专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US07109360B1 16-hydroxyestratrienes as selectively active estrogens 失效
标题翻译： 16-羟基三烯作为选择性活性雌激素
公开(公告)号：US07109360B1
公开(公告)日：2006-09-19
申请号：US09497891
申请日：2000-02-04
申请人： Hermann Kuenzer , Rudolf Knauthe , Monika Lessl , Karl-Heinrich Fritzemeier , Christa Hegele-Hartung , Ulf Boemer , Gerd Mueller , Dirk Kosemund
发明人： Hermann Kuenzer , Rudolf Knauthe , Monika Lessl , Karl-Heinrich Fritzemeier , Christa Hegele-Hartung , Ulf Boemer , Gerd Mueller , Dirk Kosemund
IPC分类号： C07J9/00 , C07J41/00
CPC分类号： A61K31/565 , C07J1/00 , C07J9/00 , C07J41/00
摘要： The invention describes new compounds as pharmaceutical active ingredients, which have in vitro a higher affinity to estrogen receptor preparations from rat prostates than to estrogen receptor preparations from rat uteri and in vivo a preferential action on bone rather than the uterus, their production, their therapeutic use and pharmaceutical dispensing forms that contain the new compounds.The new compounds are 16α- and 16β-hydroxy-estra-1,3,5(10)-estratrienes, which carry additional substituents on the steroid skeleton and can have one or more additional double bonds in the B-, C- and/or D-rings.
摘要翻译：本发明描述了作为药物活性成分的新化合物，其具有体外对来自大鼠前列腺的雌激素受体制剂的亲和力高于来自大鼠子宫的雌激素受体制剂，并且在体内对骨骼而不是子宫的优先作用，其产生，其治疗使用和含有新化合物的药物分配形式。新化合物是16α-和16beta-羟基 - 雌-1,3,5（10） - 三亚甲基，其在类固醇骨架上携带另外的取代基，并且可以在B-，C-和/ 或D形环。

12. 发明申请

US20050090477A1 Microbiological process for the production of 7-substituted 11-hydroxy steroids, 7,17-substituted 11-halogen steroids that can be produced therefrom, their process for production and use as well as pharmaceutical prepartions that contain these compounds, as well as 7-substituted estra-1,3,5(10)-trienses that can be produced therefrom 失效
标题翻译：用于生产7-取代的11-羟基类固醇，可由其制备的7,17-取代的11-卤素类固醇，其生产和使用方法以及含有这些化合物的药物制剂的微生物过程，以及7- 取代的雌-1,3,5（10） - 三核苷酸
公开(公告)号：US20050090477A1
公开(公告)日：2005-04-28
申请号：US10625559
申请日：2003-07-24
申请人： Ludwig Zorn , Rolf Bohlmann , Norbert Gallus , Hermann Kuenzer , Hans-Peter Muhn , Reinhard Nubbemeyer
发明人： Ludwig Zorn , Rolf Bohlmann , Norbert Gallus , Hermann Kuenzer , Hans-Peter Muhn , Reinhard Nubbemeyer
IPC分类号： C07J1/00 , C07J3/00 , C07J5/00 , C07J7/00 , C07J9/00 , C07J11/00 , C07J31/00 , C07J41/00 , C12P33/10 , C12P33/16
CPC分类号： C07J1/00 , C07J1/0051 , C07J3/00 , C07J5/00 , C07J7/00 , C07J9/00 , C07J11/00 , C07J31/00 , C07J41/00 , C12P33/10 , C12P33/16
摘要： A novel method of synthesis for the manufacture of upstream products for the production of compounds with general formulas 8, 10, and 12 is described. In this synthesis, compounds with general formula 4,B are produced in a microbiological reaction. The meanings of R7, R10, R11, R13, R17 and R17′ as well as of the grouping U-V-W-X-Y-Z are indicated in the claims.
摘要翻译：描述了用于制备用于生产具有通式8,10和12的化合物的上游产物的合成新方法。在该合成中，通式4的化合物B在微生物反应中产生。 R 7，R 10，R 11，R 13，R 17，R 17，R 17， SUP＆gt;和R＆lt; 17＆gt;以及分组UVWXYZ在权利要求中表示。

