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11. 发明授权

US4473156A Method and apparatus for accurately selecting storing and dispensing pills 失效
标题翻译：准确选择储存和分配药丸的方法和设备
公开(公告)号：US4473156A
公开(公告)日：1984-09-25
申请号：US439393
申请日：1982-11-05
申请人： David C. Martin
发明人： David C. Martin
IPC分类号： A61J7/04 , G09F3/00 , G09F3/08 , B65B1/24 , B65D85/56 , G09F9/00
CPC分类号： A61J7/04 , G09F3/00 , A61J2205/20
摘要： An apparatus for accurately selecting, storing and dipensing multiple varieties of pills at preselected time intervals such as morning, noon, evening and night includes a separate pill container for each unique variety of pill to be dispensed. Each pill container is identified by a distinctive color or colors to indicate the time interval(s) during which the pill in it are to be dispensed. For example, each container for pills to be dispensed in the morning will be identified at least by the color red; at noon, at least yellow; in the evening, at least blue; and at night at least black. Any particular container will, therefore, be identified by at least one and not more than four colors. A pill tray includes a plurality of pill holding compartments arranged in columns identified with each of the days of the week and in row, each row representing one of the time intervals, such as morning, noon, evening and night. Each pill holding compartment in the row representing morning is colored red, the row representing noon is colored yellow, the evening row is colored blue, and the night row is colored black. The tray is loaded by putting one pill from each container in each of the compartments colored the same as one of the colors identifying that container. Sliding panels are provided as covers for each of the columns, and the patient can access the proper medication by uncovering the appropriate compartment at the appropriate time interval. For example, on Monday morning, the patient slides the "Monday" panel down far enough to uncover the Monday morning compartment, removes the pills and ingests them.
摘要翻译：用于以预选的时间间隔（例如早晨，中午，傍晚和晚上）准确地选择，储存和接受多种药丸的装置包括用于每种独特种类的待分配药丸的单独药丸容器。每个药丸容器通过独特的颜色或颜色来标识，以指示其中要分配药丸的时间间隔。例如，每天早上要分配的药丸的容器将至少由红色识别; 中午至少黄色; 在晚上，至少蓝色; 至少在黑夜。因此，任何特定的容器将由至少一种而不是四种颜色来识别。药丸托盘包括多个药丸保持隔间，其布置在以每周中的每一天和每隔一行标识的列中，每行代表时间间隔之一，例如早晨，中午，傍晚和晚上。代表上午的行中的每个药丸保持室都是红色的，代表中午的行是黄色的，晚上的行是蓝色的，而夜行是黑色的。通过将每个容器中的每个容器中的一个药丸放入与标识该容器的颜色之一相同的隔室中来装载托盘。滑动面板被设置为每个柱的盖，并且患者可以通过在适当的时间间隔揭开适当的隔室来访问适当的药物。例如，星期一上午，患者将“星期一”面板滑落到足够远的地方，以揭开周一早上的隔间，取出药片并摄入。

