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1. 发明授权

US10670566B2 Rapid antimicrobial susceptibility testing using piezoelectric sensor 审中-公开
公开(公告)号：US10670566B2
公开(公告)日：2020-06-02
申请号：US15777750
申请日：2016-11-18
申请人： Wan Y. Shih , Wei-Heng Shih , Christopher Emery , Xin Xu , Suresh Joshi , Wei Wu
发明人： Wan Y. Shih , Wei-Heng Shih , Christopher Emery , Xin Xu , Suresh Joshi , Wei Wu
IPC分类号： C12Q1/18 , G01N29/12 , G01N29/036 , G01N29/02
摘要： A system for and method of antimicrobial susceptibility testing includes detecting a resonance peak of a sensor provided with live microbes on a surface thereof; applying a substance to the live microbes; detecting a resonance peak of said sensor after application of said substance; determining a width of a top of each of said resonance peaks before and after application of the substance from one of: (1) a phase angle versus frequency plot where the phase angle is the phase angle of the electrical impedance of said sensor. (2) a real part of a plot of an electrical impedance versus frequency of said sensor. (3) a plot of a magnitude of electrical impedance versus frequency of said sensor, and (4) a phase angle versus frequency plot where the phase angle is the phase angle between an output voltage and an input voltage of said sensor, and comparing the determined widths of tops of said resonance peaks or standard deviations of the frequency of said resonance peaks to determine antimicrobial susceptibility including the minimum inhibitory concentration (MIC).

2. 发明授权

US10357196B2 Depth measurement in tissue using piezoelectric sensors having different probe sizes 有权
公开(公告)号：US10357196B2
公开(公告)日：2019-07-23
申请号：US15109860
申请日：2015-01-07
申请人： Wan Y. Shih , Wei-Heng Shih , Xin Xu
发明人： Wan Y. Shih , Wei-Heng Shih , Xin Xu
IPC分类号： A61B5/00 , A61B5/107
摘要： An apparatus and method for determining the depth of an object below a surface or the thickness of the dermis. The apparatus and method use a plurality of piezoelectric fingers having probes with differently sized contact areas. A plurality of measurements is taken using each of the probes with differently sized contact areas in order to determine the depth of an object below a surface or the thickness of the dermis.

3. 发明申请

US20160331300A1 Depth Measurement in Tissue Using Piezoelectric Sensors Having Different Probe Sizes 审中-公开
标题翻译：具有不同探针尺寸的压电传感器在组织中的深度测量
公开(公告)号：US20160331300A1
公开(公告)日：2016-11-17
申请号：US15109860
申请日：2015-01-07
申请人： Wan Y. Shih , Wei-Heng Shih , Xin Xu
发明人： Wan Y. Shih , Wei-Heng Shih , Xin Xu
IPC分类号： A61B5/00 , A61B5/107
CPC分类号： A61B5/444 , A61B5/1075 , A61B2562/0247
摘要： An apparatus and method for determining the depth of an object below a surface or the thickness of the dermis. The apparatus and method use a plurality of piezoelectric fingers having probes with differently sized contact areas. A plurality of measurements is taken using each of the probes with differently sized contact areas in order to determine the depth of an object below a surface or the thickness of the dermis.
摘要翻译：用于确定物体在表面下方的深度或真皮厚度的装置和方法。该装置和方法使用具有不同尺寸的接触区域的探针的多个压电指状物。使用具有不同尺寸的接触区域的每个探针进行多个测量，以便确定物体在表面下方的深度或真皮的厚度。

4. 发明申请

US20220128551A1 Piezoelectric Plate Sensor and Uses Thereof 有权
公开(公告)号：US20220128551A1
公开(公告)日：2022-04-28
申请号：US17567992
申请日：2022-01-04
申请人： Wan Y. Shih , Wei Wu , Wei-Heng Shih , Mehmet Cagri Soylu , Haitao Guo , Suresh G. Joshi , Ceyhun Ekrim Kirimli , Ying-Hsiu Su
发明人： Wan Y. Shih , Wei Wu , Wei-Heng Shih , Mehmet Cagri Soylu , Haitao Guo , Suresh G. Joshi , Ceyhun Ekrim Kirimli , Ying-Hsiu Su
IPC分类号： G01N33/543 , G01N29/02 , G01N29/036 , C12Q1/6825
摘要： A piezoelectric plate sensor comprising a piezoelectric layer; two electrodes; and an insulation layer. The insulation layer is produced by soaking the piezoelectric layer and two electrodes in a mercaptopropyltrimethoxysilane solution with an amount of water from 0.1 v/v. % to about 1 v/v % and at pH from about 8 to about 150 for a period from about 8 to about 15 hours, and the mercaptopropyltrimethoxysilane solution has a concentration of mercaptopropyltrimethoxysilane from about 0.01 v/v % to about 0.5 v/v %. A method of detecting a biomolecule in a sample using the piezoelectric plate sensor in particular, that of detecting a genetic marker with PCR sensitivity and specificity without the need of DNA isolation or amplification is also provided. The piezoelectric plate sensor may be used to diagnose various diseases including breast cancer, myocardial infarction, diarrhea, Clostridium difficile infection, and hepatitis B infection.