13. 发明申请

US20100207748A1 Method for Displaying Information 有权
标题翻译：显示信息的方法
公开(公告)号：US20100207748A1
公开(公告)日：2010-08-19
申请号：US12766299
申请日：2010-04-23
申请人： Armin DISTLER , Hermann KUENZER
发明人： Armin DISTLER , Hermann KUENZER
IPC分类号： B60Q1/00
CPC分类号： B60K37/06 , B60K35/00 , B60K2350/1012 , B60K2350/1016 , B60K2350/108
摘要： In a method for displaying information relating to the assignments of functions to a group of freely assignable operating keys in a motor vehicle, a first display step outputs for each operating key of the group a brief description of the respective function assignment, and a second display step outputs for a single selected operating key of the group a more detailed description. In the first display step, the brief descriptions of all operating keys of the group are output side-by-side into screen areas, which essentially are adjacent to each other, in an edge region of a display unit of the motor vehicle. In the second display step, the more detailed description is output into the same edge region of the same display unit such that the more detailed description covers the entire screen area of the brief description of the selected operating key, and the more detailed description at least partially covers the screen area of the brief description of at least one additional operating key.
摘要翻译：在一种用于向机动车辆中的一组可自由分配的操作键显示与功能分配相关的信息的方法中，第一显示步骤针对该组的每个操作键输出各个功能分配的简要描述，以及第二显示步骤输出为组中单个选定的操作键更详细的描述。在第一显示步骤中，在机动车辆的显示单元的边缘区域中，将组的所有操作键的简要描述并排地输出到彼此相邻的屏幕区域中。在第二显示步骤中，更详细的描述被输出到同一显示单元的相同边缘区域，使得更详细的描述覆盖所选操作键的简要描述的整个屏幕区域，并且至少更详细的描述部分地覆盖至少一个附加操作键的简要描述的屏幕区域。

14. 发明申请

US20090030010A1 3-Amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents 失效
标题翻译： 3-氨基 - 吡唑并[3,4b]吡啶作为蛋白酪氨酸激酶的抑制剂，其生产和用作药剂
公开(公告)号：US20090030010A1
公开(公告)日：2009-01-29
申请号：US11302307
申请日：2005-12-14
申请人： Wolfgang Schwede , Hermann Kuenzer , Antonius Ter Laak , Benjamin Bader , Roman Hillig , Ursula Moenning , Arndt Schmitz , Dieter Zopf
发明人： Wolfgang Schwede , Hermann Kuenzer , Antonius Ter Laak , Benjamin Bader , Roman Hillig , Ursula Moenning , Arndt Schmitz , Dieter Zopf
IPC分类号： A61K31/496 , C07D471/04 , C07D213/78 , A61K31/437
CPC分类号： C07D471/04 , C07D213/85
摘要： This invention relates to compounds of general formula I in which R1 and R2 are described in this application, the use of the compounds of general formula I as inhibitors of protein tyrosine kinases for treatment of various diseases as well as the compounds of general formulas II and III as intermediate compounds for the production of compounds of general formula I, whereby X, R1a and R2a have the meaning that is described in general formulas II and III.
摘要翻译：本发明涉及通式Ⅰ化合物，其中本申请中描述了R1和R2，通式I化合物用作蛋白酪氨酸激酶抑制剂用于治疗各种疾病以及通式II和 III为制备通式I化合物的中间体化合物，其中X，R 1a和R 2a具有通式II和III所述的含义。

15. 发明授权

US07262023B2 Microbiological process for the production of 7-substituted 11-hydroxy steroids, 7,17-substituted 11-Halogen steroids and uses thereof 失效
标题翻译：用于生产7-取代的11-羟基类固醇，7,17-取代的11-卤素类固醇的微生物过程及其用途
公开(公告)号：US07262023B2
公开(公告)日：2007-08-28
申请号：US10625559
申请日：2003-07-24
申请人： Ludwig Zorn , Rolf Bohlmann , Norbert Gallus , Hermann Kuenzer , Hans-Peter Muhn , Reinhard Nubbemeyer
发明人： Ludwig Zorn , Rolf Bohlmann , Norbert Gallus , Hermann Kuenzer , Hans-Peter Muhn , Reinhard Nubbemeyer
IPC分类号： C12P33/10
CPC分类号： C07J1/00 , C07J1/0051 , C07J3/00 , C07J5/00 , C07J7/00 , C07J9/00 , C07J11/00 , C07J31/00 , C07J41/00 , C12P33/10 , C12P33/16
摘要： A novel method of synthesis for the manufacture of upstream products for the production of compounds with general formulas 8, 10, and 12 is described. In this synthesis, compounds with general formula 4,B are produced in a microbiological reaction. The meanings of R7, R10, R11, R13, R17 and R17′ as well as of the grouping U—V—W—X—Y—Z are indicated in the claims
摘要翻译：描述了用于制备用于生产具有通式8,10和12的化合物的上游产物的合成新方法。在该合成中，通式4的化合物B在微生物反应中产生。 R 7，R 10，R 11，R 13，R 17，R 17，R 17， SUP＆gt;和R＆lt; 17＆gt;以及分组UVWXYZ在权利要求中表示