12. 发明申请

US20140249645A1 HYBRID BIOELECTRICAL INTERFACE DEVICE 审中-公开
标题翻译：混合生物界面装置
公开(公告)号：US20140249645A1
公开(公告)日：2014-09-04
申请号：US13586350
申请日：2012-08-15
申请人： PAUL S. CEDERNA , BRENT M. EGELAND , MOHAMMAD REZA ABIDIAN , ANTONIO PERAMO , MELANIE G. URBANCHEK , DARYL R. KIPKE , SARAH RICHARDSON-BURNS , DAVID C. MARTIN , EUGENE D. DANESHVAR
发明人： PAUL S. CEDERNA , BRENT M. EGELAND , MOHAMMAD REZA ABIDIAN , ANTONIO PERAMO , MELANIE G. URBANCHEK , DARYL R. KIPKE , SARAH RICHARDSON-BURNS , DAVID C. MARTIN , EUGENE D. DANESHVAR
IPC分类号： A61F2/72 , A61L27/36 , A61L27/34 , A61N1/36
CPC分类号： A61F2/72 , A61F2250/0001 , A61L27/34 , A61L27/3675 , A61N1/05 , A61N1/0543 , A61N1/0551 , A61N1/36125
摘要： A hybrid bioelectrical interface (HBI) device can be an implantable device comprising an abiotic component operable to transmit charge via electrons or ions; a biological component interfacing with the neural tissue, the biological component being sourced from biologic, biologically-derived, or bio-functionalized material; and a conjugated polymer component that together provide a means to chronically interface living neural tissue with electronic devices for extended durations (e.g. greater than 10 years). In some embodiments, conjugated polymers provide a functional electrical interface for charge transfer and signal transduction between the nervous system and an electronic device (e.g. robotic prosthetic limb, retinal implant, microchip).
摘要翻译：混合生物电接口（HBI）装置可以是可植入装置，其包括可操作以经由电子或离子传递电荷的非生物成分; 与神经组织接触的生物组分，生物组分来自生物学，生物衍生的或生物功能化的材料; 共轭聚合物组分共同提供长寿命地将活体神经组织与电子装置接合以延长持续时间（例如大于10年）的手段。在一些实施方案中，共轭聚合物为神经系统和电子设备（例如机器人假肢，视网膜植入物，微芯片）之间的电荷转移和信号转导提供功能性电接口。

13. 发明授权

US08513321B2 Dual cure coating compositions, methods of coating a substrate, and related coated substrates 有权
标题翻译：双重固化涂料组合物，涂布基材的方法和相关的涂布基材
公开(公告)号：US08513321B2
公开(公告)日：2013-08-20
申请号：US12940317
申请日：2010-11-05
申请人： David C. Martin , Brian K. Rearick , Christina A. Winters , Mary Ann Fuhry , Cynthia Kutchko
发明人： David C. Martin , Brian K. Rearick , Christina A. Winters , Mary Ann Fuhry , Cynthia Kutchko
IPC分类号： C08F2/52 , C08F2/42 , C08J3/28
CPC分类号： C09D4/00
摘要： Disclosed herein are dual cure coating compositions that include (a) a melamine-group containing polyethylenically unsaturated compound and (b) an acrylate-containing compound different from (a), wherein the acrylate-containing compound is present at a level sufficient to provide a cured coating layer having a glass transition temperature of 100° C. or below and a crosslink density of 20.0 mmoles/cc or below. Also disclosed are related multi-component composite coatings, coated substrates, and methods for coating a substrate.
摘要翻译：本文公开了双重固化涂料组合物，其包含（a）含三聚氰胺基团的多烯属不饱和化合物和（b）不同于（a）的含丙烯酸酯化合物，其中含丙烯酸酯化合物的含量足以提供玻璃化转变温度为100℃以下，交联密度为20.0毫摩尔/ cc以下的固化涂层。还公开了相关的多组分复合涂层，涂覆的基底和用于涂覆基底的方法。

