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91. 发明授权

US5697945A Corneal surface marker and marking method for reducing irregular astigmatism during lamellar (LASIK) corneal surgery 失效
标题翻译：角膜表面标记和标记方法用于减少层状（LASIK）角膜手术期间的不规则散光
公开(公告)号：US5697945A
公开(公告)日：1997-12-16
申请号：US561541
申请日：1995-11-22
申请人： Michiel S. Kritzinger , Stephen A. Updegraff
发明人： Michiel S. Kritzinger , Stephen A. Updegraff
IPC分类号： A61B19/00 , A61F9/00 , A61F9/009 , A61F9/013 , A61M1/00
CPC分类号： A61F9/009 , A61B90/39 , A61F9/00802 , A61F9/0133 , A61F9/0136 , A61B2090/3937 , A61B2090/395 , A61F2009/00872 , A61F9/00 , A61M2210/0612
摘要： A corneal surface marker is used to improve centration and repositioning of a corneal cap or flap in lamellar corneal surgery. The marker has inner and outer concentric rings with marking radial and pararadials extending off the rings to provide adequate reference points for marking indicia to be placed on the corneal surface. The method involves preoperatively marking the corneal surface with suitable indicia in a pattern of radial and pararadial lines extending over the area of the cornea through which an incision will be made to excise a cap or flap and, after the keratotomy is performed, the cap or flap is replaced by realignment of the radial and pararadial lines with the area of the cornea surrounding the incision.
摘要翻译：角膜表面标记用于改善层状角膜手术中角膜盖或瓣的分离和重新定位。标记物具有内外同心环，其具有从环延伸的径向和旁向标记，以提供用于将标记放置在角膜表面上的足够参考点。该方法包括在角膜表面上进行术前标记，以合适的标记以延伸在角膜区域上的径向和旁边线的图案进行标记，通过该角度切口将切除帽或瓣，并且在进行角膜切开术之后，通过将径向和旁路线与围绕切口的角膜的面积重新对准来代替皮瓣。

92. 发明授权

US5695509A Aspherical optical molds for continuous reshaping the cornea based on topographical analysis 失效
标题翻译：基于地形分析的非球面光学模具，用于连续重塑角膜
公开(公告)号：US5695509A
公开(公告)日：1997-12-09
申请号：US401967
申请日：1995-03-10
申请人： Sami G. El Hage
发明人： Sami G. El Hage
IPC分类号： A61F9/013 , G02C7/04 , A61F9/00
CPC分类号： A61F9/013 , G02C7/047 , G02C2202/24
摘要： Continuous, aspheric optical molds for reshaping the surface of the cornea having an inner concave surface matched to the topography of the cornea. The curvatures of the molds are modified from a curve matched to a patient's corneal topography to include a flattened pressure zone applying relative pressure and thereby displacing underlying corneal tissue, a steepened relief zone raised away from the surface of the cornea to receive displaced corneal tissue, and a flattened anchor zone to control and direct movement of displaced corneal tissue into the relief zones.
摘要翻译：用于重塑角膜表面的连续非球面光学模具，其具有与角膜的形貌相匹配的内凹表面。模具的曲率从与患者的角膜形貌匹配的曲线改变为包括施加相对压力并由此移位下面的角膜组织的平坦压力区，从角膜表面升高的陡峭的减压区以接收移位的角膜组织，和平坦的锚固区域，以控制和引导移位的角膜组织进入救济区域。

