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1. 发明申请

US20070270331A1 Modulators of gluconeogenesis 失效
标题翻译：糖异生的调节剂
公开(公告)号：US20070270331A1
公开(公告)日：2007-11-22
申请号：US11717426
申请日：2007-03-13
申请人： Stephen Berasi , Christine Huard , Dongmei Li , Heather Shih , Ying Sun , Janet Paulsen , Eugene Brown , Ruth Gimeno , Robert Martinez
发明人： Stephen Berasi , Christine Huard , Dongmei Li , Heather Shih , Ying Sun , Janet Paulsen , Eugene Brown , Ruth Gimeno , Robert Martinez
IPC分类号： A61K38/02 , A61K31/7052 , A61P3/08 , C12N5/02
CPC分类号： C07K14/4702 , A61K38/1709 , C12N9/16
摘要： The present invention provides methods of affecting gluconeogenesis by altering the levels or activity of DUSP4 and/or EGR1. Pharmaceutical compositions comprising or encoding modulators of gluconeogenesis are also disclosed.
摘要翻译：本发明提供通过改变DUSP4和/或EGR1的水平或活性来影响糖异生的方法。还公开了包含或编码糖异生的调节剂的药物组合物。

2. 发明授权

US07763441B2 Modulators of gluconeogenesis 失效
标题翻译：糖异生的调节剂
公开(公告)号：US07763441B2
公开(公告)日：2010-07-27
申请号：US11717426
申请日：2007-03-13
申请人： Stephen Berasi , Christine Huard , Dongmei Li , Heather Shih , Ying Sun , Janet Paulsen , Eugene L. Brown , Ruth Gimeno , Robert Martinez
发明人： Stephen Berasi , Christine Huard , Dongmei Li , Heather Shih , Ying Sun , Janet Paulsen , Eugene L. Brown , Ruth Gimeno , Robert Martinez
IPC分类号： C12Q1/42 , C12N9/16 , G01N33/53 , A61K38/17
CPC分类号： C07K14/4702 , A61K38/1709 , C12N9/16
摘要： The present invention provides methods of affecting gluconeogenesis by altering the levels or activity of DUSP4 and/or EGR1. Pharmaceutical compositions comprising or encoding modulators of gluconeogenesis are also disclosed.
摘要翻译：本发明提供通过改变DUSP4和/或EGR1的水平或活性来影响糖异生的方法。还公开了包含或编码糖异生的调节剂的药物组合物。

3. 发明申请

US20070014776A1 Identification of adiponutrin-related proteins as esterases and methods of use for the same 审中-公开
标题翻译：脂肪素相关蛋白鉴定为酯酶及其使用方法
公开(公告)号：US20070014776A1
公开(公告)日：2007-01-18
申请号：US11450935
申请日：2006-06-09
申请人： Ruth Gimeno , Janet Paulsen , Jian-Liang Li , Andrew Lake , Wei Liu , Jae Eun Kim
发明人： Ruth Gimeno , Janet Paulsen , Jian-Liang Li , Andrew Lake , Wei Liu , Jae Eun Kim
IPC分类号： A61K38/54 , C12Q1/34 , C07H21/04 , C12P21/06 , C12N9/99
CPC分类号： C12Q1/44 , A61K38/28 , C12N9/20 , G01N33/543 , G01N2333/918 , G01N2500/00 , G01N2800/04 , G01N2800/32
摘要： The present invention provides methods of identifying polypeptides that have enzymatic activity associated with nutrient and/or energy homeostasis, and thus, are involved in the development of one or more cardiovascular and metabolic disorders, e.g., cardiovascular disease, obesity, insulin resistance, type 2 diabetes, dyslipidemia, nonalcoholic fatty liver disease, and metabolic syndrome. One such method comprises identifying a polypeptide as a member of the adiponutrin family of proteins. As such, the invention is related to the polynucleotides and polypeptides belonging to the adiponutrin family, and provides novel isolated and purified polynucleotides and polypeptides of a novel member of the adiponutrin family, patatin-like phospholipase domain 1 (PNPLA1). Also provided are methods of using the polynucleotides and polypeptides related to or provided by the invention for screening a test compound, e.g., a small molecule, antibody, etc., for the ability of the test compound to detect and/or modulate the activity of one or more members of the adiponutrin family of proteins. The present invention also is directed to novel methods for diagnosing, prognosing, and monitoring the progress of at least one cardiovascular and metabolic disorder using polynucleotides or polypeptides belonging to the adiponutrin family, and/or modulators of one or more members of the adiponutrin family. The present invention is further directed to novel therapeutics and therapeutic targets for the intervention (treatment) and prevention of cardiovascular and metabolic disorders arising from dysregulated energy homeostasis, as related to one or more members of the adiponutrin family of proteins.
摘要翻译：本发明提供了鉴定具有与营养和/或能量内稳态相关的酶活性的多肽的方法，因此涉及一种或多种心血管和代谢疾病的发展，例如心血管疾病，肥胖症，胰岛素抵抗，2型糖尿病，血脂异常，非酒精性脂肪性肝病和代谢综合征。一种这样的方法包括鉴定多肽作为脂肪细胞蛋白家族的成员。因此，本发明涉及属于脂肪调素素家族的多核苷酸和多肽，并且提供脂肪分泌素家族的新成员的新分离和纯化的多核苷酸和多肽，类似蛋白样磷脂酶结构域1（PNPLA1）。还提供了使用与本发明相关或由本发明提供的多核苷酸和多肽用于筛选测试化合物（例如小分子，抗体等）以测试化合物检测和/或调节活性的能力的方法脂肪蛋白家族蛋白的一个或多个成员。本发明还涉及使用属于脂肪素家族的多核苷酸或多肽和/或脂肪素家族的一个或多个成员的调节剂来诊断，预测和监测至少一种心血管和代谢紊乱进展的新方法。本发明进一步涉及用于干预（治疗）的新型治疗学和治疗靶标，以及与由脂肪蛋白家族蛋白质的一个或多个成员相关的由失调的能量稳态引起的心血管和代谢紊乱的预防。