14. 发明申请

US20120178893A1 SUBSTITUTED 3,4-PROPYLENEDIOXYTHIOPHENE MONOMERS AND 3,4-PROPYLENEDIOXYTHIOPHENE-BASED CROSSLINKERS AND POLYMERS THEREOF 失效
标题翻译：取代的3,4-丙烯基二甲苯单体和基于3,4-丙烯二氧基聚苯乙烯的交联剂及其聚合物
公开(公告)号：US20120178893A1
公开(公告)日：2012-07-12
申请号：US13215321
申请日：2011-08-23
申请人： David C. Martin , Kathleen E. Feldman
发明人： David C. Martin , Kathleen E. Feldman
IPC分类号： C08G75/06 , C08G77/28 , C07F7/18 , C07D495/04 , C07H15/26
CPC分类号： C07D495/04 , C08G61/126 , C08G2261/1424 , C08G2261/145 , C08G2261/44
摘要： Substituted 3,4-propylenedioxythiophene monomers may be prepared by reacting 3-allyl-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepine or 3,3-diallyl-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepine with a thiol having a hydrocarbyl moiety optionally containing one or more heteroatom-containing functional groups under radical addition conditions under radical addition conditions. Such monomers may be used in homo- or copolymerization processes to obtain thiophene-type polymers containing substituents (which may bear functional groups such as silane, thiol, hydroxyl, carboxylic acid, amine, sugar groups, polyoxyalkylene, and the like). Crosslinkers useful for introducing crosslinking into thiophene-type polymers may be prepared by reacting 3-allyl-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepine with a compound having two or more thiol groups under radical addition conditions.
摘要翻译：取代的3,4-亚丙二氧基噻吩单体可以通过使3-烯丙基-3,4-二氢-2H-噻吩并[3,4-b] [1,4]二氧杂环庚三烯或3,3-二烯丙基-3,4-二氢 -2H-噻吩并[3,4-b] [1,4]二氧杂环庚烯与在自由基加成条件下具有任选含有一个或多个含杂原子的官能团的烃基部分的硫醇。这些单体可用于均聚或共聚方法以获得含有取代基（可含有官能团如硅烷，硫醇，羟基，羧酸，胺，糖基，聚氧化烯等）的噻吩型聚合物。用于将交联引入噻吩型聚合物中的交联剂可以通过使3-烯丙基-3,4-二氢-2H-噻吩并[3,4-b] [1,4]二氧杂环庚烯与具有两个或更多个硫醇基的化合物根本添加条件。

15. 发明申请

US20110257504A1 BIOLOGICALLY INTEGRATED ELECTRODE DEVICES 审中-公开
标题翻译：生物集成电极装置
公开(公告)号：US20110257504A1
公开(公告)日：2011-10-20
申请号：US13085060
申请日：2011-04-12
申请人： Jeffrey L. Hendricks , Sarah Richardson-Burns , David C. Martin
发明人： Jeffrey L. Hendricks , Sarah Richardson-Burns , David C. Martin
IPC分类号： A61B5/04 , A61N1/362 , A61N1/36 , A61N1/39 , A61F11/04 , A61F9/08 , C08G75/06 , A61K38/43 , A61K47/34 , A61K31/7088 , A61K38/02 , A61K35/00 , A61K35/34 , A61K35/30 , A61K35/12 , A61K35/28 , C12N5/071 , B32B3/10 , H01B1/12 , A61N1/05
CPC分类号： A61B5/0408 , A61B2562/0217 , A61B2562/125 , A61N1/05 , A61N1/0531 , A61N1/0534 , A61N1/0536 , Y10T428/24355
摘要： Bioelectrodes having enhanced biocompatible and biomimetic features are provided. Methods of making and using the bioelectrodes are further provided. A biologically integrated bioelectrode device and method for detecting electronic signals using a bioelectrode comprising a first electrically conductive substrate and a biological component. The bioelectrode also comprises a conductive polymer electrically coupling the first electrically conductive substrate and the biological component to define a bioelectrode. The bioelectrode can transmit or receive an electrical signal between the electrically conductive substrate and the biological component and conductive polymer.
摘要翻译：提供具有增强的生物相容性和仿生特征的生物电极。进一步提供制造和使用生物电极的方法。一种生物集成生物电极装置和方法，用于使用包括第一导电基底和生物成分的生物电极检测电子信号。生物电极还包括导电聚合物，其电耦合第一导电基底和生物组分以限定生物电极。生物电极可以在导电基底和生物组分和导电聚合物之间传输或接收电信号。

