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61. 发明公开

EP1721831A1 SEALED VESSEL AND METHOD OF PRODUCING THE SAME 审中-公开
标题翻译： VERSCHLOSSENERBEHÄLTERUND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP1721831A1
公开(公告)日：2006-11-15
申请号：EP05710636.1
申请日：2005-02-24
申请人： Kirin Brewery Company, Limited
发明人： Nakaya, Masaki, C/O Kirin Brewery Company, Ltd , Shirakura, Akira, C/O Kirin Brewery Company, Ltd.
IPC分类号： B65D8/02 , B65B7/28 , B65D1/02 , B65D53/00 , B65D77/20
CPC分类号： B29C66/652 , B29C65/1619 , B29C65/1635 , B29C65/1654 , B29C65/1661 , B29C65/1664 , B29C65/1677 , B29C65/1683 , B29C65/76 , B29C66/112 , B29C66/1122 , B29C66/114 , B29C66/122 , B29C66/131 , B29C66/232 , B29C66/301 , B29C66/53461 , B29C66/542 , B29C66/65 , B29C66/71 , B29C66/72323 , B29C66/72325 , B29C66/72343 , B29C66/73921 , B29C66/8322 , B29C66/836 , B29C66/8432 , B29C66/91216 , B29C66/91221 , B29C66/9131 , B29C66/934 , B29C66/939 , B29K2995/0027 , B29L2031/7158 , B65B7/2878 , B65D77/2024 , B65D2543/00425 , B65D2543/00842 , Y02W30/807 , B29K2023/06 , B29K2023/086 , B29K2023/12 , B29K2023/18 , B29K2023/38 , B29K2025/06 , B29K2025/08 , B29K2027/06 , B29K2027/08 , B29K2027/18 , B29K2033/12 , B29K2033/20 , B29K2055/02 , B29K2059/00 , B29K2067/00 , B29K2067/003 , B29K2067/006 , B29K2069/00 , B29K2077/00 , B29K2081/06 , B29K2096/005
摘要： It is an object of the present invention to provide a container in which it is difficult for liquid to drip at a mouth portion having a good touch sensation by forming a structure in which a welded portion that was laser welded in a sealed container does not form a flange, and to carry out the achievement of making polymer material unnecessary and making excessive material in the wind-fastening portion unnecessary. Further, it is also an object to construct the lid and barrel of the vessel by using the same material, thereby facilitating the recycling of material. The sealed container in which a container body 1 having an opening 9 is sealed by a lid portion 3 which closes and covers said opening, comprising a welded portion 4, 14 in which an outer wall surface of a peripheral portion 2 of said opening or an edge 12 surface of said opening and an inner wall surface of said lid portion are laser welded in order to make it possible for at least an inner wall surface of the peripheral portion of said opening from an inner wall surface 6 of said container body to make contact with container contents.
摘要翻译：本发明的目的是提供一种容器，其中液体难以在具有良好触感的口部滴落，形成其中激光焊接在密封容器中的焊接部分不形成的结构并且实现不必要地制造聚合物材料，并且不需要在风紧固部分中形成过量的材料。此外，也是通过使用相同的材料来构造容器的盖和桶的目的，从而有助于材料的再循环。其中具有开口9的容器主体1的密封容器被封闭并覆盖所述开口的盖部分3密封，包括焊接部分4,14，其中所述开口的周边部分2的外壁表面或所述开口的边缘12表面和所述盖部分的内壁表面被激光焊接，以使所述开口的周边部分的至少内壁表面能够从所述容器主体的内壁表面6形成与容器内容物接触。