93. 发明授权

US5690641A Rotary device for removing ophthalmic lens 失效
标题翻译：用于去除眼科镜片的旋转装置
公开(公告)号：US5690641A
公开(公告)日：1997-11-25
申请号：US421421
申请日：1995-04-11
申请人： John T. Sorensen , Michael Mittelstein , Soheila Mirhashemi
发明人： John T. Sorensen , Michael Mittelstein , Soheila Mirhashemi
IPC分类号： A61B17/00 , A61F9/00 , A61F9/007 , A61F9/013
CPC分类号： A61F9/00763 , A61B2017/00685
摘要： A system and method for reducing and removing and ophthalmic lens of a mammalian eye. The system includes a rotary lens-reducing probe device of either straight or curved configuration, said probe device comprising a tubular outer sheath through which a rotatable drive shaft extends. A rotating lens-reducing head member is positioned on the distal end of the drive shaft. The head member is configured and constructed to draw a flow of fluid and lens matter into contact therewith, thereby facilitating complete reduction of the entire lens without requiring significant axial (i.e., longitudinal) movement of the probe within the lens capsule. The distal portion of the tubular sheath is preferably configured to shield a portion of the lens-reducing head, during operation, to avoid inadvertent damage to lens capsule. Also, the distal portion of the sheath may be aimed or positioned to direct the flow of fluid and lens matter created by the rotating head in a preferred flow path within the lens capsule. The device may incorporate means for infusing and/or withdrawing fluid and/or debris into/from the eye.
摘要翻译：用于减少和去除哺乳动物眼睛的眼科镜片的系统和方法。该系统包括直的或弯曲构造的旋转透镜减小探针装置，所述探针装置包括管状的外护套，可旋转的驱动轴通过其延伸。旋转透镜减小头部件位于驱动轴的远端。头部构件被构造和构造成将流体和透镜物质的流动与其接触，从而有助于整个透镜的完全减少，而不需要在透镜囊内显着的轴向（即纵向）移动探针。管状护套的远侧部分优选地构造成在操作期间屏蔽透镜减少头部的一部分，以避免对透镜胶囊的无意的损坏。此外，鞘的远端部分可以被瞄准或定位成将由旋转头产生的流体和透镜物质的流动引导到镜片胶囊内的优选流动路径中。该装置可以包括用于将流体和/或碎屑注入和/或从眼睛中注入的装置。

94. 发明授权

US5681869A Injectable polyethylene oxide gel implant and method for production 失效
标题翻译：注射聚乙烯氧化物凝胶植入物和生产方法
公开(公告)号：US5681869A
公开(公告)日：1997-10-28
申请号：US463591
申请日：1995-06-05
申请人： Franck L. Villain , Jean-Marie A. Parel , William Gerald Lee , Gabriel Simon
发明人： Franck L. Villain , Jean-Marie A. Parel , William Gerald Lee , Gabriel Simon
IPC分类号： A61L27/00 , A61B17/32 , A61F2/00 , A61F2/12 , A61F2/14 , A61F9/007 , A61F9/013 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/075 , C08J3/28 , C08L71/02 , C09J7/00
CPC分类号： C08J3/075 , A61F2/0059 , A61F2/147 , A61F9/007 , A61F9/0133 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/28 , C08L71/02 , A61B2017/320044 , A61F2/12 , C08J2371/02 , Y10S623/906
摘要： A biocompatible poly(ethylene oxide) gel implant and method for production which can be injected into the human body for tissue replacement and augmentation. The implant is prepared by dissolving a sample of essentially pure poly(ethylene oxide) in a saline solution in a sealed canister, removing all free oxygen from the container and replacing it with an inert gas, such as argon, and irradiating the canister with a gamma ray source to simultaneously crosslink the polyethylene oxide while sterilizing it. The gel can then be placed into a syringe and injected into the body.
摘要翻译：生物相容性聚（环氧乙烷）凝胶植入物和可以注入人体进行组织置换和增殖的生产方法。植入物通过将基本上纯的聚（环氧乙烷）样品溶解在盐溶液中的密封罐中来制备，从容器中除去所有游离氧并用惰性气体如氩气代替，并用 γ射线源同时交联聚环氧乙烷同时对其进行消毒。然后将凝胶置于注射器中并注入体内。

