Huang , Shu-Ping Yang , Ali Yahiaoui , Anthony Spencer
IPC分类号： A01N43/40 , A01N25/00 , A01N37/30
CPC分类号： A01N31/02 , A01N25/30 , A01N33/12 , A01N43/40 , A01N47/44 , A01N2300/00
摘要： An antimicrobial composition that contains an antimicrobial agent and a sugar alcohol is provided. The sugar alcohol is more generally more biocompatible and biodegradable than the antimicrobial agent. In addition, without intending to be limited by theory, it is believed that sugar alcohols increase the attraction of the antimicrobial agent to microorganisms (e.g., the cytoplasmic membrane of bacteria). Because a greater percentage of the antimicrobial agent molecules are brought into contact with the microorganisms, the efficiency of growth inhibition is increased. Thus, the antimicrobial composition provides good efficacy without the need for high levels of an antimicrobial agent.
摘要翻译：提供了含有抗微生物剂和糖醇的抗微生物组合物。糖醇通常比抗微生物剂更生物相容性和生物降解性。此外，不希望受理论限制，据信糖醇增加了抗微生物剂对微生物（例如细菌的细胞质膜）的吸引力。因为较大比例的抗微生物剂分子与微生物接触，所以生长抑制的效率增加。因此，抗微生物组合物提供良好的效力，而不需要高水平的抗微生物剂。

2. 发明授权

US08399012B2 Degradable therapeutic delivery device 有权
标题翻译：可降解治疗输送装置
公开(公告)号：US08399012B2
公开(公告)日：2013-03-19
申请号：US11405262
申请日：2006-04-17
申请人： Molly K. Smith , Kelly D. Arehart , Lei Huang , Shu-Ping Yang , Yanbin Huang
发明人： Molly K. Smith , Kelly D. Arehart , Lei Huang , Shu-Ping Yang , Yanbin Huang
IPC分类号： A61F6/06 , A61F2/00 , A61F6/14 , A61F13/00 , C08L67/02
CPC分类号： A61K47/34 , A61F6/08 , A61K9/0036 , A61K31/00 , A61K31/19 , A61M31/002 , C08G63/12 , C08G63/16 , C08G63/914
摘要： A biodegradable biodelivery device is disclosed. The biodelivery device is formed from a polymer comprising the reaction product of a polyol and a polyacid. When exposed to water, the polymer degrades through hydrolysis. Of particular advantage, the polymer can be formed so as to be elastic and flexible. In one embodiment, the polymer is formed into a vaginal insert. As the polymer degrades, the polymer releases acid to a vaginal environment for decreasing the pH of the environment.
摘要翻译：公开了一种可生物降解的生物输送装置。生物输送装置由包含多元醇和多元酸的反应产物的聚合物形成。当暴露于水时，聚合物通过水解降解。特别有利的是，聚合物可以形成为具有弹性和柔性。在一个实施方案中，聚合物形成阴道插入物。当聚合物降解时，聚合物将酸释放到阴道环境中以降低环境的pH。

3. 发明申请

US20070026074A1 Vaginal treatment composition 有权
标题翻译：阴道治疗组合物
公开(公告)号：US20070026074A1
公开(公告)日：2007-02-01
申请号：US11194064
申请日：2005-07-29
申请人： Stephanie Martin , Lei Huang , Shu-Ping Yang , Yanbin Huang , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert Johnson
发明人： Stephanie Martin , Lei Huang , Shu-Ping Yang , Yanbin Huang , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert Johnson
IPC分类号： A61K9/14 , A61K31/70 , A61K31/045
CPC分类号： A61K9/0034 , A61K31/192 , A61K31/70 , A61K47/36
摘要： A vaginal treatment composition that rapidly forms a gel when placed into contact with monovalent or polyvalent cations, such as sodium (Na+) and calcium (Ca2+) cations naturally found in vaginal mucosa, is provided. The gel may form in less than about 1 hour, in some embodiments less than about 1 minute, and in some embodiments, less than about 30 seconds. Among other things, such rapid gelation reduces the likelihood of leakage during use. In addition, because the gel may form intravaginally, it is more likely to retain its structure and shape over an extended period of time. In this manner, the gel may provide the prolonged release of a therapeutic agent that inhibits and/or treats vaginal infection. For instance, the gel may remain within the vagina for about 2 to about 48 hours to provide the desired effect.
摘要翻译：当与一价或多价阳离子接触时迅速形成凝胶的阴道处理组合物，例如天然存在的钠（Na +）+和钙（Ca 2+）+阳离子提供阴道粘膜。凝胶可以在小于约1小时，在一些实施方案中小于约1分钟，并且在一些实施方案中小于约30秒形成。除此之外，这种快速凝胶化可降低使用过程中泄漏的可能性。另外，因为凝胶可以阴道内形成，所以更可能在延长的时间段内保持其结构和形状。以这种方式，凝胶可提供抑制和/或治疗阴道感染的治疗剂的延长释放。例如，凝胶可以保留在阴道内约2至约48小时以提供期望的效果。

