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1. 发明申请

US20110207751A1 HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS 审中-公开
标题翻译：杂环化合物和作为反应剂的用途
公开(公告)号：US20110207751A1
公开(公告)日：2011-08-25
申请号：US13031134
申请日：2011-02-18
申请人： Long Mao , Xiaobo Wang , Xiao Xu , Li Zhao , Jia Liu
发明人： Long Mao , Xiaobo Wang , Xiao Xu , Li Zhao , Jia Liu
IPC分类号： A61K31/519 , C07D487/04 , A61P35/00 , A61P35/02 , A61K31/429 , C07D513/04 , A61K31/4439
CPC分类号： C07D471/04 , C07D513/04
摘要： Novel compounds having a fused bicyclic heteroaromatic ring system substituted with a thiazole ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.
摘要翻译：公开了具有被噻唑环取代的稠合双环杂芳环体系的新型化合物。这些化合物抑制多种类型的癌细胞的生长，因此可用于治疗癌症。通过用于监测细胞生长/迁移的系统来证明这些化合物的功效，这表明它们是癌细胞的生长和/或迁移的有效抑制剂。此外，本发明的化合物被证明可以在体内停止肿瘤生长，并减少体内肿瘤的大小。公开了包含这些化合物的组合物，以及使用这些化合物和用于治疗癌症的组合物的方法。

2. 发明授权

US10215748B2 Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways 有权
公开(公告)号：US10215748B2
公开(公告)日：2019-02-26
申请号：US13403976
申请日：2012-02-23
申请人： Yama A. Abassi , Li Zhao , Ning Ke , Xiaobo Wang , Xiao Xu
发明人： Yama A. Abassi , Li Zhao , Ning Ke , Xiaobo Wang , Xiao Xu
IPC分类号： C40B30/04 , G01N33/50 , C12Q1/00 , G01N33/543
摘要： Use of impedance devices in methods of generating a time dependent cellular profiles (TCRP) for the modulation of oncogene addicted cells and comparing the impedance-based TCRP to controls or knowns to identify signature time dependent cellular profiles.

3. 发明申请

US20110300569A1 DATA ANALYSIS OF IMPEDANCE-BASED CARDIOMYOCYTE-BEATING SIGNALS AS DETECTED ON REAL-TIME CELL ANALYSIS (RTCA) CARDIO INSTRUMENTS 有权
标题翻译：基于实时细胞分析（RTCA）心脏仪器检测的基于阻抗的心脏纤维化信号的数据分析
公开(公告)号：US20110300569A1
公开(公告)日：2011-12-08
申请号：US13109809
申请日：2011-05-17
申请人： Nan Li , Xiaobo Wang , Yama A. Abassi , Biao Xi , Wen Fu Zhang , Xiao Xu
发明人： Nan Li , Xiaobo Wang , Yama A. Abassi , Biao Xi , Wen Fu Zhang , Xiao Xu
IPC分类号： C12Q1/02
CPC分类号： G01N33/48728 , G01N33/4836 , G01N33/5008 , G01N33/5014 , G01N33/5061 , G01N33/5073 , G01N2800/326 , G01N2800/52
摘要： A method of determining one or more beating parameters for use in cardiomyocyte beating analysis including: providing a cell analysis device including wells, each well including a sensor capable of monitoring beating of cardiomyoctes in millisecond time resolution; adding cardiomyocytes to the wells; monitoring the beating of the cardiomyocytes in millisecond time resolution to obtain a plurality of beating measurements; and calculating one or more beating parameters from the plurality of beating measurements.
摘要翻译：一种确定用于心肌细胞搏动分析的一个或多个跳动参数的方法，包括：提供包括孔的细胞分析装置，每个孔包括能以毫秒时间分辨率监测心脏跳动的传感器; 向心脏中加入心肌细胞; 以毫秒时间分辨率监测心肌细胞的搏动以获得多次打浆测量; 以及从所述多次跳动测量中计算一个或多个跳动参数。