62. 发明授权

EP1197581B1 DLC FILM, DLC-COATED PLASTIC CONTAINER, AND METHOD AND APPARATUS FOR MANUFACTURING DLC-COATED PLASTIC CONTAINER 有权
标题翻译： DLC膜，制造这样的集装箱DLC镀覆塑料容器和方法及装置
公开(公告)号：EP1197581B1
公开(公告)日：2006-10-25
申请号：EP00919156.0
申请日：2000-04-21
申请人： MITSUBISHI SHOJI PLASTICS CORPORATION , Hokkai Can Co., Ltd , Kirin Brewery Company, Limited
发明人： Yamashita, Yuuji , Kage, Tsuyoshi, Mitsubishi Shoji Plastics Corp. , Mori, Shigeki
IPC分类号： C23C16/26 , C08J7/06 , B65D1/00
CPC分类号： C23C16/045 , C23C16/26
摘要： A plastic container is coated with DLC film as a desirable oxygen barrier so that it is suitable for containing oxygen-sensitive or carbonated beverage. A coating device comprises an outer electrode arranged outside a plastic container (5), an inner electrode (11) arranged inside the plastic container (5), a pipe (12) through which carbon source gas is supplied to the plastic container (5) pumped to a low pressure, and a high-frequency oscillator (9) for applying voltage between the outer electrode and the inner electrode (11) after supplying the source gas to generate a plasma for depositing DLC film on the inner wall of the plastic container (5). The outer electrode includes a bottom electrode (4) arranged along the bottom of the plastic container (5) and a wall electrode (3) arranged along the inner wall of the plastic container. The bottom electrode (4) is located below half the complete height of the plastic container (5).

63. 发明公开

EP1614693A4 PURIFICATION OF HUMAN MONOCLONAL ANTIBODY AND HUMAN POLYCLONAL ANTIBODY 审中-公开
标题翻译：清洁人单克隆抗体和人多克隆抗体
公开(公告)号：EP1614693A4
公开(公告)日：2006-07-19
申请号：EP04720750
申请日：2004-03-15
申请人： KIRIN BREWERY
发明人： ISHIHARA TAKASHI
IPC分类号： C07K1/18 , C07K1/20 , C07K1/22 , C07K1/36 , C07K16/06 , C07K16/18
CPC分类号： C07K16/065 , C07K1/18 , C07K1/20 , C07K1/22 , C07K1/36 , C07K2317/21
摘要： It is intended to provide a method of separating and purifying a human monoclonal antibody and a human polyclonal antibody which are employed mainly for therapeutic purposes and for diagnostic and reagent purposes in some cases. Namely, a method of purifying such an antibody from a mixture containing the same which at least involves the following steps: (1) the step of purifying by anion exchange chromatography; and (2) the step following (1) of purifying by cation exchange chromatography. It is also intended to provide a method of separating a human antibody from an artiodactyl antibody in a mixture containing the human antibody and the artiodactyl antibody by protein A affinity chromatography under a pH gradient.

64. 发明公开

EP1618875A4 COMPOSITION FOR INHIBITION OR PREVENTION OF BONE DENSITY LOWERING AND REFRESHMENT THEREFOR 有权
标题翻译：成分用于抑制或预防骨密度和再生其还原
公开(公告)号：EP1618875A4
公开(公告)日：2006-05-24
申请号：EP04726643
申请日：2004-04-08
申请人： KIRIN BREWERY
发明人： TAJIMA OSAMU , KATAYAMA MIKIO
IPC分类号： A23L1/30 , A23L2/52 , A61K31/12 , A61K36/185 , A61P19/10 , A23L2/38
CPC分类号： A61K31/12 , A23L33/105 , A61K36/185
摘要： A composition for inhibition or prevention of bone density lowering, comprising isoxanthohumol or an isomerized hop extract as an effective ingredient; or a refreshment for such a use. Inhibition or prevention of bone density lowering, while avoiding the problem of possible side effects upon use of estrogen preparations, can be attained by the use of such a composition or refreshment.

65. 发明授权

EP0957161B1 METHOD FOR ACTIVATING HUMAN ANTIGEN PRESENTING CELLS, ACTIVATED HUMAN ANTIGEN PRESENTING CELLS, AND USE OF THE SAME 失效
标题翻译：方法激活人力，抗原活化细胞活化的人，抗原活化细胞及其用途
公开(公告)号：EP0957161B1
公开(公告)日：2006-05-10
申请号：EP97949237.8
申请日：1997-12-25
申请人： Kirin Brewery Company, Ltd.
发明人： KOEZUKA, Yasuhiko, Kirin Brewery Company, Ltd. , YAMAGUCHI, Yasunori, Kirin Brewery Company, Ltd , MOTOKI, Kazuhiro, Kirin Brewery Company, Ltd.
IPC分类号： C07H15/04 , C12N5/08
CPC分类号： C07H15/04 , A61K2039/5154 , C12N5/0639 , C12N2501/22 , C12N2501/23 , C12N2501/90
摘要： A method for activating human antigen presenting cells characterized by culturing in vitro antigen presenting cells with a human origin together with at least one of glycoside compounds represented by general formula (A) or salts thereof preferably exemplified by (2S, 3S, 4R)-1-(α-D-galactopyranosyloxy)-2-hexacosanoylamino-3,4-octadecanediol; the human antigen presenting cells thus activated; methods for treating cancer or infectious diseases such as AIDS by using activated human antigen presenting cells; and the use of activated human antigen presenting cells in the production of drugs for treating these diseases. Thus, sufficient therapeutic effects can be achieved on cancer and infectious diseases such as AIDS without effecting any pulse therapy with the use of tumor antigens.