4. 发明申请

US20070243229A1 Degradable therapeutic delivery device 有权
标题翻译：可降解治疗输送装置
公开(公告)号：US20070243229A1
公开(公告)日：2007-10-18
申请号：US11405262
申请日：2006-04-17
申请人： Molly Smith , Kelly Arehart , Lei Huang , Shu-Ping Yang , Yanbin Huang
发明人： Molly Smith , Kelly Arehart , Lei Huang , Shu-Ping Yang , Yanbin Huang
IPC分类号： A61F2/02 , C08G63/91
CPC分类号： A61K47/34 , A61F6/08 , A61K9/0036 , A61K31/00 , A61K31/19 , A61M31/002 , C08G63/12 , C08G63/16 , C08G63/914
摘要： A biodegradable biodelivery device is disclosed. The biodelivery device is formed from a polymer comprising the reaction product of a polyol and a polyacid. When exposed to water, the polymer degrades through hydrolysis. Of particular advantage, the polymer can be formed so as to be elastic and flexible. In one embodiment, the polymer is formed into a vaginal insert. As the polymer degrades, the polymer releases acid to a vaginal environment for decreasing the pH of the environment.
摘要翻译：公开了一种可生物降解的生物输送装置。生物输送装置由包含多元醇和多元酸的反应产物的聚合物形成。当暴露于水时，聚合物通过水解降解。特别有利的是，聚合物可以形成为具有弹性和柔性。在一个实施方案中，聚合物形成阴道插入物。当聚合物降解时，聚合物将酸释放到阴道环境中以降低环境的pH。

5. 发明授权

US07258878B2 Anti-microbial composition and methods of use thereof 有权
标题翻译：抗微生物组合物及其使用方法
公开(公告)号：US07258878B2
公开(公告)日：2007-08-21
申请号：US11017226
申请日：2004-12-20
申请人： Sharon Linda Greene , Yanbin Huang , Lei Huang , Ilona F. Weart , Shu-Ping Yang , Sohail Malik , Robert B. Johnson
发明人： Sharon Linda Greene , Yanbin Huang , Lei Huang , Ilona F. Weart , Shu-Ping Yang , Sohail Malik , Robert B. Johnson
IPC分类号： A61K36/752
CPC分类号： A61K45/06 , A61K31/19 , A61K31/215 , A61K31/7048 , A61K36/61 , A61K2300/00
摘要： The present invention is directed to anti-microbial compositions and methods for treating fungal and yeast infections.
摘要翻译：本发明涉及用于治疗真菌和酵母菌感染的抗微生物组合物和方法。

