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    • 8. 发明申请
    • Ordered particle structures and methods of making same
    • 有序粒子结构及其制作方法
    • US20050228075A1
    • 2005-10-13
    • US10878656
    • 2004-06-28
    • Costas GogosMing-Wan YoungRajesh DaveRobert PfefferTheodore DavidsonDavid ToddBainian QianJun Yang
    • Costas GogosMing-Wan YoungRajesh DaveRobert PfefferTheodore DavidsonDavid ToddBainian QianJun Yang
    • C06B21/00C06B45/02C08J3/20C08K7/00C10L5/00D03D23/00
    • C08J3/20C06B21/0025C06B21/0083C06B45/02
    • Techniques and methods of formation of ordered mixtures of particles by “clustering”. Clustering comprises local “structuring” consisting of a large “host” and smaller “guest” particles by various techniques. Small amounts of polymer are coated onto solid particles by various means. In one embodiment, an ordered mixture is created wherein the material that is of lesser quantity is of small particle size (the “B” particles) and the “A” particles are of larger size. The “B” particles are then coated onto a single A particle. By creating this ordered structure, each composite particle has the proper or stoichiometric amount of all ingredients. This dry composite material produced is appropriately used in various applications such as pharmaceutical formulations in the form of tablets, capsules, oral suspensions, inhalant, parenteral formulations and the like; energetics manufacture such as but not limited to explosives, propellants and pyrotechnics; agricultural products including but not limited to fertilizers, herbicides and pesticides; nutritional supplements and the like.
    • 通过“聚类”形成有序粒子混合物的技术和方法。 聚类包括通过各种技术由大型“主机”和较小的“客体”粒子组成的本地“结构化”。 少量聚合物通过各种方式涂覆在固体颗粒上。 在一个实施方案中,产生有序混合物,其中少量的材料具有较小的粒度(“B”颗粒)和“A”颗粒的尺寸较大。 然后将“B”颗粒涂覆到单个A颗粒上。 通过创建这种有序结构,每个复合颗粒具有适当或化学计量的所有成分。 生产的这种干燥复合材料适用于各种应用,例如片剂,胶囊,口服悬浮液,吸入剂,肠胃外制剂等药物制剂; 能源制造,例如但不限于爆炸物,推进剂和烟火; 农产品包括但不限于化肥,除草剂和农药; 营养补品等。