4. 发明申请

US20070286858A1 Methods and Compositions for Antagonism of RAGE 审中-公开
标题翻译： RAGE拮抗剂的方法与组合
公开(公告)号：US20070286858A1
公开(公告)日：2007-12-13
申请号：US11689480
申请日：2007-03-21
申请人： Brian Clancy , Debra Pittman , Xiang-Yang Tan , Lioudmila Tchistiakova , Kodangattil Sreekumar , Janet Paulsen , Angela Widom , Nicole Piche-Nicholas , Ying Sun
发明人： Brian Clancy , Debra Pittman , Xiang-Yang Tan , Lioudmila Tchistiakova , Kodangattil Sreekumar , Janet Paulsen , Angela Widom , Nicole Piche-Nicholas , Ying Sun
IPC分类号： A61K39/395 , A61P19/02 , A61P7/12 , C07H21/04 , C07K16/28
CPC分类号： C07K16/2803 , A61K2039/505 , C07K14/705 , C07K14/70503 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Antibodies that bind specifically to receptor for advanced glycation end products (RAGE) and RAGE-binding fragments thereof are disclosed. Also disclosed are pharmaceutical compositions comprising such anti-RAGE antibodies and RAGE-binding antibody fragments thereof, and their use for treatment of RAGE related diseases.
摘要翻译：公开了特异性结合用于晚期糖基化终产物（RAGE）和RAGE结合片段的受体的抗体。还公开了包含这种抗RAGE抗体和其RAGE结合抗体片段的药物组合物及其用于治疗RAGE相关疾病的用途。

5. 发明授权

US6165748A Frazzled nucleotide sequences and expression products 失效
标题翻译：粉刺的核苷酸序列和表达产物
公开(公告)号：US6165748A
公开(公告)日：2000-12-26
申请号：US893654
申请日：1997-07-11
申请人： Lisa Racie , Edward Lavallie , Janet Paulsen , Hazel Sive , Benjamin Sun
发明人： Lisa Racie , Edward Lavallie , Janet Paulsen , Hazel Sive , Benjamin Sun
IPC分类号： C12N15/09 , A61K38/00 , A61P19/00 , C07K14/46 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/10 , C07K14/71
CPC分类号： C07K14/463 , A61K38/00
摘要： Purified Frazzled proteins, including WG67-16, WG67-19 and WA628, and processes for producing them are disclosed. DNA molecules encoding the Frazzled proteins, including WG67-16, WG67-19 and WA628, are also disclosed. The proteins may be used in modulating the binding of Wnt genes to their receptor. They are useful in the modulation of cellular formation, growth, differentiation, proliferation and/or maintenance of a variety of adult and embryonic tissues and organs.
摘要翻译：公开了包括WG67-16，WG67-19和WA628在内的纯化的Frazzled蛋白质及其生产方法。还公开了编码Frazzled蛋白质的DNA分子，包括WG67-16，WG67-19和WA628。蛋白质可用于调节Wnt基因与其受体的结合。它们可用于调节多种成体和胚胎组织和器官的细胞形成，生长，分化，增殖和/或维持。

