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1. 发明授权

US11388794B2 Method and illumination system for simulating CIE standard illuminant with multi-channel LED 有权
公开(公告)号：US11388794B2
公开(公告)日：2022-07-12
申请号：US17382234
申请日：2021-07-21
申请人： Peng Jin
发明人： Peng Jin
IPC分类号： H05B45/14 , H05B45/28 , H05B45/24 , F21K9/64 , F21Y115/10
摘要： A method and an illumination system for simulating a CIE standard illuminant with a multi-channel LED are disclosed. The method includes adjusting a brightness of the main light source control channel, the wavelength complementary control channel, the color temperature adjustment control channel to make a mixed chromaticity coordinate meet a chromaticity coordinate of the CIE standard illuminant to be simulated according to chromaticity coordinates. The LED control channels are reduced through group optimization, and a technology which is discarded by multi-channel LED such as a filter is used, a control of a light source substantially reducing number of control channels and enabling a multi-channel LED to simulate a standard illuminant is formed, such that a single chromaticity control rather than a chromaticity control which must be transformed by a spectral conversion is achieved.

2. 发明授权

US08618077B2 Compositions and methods for treating fragile X premutation RVGG repeats-mediated toxicity 有权
标题翻译：用于治疗脆性X前体RVGG重复介导的毒性的组合物和方法
公开(公告)号：US08618077B2
公开(公告)日：2013-12-31
申请号：US13457718
申请日：2012-04-27
申请人： Peng Jin , Abrar Qurashi
发明人： Peng Jin , Abrar Qurashi
IPC分类号： A61K31/7068
CPC分类号： A61K31/11 , A61K31/12 , A61K31/16 , A61K31/225 , A61K31/35 , A61K31/404 , A61K31/443 , A61K31/473 , A61K31/54 , A61K31/56 , A61K31/58 , A61K31/7068
摘要： Compositions and methods of treatment or prophylaxis of fragile-X associated disorders are provided, as well as methods of screening compounds and kits to screen a library of compounds.
摘要翻译：提供了治疗或预防脆性-X相关病症的组合物和方法，以及筛选化合物和试剂盒筛选化合物文库的方法。

3. 发明申请

US20080312279A1 Compositions for Treating Fragile X and Other Disorders Methods of Use Thereof, and Screening for Compounds for Fragile X and Other Disorders 审中-公开
标题翻译：用于治疗脆性X和其他疾病的组合物使用方法和筛选用于脆性X和其他疾病的化合物
公开(公告)号：US20080312279A1
公开(公告)日：2008-12-18
申请号：US12091549
申请日：2006-10-26
申请人： Stephen T. Warren , Shuang Chang , Peng Jin
发明人： Stephen T. Warren , Shuang Chang , Peng Jin
IPC分类号： A61K31/4462 , C40B30/06 , A61K31/4178
CPC分类号： A61K31/4462 , A61K31/4178 , G01N33/5085 , G01N2800/28
摘要： Methods of screening compounds, active compositions, pharmaceutical compositions, methods of treating disorders, methods of preventing disorders, and kits to screen a library of compounds, are disclosed.
摘要翻译：公开了筛选化合物，活性组合物，药物组合物，治疗障碍的方法，预防病症的方法以及筛选化合物文库的试剂盒的方法。

4. 发明授权

US07432052B2 Method and identification of downstream mRNA ligands to FMRP and their role in fragile X syndrome and associated disorders 失效
标题翻译： FMRP下游mRNA配体的方法和鉴定及其在脆性X综合征及相关疾病中的作用
公开(公告)号：US07432052B2
公开(公告)日：2008-10-07
申请号：US10495728
申请日：2002-11-15
申请人： Stephen T. Warren , Victoria Brown-Kennerly , Peng Jin , Stephanie Ceman , Robert B. Darnell , Jennifer C. Darnell , Jack D. Keene , Scott A. Tenenbaum
发明人： Stephen T. Warren , Victoria Brown-Kennerly , Peng Jin , Stephanie Ceman , Robert B. Darnell , Jennifer C. Darnell , Jack D. Keene , Scott A. Tenenbaum
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q2600/158
摘要： Compositions and methods for identifying and/or modulating RNA transcripts and/or genes involved in fragile X syndrome and other associated disorders are provided. In particular, RNA targets for fragile X mental retardation protein (FMRP) have been identified by a novel monoclonal antibody to FMRP and a consensus sequence for the RNA binding region has been identified. Arrays for identifying compounds, proteins, nucleotides, and the like that modulate the RNA targets or associated genes are provided. Additionally, methods for modulating RNA targets are provided.
摘要翻译：提供了用于鉴定和/或调节涉及脆性X综合征和其它相关病症的RNA转录物和/或基因的组合物和方法。特别地，已经通过FMRP的新型单克隆抗体鉴定了脆性X智力迟钝蛋白（FMRP）的RNA靶标，并且已经鉴定了RNA结合区域的共有序列。提供了用于鉴定调节RNA靶标或相关基因的化合物，蛋白质，核苷酸等的阵列。另外，提供了调节RNA靶标的方法。