16. 发明申请

US20060252737A1 18-Methyl-19-nor-17-pregn-4-ene-21,17-carbolactones, as well as pharmaceutical preparations that contain the latter 失效
标题翻译： 18-甲基-19-去甲-17-孕-4-烯-21,17-碳内酯，以及含有后者的药物制剂
公开(公告)号：US20060252737A1
公开(公告)日：2006-11-09
申请号：US11321449
申请日：2005-12-30
申请人： Rolf Bohlmann , Dieter Bittler , Hermann Kuenzer , Peter Esperling , Hans-Peter Muhn , Karl-Heinrich Fritzemeier , Ulrike Fuhrmann , Katja Prelle , Steffen Borden
发明人： Rolf Bohlmann , Dieter Bittler , Hermann Kuenzer , Peter Esperling , Hans-Peter Muhn , Karl-Heinrich Fritzemeier , Ulrike Fuhrmann , Katja Prelle , Steffen Borden
IPC分类号： A61K31/58 , C07J19/00
CPC分类号： C07J19/00
摘要： This invention describes the new 18-methyl-19-nor-17-pregn-4-ene-21,17-carbolactones of general formula I in which Z means an oxygen atom, two hydrogen atoms, a grouping ═NOR or ═NNHSO2R, whereby R is a hydrogen atom or a straight-chain or branched-chain alkyl group with 1 to 4 or 3 to 4 carbon atoms, R4 is a hydrogen atom, a halogen atom, a methyl group, or a trifluoromethyl group, R6 and/or R7 can be in α- or β-position, and, independently of one another, mean a straight-chain or branched-chain alkyl group with 1 to 4 or 3 to 4 carbon atoms, or R6 means a hydrogen atom, and R7 means an α- or β-position, straight-chain or branched-chain alkyl group with 1 to 4 or 3 to 4 carbon atoms, or R6 and R7 each mean a hydrogen atom, or R6 and R7 together mean an α- or β-position methylene group or an additional bond. The new compounds have gestagenic and anti-mineralocorticoid action and are suitable for the production of pharmaceutical preparations, for example for oral contraception and the treatment of pre-, peri- and post-menopausal symptoms.
摘要翻译：本发明描述了通式I的新的18-甲基-19-去甲-17-孕甾-4-烯-21,17-碳内酯，其中Z表示氧原子，两个氢原子，-NOR或-NNHSO- R 2是氢原子或具有1至4或3至4个碳原子的直链或支链烷基，R 4是氢原子，卤素原子，甲基或三氟甲基，R 6和/或R 7可以是α-或β-位，并且独立地为一个另一个是指具有1至4或3至4个碳原子的直链或支链烷基，或R 6表示氢原子，R 7表示具有1至4或3至4个碳原子的α-或β-位的直链或支链烷基，或R 6和R 7各自表示氢原子或R 6和R 7一起是指α-或β-位亚甲基或另外的键。新化合物具有孕激素和抗盐皮质激素的作用，并且适用于制备药物制剂，例如用于口服避孕和治疗绝经前，绝经期和绝经后症状。

17. 发明申请

US20050182081A1 Benzocycloheptenes, process for their production, pharmaceutical preparations that contain the latter as well as their use for the production of pharmaceutical agents 失效
标题翻译：苯并环庚三烯，其生产方法，含有后者的药物制剂及其制备药剂的用途
公开(公告)号：US20050182081A1
公开(公告)日：2005-08-18
申请号：US11102840
申请日：2005-04-11
申请人： Rolf Bohlmann , Jorg Kroll , Hermann Kuenzer , Christa Hegele-Hartung , Monika Lessl , Rosemarie Lichtner , Yukishige Nishino
发明人： Rolf Bohlmann , Jorg Kroll , Hermann Kuenzer , Christa Hegele-Hartung , Monika Lessl , Rosemarie Lichtner , Yukishige Nishino
IPC分类号： A61K31/10 , A61K31/133 , A61K31/135 , A61K31/165 , A61K31/341 , A61K31/381 , A61K31/4402 , A61P5/32 , A61P15/00 , A61P19/00 , A61P19/10 , C07C43/215 , C07C43/225 , C07C217/18 , C07C217/20 , C07C217/28 , C07C317/18 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C323/60 , C07C327/28 , C07D213/32 , C07D213/34 , C07D307/38 , C07D333/18 , A61K31/44 , A61K31/40
CPC分类号： C07D307/38 , C07C217/20 , C07C317/18 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C323/60 , C07C327/28 , C07C2602/12 , C07D213/32 , C07D213/34 , C07D333/18
摘要： Benzocycloheptenes of formula (I), in which R1, R2 and Y have the meanings that indicated herein, exhibit selective estrogenic activity on bones and are suitable for the production of pharmaceutical agents, especially for prophylaxis and therapy of osteoporosis:
摘要翻译：其中R 1，R 2，R 2和Y具有本文所表示的含义的式（I）的苯并环庚烯在骨上显示出选择性雌激素活性，并且适用于生产药剂，特别是预防和治疗骨质疏松症：

