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1. 发明申请

US20120272969A1 INTRAUTERINE SYSTEM 有权
标题翻译： INTRAUTERINE系统
公开(公告)号：US20120272969A1
公开(公告)日：2012-11-01
申请号：US13499701
申请日：2010-09-30
申请人： Taina Tjäder , Ulla Calvo Alonso , Pirjo Inki , Harri Jukarainen , Ilkka Jutila , Pirjo Kortesuo , Juha Lehtinen , Eeva Lukkari-Lax , Heikki Lyytikäinen , Joachim Moede , Hannu Nikander , Pirjo Sallinen , Faisal Shafiq , Wolfgang Kaufhold , Christian Wamprecht
发明人： Taina Tjäder , Ulla Calvo Alonso , Pirjo Inki , Harri Jukarainen , Ilkka Jutila , Pirjo Kortesuo , Juha Lehtinen , Eeva Lukkari-Lax , Heikki Lyytikäinen , Joachim Moede , Hannu Nikander , Pirjo Sallinen , Faisal Shafiq , Wolfgang Kaufhold , Christian Wamprecht
IPC分类号： A61F6/06 , B29C45/14 , C08L75/06
CPC分类号： A61F6/142 , A61K9/0039
摘要： The present invention relates to novel intrauterine systems and to methods for manufacturing these systems. An intrauterine system according to the invention comprises a reservoir and a continuous, closed and flexible frame. The frame comprises a thermoplastic polyurethane elastomer made of a polycarbonate diol, 1,6-hexamethylenediisocyanate, and a chain extender.
摘要翻译：本发明涉及新颖的子宫内系统和用于制造这些系统的方法。根据本发明的子宫内系统包括储存器和连续的，封闭且柔性的框架。框架包括由聚碳酸酯二醇，1,6-六亚甲基二异氰酸酯和扩链剂制成的热塑性聚氨酯弹性体。

2. 发明授权

US09949869B2 Intrauterine system 有权
公开(公告)号：US09949869B2
公开(公告)日：2018-04-24
申请号：US13499701
申请日：2010-09-30
申请人： Taina Tjäder , Ulla Calvo Alonso , Pirjo Inki , Harri Jukarainen , Ilkka Jutila , Pirjo Kortesuo , Juha Lehtinen , Eeva Lukkari-Lax , Heikki Lyytikäinen , Joachim Moede , Hannu Nikander , Pirjo Sallinen , Faisal Shafiq , Wolfgang Kaufhold , Christian Wamprecht
发明人： Taina Tjäder , Ulla Calvo Alonso , Pirjo Inki , Harri Jukarainen , Ilkka Jutila , Pirjo Kortesuo , Juha Lehtinen , Eeva Lukkari-Lax , Heikki Lyytikäinen , Joachim Moede , Hannu Nikander , Pirjo Sallinen , Faisal Shafiq , Wolfgang Kaufhold , Christian Wamprecht
IPC分类号： A61F6/14 , A61K9/00
CPC分类号： A61F6/142 , A61K9/0039
摘要： The present invention relates to novel intrauterine systems and to methods for manufacturing these systems. An intrauterine system according to the invention comprises a reservoir and a continuous, closed and flexible frame. The frame comprises a thermoplastic polyurethane elastomer made of a polycarbonate diol, 1,6-hexamethylenediisocyanate, and a chain extender.

3. 发明申请

US20110056501A1 INTRAUTERINE SYSTEM 审中-公开
标题翻译： INTRAUTERINE系统
公开(公告)号：US20110056501A1
公开(公告)日：2011-03-10
申请号：US12935953
申请日：2009-04-01
申请人： Pirjo Kortesuo , Ulla Calvo Alonso , Pirjo Inki , Harri Jukarainen , Ilkka Jutila , Juha Lehtinen , Eeva Lukkari-Lax , Heikki Lyytikäinen , Joachim Moede , Hannu Nikander , Pirjo Sallinen , Taina Tjäder , Andrew Macleod , Michael Noble , David Whitaker
发明人： Pirjo Kortesuo , Ulla Calvo Alonso , Pirjo Inki , Harri Jukarainen , Ilkka Jutila , Juha Lehtinen , Eeva Lukkari-Lax , Heikki Lyytikäinen , Joachim Moede , Hannu Nikander , Pirjo Sallinen , Taina Tjäder , Andrew Macleod , Michael Noble , David Whitaker
IPC分类号： A61F6/06 , B29C45/14 , B29C47/00 , B29C43/18
CPC分类号： A61F6/142 , A61B34/20 , A61B90/39 , A61B2034/2065 , A61F6/18
摘要： The present invention relates to novel intrauterine systems and to methods for manufacturing these systems. An intrauterine system according to the invention comprises a reservoir and a continuous, closed and flexible frame.
摘要翻译：本发明涉及新颖的子宫内系统和用于制造这些系统的方法。根据本发明的子宫内系统包括储存器和连续的，封闭且柔性的框架。

