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1. 发明授权

US09096504B2 Controlled chemical release of hydrogen sulfide 有权
标题翻译：硫化氢的控制化学释放
公开(公告)号：US09096504B2
公开(公告)日：2015-08-04
申请号：US13989971
申请日：2011-12-01
申请人： Ming Xian , Yu Zhao
发明人： Ming Xian , Yu Zhao
IPC分类号： A61K31/21 , C07C381/00 , A61K31/095 , A61K31/165 , A61K31/166 , C07C327/00
CPC分类号： C07C381/00 , A61K31/095 , A61K31/165 , A61K31/166 , C07C327/00
摘要： Agents of formula: where R1 and R2 vary independently and are acyl, sulfonyl, phosphoryl, alkyl, substituted alkyl, halogen, aryl, arylalkyl, substituted aryl, heteroaryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, heterocycle, or heteroatoms; and R3 is H or a member of a ring structure which includes R2, are provided; as are agents of formula: where R1, R2 and R3 vary independently and: R1=OH, OR′, NHR′, NR′R″ (with R′ R″=alkyl, aryl, heteroaryl, etc); R2=acyl, alkyl, aryl, sulfonyl, etc; R3=alkyl, aryl, substituted aryl, heteroaryl, etc; and R4 and R5 are (independently) H, methyl or alkyl, substituted alkyl, aryl, substituted aryl, etc. Methods of using the agents to treat e.g. cardiovascular disease, stroke, shock, injuries caused by hypoxia, male erectile dysfunction, and Alzheimer's are provided.
摘要翻译：酰基，磺酰基，磷酰基，烷基，取代的烷基，卤素，芳基，芳基烷基，取代的芳基，杂芳基，烯基，取代的烯基，炔基，取代的炔基，环烷基，杂环或杂原子 ; 并且R3是H或包括R2的环结构的构件; 如下式所示：其中R1，R2和R3独立变化：R1 = OH，OR'，NHR'，NR'R“（R'R”=烷基，芳基，杂芳基等）; R2 =酰基，烷基，芳基，磺酰基等; R3 =烷基，芳基，取代的芳基，杂芳基等; 并且R 4和R 5是（独立地）H，甲基或烷基，取代的烷基，芳基，取代的芳基等。提供心血管疾病，中风，休克，由缺氧引起的损伤，男性勃起功能障碍和阿尔茨海默病。

2. 发明申请

US20130253051A1 CONTROLLED CHEMICAL RELEASE OF HYDROGEN SULFIDE 有权
标题翻译：硫化氢的控制化学释放
公开(公告)号：US20130253051A1
公开(公告)日：2013-09-26
申请号：US13989971
申请日：2011-12-01
申请人： Ming Xian , Yu Zhao
发明人： Ming Xian , Yu Zhao
IPC分类号： C07C381/00 , C07C327/00
CPC分类号： C07C381/00 , A61K31/095 , A61K31/165 , A61K31/166 , C07C327/00
摘要： Agents of formula: where R1 and R2 vary independently and are acyl, sulfonyl, phosphoryl, alkyl, substituted alkyl, halogen, aryl, arylalkyl, substituted aryl, heteroaryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, heterocycle, or heteroatoms; and R3 is H or a member of a ring structure which includes R2, are provided; as are agents of formula: where R1, R2 and R3 vary independently and: R1=OH, OR′, NHR′, NR′R″ (with R′ R″=alkyl, aryl, heteroaryl, etc); R2=acyl, alkyl, aryl, sulfonyl, etc; R3=alkyl, aryl, substituted aryl, heteroaryl, etc; and R4 and R5 are (independently) H, methyl or alkyl, substituted alkyl, aryl, substituted aryl, etc. Methods of using the agents to treat e.g. cardiovascular disease, stroke, shock, injuries caused by hypoxia, male erectile dysfunction, and Alzheimer's are provided.
摘要翻译：酰基，磺酰基，磷酰基，烷基，取代的烷基，卤素，芳基，芳基烷基，取代的芳基，杂芳基，烯基，取代的烯基，炔基，取代的炔基，环烷基，杂环或杂原子 ; 并且R3是H或包括R2的环结构的构件; 其中R 1，R 2和R 3独立地独立地变化：R 1 = OH，OR'，NHR'，NR'R“（R'R”=烷基，芳基，杂芳基等）; R2 =酰基，烷基，芳基，磺酰基等; R3 =烷基，芳基，取代的芳基，杂芳基等; 并且R 4和R 5是（独立地）H，甲基或烷基，取代的烷基，芳基，取代的芳基等。提供心血管疾病，中风，休克，由缺氧引起的损伤，男性勃起功能障碍和阿尔茨海默病。