95. 发明授权

US5662668A Blade for intrastromal radial keratotomy 失效
标题翻译：用于胸腔径向角膜切开术的刀片
公开(公告)号：US5662668A
公开(公告)日：1997-09-02
申请号：US427404
申请日：1995-04-24
申请人： Badrudin Kurwa
发明人： Badrudin Kurwa
IPC分类号： A61F9/013 , A61F9/00
CPC分类号： A61F9/0133
摘要： The horizontal base of an L-shaped blade is inserted within an existing incision performed as part of a traditional radial keratotomy procedure to permit an intrastromal cut to be made to urge corneal collapse and provide myopia correction without incurring glare and central vision distortion for the patient. The base of the blade extends approximately 1 mm to a very sharp vertical edge from the vertical arm attached to a blade holder to permit up to an equivalent length intrastromal cut until the end of the arm reaches the end of the preexisting incision through Bowman's membrane and the epithelium. The height of the base and length of the cutting edge is approximately 450 microns to prevent cutting or perforation of either of Bowman's or Descemet's membranes.
摘要翻译：将L形刀片的水平底座插入到作为传统径向角膜切开术程序的一部分的现有切口内，以允许进行腔内切割以促进角膜塌陷并提供近视矫正，而不会对患者产生眩光和中心视力变形。叶片的基部从连接到刀片保持器的垂直臂延伸大约1mm的非常锋利的垂直边缘，以允许达到相当长度的基质内切割，直到臂的端部通过鲍曼氏膜到达预先存在的切口的端部，并且上皮细胞。基座的高度和切割刃的长度约为450微米，以防止Bowman或Descemet膜中的任何一个的切割或穿孔。

96. 发明授权

US5634921A Method and apparatus for modifications of visual acuity by thermal means 失效
标题翻译：用于通过热装置修改视力的方法和装置
公开(公告)号：US5634921A
公开(公告)日：1997-06-03
申请号：US488829
申请日：1995-06-08
申请人： Larry Hood , Antonio G. Mendez
发明人： Larry Hood , Antonio G. Mendez
IPC分类号： A61B18/04 , A61B18/00 , A61B18/08 , A61B18/14 , A61B19/00 , A61F9/00 , A61F9/007 , A61F9/01 , A61F9/013 , A61N1/00 , A61N1/04 , A61N1/28 , A61B17/36
CPC分类号： A61F9/008 , A61B18/14 , A61F9/00821 , A61F9/0133 , A61B18/1815 , A61B2018/00178 , A61B2018/00761 , A61B2018/00886 , A61B2018/00988 , A61B2018/143 , A61B2018/1475 , A61B2090/036 , A61F2009/0052 , A61F2009/00844 , A61F2009/00853 , A61F2009/00872 , A61F9/0079
摘要： A thermokeratoplasty system and method for locally heating and reshaping a cornea in a manner that produces a minimal regression of the corneal correction. The system includes a probe that is coupled to a power source which can provide current at a predetermined power, frequency and time duration. The probe has a sharp tip that is inserted into the stroma of the cornea. The tip has an insulated stop that controls the depth of tip penetration. Current flows into the cornea through the probe tip to locally heat and denature the corneal tissue. The denatured tissue causes a subsequent shrinkage of the cornea. A pattern of denatured areas can be created around the cornea to correct the vision of the eye.
摘要翻译：一种用于局部加热和重塑角膜的热机器人成形术系统和方法，其产生角膜矫正的最小回归。该系统包括耦合到能够以预定功率，频率和持续时间提供电流的电源的探针。探头有一个尖锐的尖端插入角膜的基质。尖端具有控制尖端穿透深度的绝缘挡块。电流通过探针尖端流入角膜，以局部加热和变形角膜组织。变性组织导致角膜随后的收缩。可以在角膜周围形成变性区域的图案，以矫正眼睛的视力。