66. 发明公开

EP1508525A1 DLC FILM COATED PLASTIC CONTAINER, AND DEVICE AND METHOD FOR MANUFACTURING THE PLASTIC CONTAINER 有权
标题翻译： Vorrichtung zur Beschichtung einesKunststoffbehältersmit einerdiamantähnlichenKohlenstoffschicht
公开(公告)号：EP1508525A1
公开(公告)日：2005-02-23
申请号：EP03733060.2
申请日：2003-05-26
申请人： Kirin Brewery Company, Ltd.
发明人： YAMASAKI, Teruyuki, KIRIN BREWERY COMPANY, LTD. , SHIRAKURA, Akira, KIRIN BREWERY COMPANY, LTD. , ANDO, Hideyasu, KIRIN BREWERY COMPANY, LTD.
IPC分类号： B65D23/02 , C23C16/26
CPC分类号： C23C16/26 , B65D1/0215 , B65D23/0814 , C23C16/045 , C23C16/505 , Y10T428/1352
摘要： The present invention provides a plastic container having a inner wall surface coated with DLC film which has same level of oxygen barrier property as prior art and can prevent a coloring of the DLC film formed on a neck portion of the container, manufacturing apparatus therefor and manufacturign method thereof.
The apparatus for manufacturing the DLC film coated plastic container, comprising: a container side electrode which forms one portion of a pressure-reducing chamber which houses a container formed from plastic, a facing electrode which faces said container side electrode and is arranged inside said container or above said opening, wherein said container side electrode and said facing electrode are made to face each other via an insulating body which forms a portion of said pressure-reducing chamber, source gas supply means which includes a supply gas inlet pipe, exhaust means, and high frequency supply means; wherein said container side electrode is formed so that the average inner hole diameter of the inner wall surrounding said neck portion when the container is housed becomes smaller than the average inner hole diameter of the inner wall surrounding said body portion, and the average distance between the outer wall of said container and the inner wall of said container side electrode in a horizontal cross section with respect to the vertical direction of said container at said neck portion becomes longer than the average distance between the outer wall of said container and the inner wall of said container side electrode in a horizontal cross section with respect to the vertical direction of said container at said body portion.
摘要翻译：本发明提供了一种塑料容器，其具有涂覆有DLC膜的内壁表面，其具有与现有技术相同的氧阻隔性能，并且可以防止形成在容器的颈部上的DLC膜的着色，其制造装置和制造方法。＆lt; D＆gt;用于制造DLC薄膜包衣的塑料容器的装置包括：容器侧电极，其形成容纳由塑料形成的容器的减压室的一部分;面向所述容器侧电极的面对电极，布置在所述容器内或所述开口上方，其中所述容器侧电极和所述面对电极经由形成所述减压室的一部分的绝缘体彼此面对，源气体供应装置包括供给气体入口管排气装置和高频供给装置; 其特征在于，所述容器侧电极被形成为使得当容纳容器时围绕所述颈部的内壁的平均内孔直径小于围绕所述主体部分的内壁的平均内孔直径，所述容器的外壁和所述容器侧电极的内壁在所述颈部处相对于所述容器的垂直方向呈水平截面，变得比所述容器的外壁和所述容器的外壁之间的平均距离所述容器侧电极在所述主体部分处于相对于所述容器的垂直方向的水平横截面。