3. 发明申请

US20070276144A1 Synthesis Of Discodermolide And Variants Thereof 有权
标题翻译：糖皮质激素及其变体的合成
公开(公告)号：US20070276144A1
公开(公告)日：2007-11-29
申请号：US10575136
申请日：2004-10-12
申请人： Amos Smith , Brian Freeze , Ming Xian
发明人： Amos Smith , Brian Freeze , Ming Xian
IPC分类号： C07D309/10 , C07B41/02 , C07D263/06
CPC分类号： C07F7/1892 , C07D309/30 , C07D309/32 , C07F7/1804
摘要： Processes for synthesizing a compound of Formula (I) are provided by reacting a compound of Formula (i) with a compound of Formula (xx).
摘要翻译：合成式（I）化合物的方法通过使式（ⅰ）化合物与式（Ⅹx）化合物反应来制备。

4. 发明授权

US09243028B2 Facile amide formation via S-nitroso thioacid intermediates 有权
标题翻译：通过S-亚硝基硫代酸中间体形成酰胺
公开(公告)号：US09243028B2
公开(公告)日：2016-01-26
申请号：US13359372
申请日：2012-01-26
申请人： Ming Xian , Jia Pan
发明人： Ming Xian , Jia Pan
IPC分类号： C07C231/10 , C07D295/192 , C07K1/02 , C07C269/06 , C07C381/00 , C07D207/10 , C07D209/20 , C07D295/185
CPC分类号： C07K1/02 , C07C231/10 , C07C269/06 , C07C381/00 , C07D207/10 , C07D209/20 , C07D295/185 , C07D295/192 , C07C233/65 , C07C233/83 , C07C233/87 , C07C271/12 , C07C271/22
摘要： Provided are methods for forming a reactive S-nitroso thioacid (NTA), comprising nitrosation of a thioacid with a nitrosation reagent. Also provided are methods for: acylating a nucleophile including selective acylation with a high degree of selectivity toward amines over hydroxyls; amide or peptide bond formation; forming a dipeptide or polypeptide; and peptide coupling/ligation, comprising use of thioacid and amine starting materials, wherein the reactions are mediated by very reactive S-nitroso thioacid (NTA) intermediates enabling extremely fast reactions under mild conditions, providing for broad applications.
摘要翻译：提供了形成反应性S-亚硝基硫代酸（NTA）的方法，其包括用亚硝化试剂亚硫酸化的硫代酸。还提供了以下方法：酰化包括选择性酰化在内的亲核试剂与胺相对于羟基的高度选择性; 酰胺或肽键形成; 形成二肽或多肽; 和肽偶联/连接，其包括使用硫代酸和胺起始物质，其中所述反应由非常活泼的S-亚硝基硫代酸（NTA）中间体介导，在温和条件下能够进行极快的反应，提供广泛的应用。

5. 发明申请

US20110172440A1 ROSIN DERIVED EPOXIDES AND CURING AGENTS 审中-公开
标题翻译：罗辛衍生的环氧化物和固化剂
公开(公告)号：US20110172440A1
公开(公告)日：2011-07-14
申请号：US13119146
申请日：2009-09-16
申请人： Jinwen Zhang , Xiaoqing Liu , Ming Xian
发明人： Jinwen Zhang , Xiaoqing Liu , Ming Xian
IPC分类号： C07D303/18 , C07D405/14 , C07D307/77 , C07D407/12
CPC分类号： C07D407/12 , C07D209/02 , C07D303/17 , C07D405/14 , C07D407/14
摘要： An epoxide agent for an epoxy resin system, the epoxide agent comprising at least one non-acid functional rosin moiety and at least one epoxide moiety. Another embodiment is a curing agent for an epoxy resin system comprising at least one non-acid functional rosin moiety and at least one moiety that is reactive with an epoxy.
摘要翻译：用于环氧树脂体系的环氧化物，所述环氧化物包含至少一种非酸性功能性松香部分和至少一种环氧化物部分。另一个实施方案是用于环氧树脂体系的固化剂，其包含至少一种非酸官能化松香部分和至少一个与环氧树脂反应的部分。

