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11. 发明申请

US20220362404A1 MODULATION OF CELLULAR VIABILITY 有权
公开(公告)号：US20220362404A1
公开(公告)日：2022-11-17
申请号：US17754597
申请日：2020-10-21
申请人： Macquarie University
发明人： Stephanie Rayner , Albert Lee , Jennilee Davidson , Roger Chung
IPC分类号： A61K48/00
摘要： Provided herein are methods for enhancing survival of a neuron, for inhibiting degeneration of a neuron, and for inhibiting abnormal protein accumulation in a neuron, optionally a motor neuron, comprising, consisting or consisting essentially of increasing the level of cyclin F in the neuron regardless of the neuron's level or activity of endogenous cyclin F. Optionally the neuron is in a subject with a neurodegenerative condition or at risk of developing a neurodegenerative condition, typically a neurodegenerative condition associated with a neuronal TDP-43 proteinopathy.

12. 发明申请

US20220288082A1 TREATMENT OF DEMENTIA 有权
公开(公告)号：US20220288082A1
公开(公告)日：2022-09-15
申请号：US17754135
申请日：2020-09-25
申请人： Macquarie University
发明人： Lars Ittner , Yazi Diana Ke
IPC分类号： A61K31/519 , A61P25/28
摘要： Provided herein are methods for treating, delaying the onset of, or ameliorating at least one symptom of, dementia associated with #-amyloid (A#) accumulation, and for improving memory in subjects suffering from dementia associated with A# accumulation, comprising administering to subjects in need thereof an effective amount of an inhibitor of LIMK1, wherein the inhibitor comprises a compound of Formula (I) as defined herein, or a pharmaceutically acceptable salt thereof. Also provided are methods for reducing A# toxicity in neurons, comprising exposing neurons to an effective amount of an inhibitor of LIMK1, wherein the inhibitor comprises a compound of Formula (I) as defined herein, or a pharmaceutically acceptable salt thereof.

13. 发明授权

US11428075B2 System and method of distributed sensing in downhole drilling environments 有权
公开(公告)号：US11428075B2
公开(公告)日：2022-08-30
申请号：US16944796
申请日：2020-07-31
申请人： SAUDI ARABIAN OIL COMPANY , Macquarie University
发明人： Chinthaka Pasan Gooneratne , Subhas Mukhopadhyay , Bodong Li , Guodong Zhan , Arturo Magana-Mora , Timothy Eric Moellendick
IPC分类号： E21B41/00 , E21B47/26 , E21B47/00 , E21B47/12 , G01V11/00 , H01M10/46 , H02N1/04 , H02N2/18
摘要： A system includes sensing modules positioned along a length of a drill string. Each sensing module includes a structure arrangement composed of an outer structure body having a cavity and an inner structure body rotatably supported within the cavity. The structure arrangement is coupled to the drill string such that rotation of the drill string produces a relative rotation between the structure bodies. Ball elements are disposed in a gap between the structure bodies and move along a predetermined path defined in the gap in response to relative rotation between the structure bodies. Movable elements are positioned to physically interact with the ball elements as the ball elements move along the predetermined path. Energy harvesters in the sensor modules generate electrical energy from the mechanical energy produced by physical interaction between the ball elements and movable elements. The sensing modules include sensors to measure parameters in the drill string environment.

14. 发明授权

US11322905B2 Single longitudinal mode ring Raman laser 有权
公开(公告)号：US11322905B2
公开(公告)日：2022-05-03
申请号：US16475747
申请日：2017-12-22
申请人： Macquarie University
发明人： David James Spence , Ondrej Kitzler , Jipeng Lin , Richard Paul Mildren , Helen M. Pask , Graeme P. A. Malcolm , Nils Hempler , Stephen Webster
IPC分类号： H01S3/08 , H01S3/081 , H01S3/083 , H01S3/139 , H01S3/30
摘要： A single longitudinal mode ring Raman laser including: a pump source outputting a pump light power, resonantly coupled to a first ring resonator; a optical measurement and piezo-actuator for stabilising the resonant coupling of the pump light power to a first ring resonator; a first ring resonator including a Raman gain medium, wherein the Raman gain medium receives the pump light power and undergoes Raman lasing generating resonated Stokes power at the corresponding Stokes output wavelength; the first ring resonator acting as a feedback loop for the pump light power and the resonated Stokes power and outputting a portion of the Stokes power as the laser output.

15. 发明授权

US11194005B2 Direction of arrival estimation 有权
公开(公告)号：US11194005B2
公开(公告)日：2021-12-07
申请号：US16345225
申请日：2017-10-27
申请人： MACQUARIE UNIVERSITY
发明人： Sam Reisenfeld , Audri Biswas
IPC分类号： G01S3/04 , G01S3/48 , G01S3/72 , G01S3/80
摘要： Iterative methods for direction of arrival estimation of a signal at a receiver with a plurality of spatially separated sensor elements are described. A quantized estimate of the angle of arrival is obtained from a compressive sensing solution of a set of equations. The estimate is refined in a subsequent iteration by a computed error based a quantized estimate of the direction of arrival in relation to quantization points offset from the quantization points for the first quantized estimate of the angle of arrival. The iterations converge on an estimated direction of arrival.