67. 发明公开

EP0933354A4 CALCIUM RECEPTOR-ACTIVE COMPOUNDS 失效
标题翻译： VERBINDUNGEN DIE DIEAKTIVITÄTVON CALCIUM-REZEPTOREN BEEINFLUSSEN
公开(公告)号：EP0933354A4
公开(公告)日：2004-09-29
申请号：EP97929555
申请日：1997-07-08
申请人： KIRIN BREWERY , NPS PHARMA INC
发明人： SAKAI TERUYUKI , TAKAMI ATSUYA , NAGAO RIKA
IPC分类号： A61K31/165 , A61K31/4035 , A61P5/20 , C07C211/30 , C07C217/20 , C07C217/58 , C07C237/06 , C07C237/08 , C07C237/10 , C07C317/18 , C07C317/28 , C07C323/25 , C07D207/32 , C07D207/335 , C07D209/08 , C07D209/14 , C07D209/44 , C07D209/88 , C07D213/38 , C07D213/40 , C07D213/70 , C07D215/36 , C07D241/12 , C07D263/58 , C07D277/28 , C07D277/74 , C07D281/06 , C07D307/52 , C07D307/91 , C07D311/30 , C07D317/58 , C07D333/20 , C07D333/34 , C07C211/27 , C07C211/29 , C07C217/14 , C07C225/16 , C07C237/04 , C07C317/26 , C07C323/23 , C07D209/12
CPC分类号： C07D207/335 , C07B2200/07 , C07C211/30 , C07C217/20 , C07C217/58 , C07C237/06 , C07C237/08 , C07C237/10 , C07C317/18 , C07C317/28 , C07C323/25 , C07C2603/18 , C07D209/08 , C07D209/14 , C07D209/88 , C07D213/38 , C07D213/40 , C07D213/70 , C07D215/36 , C07D241/12 , C07D263/58 , C07D277/28 , C07D277/74 , C07D281/06 , C07D307/52 , C07D307/91 , C07D311/30 , C07D317/58 , C07D333/20 , C07D333/34
摘要： Novel calcium receptor-active compounds represented by the following general formula: Ar1-[CR1R2]p-X-[CR3R4]q-[CR?5R6]-NR7-[CR8R9]-Ar¿2 wherein Ar1 is selected from the group consisting of aryl, heteroaryl, bis(arylmethyl)amino, bis(heteroaryl-methyl)amino and arylmethyl(heteroarylmethyl)amino; X is selected from the group consisting of oxygen, sulfur, sulfinyl, sulfonyl, carbonyl and amino; R?1, R2, R3, R4, R5, R6, R7, R8 and R9¿ represent, for example, each hydrogen or alkyl; Ar¿2? is selected from the group consisting of aryl and heteroaryl; p is an integer of from 0 to 6; and q is an integer of from 0 to 14.
摘要翻译：提供具有下式的新型钙受体活性化合物：Ar1-ÄCR1 R 2ÜP-X-ÄCR3 R 4Üq-ÄCR5 R 6 - NR 7 Ar 1选自芳基，杂芳基，双（芳基甲基）氨基，双（杂芳基甲基）氨基和芳基甲基（杂芳基甲基）氨基; X选自氧，硫，亚磺酰基，磺酰基，羰基和氨基; R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9是例如氢或烷基; Ar 2选自芳基和杂芳基; p是0至6的整数，包括0和6; q为0〜14的整数，包括端值。

68. 发明公开

EP1382604A4 QUINOLINE DERIVATIVE HAVING AZOLYL GROUP AND QUINAZOLINE DERIVATIVE 有权转让
标题翻译：喹啉WITH A唑衍生物和喹唑啉衍生物
公开(公告)号：EP1382604A4
公开(公告)日：2004-09-08
申请号：EP02724651
申请日：2002-04-26
申请人： KIRIN BREWERY
发明人： KUBO KAZUO , SAKAI TERUYUKI , NAGAO RIKA , FUJIWARA YASUNARI , ISOE TOSHIYUKI , HASEGAWA KAZUMASA
IPC分类号： A61K31/4709 , A61K31/517 , A61P3/10 , A61P9/10 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , A61K31/435 , A61K31/495
CPC分类号： C07D413/12 , C07D401/12 , C07D403/12 , C07D417/12
摘要： A compound having strong antitumor activity. It is a compound represented by the formula (I) or a pharmaceutically acceptable salt or solvate thereof: (I) wherein X and Z each represents CH or nitrogen; Y represents oxygen or sulfur; R?1, R2, and R3¿ each represents hydrogen, alkoxy, etc.; R4 represents hydrogen; R?5, R6, R7, and R8¿ each represents hydrogen, halogeno, alkoxy, etc.; R?9 and R10¿ each represents hydrogen, alkyl, etc.; and R11 represents optionally substituted azolyl.