6. 发明申请

US20070026463A1 Compositions and methods of mutant Nogo-66 domain proteins 审中-公开
标题翻译：突变Nogo-66结构域蛋白的组成和方法
公开(公告)号：US20070026463A1
公开(公告)日：2007-02-01
申请号：US11495061
申请日：2006-07-28
申请人： Yuhong Xie , Brian Bates , Janet Paulsen
发明人： Yuhong Xie , Brian Bates , Janet Paulsen
IPC分类号： C40B30/06 , G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： G01N33/566 , C07K14/47 , C07K2319/61 , G01N2333/475 , G01N2500/02
摘要： To facilitate the study of Nogo-66 interaction with its neuronal receptors, and to explore therapeutic opportunities, the present invention provides mutant human Nogo-66 domain-based proteins that do not aggregate during isolation or purification procedures, and methods for using these proteins. Aggregates of Nogo-66 domain containing proteins do not effectively or efficiently bind to the NgR1 receptor, and therefore limit the utility of Nogo-66 domain-based reagents. To overcome aggregation problems, the invention provides proteins that comprise a mutant human Nogo-66 domain, wherein the cysteine at position 47 of the wild-type human Nogo-66 domain is mutated. The invention also provides for various Nogo-66 domain fusion reporter proteins that are able to bind to NgR1, and therefore can be used in high-throughput assays to identify drug candidate compounds that can block binding of the Nogo-66 domain to NgR1, indicating that these compounds may be potential therapeutic agents for neurodegenerative diseases and neuronal repair.
摘要翻译：为了促进Nogo-66与其神经元受体的相互作用的研究，并且为了探索治疗机会，本发明提供了在分离或纯化过程中不聚合的突变型人Nogo-66结构域的蛋白质，以及使用这些蛋白质的方法。含有Nogo-66结构域的蛋白质的聚集体不能有效或有效地结合NgR1受体，因此限制了Nogo-66结构域的试剂的效用。为了克服聚集问题，本发明提供了包含突变人Nogo-66结构域的蛋白质，其中野生型人Nogo-66结构域的位置47处的半胱氨酸被突变。本发明还提供了能够结合NgR1的各种Nogo-66结构域融合报道蛋白，因此可用于高通量测定以鉴定可阻断Nogo-66结构域与NgR1结合的药物候选化合物，表明这些化合物可能是神经变性疾病和神经元修复的潜在治疗剂。

7. 发明申请

US20070031860A1 G-protein coupled receptor and uses therefor 审中-公开
标题翻译： G蛋白偶联受体及其用途
公开(公告)号：US20070031860A1
公开(公告)日：2007-02-08
申请号：US11396960
申请日：2006-04-03
申请人： Maria Blatcher , Brian Bates , Janet Paulsen
发明人： Maria Blatcher , Brian Bates , Janet Paulsen
IPC分类号： C12Q1/68 , G01N33/567 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： C07K14/70571 , A01K2217/075
摘要： The present invention is based on the identification of a G-protein coupled receptor (GPCR) that is expressed predominantly in the brain and placenta and nucleic acid molecules that encoded the GPCR, which is referred to herein as the hCAR protein and hCAR gene respectively (for human Constitutively Active Receptor). Based on this identification, the present invention provides: (1) isolated hCAR protein; (2) isolated nucleic acid molecules that encode an hCAR protein; (3) antibodies that selectively bind to the hCAR protein; (4) methods of isolating allelic variants of the hCAR protein and gene; (5) methods of identifying cells and tissues that express the hCAR protein/gene; (6) methods of identifying agents and cellular compounds that bind to the hCAR protein; (7) methods of identifying agents that modulate the expression of the hCAR gene; and (8) methods of modulating the activity of the hCAR protein in a cell or organism.
摘要翻译：本发明基于主要在脑和胎盘中表达的G蛋白偶联受体（GPCR）的鉴定和编码GPCR的核酸分子（分别在本文中称为hCAR蛋白和hCAR基因）对于人类组成型活性受体）。基于该鉴定，本发明提供：（1）分离的hCAR蛋白; （2）编码hCAR蛋白的分离的核酸分子; （3）选择性结合hCAR蛋白的抗体; （4）分离hCAR蛋白和基因的等位基因变体的方法; （5）鉴定表达hCAR蛋白/基因的细胞和组织的方法; （6）鉴定与hCAR蛋白结合的试剂和细胞化合物的方法; （7）鉴定调节hCAR基因表达的试剂的方法; 和（8）调节细胞或生物体中hCAR蛋白活性的方法。

8. 发明申请

US20060088912A1 Compositions and methods of purifying myelin-associated glycoprotein (MAG) 审中-公开
标题翻译：髓鞘相关糖蛋白（MAG）的组成和方法
公开(公告)号：US20060088912A1
公开(公告)日：2006-04-27
申请号：US11180855
申请日：2005-07-13
申请人： Gouying Yan , Yuhong Xie , Janet Paulsen , Jimin Zhang , Dionna Rookey , Brian Bates , Zhijian Lu , Robert Mark , Susie Campos
发明人： Gouying Yan , Yuhong Xie , Janet Paulsen , Jimin Zhang , Dionna Rookey , Brian Bates , Zhijian Lu , Robert Mark , Susie Campos
IPC分类号： C12P21/06 , C07H21/04 , C12N5/06 , C07K14/47
CPC分类号： C07K14/70503 , C07K14/4713 , C07K2319/21
摘要： The present invention provides compositions and methods useful for purifying recombinant myelin-associated glycoprotein (MAG) and fragments thereof. In particular, the invention provides a one-step purification method for MAG and MAG fragments. Novel forms of human recombinant MAG protein are also disclosed in addition to methods of reliably producing and storing stable recombinant MAG proteins.
摘要翻译：本发明提供了用于纯化重组髓鞘相关糖蛋白（MAG）及其片段的组合物和方法。特别地，本发明提供了MAG和MAG片段的一步法纯化方法。除了可靠地生产和储存稳定的重组MAG蛋白质的方法之外，还公开了新的形式的人重组MAG蛋白质。

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