16. 发明授权

US07708908B2 Carboxylic acid-modified EDOT for bioconjugation 有权
标题翻译：用于生物共轭的羧酸改性的EDOT
公开(公告)号：US07708908B2
公开(公告)日：2010-05-04
申请号：US12038138
申请日：2008-02-27
申请人： Jinsang Kim , Jae Cheol Cho , Laura K. Povlich , David C. Martin
发明人： Jinsang Kim , Jae Cheol Cho , Laura K. Povlich , David C. Martin
IPC分类号： H01B1/12 , C08G75/00 , C07D333/10 , G01N31/00
CPC分类号： C07D495/04
摘要： An electroconductive carboxylic acid functionalized monomer corresponding to Formula (I), wherein A represents a hydrogen or a carboxyl group. Polymerized monomers of Formula (I) conjugated with a biomolecule result in conjugated PEDOT polymers of Formula (III) wherein A is a hydrogen or a carboxylic acid group and B is a biomolecule selected from the group consisting of a peptide, a protein, a lipid, a carbohydrate and a polynucleotide. The biomolecule conjugated polymers can be disposed onto an electrically conductive substrate wherein the substrate has a first layer of PEDOT polymerized on a surface of the substrate and a second layer of biomolecule conjugated PEDOT polymer of Formula (III) polymerized on the first layer of PEDOT. The first and second layers form a charge transport material in electrical communication with the conductive substrate. The electrically conductive substrate further comprises a dopant.
摘要翻译：对应于式（I）的导电羧酸官能化单体，其中A表示氢或羧基。与生物分子缀合的式（I）的聚合单体导致式（III）的共轭PEDOT聚合物，其中A是氢或羧酸基团，B是选自肽，蛋白质，脂质的生物分子，碳水化合物和多核苷酸。生物分子共轭聚合物可以设置在导电基底上，其中基底具有在基底表面上聚合的第一层PEDOT和在第一层PEDOT上聚合的式（III）的生物分子共轭PEDOT聚合物的第二层。第一和第二层形成与导电基底电连通的电荷传输材料。导电衬底还包括掺杂剂。

17. 发明授权

US5888618A Fire-resistant, retroreflective structure 失效
标题翻译：耐火，回射结构
公开(公告)号：US5888618A
公开(公告)日：1999-03-30
申请号：US756391
申请日：1996-11-26
申请人： David C. Martin
发明人： David C. Martin
IPC分类号： B32B3/10 , B32B3/18 , B32B3/26 , B32B27/08 , B32B27/18 , B32B27/30 , G02B5/124 , B32B5/30
CPC分类号： G02B5/124 , B32B3/10 , B32B3/18 , Y10S428/92 , Y10S428/921 , Y10T428/24479 , Y10T428/24521 , Y10T428/2457 , Y10T428/31507 , Y10T428/3158 , Y10T428/31797 , Y10T428/31917 , Y10T428/3192 , Y10T428/31928
摘要： A fire-resistant retroreflective structure having an array of rigid retroreflective elements and a method for making the structure are disclosed. The retroreflective structure is formed of an array of rigid retroreflective elements having a first side and a second side. A transparent polymeric film is attached to the first side of the array of rigid retroreflective elements. A transparent fire-resistant outerlayer is attached to the transparent polymeric film. A flame-retardant layer is placed proximate to the second side of the array of rigid retroreflective elements. A fire-resistant polymer underlayer is attached to the flame-retardant layer. The five resistant polymer underlayer can be bonded to the transparent polymeric film through the array of rigid retroreflective elements and the flame-retardant layer.
摘要翻译：公开了具有刚性回射元件阵列的耐火逆反射结构和制造该结构的方法。回射结构由具有第一侧和第二侧的刚性回射元件的阵列形成。透明聚合物膜连接到刚性回射元件阵列的第一侧。透明耐火外层附着在透明聚合物膜上。将阻燃层放置成靠近刚性回射元件阵列的第二侧。耐火聚合物底层附着在阻燃层上。五个耐电聚合物底层可以通过刚性回射元件阵列和阻燃层结合到透明聚合物膜上。

18. 发明授权

US5831766A Retroreflective structure 失效
公开(公告)号：US5831766A
公开(公告)日：1998-11-03
申请号：US596805
申请日：1996-02-05
申请人： David C. Martin , Edward D. Phillips , William P. Rowland
发明人： David C. Martin , Edward D. Phillips , William P. Rowland
IPC分类号： B32B3/00 , G02B5/122 , G02B5/124
CPC分类号： G02B5/124 , Y10S428/913 , Y10T428/164 , Y10T428/24372 , Y10T428/24612
摘要： A retroreflective structure is described in which an array of transparent prisms is formed on a release coating of a sheet. The facet side of the prisms is made reflective and the prisms are either released to form a plurality of individual retroreflective structures or the array is adhered to a supporting substrate and then released from the base sheet. In the latter case, the array can be applied to a pre-existing structure formed of compatible fabrics, such as tarpaulins.