4. 发明申请

US20110162656A1 INSERTER 有权
标题翻译：插入
公开(公告)号：US20110162656A1
公开(公告)日：2011-07-07
申请号：US13119397
申请日：2009-09-14
申请人： Ilkka Jutila , Heikki Lyytikäinen , Ulla Calvo Alonso , Taina Tjäder , Marjo Ali-Äijälä
发明人： Ilkka Jutila , Heikki Lyytikäinen , Ulla Calvo Alonso , Taina Tjäder , Marjo Ali-Äijälä
IPC分类号： A61F6/06
CPC分类号： A61F6/18 , A61F6/142 , A61F6/144
摘要： The invention relates to an inserter for an intrauterine system, comprising a handle (3) having a longitudinal opening (8) at its first end, said opening (8) having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end (8a) and a second end (8b), a movable slider (5) arranged in said longitudinal opening (8) and having a first end (5a) and a second end (5b), a plunger (2) attached to the handle (3), an insertion tube (6) arranged around the plunger (2) having a first end and a second end, with its second end attached to the slider (5), wherein the inserter further comprises locking means for reversibly locking the intrauterine system in relation to the plunger (2) via a removal string of the intrauterine system, said locking means being controllable by the slider (5) and/or the insertion tube (6).
摘要翻译：本发明涉及一种用于子宫内系统的插入器，包括在其第一端具有纵向开口（8）的手柄（3），所述开口（8）具有平行于插入器的纵向轴线的纵向轴线，第一端（8a）和第二端（8b），布置在所述纵向开口（8）中并具有第一端（5a）和第二端（5b）的可移动滑动件（5），连接到手柄（3），布置在所述柱塞（2）周围的插入管（6）具有第一端和第二端，其第二端连接到所述滑块（5），其中所述插入器还包括锁定装置，用于可逆地锁定所述子宫内系统通过宫内系统的移除线相对于柱塞（2），所述锁定装置可由滑块（5）和/或插入管（6）控制。

5. 发明授权

US09668912B2 Inserter 有权
公开(公告)号：US09668912B2
公开(公告)日：2017-06-06
申请号：US13119397
申请日：2009-09-14
申请人： Ilkka Jutila , Heikki Lyytikäinen , Ulla Calvo Alonso , Taina Tjäder , Marjo Ali-Äijälä
发明人： Ilkka Jutila , Heikki Lyytikäinen , Ulla Calvo Alonso , Taina Tjäder , Marjo Ali-Äijälä
IPC分类号： A61F6/06 , A61F6/18 , A61F6/14
CPC分类号： A61F6/18 , A61F6/142 , A61F6/144
摘要： The invention relates to an inserter for an intrauterine system, comprising a handle (3) having a longitudinal opening (8) at its first end, said opening (8) having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end (8a) and a second end (8b), a movable slider (5) arranged in said longitudinal opening (8) and having a first end (5a) and a second end (5b), a plunger (2) attached to the handle (3), an insertion tube (6) arranged around the plunger (2) having a first end and a second end, with its second end attached to the slider (5), wherein the inserter further comprises locking means for reversibly locking the intrauterine system in relation to the plunger (2) via a removal string of the intrauterine system, said locking means being controllable by the slider (5) and/or the insertion tube (6).