5. 发明申请

US20160319272A1 Method for Directed DNA Evolution using Combinatorial DNA Libraries 审中-公开
标题翻译：使用组合DNA文库进行定向DNA进化的方法
公开(公告)号：US20160319272A1
公开(公告)日：2016-11-03
申请号：US15140408
申请日：2016-04-27
申请人： Zhen Kang , Jian Chen , Guocheng Du , Peng Jin
发明人： Zhen Kang , Jian Chen , Guocheng Du , Peng Jin
IPC分类号： C12N15/10
CPC分类号： C12N15/1058 , C12N15/1031 , C12Q2521/101 , C12Q2521/501 , C12Q2531/113 , C12Q2533/101 , C12Q2563/179
摘要： The present invention provides a method of rapid directed DNA evolution based on single-stranded combinatorial DNA mutant library. The single- and double-stranded mutant library are constructed either separately or simultaneously using editing primers that contain mutated nucleotides and are targeted to different regions of the parent DNA sequence. The mutant library is then inserted into expression vectors and mutants with desired property are obtained by high throughput screening. Evolution of promoters, enzymes and metabolic pathways were successfully achieved using this method and mutants with excellent properties were obtained. The method of the present invention is simple, rapid, and efficient. It can be used for directed evolution of regulatory sequence such as promoters and ribosome binding sites, and is especially suitable for introducing diverse mutations into protein encoding genes, leading to rapid directed evolution of gene of interest.
摘要翻译：本发明提供了基于单链组合DNA突变体文库的快速定向DNA进化的方法。使用含有突变核苷酸的编辑引物单独或同时构建单链和双链突变体文库，并且靶向母DNA序列的不同区域。然后将突变型文库插入表达载体中，并通过高通量筛选获得具有所需性质的突变体。使用该方法成功实现了启动子，酶和代谢途径的进化，获得了具有优异性能的突变体。本发明的方法简单，快速，高效。它可以用于调节序列的定向进化，如启动子和核糖体结合位点，特别适用于将多种突变引入到蛋白质编码基因中，导致感兴趣的基因的快速定向进化。

6. 发明申请

US20120071539A1 COMPOUNDS AND METHODS FOR MODULATING THE SILENCING OF A POLYNUCLEOTIDE OF INTEREST 审中-公开
标题翻译：用于调节多焦点的沉降的化合物和方法
公开(公告)号：US20120071539A1
公开(公告)日：2012-03-22
申请号：US12519062
申请日：2007-12-12
申请人： Peng Jin
发明人： Peng Jin
IPC分类号： A61K31/713 , A61K31/4439 , A61K31/352 , A61K31/575 , A61K31/192 , A61K31/366 , A61K31/16 , A61K31/52 , A61K31/357 , A61K31/395 , A61K31/4985 , A61K31/7105 , A61K8/60 , A61K31/365 , A61P31/12 , A61P43/00 , A61K31/496 , C12Q1/68 , C40B30/06 , A61K31/444 , A61K31/4409 , A61P35/00 , A61P35/02 , A61P25/28 , A61P25/16 , C12N5/071
CPC分类号： A61K31/4439
摘要： Methods and compositions comprising chemical compounds that modulate the silencing of a polynucleotide of interest in a cell are provided. Such chemical compounds when used in combination with an appropriate silencing element can be used to modulate (increase or decrease) the level of the polynucleotide targeted by the silencing element. Methods of using such compositions both in therapies involving RNAi-mediated suppression of gene expression, as well as, in vitro methods that allow for the targeted modulation of expression of a polynucleotide of interest are provided. Pharmaceutical or cosmetic compositions comprising such compounds and silencing elements also are disclosed. Methods for screening a compound of interest for the ability to modulate the activity of a heterologous silencing element also are provided.
摘要翻译：提供了包含调节细胞中目的多核苷酸沉默的化合物的方法和组合物。当与适当的沉默元件组合使用时，这种化合物可用于调节（增加或减少）沉默元件靶向的多核苷酸的水平。提供了在涉及RNAi介导的基因表达抑制的治疗中使用这些组合物的方法，以及允许针对目的调节感兴趣的多核苷酸表达的体外方法。还公开了包含这些化合物和沉默元件的药物或化妆品组合物。还提供了筛选感兴趣的化合物调节异源沉默元件的活性能力的方法。