5. 发明授权

US10517967B2 Tin sulfide quantum dots for in vivo near infrared imaging 有权
公开(公告)号：US10517967B2
公开(公告)日：2019-12-31
申请号：US15851782
申请日：2017-12-22
申请人： Wei-Heng Shih , Wan Y. Shih , Song Han , Xiaomin Niu , Shi Fang
发明人： Wei-Heng Shih , Wan Y. Shih , Song Han , Xiaomin Niu , Shi Fang
IPC分类号： C09K11/02 , A61K49/18 , A61K49/00 , C09K11/66 , B82Y40/00 , B82Y15/00 , B82Y30/00
摘要： An aqueous approach to synthesize capped SnS quantum dots (QDs) followed by optional capping molecule extension by attaching one or more extending molecules to the capping molecule via peptide bond formation at elevated temperature. The capped SnS QDs may have a capping molecule:Sn:S molar ratio of 16:3:1 to 16:12:1. A suspension of SnS QDs was heat-treated at 200° C. for 0.5-4 hrs. The obtained SnS QDs showed an NIR emission peak at 820-835 nm with an excitation wavelength at 690 nm. The as synthesized SnS QDs were found to have high positive zeta potential of ˜30 mV and thus were toxic to cells. By neutralizing the SnS QDs the cytotoxicity was reduced to an accepted level. The heat-treatment step can be obviated by adding a glycerol solution containing S2− anions and capping molecule to a glycerol solution of Sn2+ ions.

6. 发明授权

US10197565B2 Piezoelectric plate sensor and uses thereof 有权
公开(公告)号：US10197565B2
公开(公告)日：2019-02-05
申请号：US15101788
申请日：2014-12-19
申请人： Wan Y. Shih , Wei Wu , Wei-Heng Shih , Mehmet Cagri Soylu , Haitao Guo , Suresh G. Joshi , Ceyhun Ekrim Kirimli , Ying-Hsiu Su
发明人： Wan Y. Shih , Wei Wu , Wei-Heng Shih , Mehmet Cagri Soylu , Haitao Guo , Suresh G. Joshi , Ceyhun Ekrim Kirimli , Ying-Hsiu Su
IPC分类号： G01N33/543 , G01N29/02 , G01N29/036 , C12Q1/6825
摘要： A piezoelectric plate sensor comprising a piezoelectric layer; two electrodes; and an insulation layer. The insulation layer is produced by soaking the piezoelectric layer and two electrodes in a mercaptopropyltrimethoxysilane solution with an amount of water from 0.1 v/v. % to about 1 v/v % and at pH from about 8 to about 150 for a period from about 8 to about 15 hours, and the mercaptopropyltrimethoxysilane solution has a concentration of mercaptopropyltrimethoxysilane from about 0.01 v/v % to about 0.5 v/v %. A method of detecting a biomolecule in a sample using the piezoelectric plate sensor in particular, that of detecting a genetic marker with PCR sensitivity and specificity without the need of DNA isolation or amplification is also provided. The piezoelectric plate sensor may be used to diagnose various diseases including breast cancer, myocardial infarction, diarrhea, Clostridium difficile infection, and hepatitis B infection.

7. 发明申请

US20170212121A1 CAPPED AND CONJUGATED QUANTUM DOTS 审中-公开
公开(公告)号：US20170212121A1
公开(公告)日：2017-07-27
申请号：US15202710
申请日：2016-07-06
申请人： Wei-Heng Shih , Wan Y. Shih , Giang Au , Ari D. Brooks , Vanlila K. Swami
发明人： Wei-Heng Shih , Wan Y. Shih , Giang Au , Ari D. Brooks , Vanlila K. Swami
IPC分类号： G01N33/574 , C07K16/22 , C07K16/30 , G01N33/533 , G01N33/58
摘要： One or more aqueous, near infrared emitting, high yield, highly photoluminescent, stable quantum dots conjugated to one or more biomarkers specific moieties. The conjugated quantum dots have an enhanced detection sensitivity and selectivity and may be formed using a novel and efficient method for conjugating one or more biomarker specific moieties to the quantum dots. The invention is further directed to a method for using the conjugated quantum dots for cancer detection in the margin of excised tissue.