6. 发明申请

US20110166508A1 INSERTER 审中-公开
标题翻译：插入
公开(公告)号：US20110166508A1
公开(公告)日：2011-07-07
申请号：US13119401
申请日：2009-09-16
申请人： Heikki Lyytikäinen , Ilkka Jutila , Ulla Calvo Alonso , Harri Jukarainen , Taina Träder , Andrew Macleod , Michael Noble , David Whitaker
发明人： Heikki Lyytikäinen , Ilkka Jutila , Ulla Calvo Alonso , Harri Jukarainen , Taina Träder , Andrew Macleod , Michael Noble , David Whitaker
IPC分类号： A61M31/00
CPC分类号： A61F6/18 , A61F6/142 , A61F6/144 , A61M31/00
摘要： The present invention relates to an inserter for an intrauterine system comprising a handle (3), and an insertion tube (6) having a first end and a second end, and being arranged in connection with the handle. The inserter is characterized in that the first end of the insertion tube (6) comprises at least one frame slot for receiving a frame of the intrauterine system. The invention also relates to a kit comprising an inserter according to the present invention and an intrauterine system, wherein the intrauterine system (1) comprises a therapeutic component (1b) and a continuous, closed frame (1a), the therapeutic component (1b) being connected to the frame (1a) at least one point, and therapeutic component (1b) of the intrauterine system (1) is at least mainly arranged inside the first end of the insertion tube (6) and the frame (1a) of the intrauterine system (1) is at least mainly arranged outside the first end of the insertion tube (6).
摘要翻译：本发明涉及一种用于子宫内系统的插入器，其包括手柄（3）和具有第一端和第二端的插入管（6），并且与手柄相连。插入器的特征在于，插入管（6）的第一端包括用于接收子宫内系统的框架的至少一个框架槽。本发明还涉及一种包括根据本发明的插入器和子宫内系统的套件，其中宫内系统（1）包括治疗组件（1b）和连续的闭合框架（1a），治疗组件（1b）至少一点连接到框架（1a），并且宫内系统（1）的治疗部件（1b）至少主要布置在插入管（6）的第一端和第二端的框架（1a）的内部子宫内系统（1）至少主要布置在插入管（6）的第一端的外侧。

7. 发明授权

US10149784B2 Inserter for an intrauterine system 有权
公开(公告)号：US10149784B2
公开(公告)日：2018-12-11
申请号：US13882264
申请日：2011-10-26
申请人： Ilkka Jutila , Heikki Lyytikäinen
发明人： Ilkka Jutila , Heikki Lyytikäinen
IPC分类号： A61F6/18 , A61F6/14
摘要： An inserter for an intrauterine system includes a handle. The handle has a longitudinal opening at its first end, the opening having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end and a second end, a movable slider arranged in the longitudinal opening and having a first end and a second end. The inserter also includes a movable plunger and an insertion tube arranged around the plunger having a first end and a second end, with its second end attached to the slider. The handle further includes a lock for reversibly locking the intrauterine system in relation to the plunger via a removal string of the intrauterine system, the lock being attached to the plunger and being controllable at least by a part or an extension of the slider and/or of the insertion tube or of the handle.

8. 发明申请

US20110146693A1 INTRAUTERINE DELIVERY SYSTEM FOR CONTRACEPTION 审中-公开
标题翻译：输血管递送系统
公开(公告)号：US20110146693A1
公开(公告)日：2011-06-23
申请号：US12995905
申请日：2009-07-01
申请人： Bernd Duesterberg , Manja Ahola , Jyrki Pihlaja , Heikki Lyytikäinen , Harri Jukarainen , Satu Kleemola , Tero Parkatti
发明人： Bernd Duesterberg , Manja Ahola , Jyrki Pihlaja , Heikki Lyytikäinen , Harri Jukarainen , Satu Kleemola , Tero Parkatti
IPC分类号： A61F6/14 , A61K31/56
CPC分类号： A61K9/0039 , A61K31/195 , A61K31/196 , A61K31/565 , A61K31/567 , A61K31/569 , A61K31/57 , A61K31/58 , A61K45/06 , A61K2300/00
摘要： The invention relates to a method for contraception and for reducing menstrual problems and inducing amenorrhea, wherein an intrauterine delivery device is used for the controlled release of a combination of progestogen or a drug having a progestogenic activity and at least one therapeutically active substance capable of preventing or suppressing abnormal and/or irregular endometrial bleeding over a prolonged period of time.
摘要翻译：本发明涉及一种用于避孕和减少月经问题和诱导闭经的方法，其中子宫内递送装置用于控制释放孕激素或具有孕激素活性的药物和至少一种能预防的治疗活性物质的组合或在长时间内抑制异常和/或不规则的子宫内膜出血。