19. 发明授权

US5512219A Method of casting a microstructure sheet having an array of prism elements using a reusable polycarbonate mold 失效
标题翻译：使用可重复使用的聚碳酸酯模具铸造具有棱镜元件阵列的微结构片材的方法
公开(公告)号：US5512219A
公开(公告)日：1996-04-30
申请号：US253676
申请日：1994-06-03
申请人： William P. Rowland , David C. Martin
发明人： William P. Rowland , David C. Martin
IPC分类号： B29C33/38 , B29C33/42 , B29C33/56 , B29C39/14 , B29D11/00 , G02B5/124 , B29C33/40
CPC分类号： B29C33/56 , B29C33/3857 , B29C33/424 , B29C39/148 , B29D11/00605 , G02B5/124 , B29K2995/003
摘要： A durable reusable polymeric mold for casting a microstructure sheet having an array of prism elements and a method for forming the microstructure sheet are disclosed. A polymeric mold has a facet side and a base side including an array of prism elements upon which an radiation cured sheet can be formed. A protective surface layer can be formed on the facet side of the polymeric mold. The protective surface layer is sufficiently opaque to radiation to protect the polymeric mold from damage when the curable sheet is formed and is sufficiently bonded to the polymeric mold to allow the cured sheet to be removed from the protective surface layer while not substantially removing the protective surface layer from the polymeric mold. The microstructure sheet can be used as a retroreflective structure.
摘要翻译：公开了一种用于铸造具有棱镜元件阵列的微结构片的耐用的可重复使用的聚合物模具和用于形成微结构片材的方法。聚合物模具具有小面侧和底侧，其包括可以形成辐射固化片的棱镜元件阵列。可以在聚合物模具的小面上形成保护性表面层。保护性表面层与辐射完全不透明以保护聚合物模具免受损伤，当可固化片材形成时，并且充分粘合到聚合物模具上以允许固化片材从保护表面层移除，而基本不除去保护表面层。微结构片可用作回射结构。

20. 发明授权

US4801193A Retroreflective sheet material and method of making same 失效
标题翻译：逆反射片材及其制造方法
公开(公告)号：US4801193A
公开(公告)日：1989-01-31
申请号：US164184
申请日：1988-03-04
申请人： David C. Martin
发明人： David C. Martin
IPC分类号： G02B5/124 , G02B5/136
CPC分类号： G02B5/124 , Y10S359/90
摘要： A retroreflective sheeting has microretroreflective formations on one surface which are partially metallized and partially exposed to the atmosphere about them. It is produced by forming a coating on microprism surface, and this coating includes a thin metallic deposit over substantially the entire surface and a second coating material over only a portion of the surface. The coated surface is then exposed to a solvent to remove the coating from its predominant area and leave the metal deposit on only a minor portion of the area. A backing sheet is then applied over the microprisms and bonded to the retroreflective sheeting so as to leave an air interface about the predominant area of the microprisms. As a result, some light rays are retroreflected by the metal deposit and some are retroreflected by the atmosphere interface. The sheeting exhibits daytime whiteness over the bulk of its surface area.
摘要翻译：定向反光片在一个表面上具有微反射层，其部分金属化并且部分地暴露于围绕它们的气氛。其通过在微棱镜表面上形成涂层而产生，并且该涂层在基本上整个表面上包括薄的金属沉积物，并且仅在表面的一部分上包括第二涂层材料。然后将涂覆的表面暴露于溶剂以从其主要区域去除涂层，并将金属沉积物留在该区域的少部分上。然后将背衬片施加在微棱镜上并结合到回射片材上，以便在微棱镜的主要区域上留下空气界面。结果，一些光线被金属沉积物回射，一些光线被大气界面回射。该片材在其表面积的大部分表现出白天的白度。

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