18. 发明授权

US07977325B2 3-amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents 失效
标题翻译： 3-氨基 - 吡唑并[3,4b]吡啶作为蛋白酪氨酸激酶的抑制剂，其生产和用作药剂
公开(公告)号：US07977325B2
公开(公告)日：2011-07-12
申请号：US11302307
申请日：2005-12-14
申请人： Wolfgang Schwede , Hermann Kuenzer , Antonius Ter Laak , Benjamin Bader , Roman Hillig , Ursula Moenning , Arndt Schmitz , Dieter Zopf
发明人： Wolfgang Schwede , Hermann Kuenzer , Antonius Ter Laak , Benjamin Bader , Roman Hillig , Ursula Moenning , Arndt Schmitz , Dieter Zopf
IPC分类号： A61K31/497 , A61K31/44 , C07D401/00 , C07D515/02
CPC分类号： C07D471/04 , C07D213/85
摘要： This invention relates to compounds of general formula I in which R1 and R2 are described in this application, the use of the compounds of general formula I as inhibitors of protein tyrosine kinases for treatment of various diseases as well as the compounds of general formulas II and III as intermediate compounds for the production of compounds of general formula I, wherein X, R1a and R2a have the meaning that is described in general formulas II and III.
摘要翻译：本发明涉及通式Ⅰ化合物，其中本申请中描述了R1和R2，通式I化合物用作蛋白酪氨酸激酶抑制剂用于治疗各种疾病以及通式II和 III作为制备通式I化合物的中间体化合物，其中X，R 1a和R 2a具有通式II和III所述的含义。

19. 发明授权

US07361645B2 Androgenic 7-substituted 11-halogen steroids 失效
标题翻译：雄激素7-取代的11-卤素类固醇
公开(公告)号：US07361645B2
公开(公告)日：2008-04-22
申请号：US10467352
申请日：2002-01-24
申请人： Rolf Bohlmann , Hermann Kuenzer , Reinhard Nubbemeyer , Dieter Zopf
发明人： Rolf Bohlmann , Hermann Kuenzer , Reinhard Nubbemeyer , Dieter Zopf
IPC分类号： A61K31/56 , C07J1/00
CPC分类号： C07J1/0074 , C07J1/0022 , C07J1/0025 , C07J1/007
摘要： The invention relates to 11β-halogen steroids with general formula (I), whereby R11 is halogen, X—Y-Z represents a group with one of the two structures CH═C—C or CH2—C═C and the other radicals have the meaning that is indicated in the claims, also the production and use of these compounds for the production of pharmaceutical agents as well as pharmaceutical preparations that contain 11β-halogen steroids.
摘要翻译：本发明涉及具有通式（I）的11b-卤素类固醇，其中R 11是卤素，XYZ代表具有两个结构之一的CH-CC或CH 2 2的基团 > -CC，其它基团具有权利要求书中所示的含义，以及这些化合物用于生产药物的生产和使用以及含有11b-卤素类固醇的药物制剂。

20. 发明申请

US20070298456A1 Microbiological process for the production of 7-substitued 11-hydroxy steroids, 7,17-substituted 11-halogen steroids, and uses thereof 审中-公开
标题翻译：用于制备7-取代的11-羟基类固醇，7,17-取代的11-卤素类固醇的微生物过程及其用途
公开(公告)号：US20070298456A1
公开(公告)日：2007-12-27
申请号：US11826633
申请日：2007-07-17
申请人： Lud-wig Zorn , Rolf Bohlmann , Norbert Gallus , Hermann Kuenzer , Hans-Peter Muhn , Reinhard Nubbemeyer
发明人： Lud-wig Zorn , Rolf Bohlmann , Norbert Gallus , Hermann Kuenzer , Hans-Peter Muhn , Reinhard Nubbemeyer
IPC分类号： C12P33/00
CPC分类号： C07J1/00 , C07J1/0051 , C07J3/00 , C07J5/00 , C07J7/00 , C07J9/00 , C07J11/00 , C07J31/00 , C07J41/00 , C12P33/10 , C12P33/16
摘要： A novel method of synthesis for the manufacture of upstream products for the production of compounds with general formulas 8, 10, and 12 is described. In this synthesis, compounds with general formula 4,B are produced in a microbiological reaction. The meanings of R7, R10, R11, R13, R17 and R17′ as well as of the grouping U—V—W—X—Y-Z are indicated in the claims.
摘要翻译：描述了用于制备用于生产具有通式8,10和12的化合物的上游产物的合成新方法。在该合成中，通式4的化合物B在微生物反应中产生。 R 7，R 10，R 11，R 13，R 17，R 17，R 17， SUP＆gt;和R＆lt; 17＆gt;以及分组UVWXYZ在权利要求中表示。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式