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    • 3. 发明申请
    • CONTROLLED CHEMICAL RELEASE OF HYDROGEN SULFIDE
    • 硫化氢的控制化学释放
    • WO2012075242A2
    • 2012-06-07
    • PCT/US2011062820
    • 2011-12-01
    • UNIV WASHINGTON STATE RES FDNXIAN MINGZHAO YU
    • XIAN MINGZHAO YU
    • A61K31/255A61K31/095A61K31/265A61K31/27A61P9/00A61P25/28
    • C07C381/00A61K31/095A61K31/165A61K31/166C07C327/00
    • Agents of formula: where R1 and R2 vary independently and are acyl, sulfonyl, phosphoryl, alkyl, substituted alkyl, halogen, aryl, arylalkyl, substituted aryl, heteroaryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, heterocycle, or heteroatoms; and R3 is H or a member of a ring structure which includes R2, are provided; as are agents of formula: where R1, R2 and R3 vary independently and: R1 = OH, OR', NHR', NR'R" (with R' R" = alkyl, aryl, heteroaryl, etc); R2 = acyl, alkyl, aryl, sulfonyl, etc; R3 = alkyl, aryl, substituted aryl, heteroaryl, etc; and R4 and R5 are (independently) H, methyl or alkyl, substituted alkyl, aryl, substituted aryl, etc. Methods of using the agents to treat e.g. cardiovascular disease, stroke, shock, injuries caused by hypoxia, male erectile dysfunction, and Alzheimer's are provided.
    • 下式的试剂:其中R1和R2独立地变化,并且是酰基,磺酰基,磷酰基,烷基,取代的烷基,卤素,芳基,芳基烷基,取代的芳基,杂芳基,烯基,取代的烯基,炔基,取代的炔基,环烷基,杂环或杂原子 ; 并且R3是H或包含R2的环结构的成员; 如下式的试剂:其中R 1,R 2和R 3独立地变化并且:R 1 = OH,OR',NHR',NR'R“(其中R'R”=烷基,芳基,杂芳基等) R2 =酰基,烷基,芳基,磺酰基等; R3 =烷基,芳基,取代的芳基,杂芳基等; 并且R 4和R 5是(独立地)H,甲基或烷基,取代的烷基,芳基,取代的芳基等。 心血管疾病,中风,休克,缺氧引起的损伤,男性勃起功能障碍和阿尔茨海默病。
    • 8. 发明申请
    • BICYCLIC OXO-THIOLACTONES
    • 双酚OXO-THIOLACTONES
    • WO1980002025A1
    • 1980-10-02
    • PCT/US1980000352
    • 1980-03-20
    • AMERICAN HOME PROD CORP
    • AMERICAN HOME PROD CORPKIM D
    • C07D513/04
    • C07D513/04C07C323/00C07C327/00C07D207/16
    • Bicyclic oxo-thiolactones of the formula: (FORMULA) in which R u is hydrogen or lower alkyl; R u and R u are, independently, hydrogen, hydroxy, halogen, lower alkyl, lower alkoxy, or aryl; and R u, R u, and R u are, independently, hydrogen, lower alkyl, lower hydroxyalkyl, aryl, or arylalkyl, except that R u and R u may not both be aryl. These compounds act as inhibitors of angiotensin converting enzyme and are useful as agents for the treatment of hypertension in mammals. The compounds are stable against oxidation of the sulfur. Also disclosed is a method of preparation of such compounds.
    • 下式的双环氧代 - 硫代内酯:其中R u是氢或低级烷基的式(式) R u和R u独立地是氢,羟基,卤素,低级烷基,低级烷氧基或芳基; 并且R u,R u和R u独立地是氢,低级烷基,低级羟基烷基,芳基或芳烷基,不同之处在于R u和R u可以 不是都是芳基。 这些化合物作为血管紧张素转化酶的抑制剂,可用作哺乳动物高血压治疗剂。 该化合物对硫的氧化是稳定的。 还公开了这种化合物的制备方法。