97. 发明授权

US5607437A Instruments for use in performing gel injection adjustable keratoplasty 失效
标题翻译：用于执行凝胶注射可调角膜移植术的仪器
公开(公告)号：US5607437A
公开(公告)日：1997-03-04
申请号：US299423
申请日：1994-09-01
申请人： Gabriel Simon , William G. Lee , Jean-Marie A. Parel
发明人： Gabriel Simon , William G. Lee , Jean-Marie A. Parel
IPC分类号： A61F9/007 , A61B17/32 , A61F2/00 , A61F2/12 , A61F2/14 , A61F9/013 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/075 , C08J3/28 , C08L71/02 , A61B17/00
CPC分类号： A61F2/147 , A61F9/007 , A61F9/0133 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/075 , C08J3/28 , C08L71/02 , A61B2017/320044 , A61F2/0059 , A61F2/12 , A61L2430/16 , C08J2371/02
摘要： The present invention provides a surgical technique and instrument kit that allows for subtle modification of the corneal curvature by interlamellar injection of a synthetic gel at the corneal periphery while sparing the optical zone. The gel viscosity, volume and disposition within the surgical annular track as well as the diameter of the track, width, depth, and location are all parameters in the refractive change obtained. Following ultrasonic pachymetry performed centrally and at a selected wound entrance located about 2.5 to 3.5 mm from the apex, a one millimeter or so wide, about 75-85% corneal thickness depth radial incision is performed with a micrometric diamond knife adjusted to about 86% corneal thickness. Inserted through the partial-depth incision, a corkscrew-like dissector or helicoidal spatula forms a 360.degree. annular track centered about the apex. A transparent gel is manually injected through the incision, filling the annular channel. Using a surgical keratometer mounted to an operation microscope, the final corneal power is adjusted by massaging and removing the gel as necessary during the primary procedure or subsequent procedures, as the GIAK technique is reversible.
摘要翻译：本发明提供了一种手术技术和仪器套件，其允许通过在保护光学区域的同时在角膜周边层间注射合成凝胶来微调角膜曲率。手术环形轨道内的凝胶粘度，体积和配置以及轨迹的直径，宽度，深度和位置都是获得的折射变化的参数。在中心进行超声波比重测量并且位于离顶点大约2.5至3.5mm的选定的伤口处，使用调节至约86％的微测金刚石刀片进行一毫米或更宽，约75-85％的角膜厚度深度径向切口，角膜厚度。通过部分深度切口插入，开瓶塞式解剖器或螺旋刮刀形成以顶点为中心的360°环形轨道。通过切口手动注入透明凝胶，填充环形通道。使用安装在手术显微镜上的外科角膜曲率计，通过在主要手术或随后程序中根据需要按摩和去除凝胶来调整最终的角膜功能，因为GIAK技术是可逆的。

98. 发明授权

US5582608A Lamellar illumination apparatus for eye surgery 失效
标题翻译：用于眼科手术的层状照明装置
公开(公告)号：US5582608A
公开(公告)日：1996-12-10
申请号：US420129
申请日：1995-04-11
申请人： Alan W. Brown
发明人： Alan W. Brown
IPC分类号： A61B17/02 , A61B19/00 , A61F9/007 , A61F9/013 , A61N5/06
CPC分类号： A61F9/007 , A61B17/0231 , A61B3/0008 , A61F9/013 , A61B2090/306 , A61B90/30
摘要： Apparatus for illuminating a central area of an eye by lamellar lighting during eye surgery. Basically, a support fixture carrying a light emitter is adapted to be placed adjacent to the surgical field. The support fixture, when in place on an eye, directs light from the light emitter toward the surgical field tangentially to the cornea, at an angle of from about 0 to 45.degree. to the plane of the eye iris. The light entering the eye travels along the lamellae of the cornea in the manner of a light pipe. Very little, if any light reaches the back of the eye, avoiding patient discomfort, or is directed toward the surgical microscope as glare. This lamellar lighting combines scleral scatter and retro illumination. In preferred embodiments, the light emitter may be mounted on, or incorporated in, a conventional eyelid speculum or a fixation ring.
摘要翻译：用于在眼睛手术期间通过层状照明来照射眼睛的中心区域的装置。基本上，携带光发射器的支撑夹具适于放置在手术区域附近。当眼睛处于适当位置时，支撑固定件以与眼睛的平面成约0至45度的角度将来自发光体的光引导到与角膜切向的外科手术区域。进入眼睛的光以光管的方式沿着角膜的薄片行进。很少，如果有的光到达眼睛后面，避免患者的不适，或者指向外科手术显微镜作为眩光。这种层状照明结合巩膜散射和复古照明。在优选实施例中，光发射器可以安装在传统的眼睑窥镜或固定环上或并入其中。