4. 发明申请

US20110117542A1 REAL TIME ELECTRONIC CELL SENSING SYSTEM AND APPLICATIONS FOR CYTOTOXICITY PROFILING AND COMPOUND ASSAYS 有权
标题翻译：实时电子细胞感测系统及其应用于细胞毒性分析和化合物测定
公开(公告)号：US20110117542A1
公开(公告)日：2011-05-19
申请号：US13011725
申请日：2011-01-21
申请人： Yama Abassi , Xiaobo Wang , Xiao Xu
发明人： Yama Abassi , Xiaobo Wang , Xiao Xu
IPC分类号： C12Q1/02 , C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/025 , C12Q1/002 , G01N27/02 , G01N33/4836 , G01N33/5014 , G01N33/5438
摘要： The invention provides methods of investigating a mechanism of action of a compound, which includes providing a device for monitoring cell-substrate impedance; attaching the device to an impedance analyzer; adding cells to two or more wells; adding a test compound to at least one of the wells and providing at least one control well; monitoring impedance of the wells to obtain a series of impedance measurements; plotting impedance measurements to obtain impedance curves and comparing the impedance curves to determine a time frame at which the test compound has a significant effect on cell growth or behavior. Determining the time frame provides information on changes in cell status in response to the test compound, including cell attachment or adhesion status, cell growth or proliferation status, the number of viable or dead cells, cytoskeletal organization or structure, and the number of cells going through apoptosis or necrosis.
摘要翻译：本发明提供了研究化合物作用机理的方法，其包括提供用于监测细胞 - 基底阻抗的装置; 将设备连接到阻抗分析仪; 将细胞添加到两个或更多个孔中; 向至少一个孔中加入测试化合物并提供至少一个对照孔; 监测井的阻抗以获得一系列阻抗测量; 绘制阻抗测量以获得阻抗曲线并比较阻抗曲线以确定测试化合物对细胞生长或行为具有显着影响的时间框架。确定时间框架提供了响应于测试化合物的细胞状态变化的信息，包括细胞附着或粘附状态，细胞生长或增殖状态，活细胞或死细胞的数量，细胞骨架组织或结构以及细胞数目通过凋亡或坏死。

5. 发明授权

US07622507B2 Substituted organosulfur compounds and methods of using thereof 有权
标题翻译：取代的有机硫化合物及其使用方法
公开(公告)号：US07622507B2
公开(公告)日：2009-11-24
申请号：US11110203
申请日：2005-04-20
申请人： Xiao Xu , Haoyun An , Xiaobo Wang
发明人： Xiao Xu , Haoyun An , Xiaobo Wang
IPC分类号： A61K31/105 , C07C321/16
CPC分类号： C07C323/07 , C07C321/20 , C07C323/16 , C07C323/20
摘要： The present invention provides substituted di-, tri-, tetra- and penta-sulfide compounds and compositions, and methods of using the same for the treatment and/or prevention of a cell proliferative disorder. The present invention also provides methods for preparing trisulfide compounds and compositions.
摘要翻译：本发明提供取代的二，三，四和五硫化物化合物和组合物，及其用于治疗和/或预防细胞增殖性疾病的方法。本发明还提供了制备三硫化物和组合物的方法。

6. 发明申请

US20090205201A1 Impedance Based Devices and Methods for Use in Assays 有权
标题翻译：基于阻抗的器件和用于测定的方法
公开(公告)号：US20090205201A1
公开(公告)日：2009-08-20
申请号：US12325530
申请日：2008-12-01
申请人： Xiao Xu , Xiaobo Wang
发明人： Xiao Xu , Xiaobo Wang
IPC分类号： H01R43/00 , B23K26/00
CPC分类号： G01N27/02 , C12M23/12 , C12M41/36 , G01N27/3276 , Y10T29/49117
摘要： A device for detecting cells and/or molecules on an electrode surface is disclosed. The device detects cells and/or molecules through measurement of impedance changes resulting from the cells and/or molecules. A disclosed embodiment of the device includes a substrate having two opposing ends along a longitudinal axis. A plurality of electrode arrays are positioned on the substrate. Each electrode array includes at least two electrodes, and each electrode is separated from at least one adjacent electrode in the electrode array by an expanse of non-conductive material. The electrode has a width at its widest point of more than about 1.5 and less than about 10 times the width of the expanse of non-conductive material. The device also includes electrically conductive traces extending substantially longitudinally to one of the two opposing ends of the substrate without intersecting another trace. Each trace is in electrical communication with at least one of the electrode arrays.
摘要翻译：公开了一种用于检测电极表面上的电池和/或分子的装置。该装置通过测量由细胞和/或分子产生的阻抗变化来检测细胞和/或分子。所述装置的公开实施例包括具有沿着纵向轴线的两个相对端部的基板。多个电极阵列位于基板上。每个电极阵列包括至少两个电极，并且每个电极由电极阵列中的至少一个相邻的电极通过一片非导电材料分开。电极的最宽点处的宽度大于非导电材料的宽度的大约1.5倍且小于约10倍。该器件还包括基本上纵向延伸到衬底的两个相对端之一的导电迹线，而不与另一迹线相交。每个迹线与至少一个电极阵列电连通。

7. 发明申请

US20090048271A1 HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS 有权
标题翻译：杂环化合物和作为反应剂的用途
公开(公告)号：US20090048271A1
公开(公告)日：2009-02-19
申请号：US12175154
申请日：2008-07-17
申请人： Haoyun An , Biao Xi , Yama Abassi , Xiaobo Wang , Xiao Xu
发明人： Haoyun An , Biao Xi , Yama Abassi , Xiaobo Wang , Xiao Xu
IPC分类号： A61K31/519 , A61P35/00 , C07D487/04 , A61K31/429 , C07D513/04
CPC分类号： C07D487/04 , C07D498/04 , C07D513/04
摘要： Novel compounds having a fused bicyclic heteroaromatic ring system substituted with a heteroaryl five-membered ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.
摘要翻译：公开了具有被杂芳基五元环取代的稠合双环杂芳环系的新型化合物。这些化合物抑制多种类型的癌细胞的生长，因此可用于治疗癌症。通过用于监测细胞生长/迁移的系统来证明这些化合物的功效，这表明它们是癌细胞的生长和/或迁移的有效抑制剂。此外，本发明的化合物被证明可以在体内停止肿瘤生长，并减少体内肿瘤的大小。公开了包含这些化合物的组合物，以及使用这些化合物和用于治疗癌症的组合物的方法。