8. 发明授权

US09431598B2 Sol-gel precursors and methods for making lead-based perovskite films 有权
标题翻译：溶胶凝胶前体和制备铅基钙钛矿薄膜的方法
公开(公告)号：US09431598B2
公开(公告)日：2016-08-30
申请号：US12513308
申请日：2007-11-06
申请人： Wei-Heng Shih , Wan Y. Shih , Zuyan Shen , Huidong Li , Xiaotong Gao
发明人： Wei-Heng Shih , Wan Y. Shih , Zuyan Shen , Huidong Li , Xiaotong Gao
IPC分类号： H01L41/00 , H01L41/318 , H01L41/187 , H01L41/09
CPC分类号： H01L41/318 , H01L41/094 , H01L41/0973 , H01L41/1875
摘要： A simple, economical sol-gel method was invented to produce thick and dense lead zirconate titanate (PZT) thin films that exhibit the stoichiometric chemical composition and unprecedented electrical and dielectric properties. The PZT films are the foundation of many microelectromechanical systems (MEMS) and nanoelectromechanical systems (NEMS) for micro/nano sensors and actuators applications.
摘要翻译：发明了一种简单经济的溶胶 - 凝胶法，以生产厚而致密的锆钛酸铅（PZT）薄膜，其表现出化学计量的化学成分和前所未有的电和介电性能。 PZT薄膜是用于微/纳米传感器和致动器应用的许多微机电系统（MEMS）和纳米机电系统（NEMS）的基础。

9. 发明授权

US08865477B2 Water soluble nanocrystalline quantum dots capable of near infrared emissions 有权
标题翻译：具有近红外辐射的水溶性纳米晶体量子点
公开(公告)号：US08865477B2
公开(公告)日：2014-10-21
申请号：US12428000
申请日：2009-04-22
申请人： Wei-Heng Shih , Wan Y. Shih , Hui Li , Ian McDonald , Andrew Kopek , Ryan O'Malley , Yu-Chieh Lu
发明人： Wei-Heng Shih , Wan Y. Shih , Hui Li , Ian McDonald , Andrew Kopek , Ryan O'Malley , Yu-Chieh Lu
IPC分类号： C01B17/20 , C01G21/21 , C01G11/02 , G01N33/532 , B82Y15/00 , G01N33/58 , B82Y5/00 , G01N33/53
CPC分类号： G01N33/588 , B82Y5/00 , B82Y15/00 , G01N33/532 , Y10S977/774
摘要： A novel quantum dot capable of near infrared emissions at wavelengths of 750-1100 is made by forming solid solutions of metal sulfide, metal selenide or metal sulfide selenide by incorporating a suitable amount of an additional metallic element or elements to provide an emission wavelength in the range of 750 nm to 1100 nm. The quantum dots may be enabled for bioconjugation and may be used in a method for tissue imaging and analyte detection.
摘要翻译：通过加入适量的附加金属元素以形成发射波长，通过形成金属硫化物，金属硒化物或金属硫化物硒化物的固溶体，可以制成750-1100波长的近红外发射的新型量子点。范围为750nm至1100nm。量子点可以用于生物共轭，并且可以用于组织成像和分析物检测的方法中。

10. 发明授权

US08857248B2 Piezoelectric microcantilevers and uses in atomic force microscopy 有权
标题翻译：压电微悬臂梁和原子力显微镜的应用
公开(公告)号：US08857248B2
公开(公告)日：2014-10-14
申请号：US13160304
申请日：2011-06-14
申请人： Wan Y. Shih , Wei-Heng Shih , Zuyan Shen , Qing Zhu
发明人： Wan Y. Shih , Wei-Heng Shih , Zuyan Shen , Qing Zhu
IPC分类号： G01B5/28 , G01B9/04 , G01Q10/04 , G01Q20/04 , G01Q60/38 , B82Y35/00
CPC分类号： G01Q60/38 , B82Y35/00 , G01B9/04 , G01Q10/045 , G01Q20/04 , Y10T29/42
摘要： The invention is direct to a piezoelectric microcantilever for static contact and dynamic noncontact atomic force microscopy which may be carried out in solution. The piezoelectric microcantilever, which includes a piezoelectric layer and a non-piezoelectric layer is capable of self actuation and detection. The piezoelectric layer may be constructed from a lead magnesium niobate-lead titanate (Pb(Mg1/3Nb2/3)O3)0.65—(PbTiO3)0.35(PMN0.65-PT0.35) (PMN-PT), zirconate titanate (PZT)/SiO2 or from any lead-free piezoelectric materials such as doped sodium-potassium niobate-lithium niobate. The piezoelectric layers of the microcantilevers may have dielectric constants of from 1600-3000 and thicknesses below 10 μm. Also disclosed are methods for fabricating microcantilever sensors and methods for atomic force microscopy employing the microcantilevers.
摘要翻译：本发明直接用于静态接触和动态非接触原子力显微镜的压电微悬臂梁，其可以在溶液中进行。包括压电层和非压电层的压电微悬臂梁能够自动启动和检测。压电层可以由铌酸铅镁酸铅（Pb（Mg1 / 3Nb2 / 3）O3）0.65-（PbTiO3）0.35（PMN0.65-PT0.35）（PMN-PT），锆钛酸铅（PZT））/ SiO 2或来自任何无铅压电材料如掺杂的铌酸钠 - 铌酸锂 - 铌酸锂。微悬臂梁的压电层可以具有1600-3000的介电常数和低于10μm的厚度。还公开了用于制造微悬臂梁传感器的方法和使用微悬臂梁的原子力显微镜的方法。

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