69. 发明公开

EP1010773A4 METHOD AND APPARATUS FOR PRODUCING PLASTIC CONTAINER HAVING CARBON FILM COATING 失效
标题翻译：对于碳膜的制备镀覆塑料容器的方法和装置
公开(公告)号：EP1010773A4
公开(公告)日：2004-08-25
申请号：EP98902252
申请日：1998-02-17
申请人： KIRIN BREWERY
发明人： SHIMAMURA EIHAKU
IPC分类号： B29C59/14 , C23C16/04 , C23C16/26 , C23C16/44 , C23C16/505 , C08J7/00 , C08J7/04 , C08J7/06 , C23C16/50 , C23C16/509
CPC分类号： B29C59/142 , B29L2031/7158 , C23C16/045 , C23C16/26 , C23C16/4412 , C23C16/505
摘要： When a rigid carbon film is formed on an inner wall of a plastic container by storing the plastic container inside a vacuum chamber formed on the inner side of an external electrode and to the same size as the outer shape of the container and generating plasma by inserting an internal electrode into the container, inserting rings (12, 13) having an inner wall surface formed into the same shape as the outer surface shape of the container are fitted to portions of the outer wall surface of the plastic container at which protuberances are formed, and are accomodated together with the container in the vacuum chamber of the external electrode and interposed between the inner wall surface of the vacuum chamber and the outer peripheral surface of the container. When a plastic container having a carbon film coating is mass-produced by connecting a plurality of external electrodes (CR, CC, CL) to a radio frequency power source (Rf), these external electrodes (CR, CC, CL) are connected mutually by leads (13R, 13L).

70. 发明公开

EP1375616A4 FILM COATING MATERIAL 有权
标题翻译： FILMÜBERZUGSMATERIAL
公开(公告)号：EP1375616A4
公开(公告)日：2004-05-06
申请号：EP01273955
申请日：2001-12-18
申请人： KIRIN BREWERY
发明人： KASAI TAKAHIDE , EGUCHI TAKAHIRO
IPC分类号： A21D13/00 , A21D13/08 , A23K1/00 , A23L1/00 , A23P1/08 , A61K9/28 , C05G3/00 , C09D105/00 , C09D199/00
CPC分类号： A23K40/30 , A21D13/26 , A23P10/30 , A23V2002/00 , C05G3/0041 , C09D199/00 , C08L2666/28 , A23V2200/22 , A23V2250/218 , A23V2250/60
摘要： A coating material which is applicable even at 100% water, is tack-free, is free from adhesion of particles to one another after coating, and functions to control dissolution period; and a film which is formed from the coating material and is useful as a packaging material having an extremely low oxygen permeability coefficient even under high-humidity conditions. An oxygen-barrier property improver such as glucose, mannose, maltose, trehalose, fructose, arabinose, nigero-oligosaccharide, lactose, D-glucono-1,5-lactone, arginine hydrochloride, ferrous sulfate, sodium dihydrogen phosphate, palatinit, or vitamin C is added to a yeast cell wall fraction comprising microorganism residues obtained by removing soluble intracellular components from a yeast treated with an enzyme or to a fraction obtained by treating that fraction with an acid aqueous solution. Thus, the coating material is prepared. The film formed from this coating material has an oxygen permeability coefficient less than 0.1 as measured at a relative humidity of 60%.
摘要翻译：即使在100％的水中也可使用的涂层材料是不粘的，在涂覆后彼此之间没有颗粒之间的粘附，并起到控制溶解时间的作用; 以及由该涂料形成的膜，并且即使在高湿度条件下也可用作具有极低透氧系数的包装材料。葡萄糖，甘露糖，麦芽糖，海藻糖，果糖，阿拉伯糖，黑寡糖，乳糖，D-葡萄糖酸-1,5-内酯，盐酸精氨酸，硫酸亚铁，磷酸二氢钠，palatinit或维生素等阻氧性改良剂将C加入到酵母细胞壁部分中，所述酵母细胞壁部分包含通过从经酶处理的酵母中去除可溶性细胞内成分而获得的微生物残余物或通过用酸性水溶液处理该部分获得的部分。由此制备涂料。由该涂料形成的膜在相对湿度60％下测得的氧渗透系数小于0.1。

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