99. 发明授权

US5578049A Optical zone marker for refractive surgery 失效
$Optical zone marker for refractive surgery$
标题翻译：屈光手术的光学区域标记
公开(公告)号：US5578049A
公开(公告)日：1996-11-26
申请号：US315535
申请日：1994-09-30
申请人： Fred T. Feaster
发明人： Fred T. Feaster
IPC分类号： A61F9/013 , A61F9/00
CPC分类号： A61F9/0136
摘要： The marker is a hollow cylindrical member having a given height between two opposite ends and a given radius with an opening extending therethrough between the two ends and a central axis extending through the opening. One of the ends is a cornea engaging end and the other end is a viewing end. Two aligned spaced apart pointing members extend radially inward to the central axis of the opening from one side of the member such that when viewed from either end, from the central axis, the two pointing members are radially aligned. The pointing member closest to the viewing end has a width not greater then the width of the other pointing member. In another embodiment, a solid pointing plate is employed instead of the two pointing members.
摘要翻译：标记是在两个相对端之间具有给定高度的中空圆柱形构件和具有在两端之间延伸通过的开口的给定半径和延伸穿过开口的中心轴线。其中一个角度是角膜接合端，另一端是观察端。两个对齐的间隔开的指向构件从构件的一侧向内径向向内延伸到开口的中心轴线，使得当从任一端观察时，从中心轴线观察，两个指向构件是径向对准的。最靠近观察端的指向构件具有不大于另一个指向构件的宽度的宽度。在另一个实施例中，使用固体指示板代替两个指向构件。

100. 发明授权

US5571124A Apparatus and method for performing surgery on the cornea of an eye 失效
标题翻译：用于对眼睛的角膜进行手术的装置和方法
公开(公告)号：US5571124A
公开(公告)日：1996-11-05
申请号：US421316
申请日：1995-04-13
申请人： Jerry Zelman
发明人： Jerry Zelman
IPC分类号： A61F9/013 , A61F9/00
CPC分类号： A61F9/0136 , A61F9/0133
摘要： The present invention includes a cutting blade for performing eye surgery. The cutting blade has a dull distal edge. The sides of the cutting blade have edges, at least a portion of which are sharp. The distal edge extends between the first and second edges in a single plane thereby defining a single line from the first edge to the second edge. The cutting blade may be mounted on a handpiece such that the dull distal edge is disposed substantially perpendicular to a longitudinal axis of the handle. The handpiece may include a micrometer control for controlling the amount of the blade which extends from the handpiece. In one embodiment the handpiece is weighted to assist the surgeon in deepening the incision. In addition, transparent footplates may be mounted on the handpiece. In use, the blade of the present invention may be used alone or in combination with conventional surgical blades. With the use of the dull distal edge and the sharp edges of the blade of the present invention, an incision made in the cornea of an eye may be evened-out at its bottom and deepened across almost its entire length to almost 100% of the cornea thickness without perforating the cornea. In one embodiment, prior to cutting, a marking device of the present invention may be used to mark a pattern of incisions on the cornea of the eye. The marking device of the present invention includes concentric rings attached to each other by radially extending supports and the combination is attached to an end of a handle. The two concentric rings define the maximum length of the radial incisions.
摘要翻译：本发明包括用于进行眼外科手术的切割刀片。切割刀片具有钝的远端边缘。切割刀片的侧面具有至少一部分锋利的边缘。远侧边缘在单个平面中在第一和第二边缘之间延伸，从而限定从第一边缘到第二边缘的单线。切割刀片可以安装在手持件上，使得钝的远侧边缘基本上垂直于手柄的纵向轴线设置。手持件可以包括用于控制从手持件延伸的刀片的量的千分尺控制。在一个实施例中，手持件被加权以帮助外科医生加深切口。此外，透明脚板可以安装在手持件上。在使用中，本发明的刀片可以单独使用或与常规手术刀片组合使用。通过使用本发明的钝的远端边缘和刀片的锋利边缘，在眼睛的角膜中制成的切口可以在其底部平整并且几乎在其整个长度上加深到几乎100％的角膜厚度无穿孔角膜。在一个实施例中，在切割之前，本发明的标记装置可用于在眼睛的角膜上标记切口图案。本发明的标记装置包括通过径向延伸的支撑件彼此附接的同心环，并且组合附接到手柄的端部。两个同心圆定义径向切口的最大长度。

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