7. 发明授权

US07910292B2 Lithographic process 失效
标题翻译：平版印刷工艺
公开(公告)号：US07910292B2
公开(公告)日：2011-03-22
申请号：US10582033
申请日：2004-12-01
申请人： Kyle Jiang , Peng Jin
发明人： Kyle Jiang , Peng Jin
IPC分类号： G03F7/00
CPC分类号： G03F7/2008 , G03F7/20
摘要： The present invention provides a lithographic process for producing high aspect ratio parts from an epoxy-type negative photoresist comprising the steps of: (i) irradiating a prebaked masked epoxy-type negative photoresist on a substrate with light at a total energy density of from 18,000 to 35,000 mJ/cm2, (ii) post-baking the exposed photoresist at elevated temperature, and (iii) developing the exposed photoresist in a solvent, wherein no more than 15% of the energy density is contributed by light having a wavelength of 400 nm or less. The invention also discloses a reciprocating microengine (10) comprising a cylinder (14), piston (12) and crankshaft made by the process.
摘要翻译：本发明提供了一种用于从环氧型负型光致抗蚀剂制造高纵横比部件的光刻工艺，其特征在于包括以下步骤：（i）在总能量密度为18,000的光照射基底上的预焙掩膜的环氧型负性光致抗蚀剂（iii）在升高的温度下对曝光的光致抗蚀剂进行后烘烤，以及（iii）在溶剂中显影曝光的光致抗蚀剂，其中不超过15％的能量密度由波长为400的光 nm以下。本发明还公开了一种往复式微发动机（10），其包括由该过程制成的气缸（14），活塞（12）和曲轴。

8. 发明申请

US20060215422A1 LED light bulb 失效
标题翻译： LED灯泡
公开(公告)号：US20060215422A1
公开(公告)日：2006-09-28
申请号：US11343450
申请日：2006-01-30
申请人： Robert Laizure , Wojciech Pawelko , Lee Cote , Peng Jin
发明人： Robert Laizure , Wojciech Pawelko , Lee Cote , Peng Jin
IPC分类号： H01R33/00 , F21V31/00
CPC分类号： F21V31/005 , F21K9/232 , F21V3/00 , F21Y2107/00 , F21Y2107/90 , F21Y2115/10 , Y10S362/80
摘要： A light emitting diode (LED) light bulb configured to replicate the light output of a conventional incandescent light bulb is provided. The LED light bulb includes a base for coupling the bulb to a power source having at least one side wall defining a cavity; a generally rectangular substrate having a first end and a second end, the second end disposed in the cavity and electrically coupled to the base; a plurality of LEDs electrically coupled and disposed on the first end of the substrate, the plurality of LEDS arranged on a front face, back face and top edge of the first end of the substrate to emit light in a spherical output; and a light transmissive cover configured to enclose the plurality of LEDs, the cover being coupled to the base.
摘要翻译：提供了配置成复制常规白炽灯泡的光输出的发光二极管（LED）灯泡。 LED灯泡包括用于将灯泡耦合到具有限定空腔的至少一个侧壁的电源的基座; 具有第一端和第二端的大致矩形的基板，所述第二端设置在所述空腔中并电耦合到所述基座; 电耦合并设置在所述基板的第一端上的多个LED，所述多个LED布置在所述基板的第一端的前表面，背面和顶边缘上以发射球形输出的光; 以及被配置为包围所述多个LED的透光盖，所述盖耦合到所述基座。

9. 外观设计

USD982171S1 Massage gun 有权
公开(公告)号：USD982171S1
公开(公告)日：2023-03-28
申请号：US29811835
申请日：2021-10-18
申请人： Peng Jin
设计人： Peng Jin

10. 发明授权

US10656095B2 Systems and methods for wavelength spectrum analysis for detection of various gases using a treated tape 有权
公开(公告)号：US10656095B2
公开(公告)日：2020-05-19
申请号：US13024022
申请日：2011-02-09
申请人： Peng Jin
发明人： Peng Jin
IPC分类号： G01N21/84
摘要： An apparatus including a treated tape, an adjustable color source, a photodiode, and a processor is provided. The adjustable color source emits a first radiation toward the treated tape and operates at each of a plurality of different target wavelengths in a spectrum. The photodiode measures a second radiation reflected from the treated tape, and the processor analyzes measurements from the photodiode to determine a peak wavelength from the plurality of target wavelengths. Based on the peak wavelength, the processor determines a color and darkness of a color stain on the treated tape. Based on the determined color and darkness of the color stain, the processor also determines a type and concentration of gas to which the treated tape is exposed.

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