6. 发明申请

US20060217446A1 Method for preventing and/or treating trichomonas vaginitis 审中-公开
标题翻译：预防和/或治疗滴虫性阴道炎的方法
公开(公告)号：US20060217446A1
公开(公告)日：2006-09-28
申请号：US11091206
申请日：2005-03-28
申请人： Lei Huang , Shu-Ping Yang
发明人： Lei Huang , Shu-Ping Yang
IPC分类号： A61K31/045 , C12Q1/18
CPC分类号： A61K31/045
摘要： The invention provides a method for treating and/or preventing vaginal infections, such as trichomonas vaginitis, by administering a sugar alcohol-polyol to a subject in need of treatment. Particularly suitable sugar alcohol-polyols are pentitol and hexitol polyols, such as xylitol, arabitol/arabinitol, adonitol, ribitol, glycerol, dulcitol, inositol, mannitol and sorbitol. A composition containing a sugar alcohol-polyol for treating vaginal infections is also disclosed. It has been found that sugar alcohol-polyols are capable of selectively inhibiting the growth of Trichomonas vaginalis, a parasite that causes one of the most common vaginal infections, trichomonas vaginitis, while not inhibiting the growth of Lactobacillus acidophilus, the dominant bacteria in a healthy vaginal ecosystem. Sugar alcohol-polyols are safe and cost-effective, and can be used alone, with other polyols or incorporated into different vaginal health products to treat and/or prevent trichomonas vaginitis.
摘要翻译：本发明提供了通过向需要治疗的受试者施用糖醇多元醇来治疗和/或预防阴道感染如滴虫性阴道炎的方法。特别合适的糖醇多元醇是戊糖醇和己糖醇多元醇，例如木糖醇，阿糖醇/阿拉伯糖醇，阿丹糖醇，核糖醇，甘油，二糖醇，肌醇，甘露糖醇和山梨糖醇。还公开了含有用于治疗阴道感染的糖醇多元醇的组合物。已经发现，糖醇多元醇能够选择性地抑制阴道毛滴虫的生长，其是引起最常见的阴道感染，毛滴虫性阴道炎之一的寄生虫，同时不抑制嗜酸乳杆菌的生长，这是健康的主要细菌阴道生态系统。糖醇多元醇是安全和成本有效的，并且可以与其它多元醇一起使用或并入不同的阴道保健品中以治疗和/或预防滴虫性阴道炎。

7. 发明申请

US20060134237A1 Anti-microbial composition and methods of use thereof 有权
标题翻译：抗微生物组合物及其使用方法
公开(公告)号：US20060134237A1
公开(公告)日：2006-06-22
申请号：US11017226
申请日：2004-12-20
申请人： Sharon Greene , Yanbin Huang , Lei Huang , Ilona Weart , Shu-Ping Yang , Sohail Malik , Robert Johnson
发明人： Sharon Greene , Yanbin Huang , Lei Huang , Ilona Weart , Shu-Ping Yang , Sohail Malik , Robert Johnson
IPC分类号： A61K31/7048 , A61K31/192 , A61K36/61
CPC分类号： A61K45/06 , A61K31/19 , A61K31/215 , A61K31/7048 , A61K36/61 , A61K2300/00
摘要： The present invention is directed to anti-microbial compositions and methods for treating fungal and yeast infections.
摘要翻译：本发明涉及用于治疗真菌和酵母菌感染的抗微生物组合物和方法。

8. 发明申请

US20060105963A1 Therapeutic agents for inhibiting and/or treating vaginal infection 失效
标题翻译：用于抑制和/或治疗阴道感染的治疗剂
公开(公告)号：US20060105963A1
公开(公告)日：2006-05-18
申请号：US11194039
申请日：2005-07-29
申请人： Shu-Ping Yang , Lei Huang , Stephanie Martin , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert Johnson
发明人： Shu-Ping Yang , Lei Huang , Stephanie Martin , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert Johnson
IPC分类号： A61K31/70 , A61K31/045
CPC分类号： A61K31/7004 , A61K9/0034 , A61K31/047
摘要： A vaginal treatment composition that employs a therapeutic agent to inhibit and/or treat vaginal infection is provided. The therapeutic agent is capable of inhibiting and/or killing Gardnerella (e.g., Gardnerella vaginalis), Candida (e.g., Candida albicans), and/or Trichomonas (e.g., Trichomonas vaginalis) pathogens. Desirably, such antimicrobial efficacy is achieved without substantially inhibiting the growth of Lactobacillus acidophilus. For instance, sugars and/or sugar alcohols may be employed in the present invention as a therapeutic agent for inhibiting and/or treating vaginal infection. In one particular embodiment, D-xylitol is used as the therapeutic agent.
摘要翻译：提供了使用治疗剂抑制和/或治疗阴道感染的阴道治疗组合物。治疗剂能够抑制和/或杀死加德纳（Gardnerella vaginalis），假丝酵母（例如白色假丝酵母）和/或毛滴虫（例如阴道毛滴虫）病原体。理想地，实现了这样的抗微生物效能，而基本上不抑制嗜酸乳杆菌的生长。例如，本发明中可以使用糖和/或糖醇作为抑制和/或治疗阴道感染的治疗剂。在一个具体实施方案中，D-木糖醇用作治疗剂。