16. 发明授权

US09816926B2 Multiplex suspension assay/array using lifetime coding 有权
公开(公告)号：US09816926B2
公开(公告)日：2017-11-14
申请号：US14410015
申请日：2013-06-21
申请人： Macquarie University
发明人： Dayong Jin , Yiqing Lu , Jiangbo Zhao
IPC分类号： G01N21/64 , C40B70/00 , C09K11/02 , C09K11/06 , C09D11/50 , C09K11/77 , B42D25/382 , B42D25/387 , G01N33/542 , G01N33/58
CPC分类号： G01N21/6408 , B42D25/382 , B42D25/387 , C09D11/50 , C09K11/02 , C09K11/025 , C09K11/06 , C09K11/7773 , C09K2211/182 , C40B70/00 , G01N21/6428 , G01N33/542 , G01N33/582
摘要： A system, device and/or method for multiplex assays. In a particular, but non-limiting, example there is provided a multiplex array, such as a suspension array. Luminescence decay lifetimes are utilized for probes in a suspension array, and coding/decoding the codes from time-resolved spectra. Lifetime populations can be generated at distinct color bands. A novel temporal technique or dimension is applied over conventional spectral and intensity combinations, thereby expanding the multiplexing capacity of a suspension array. In one example form, the multiplexing capacity of a suspension array can be expanded to the order of about 58. This provides a reliable, high-throughput and relatively inexpensive solution for multiplex assays in various areas of application such as life sciences, data storage and security.

17. 发明授权

US08298783B2 Detecting molecules 失效
标题翻译：检测分子
公开(公告)号：US08298783B2
公开(公告)日：2012-10-30
申请号：US10569107
申请日：2004-08-20
申请人： Mark S. Baker
发明人： Mark S. Baker
IPC分类号： G01N33/53 , G01N31/00
CPC分类号： C07K16/065 , C07K1/22
摘要： Disclosed are processes to increase the relative abundance of a molecule that is present in a test sample at relatively low abundance. The process includes fractionating a sample and immunizing hosts with the fractions. The antibodies produced from the fractionated test sample are directed primarily to molecules that are in relatively high abundance in the test sample fractions. These antibodies are then contacted with the test sample or a test sample to immuno-deplete relatively high abundance molecules from the sample to form a first depleted sample. These steps can be repeated a reiterative process of immuno-subtraction to produce second and third depleted samples where the relative abundance of the “low abundance” molecule is increased.
摘要翻译：公开的是以相对低的丰度增加存在于测试样品中的分子的相对丰度的方法。该方法包括对样品进行分级并用分数免疫宿主。从分级测试样品产生的抗体主要针对测试样品部分中相对较高丰度的分子。然后将这些抗体与测试样品或测试样品接触以从样品中免除耗尽相对高丰度的分子以形成第一个耗尽的样品。这些步骤可以重复免疫减除的重复过程，以产生其中低丰度分子的相对丰度增加的第二和第三贫化样品。

18. 发明申请

US20120214194A1 PROCESS FOR SYNTHESIZING EPICCONONE ANALOGS 有权
标题翻译：合成EPICCONONE ANALOGS的方法
公开(公告)号：US20120214194A1
公开(公告)日：2012-08-23
申请号：US13503880
申请日：2010-10-25
申请人： Xavier Franck , Philippe Peixoto , Peter Helmuth Karuso
发明人： Xavier Franck , Philippe Peixoto , Peter Helmuth Karuso
IPC分类号： G01N21/64 , C07D493/14
CPC分类号： C07D493/04 , C07D307/58 , C07D311/76 , C09B61/00
摘要： The present invention relates to a process for the total synthesis of epicocconone analogs of formula (I): The invention also relates to novel epicocconone analogs.
摘要翻译：本发明涉及一种总体合成式（I）表皮素类似物的方法：本发明还涉及新颖的表皮素类似物。

19. 发明申请

US20110152313A1 SYNTHESIS OF AGELADINE A AND ANALOGS THEREOF 审中-公开
标题翻译： AGELADINE A及其类似物的合成
公开(公告)号：US20110152313A1
公开(公告)日：2011-06-23
申请号：US12999046
申请日：2009-06-19
申请人： Peter Helmuth Karuso , Sudhir Ramnathrao Shengule
发明人： Peter Helmuth Karuso , Sudhir Ramnathrao Shengule
IPC分类号： A61K31/437 , C07D471/02 , A61P35/00 , A61P27/02
CPC分类号： C07D471/04 , A61K31/437
摘要： The invention describes a one pot process for synthesizing a compound of structure (I), or a tautomer thereof. A compound of structure (II), or a tautomer thereof, and an aldehyde of structure RdCHO are condensed to form a condensation product. The resulting condensation product is then oxidized in the same reaction mixture to produce the compound of structure (I) or a tautomer thereof.
摘要翻译：本发明描述了一种用于合成结构（I）化合物或其互变异构体的一锅方法。将结构（II）的化合物或其互变异构体和结构RdCHO的醛缩合形成缩合产物。然后将所得缩合产物在相同的反应混合物中氧化，生成结构（I）化合物或其互变异构体。

20. 发明申请

US20090137061A1 DETECTING MOLECULES 审中-公开
标题翻译：检测分子
公开(公告)号：US20090137061A1
公开(公告)日：2009-05-28
申请号：US11813443
申请日：2006-01-06
申请人： Mark S. Baker
发明人： Mark S. Baker
IPC分类号： G01N1/18
CPC分类号： C07K1/36 , G01N33/5306 , Y10T436/25375
摘要： The invention relates to separating molecules, in particular, to proteins comprised in biological fluid such as serum, to purifying molecules and to producing antisera to molecules.
摘要翻译：本发明涉及分离分子，特别是分离生物流体例如血清中的蛋白质，以分离纯化分子和产生分子的抗血清。

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