6. 发明授权

US09029566B2 Rosin derived epoxides and curing agents 有权
标题翻译：松香衍生环氧化物和固化剂
公开(公告)号：US09029566B2
公开(公告)日：2015-05-12
申请号：US13119146
申请日：2009-09-16
申请人： Jinwen Zhang , Xiaoqing Liu , Ming Xian
发明人： Jinwen Zhang , Xiaoqing Liu , Ming Xian
IPC分类号： C07D405/14 , C07D407/12 , C07D407/14 , C07D209/02 , C07D303/17
CPC分类号： C07D407/12 , C07D209/02 , C07D303/17 , C07D405/14 , C07D407/14
摘要： An epoxide agent for an epoxy resin system, the epoxide agent comprising at least one non-acid functional rosin moiety and at least one epoxide moiety. Another embodiment is a curing agent for an epoxy resin system comprising at least one non-acid functional rosin moiety and at least one moiety that is reactive with an epoxy.
摘要翻译：用于环氧树脂体系的环氧化物，所述环氧化物包含至少一种非酸性功能性松香部分和至少一种环氧化物部分。另一个实施方案是用于环氧树脂体系的固化剂，其包含至少一种非酸官能化松香部分和至少一个与环氧树脂反应的部分。

7. 发明申请

US20120190820A1 FACILE AMIDE FORMATION VIA S-NITROSO THIOACID INTERMEDIATES 有权
标题翻译：通过S-NITROSO THIOACID INTERMEDIATES的可能的酰胺形成
公开(公告)号：US20120190820A1
公开(公告)日：2012-07-26
申请号：US13359372
申请日：2012-01-26
申请人： Ming Xian , Jia Pan
发明人： Ming Xian , Jia Pan
IPC分类号： C07K1/02 , C07D209/20 , C07D295/194 , C07C227/10 , C07C381/00 , C07C231/10
CPC分类号： C07K1/02 , C07C231/10 , C07C269/06 , C07C381/00 , C07D207/10 , C07D209/20 , C07D295/185 , C07D295/192 , C07C233/65 , C07C233/83 , C07C233/87 , C07C271/12 , C07C271/22
摘要： Provided are methods for forming a reactive S-nitroso thioacid (NTA), comprising nitrosation of a thioacid with a nitrosation reagent. Also provided are methods for: acylating a nucleophile including selective acylation with a high degree of selectivity toward amines over hydroxyls; amide or peptide bond formation; forming a dipeptide or polypeptide; and peptide coupling/ligation, comprising use of thioacid and amine starting materials, wherein the reactions are mediated by very reactive S-nitroso thioacid (NTA) intermediates enabling extremely fast reactions under mild conditions, providing for broad applications.
摘要翻译：提供了形成反应性S-亚硝基硫代酸（NTA）的方法，其包括用亚硝化试剂亚硫酸化的硫代酸。还提供了以下方法：酰化包括选择性酰化在内的亲核试剂与胺相对于羟基的高度选择性; 酰胺或肽键形成; 形成二肽或多肽; 和肽偶联/连接，其包括使用硫代酸和胺起始物质，其中所述反应由非常活泼的S-亚硝基硫代酸（NTA）中间体介导，在温和条件下能够进行极快的反应，提供广泛的应用。

8. 发明授权

US07700783B2 Synthesis of discodermolide and variants thereof 有权
标题翻译： discodermolide及其变体的合成
公开(公告)号：US07700783B2
公开(公告)日：2010-04-20
申请号：US10575136
申请日：2004-10-12
申请人： Amos B Smith, III , Brian Scott Freeze , Ming Xian
发明人： Amos B Smith, III , Brian Scott Freeze , Ming Xian
IPC分类号： C07D263/00 , C07D315/00 , C07B41/00
CPC分类号： C07F7/1892 , C07D309/30 , C07D309/32 , C07F7/1804
摘要： Processes for synthesizing a compound of Formula (I) are provided by reacting a compound of Formula (i) with a compound of Formula (xx).
摘要翻译：合成式（I）化合物的方法通过使式（ⅰ）化合物与式（Ⅹx）化合物反应来制备。

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