9. 发明授权

US07786176B2 Vaginal treatment composition containing xylitol 有权
标题翻译：含有木糖醇的阴道治疗组合物
公开(公告)号：US07786176B2
公开(公告)日：2010-08-31
申请号：US11194064
申请日：2005-07-29
申请人： Stephanie M. Martin , Lei Huang , Shu-Ping Yang , Yanbin Huang , Julie Villanueva , Sharon Linda Greene , Kelly Arehart , Curtis Sayre , Robert B. Johnson
发明人： Stephanie M. Martin , Lei Huang , Shu-Ping Yang , Yanbin Huang , Julie Villanueva , Sharon Linda Greene , Kelly Arehart , Curtis Sayre , Robert B. Johnson
IPC分类号： A61K31/045
CPC分类号： A61K9/0034 , A61K31/192 , A61K31/70 , A61K47/36
摘要： A vaginal treatment composition that rapidly forms a gel when placed into contact with monovalent or polyvalent cations, such as sodium (Na+) and calcium (Ca2+) cations naturally found in vaginal mucosa, is provided. The gel may form in less than about 1 hour, in some embodiments less than about 1 minute, and in some embodiments, less than about 30 seconds. Among other things, such rapid gelation reduces the likelihood of leakage during use. In addition, because the gel may form intravaginally, it is more likely to retain its structure and shape over an extended period of time. In this manner, the gel may provide the prolonged release of a therapeutic agent that inhibits and/or treats vaginal infection. For instance, the gel may remain within the vagina for about 2 to about 48 hours to provide the desired effect.
摘要翻译：提供了一种当与阴离子粘膜天然存在的单价或多价阳离子（例如钠（Na +）和钙（Ca 2+））阳离子接触时，迅速形成凝胶的阴道治疗组合物。凝胶可以在小于约1小时，在一些实施方案中小于约1分钟，并且在一些实施方案中小于约30秒形成。除此之外，这种快速凝胶化可降低使用过程中泄漏的可能性。另外，因为凝胶可以阴道内形成，所以更可能在延长的时间段内保持其结构和形状。以这种方式，凝胶可提供抑制和/或治疗阴道感染的治疗剂的延长释放。例如，凝胶可以保留在阴道内约2至约48小时以提供期望的效果。

10. 发明授权

US07619008B2 Xylitol for treatment of vaginal infections 失效
标题翻译：木糖醇用于治疗阴道感染
公开(公告)号：US07619008B2
公开(公告)日：2009-11-17
申请号：US11194039
申请日：2005-07-29
申请人： Shu-Ping Yang , Lei Huang , Stephanie M. Martin , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert B. Johnson
发明人： Shu-Ping Yang , Lei Huang , Stephanie M. Martin , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert B. Johnson
IPC分类号： A61K31/045
CPC分类号： A61K31/7004 , A61K9/0034 , A61K31/047
摘要： A vaginal treatment composition that employs a therapeutic agent to inhibit and/or treat vaginal infection is provided. The therapeutic agent is capable of inhibiting and/or killing Gardnerella (e.g., Gardnerella vaginalis), Candida (e.g., Candida albicans), and/or Trichomonas (e.g., Trichomonas vaginalis) pathogens. Desirably, such antimicrobial efficacy is achieved without substantially inhibiting the growth of Lactobacillus acidophilus. For instance, sugars and/or sugar alcohols may be employed in the present invention as a therapeutic agent for inhibiting and/or treating vaginal infection. In one particular embodiment, D-xylitol is used as the therapeutic agent.
摘要翻译：提供了使用治疗剂抑制和/或治疗阴道感染的阴道治疗组合物。治疗剂能够抑制和/或杀死加德纳（Gardnerella vaginalis），念珠菌（例如白色念珠菌）和/或滴虫（例如阴道毛滴虫）病原体。理想地，实现了这样的抗微生物效能，而基本上不抑制嗜酸乳杆菌的生长。例如，本发明中可以使用糖和/或糖醇作为抑制和/或治疗阴道感染的治疗剂。在一个具体实施方案中，D-木糖醇用作治疗剂。

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