9. 发明申请

US20130255695A1 INSERTER FOR AN INTRAUTERINE SYSTEM 审中-公开
标题翻译：内插系统插入器
公开(公告)号：US20130255695A1
公开(公告)日：2013-10-03
申请号：US13882264
申请日：2011-10-26
申请人： Ilkka Jutila , Heikki Lyytikäinen
发明人： Ilkka Jutila , Heikki Lyytikäinen
IPC分类号： A61F6/18
CPC分类号： A61F6/18 , A61F6/144
摘要： The present invention relates to an inserter for an intrauterine system, comprising a handle (3) having a longitudinal opening (8) at its first end, said opening having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end and a second end, a movable slider (5) arranged in said longitudinal opening and having a first end and a second end, a movable plunger (2), an insertion tube (6) arranged around the plunger having a first end and a second end, with its second end attached to the slider, locking means for reversibly locking the intrauterine system in relation to the plunger via a removal string of the intrauterine system, said locking means being attached to the plunger and being controllable at least by a part or an extension of the slider and/or of the insertion tube or of the handle. A typical inserter according to this invention further comprises movement means (18), which comprise a rotation part (19) arranged to rotate around a rotation axis that is perpendicular to the longitudinal axis of the inserter, the rotation part being arranged in functional connection with the plunger and with the slider, such that the movement of the slider generates simultaneous movement of the plunger and of the insertion tube along the longitudinal axis of the inserter, in opposite directions.
摘要翻译：本发明涉及一种用于子宫内系统的插入器，包括在其第一端具有纵向开口（8）的手柄（3），所述开口具有平行于插入器的纵向轴线的纵向轴线，第一端和第二端，布置在所述纵向开口中并具有第一端和第二端的可移动滑动件（5），可移动柱塞（2），布置在所述柱塞周围的插入管（6），所述插入管具有第一端和第二端，其第二端连接到滑块，锁定装置用于通过子宫内系统的移除柱可逆地将子宫内系统相对于柱塞锁定，所述锁定装置附接到柱塞并且至少可以通过一部分或延伸部的滑块和/或插入管或手柄。根据本发明的典型的插入器还包括运动装置（18），其包括旋转部分（19），旋转部分（19）布置成围绕垂直于插入器的纵向轴线的旋转轴线旋转，旋转部分与柱塞和滑块，使得滑块的运动在相反的方向上产生柱塞和插入管沿着插入器的纵向轴线的同时移动。

10. 发明授权

US07252839B2 Delivery system and a manufacturing process of a delivery system 有权
标题翻译：配送系统和配送系统的制造过程
公开(公告)号：US07252839B2
公开(公告)日：2007-08-07
申请号：US10528237
申请日：2003-09-04
申请人： Esa Hallinen , Heikki Lyytikäinen , Pentti Järvelä , Ilkka Kivi
发明人： Esa Hallinen , Heikki Lyytikäinen , Pentti Järvelä , Ilkka Kivi
IPC分类号： A61K9/48 , A61K9/127 , B01J13/02 , B01J13/04
CPC分类号： A61F6/14
摘要： A delivery system including a body construction (7) and at least one capsule (8) containing a pharmaceutical composition, the capsule having at least a first end and a second end. The body construction (7, 12, 34) has at least two locking parts (9, 10), each locking part (9, 10) having at least a first end and a second end, the first end of each locking part (9, 10) having a surface adapted to face and cover one of the at least first and second ends of the capsule (8). The diameter of at least one of the locking parts varies along its length between the first end and the second end, and the capsule (8) is mounted between the at least two locking parts. Also disclosed is a manufacturing process of a delivery system, the system including a body construction and at least one capsule containing a pharmaceutical composition.
摘要翻译：一种输送系统，包括主体结构（7）和至少一个包含药物组合物的胶囊（8），所述胶囊具有至少第一端和第二端。主体结构（7,12,34）具有至少两个锁定部分（9,10），每个锁定部分（9,10）具有至少第一端和第二端，每个锁定部分（9）的第一端，10）具有适于面对并覆盖胶囊（8）的至少第一和第二端中的一个的表面。至少一个锁定部件的直径沿其长度在第一端部和第二端部之间变化，并且胶囊（8）安装在至少两个锁定部件之间。还公开了一种输送系统的制造方法，所述系统包括主体结构和至少一个含有药物组合物的胶囊。

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