8. 发明授权

US09612234B2 Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments 有权
公开(公告)号：US09612234B2
公开(公告)日：2017-04-04
申请号：US13109809
申请日：2011-05-17
申请人： Nan Li , Xiaobo Wang , Yama A. Abassi , Biao Xi , Wen Fu Zhang , Xiao Xu
发明人： Nan Li , Xiaobo Wang , Yama A. Abassi , Biao Xi , Wen Fu Zhang , Xiao Xu
IPC分类号： C40B30/06 , G01N7/00 , C12Q1/00 , G01N33/50 , G01N33/483
CPC分类号： G01N33/48728 , G01N33/4836 , G01N33/5008 , G01N33/5014 , G01N33/5061 , G01N33/5073 , G01N2800/326 , G01N2800/52
摘要： A method of determining one or more beating parameters for use in cardiomyocyte beating analysis including: providing a cell analysis device including wells, each well including a sensor capable of monitoring beating of cardiomyoctes in millisecond time resolution; adding cardiomyocytes to the wells; monitoring the beating of the cardiomyocytes in millisecond time resolution to obtain a plurality of beating measurements; and calculating one or more beating parameters from the plurality of beating measurements.

9. 发明授权

US08921041B2 Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses 有权
标题翻译：分子进入细胞的基于电穿孔的装置和方法以及细胞反应的动态监测
公开(公告)号：US08921041B2
公开(公告)日：2014-12-30
申请号：US13474355
申请日：2012-05-17
申请人： Xiaobo Wang , Yama A. Abassi , Josephine Atienza , Xiao Xu , Junquan Xu
发明人： Xiaobo Wang , Yama A. Abassi , Josephine Atienza , Xiao Xu , Junquan Xu
IPC分类号： C12Q1/68 , C12M1/42 , C12N15/87
CPC分类号： C12N15/87 , C12M35/02 , G01N15/12 , G01N33/48728
摘要： The present invention includes devices and methods for transfecting a cell or cell population and dynamic monitoring of cellular events. A variety of microelectronic devices are provide that incorporate functions such as electroporation, modulation of a transmembrane potential and dynamic monitoring of cellular functions and mechanisms.
摘要翻译：本发明包括用于转染细胞或细胞群的装置和方法以及细胞事件的动态监测。提供了多种微电子器件，其包括诸如电穿孔，跨膜电位的调节和细胞功能和机制的动态监测的功能。

10. 发明授权

US08344742B2 Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays 有权
标题翻译：实时电子细胞感测系统和细胞毒性分析和化合物分析的应用
公开(公告)号：US08344742B2
公开(公告)日：2013-01-01
申请号：US13011725
申请日：2011-01-21
申请人： Yama A. Abassi , Xiaobo Wang , Xiao Xu
发明人： Yama A. Abassi , Xiaobo Wang , Xiao Xu
IPC分类号： G01R27/08
CPC分类号： C12Q1/025 , C12Q1/002 , G01N27/02 , G01N33/4836 , G01N33/5014 , G01N33/5438
摘要： The invention provides methods of investigating a mechanism of action of a compound, which includes providing a device for monitoring cell-substrate impedance; attaching the device to an impedance analyzer; adding cells to two or more wells; adding a test compound to at least one of the wells and providing at least one control well; monitoring impedance of the wells to obtain a series of impedance measurements; plotting impedance measurements to obtain impedance curves and comparing the impedance curves to determine a time frame at which the test compound has a significant effect on cell growth or behavior. Determining the time frame provides information on changes in cell status in response to the test compound, including cell attachment or adhesion status, cell growth or proliferation status, the number of viable or dead cells, cytoskeletal organization or structure, and the number of cells going through apoptosis or necrosis.
摘要翻译：本发明提供了研究化合物作用机理的方法，其包括提供用于监测细胞 - 基底阻抗的装置; 将设备连接到阻抗分析仪; 将细胞添加到两个或更多个孔中; 向至少一个孔中加入测试化合物并提供至少一个对照孔; 监测井的阻抗以获得一系列阻抗测量; 绘制阻抗测量以获得阻抗曲线并比较阻抗曲线以确定测试化合物对细胞生长或行为具有显着影响的时间范围。确定时间框架提供了响应于测试化合物的细胞状态变化的信息，包括细胞附着或粘附状态，细胞生长或增殖状态，活细胞或死细胞的数量，细胞骨架组织或结构以及细胞数目通过凋亡或坏死。

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